Frontiers in Genetics,
Journal Year:
2022,
Volume and Issue:
13
Published: Sept. 27, 2022
Systemic
therapy
is
one
of
the
most
significant
cancer
treatments.
However,
drug
resistance
often
appears
and
has
become
primary
cause
failure.
Regulation
target,
metabolism
efflux,
cell
death
escape
(apoptosis,
autophagy,
et
al.),
epigenetic
changes,
many
other
variables
are
complicatedly
involved
in
mechanisms
resistance.
In
various
types
cancers,
long
non-coding
RNA
H19
(lncRNA
H19)
been
shown
to
play
critical
roles
tumor
development,
proliferation,
metastasis,
multiple
as
well.
The
efficacy
chemotherapy,
endocrine
therapy,
targeted
all
influenced
by
expression
H19,
especially
breast
cancer,
liver
lung
colorectal
cancer.
Here,
we
summarize
relationship
between
lncRNA
tumorigenesis,
illustrate
caused
This
review
may
provide
more
therapeutic
potential
targets
for
future
Journal of Experimental & Clinical Cancer Research,
Journal Year:
2022,
Volume and Issue:
41(1)
Published: July 1, 2022
Abstract
Background
One
of
the
most
malignant
tumors
in
men
is
prostate
cancer
that
still
incurable
due
to
its
heterogenous
and
progressive
natures.
Genetic
epigenetic
changes
play
significant
roles
development.
The
RNA
molecules
with
more
than
200
nucleotides
length
are
known
as
lncRNAs
these
factors
do
not
encode
protein.
They
regulate
gene
expression
at
transcriptional,
post-transcriptional
levels.
LncRNAs
vital
biological
functions
cells
pathological
events,
hence
their
undergoes
dysregulation.
Aim
review
role
alterations
development
emphasized
here.
Therefore,
were
chosen
for
this
purpose
level
interaction
other
signaling
networks
progression
examined.
Key
scientific
concepts
aberrant
has
been
well-documented
rate
tumor
regulated
via
affecting
STAT3,
NF-κB,
Wnt,
PI3K/Akt
PTEN,
among
molecular
pathways.
Furthermore,
radio-resistance
chemo-resistance
features
cells.
Overexpression
tumor-promoting
such
HOXD-AS1
CCAT1
can
result
drug
resistance.
Besides,
induce
immune
evasion
upregulating
PD-1.
Pharmacological
compounds
quercetin
curcumin
have
applied
targeting
lncRNAs.
siRNA
tool
reduce
thereby
suppressing
progression.
Prognosis
diagnosis
clinical
course
be
evaluated
by
exosomal
lncRNA-p21
investigated
serum
patients
a
reliable
biomarker.
Urological
cancers
are
among
the
most
common
malignancies
around
world.
In
particular,
bladder
cancer
severely
threatens
human
health
due
to
its
aggressive
and
heterogeneous
nature.
Various
therapeutic
modalities
have
been
considered
for
treatment
of
although
prognosis
remains
unfavorable.
It
is
perceived
that
depends
on
an
interdisciplinary
approach
combining
biology
engineering.
The
nanotechnological
approaches
introduced
in
various
cancers,
especially
cancer.
current
review
aims
emphasize
highlight
possible
applications
nanomedicine
eradication
tumor.
Nanoparticles
can
improve
efficacy
drugs
therapy
through
elevating
their
bioavailability.
potential
genetic
tools
such
as
siRNA
miRNA
gene
expression
regulation
be
boosted
using
nanostructures
by
facilitating
internalization
accumulation
at
tumor
sites
cells.
provide
photodynamic
photothermal
ROS
overgeneration
hyperthermia,
respectively,
suppression
Furthermore,
remodeling
microenvironment
infiltration
immune
cells
purpose
immunotherapy
achieved
cargo-loaded
nanocarriers.
Nanocarriers
mainly
internalized
endocytosis,
proper
design
smart
nanoparticles
pH-,
redox-,
light-responsive
nanocarriers
importance
targeted
therapy.
Bladder
biomarkers
detected
timely
diagnosis
patients.
Based
site,
they
employed
imaging.
clinical
translation
challenges
also
covered
review.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
158, P. 114204 - 114204
Published: Jan. 4, 2023
Glioblastoma
(GBM)
is
one
of
the
most
malignant
cancers
central
nervous
system
and
due
to
its
sensitive
location,
surgical
resection
has
high
risk
therefore,
chemotherapy
radiotherapy
are
utilized
for
treatment.
However,
chemoresistance
radio-resistance
other
problems
in
GBM
Hence,
new
therapies
based
on
genes
recommended
treatment
GBM.
PTEN
a
tumor-suppressor
operator
cancer
that
inhibits
PI3K/Akt/mTOR
axis
diminishing
growth,
metastasis
drug
resistance.
In
current
review,
function
PTEN/PI3K/Akt
progression
evaluated.
Mutation
or
depletion
leads
increase
progression.
Low
expression
level
mediates
poor
prognosis
by
increasing
proliferation
invasion,
promotes
malignancy
tumor
cells.
Moreover,
loss
signaling
can
result
therapy
resistance
Activation
impairs
metabolism
via
glycolysis
inhibition.
contrast
PTEN,
PI3K/Akt
oncogenic
during
progression,
enhances.
shows
positive
association
with
pathways
similar
signaling,
regulated
non-coding
RNAs.
upregulation
inhibition
anti-cancer
agents
be
beneficial
interfering
This
review
emphasizes
networks
related
provides
insights
targeting
this
effective
Pharmacological Research,
Journal Year:
2023,
Volume and Issue:
194, P. 106822 - 106822
Published: June 17, 2023
Pancreatic
cancer
(PC)
is
a
serious
gastrointestinal
tract
disease
for
which
the
5-year
survival
rate
less
than
10%,
even
in
developed
countries
such
as
USA.
The
genomic
profile
alterations
and
dysregulated
biological
mechanisms
commonly
occur
PC.
Macroautophagy/autophagy
cell
death
process
that
maintained
at
basal
level
physiological
conditions,
whereas
its
often
changes
during
tumorigenesis.
function
of
autophagy
human
cancers
dual
can
be
oncogenic
onco-suppressor.
Autophagy
potent
controller
tumorigenesis
supportive
PC
escalates
growth
cells
suppression
mediate
death.
also
determines
metastasis
cells,
it
control
EMT
affecting
migration.
Moreover,
starvation
hypoxia
stimulate
glycolysis,
glycolysis
induction
mediated
by
enhancing
Furthermore,
protective
stimulates
drug
resistance
gemcitabine
inhibition
enhance
radiosensitivity.
degrade
MHC-I
to
immune
evasion
regulates
polarization
macrophages
tumor
microenvironment.
Modulation
activity
provided
silibinin,
ursolic
acid,
chrysin
huaier
treatment
Non-coding
RNAs
are
controllers
improve
therapy
response
patients.
mitophagy
shows
dysregulation
PC,
proliferation
cells.
Therefore,
bioinformatics
analysis
demonstrates
autophagy-related
proteins
genes
biomarkers.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(4), P. 3521 - 3521
Published: Feb. 9, 2023
Glioblastoma
multiforme
(GBM)
is
the
most
common,
malignant,
poorly
promising
primary
brain
tumor.
GBM
characterized
by
an
infiltrating
growth
nature,
abundant
vascularization,
and
a
rapid
aggressive
clinical
course.
For
many
years,
standard
treatment
of
gliomas
has
invariably
been
surgical
supported
radio-
chemotherapy.
Due
to
location
significant
resistance
conventional
therapies,
prognosis
glioblastoma
patients
very
poor
cure
rate
low.
The
search
for
new
therapy
targets
effective
therapeutic
tools
cancer
current
challenge
medicine
science.
microRNAs
(miRNAs)
play
key
role
in
cellular
processes,
such
as
growth,
differentiation,
cell
division,
apoptosis,
signaling.
Their
discovery
was
breakthrough
diagnosis
diseases.
Understanding
structure
miRNAs
may
contribute
understanding
mechanisms
regulation
dependent
on
miRNA
pathogenesis
diseases
underlying
these
short
non-coding
RNAs,
including
glial
tumors.
This
paper
provides
detailed
review
latest
reports
relationship
between
changes
expression
individual
formation
development
gliomas.
use
this
also
discussed.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
160, P. 114392 - 114392
Published: Feb. 15, 2023
Prostate
cancer
is
among
most
malignant
tumors
around
the
world
and
this
urological
tumor
can
be
developed
as
result
of
genomic
mutations
their
accumulation
during
progression
towards
advanced
stage.
Due
to
lack
specific
symptoms
in
early
stages
prostate
cancer,
patients
are
diagnosed
that
cells
display
low
response
chemotherapy.
Furthermore,
enhance
aggressiveness
cells.
Docetaxel
paclitaxel
suggested
well-known
compounds
for
chemotherapy
they
possess
a
similar
function
therapy
based
on
inhibiting
depolymerization
microtubules,
impairing
balance
microtubules
subsequent
delay
cell
cycle
progression.
The
aim
current
review
highlight
mechanisms
docetaxel
resistance
cancer.
When
oncogenic
factors
such
CD133
upregulation
PTEN
tumor-suppressor
shows
decrease
expression,
malignancy
enhances
induce
drug
resistance.
phytochemicals
anti-tumor
have
been
utilized
suppressing
chemoresistance
Naringenin
lovastatin
used
enhancing
sensitivity.
Moreover,
nanostructures
polymeric
micelles
nanobubbles
delivery
decreasing
risk
development.
These
subjects
highlighted
provide
new
insight
reversing
Journal of Cancer,
Journal Year:
2024,
Volume and Issue:
15(7), P. 1916 - 1928
Published: Jan. 1, 2024
Background:
Accumulating
evidence
indicates
that
non-coding
RNAs
(ncRNA),
including
long
(lncRNAs)
and
circular
(circRNAs),
can
function
as
competitive
endogenous
(ceRNAs)
by
binding
to
microRNAs
(miRNAs)
regulating
host
gene
expression
at
the
transcriptional
or
post-transcriptional
level.Dysregulation
in
ceRNA
network
regulation
has
been
implicated
occurrence
development
of
cancer.However,
lncRNA/circRNA-miRNA-mRNA
regulatory
is
still
lacking
nasopharyngeal
carcinoma
(NPC).Methods:
Differentially
expressed
genes
(DEGs)
were
obtained
from
our
previous
sequencing
data
Gene
Expression
Omnibus
(GEO).Gene
Ontology
(GO)
Kyoto
Encyclopedia
Genes
Genomes
pathway
(KEGG)
used
explore
biological
functions
these
common
DEGs.Through
a
series
bioinformatic
analyses,
was
established.In
additional,
external
GSE102349
test
prognostic
value
hub
mRNAs
through
Kaplan-Meier
method.Results:
We
successfully
constructed
NPC,
consisting
16
lncRNAs,
6
miRNAs,
3
circRNAs
10
found
three
(TOP2A,
ZWINT,
TTK)
significantly
associated
with
overall
survival
time
(OS)
patients.
Conclusion:The
revealed
this
study
may
help
comprehensively
elucidate
mechanisms
driving
provide
novel
candidate
biomarkers
for
evaluating
prognosis
NPC.
