The spread of antibiotic resistance to humans and potential protection strategies

Ecotoxicology and Environmental Safety, Год журнала: 2023, Номер 254, С. 114734 - 114734

Опубликована: Март 10, 2023

Antibiotic resistance is currently one of the greatest threats to human health. Widespread use and residues antibiotics in humans, animals, environment can exert selective pressure on antibiotic bacteria (ARB) gene (ARG), accelerating flow resistance. As ARG spreads population, burden humans increases, which may have potential health effects people. Therefore, it critical mitigate spread reduce load humans. This review briefly described information global consumption national action plans (NAPs) combat provided a set feasible control strategies for transmission ARB three areas including (a) Reducing colonization capacity exogenous ARB, (b) Enhancing mitigating horizontal transfer (HGT) ARG, (c) Reversing With hope achieving interdisciplinary one-health prevention bacterial

Язык: Английский

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Metagenomics: An Effective Approach for Exploring Microbial Diversity and Functions

Foods, Год журнала: 2023, Номер 12(11), С. 2140 - 2140

Опубликована: Май 25, 2023

Various fields have been identified in the "omics" era, such as genomics, proteomics, transcriptomics, metabolomics, phenomics, and metagenomics. Among these, metagenomics has enabled a significant increase discoveries related to microbial world. Newly discovered microbiomes different ecologies provide meaningful information on diversity functions of microorganisms Earth. Therefore, results metagenomic studies new microbe-based applications human health, agriculture, food industry, among others. This review summarizes fundamental procedures recent advances bioinformatic tools. It also explores up-to-date study, plant research, environmental sciences, other fields. Finally, is powerful tool for studying world, it still numerous that are currently hidden awaiting discovery. this discusses future perspectives

Язык: Английский

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Recovering metagenome-assembled genomes from shotgun metagenomic sequencing data: Methods, applications, challenges, and opportunities

Microbiological Research, Год журнала: 2022, Номер 260, С. 127023 - 127023

Опубликована: Апрель 9, 2022

Язык: Английский

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Airborne bacterial community and antibiotic resistome in the swine farming environment: Metagenomic insights into livestock relevance, pathogen hosts and public risks

Environment International, Год журнала: 2023, Номер 172, С. 107751 - 107751

Опубликована: Янв. 13, 2023

Globally extensive use of antibiotics has accelerated antimicrobial resistance (AMR) in the environment. As one biggest antibiotic consumers, livestock farms are hotspots AMR prevalence, especially those atmosphere can transmit over long distances and pose inhalation risks to public. Here, we collected total suspended particulates swine ambient air an intensive farming area. Bacterial communities resistomes were analyzed using amplicon metagenomic sequencing approaches. exposure potential human-pathogenic antibiotic-resistant bacteria (HPARB) subsequently estimated with comparison reported hospital samples. The results show that shaped airborne bacterial community by increasing abundances, reducing diversities shifting compositions. Swine feces contributed 77% farm air, about 35% air. Airborne mainly conferred tetracyclines, aminoglycosides lincosamides, 48% originated from feces. Distinct Firmicutes dominant environments conditional pathogens including Clostridium, Streptococcus Aerococcus being major hosts genes (ARGs). Therein, genomes S. alactolyticus carrying (transposase/recombinase-associated) ARGs virulence factor retrieved metagenomes all samples, but they not detected any This suggests indication hazards human health. faced higher than intake HPARB a worker was three orders magnitude person who works hospital. Consequently, this study depicted atmospheric transmission

Язык: Английский

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Metagenomic surveillance of antibiotic resistome in influent and effluent of wastewater treatment plants located on the Qinghai-Tibetan Plateau

The Science of The Total Environment, Год журнала: 2023, Номер 870, С. 162031 - 162031

Опубликована: Фев. 4, 2023

Язык: Английский

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Antibiotic-Induced Recruitment of Specific Algae-Associated Microbiome Enhances the Adaptability of Chlorella vulgaris to Antibiotic Stress and Incidence of Antibiotic Resistance

Environmental Science & Technology, Год журнала: 2023, Номер 57(36), С. 13336 - 13345

Опубликована: Авг. 29, 2023

Insights into the symbiotic relation between eukaryotic hosts and their microbiome lift curtain on crucial roles of microbes in host fitness, behavior, ecology. However, it remains unclear whether how abiotic stress shapes further affects adaptability. This study first investigated effect antibiotic exposure behavior across varying algae taxa at community level. Chlorophyta, particular Chlorella vulgaris, exhibited remarkable adaptability to stress, leading dominance phytoplankton communities. Accordingly, we isolated C. vulgaris strains compared growth axenic nonaxenic ones under conditions. The positive antibiotics algal were apparent only presence bacteria. Results 16S rRNA sequencing revealed that challenges resulted recruitment specific bacterial consortia phycosphere, whose functions tightly linked promotion enhancement. In addition, phycosphere was characterized with 47-fold higher enrichment capability resistance genes (ARGs) than surrounding water. Under ARG profiles recruited presumably driven by assembly mobile genetic elements induced antibiotics. Moreover, even enhanced dissemination potential bacteria carrying ARGs from broader environmental niches. Overall, this provides an in-depth understanding functional significance antibiotic-mediated algae-associated for proliferation antibiotic-polluted waters.

Язык: Английский

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Dissemination of antibiotic resistance genes from aboveground sources to groundwater in livestock farms

Water Research, Год журнала: 2024, Номер 256, С. 121584 - 121584

Опубликована: Апрель 9, 2024

Язык: Английский

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Airborne antibiotic resistome and microbiome in pharmaceutical factories

Environment International, Год журнала: 2024, Номер 186, С. 108639 - 108639

Опубликована: Апрель 1, 2024

Antimicrobial resistance is considered to be one of the biggest public health problems, and airborne transmission an important but under-appreciated pathway for spread antibiotic genes (ARGs) in environment. Previous research has shown pharmaceutical factories a major source ARGs resistant bacteria (ARB) surrounding receiving water soil environments. Pharmaceutical are hotspots resistance, atmospheric its environmental risk remain more concerns. Here, we conducted metagenomic investigation into microbiome resistome three China. Soil (average: 38.45 %) wastewater 28.53 were contributors resistome. (vanR/vanS, blaOXA, CfxA) conferring critically clinically used antibiotics identified air samples. The treatment area had significantly higher relative abundances 0.64 copies/16 s rRNA). Approximately 28.2 % detected found associated with plasmids, this increased about 50 area. We have compiled list high-risk factories. Moreover, A total 1,043 viral operational taxonomic units linked 47 family-group taxa. Different CRISPR-Cas immune systems been bacterial hosts response phage infection. Similarly, abundance 2451.70 PPM) was Our data provide insights gene profiles (bacterial non-bacterial) reveal potential role horizontal transfer ARGs, implications human animal health.

Язык: Английский

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Unveiling soil-borne antibiotic resistome and their associated risks: A comparative study of antibiotic and non-antibiotic pharmaceutical factories

Journal of Hazardous Materials, Год журнала: 2025, Номер 486, С. 137127 - 137127

Опубликована: Янв. 5, 2025

Язык: Английский

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Critical review of antibiotic resistance genes in the atmosphere

Environmental Science Processes & Impacts, Год журнала: 2022, Номер 24(6), С. 870 - 883

Опубликована: Янв. 1, 2022

Our critical review compares ARG profiles in the atmosphere across different locations and discusses characterization methods, atmospheric transport, future research questions.

Язык: Английский

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