Antimicrobial Resistance Genes (ARGs), the Gut Microbiome, and Infant Nutrition DOI Open Access
Rufus J. Theophilus, Diana H. Taft

Nutrients, Journal Year: 2023, Volume and Issue: 15(14), P. 3177 - 3177

Published: July 18, 2023

The spread of antimicrobial resistance genes (ARGs) is a major public health crisis, with the ongoing ARGs leading to reduced efficacy antibiotic treatments. gut microbiome key reservoir for ARGs, and because diet shapes microbiome, also has potential shape resistome. This diet-gut microbiome-resistome relationship may be important in infants young children. narrative review examines what known about interaction between infant resistome, nutrition, including exploring mitigate ARG carriage. While more research needed, reduce toddler carriage an goal as part maintaining available antibiotics preserving health.

Language: Английский

The spread of antibiotic resistance to humans and potential protection strategies DOI Creative Commons
Dong Ding, Bin Wang, Xiaoan Zhang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 254, P. 114734 - 114734

Published: March 10, 2023

Antibiotic resistance is currently one of the greatest threats to human health. Widespread use and residues antibiotics in humans, animals, environment can exert selective pressure on antibiotic bacteria (ARB) gene (ARG), accelerating flow resistance. As ARG spreads population, burden humans increases, which may have potential health effects people. Therefore, it critical mitigate spread reduce load humans. This review briefly described information global consumption national action plans (NAPs) combat provided a set feasible control strategies for transmission ARB three areas including (a) Reducing colonization capacity exogenous ARB, (b) Enhancing mitigating horizontal transfer (HGT) ARG, (c) Reversing With hope achieving interdisciplinary one-health prevention bacterial

Language: Английский

Citations

110

Metagenomics: An Effective Approach for Exploring Microbial Diversity and Functions DOI Creative Commons
Nguyễn Nhật Nam, Hoang Dang Khoa, Kieu The Loan Trinh

et al.

Foods, Journal Year: 2023, Volume and Issue: 12(11), P. 2140 - 2140

Published: May 25, 2023

Various fields have been identified in the "omics" era, such as genomics, proteomics, transcriptomics, metabolomics, phenomics, and metagenomics. Among these, metagenomics has enabled a significant increase discoveries related to microbial world. Newly discovered microbiomes different ecologies provide meaningful information on diversity functions of microorganisms Earth. Therefore, results metagenomic studies new microbe-based applications human health, agriculture, food industry, among others. This review summarizes fundamental procedures recent advances bioinformatic tools. It also explores up-to-date study, plant research, environmental sciences, other fields. Finally, is powerful tool for studying world, it still numerous that are currently hidden awaiting discovery. this discusses future perspectives

Language: Английский

Citations

63

Recovering metagenome-assembled genomes from shotgun metagenomic sequencing data: Methods, applications, challenges, and opportunities DOI Creative Commons
Yunyan Zhou, Min Liu,

Jiawen Yang

et al.

Microbiological Research, Journal Year: 2022, Volume and Issue: 260, P. 127023 - 127023

Published: April 9, 2022

Language: Английский

Citations

43

Airborne bacterial community and antibiotic resistome in the swine farming environment: Metagenomic insights into livestock relevance, pathogen hosts and public risks DOI Creative Commons
Fang-Zhou Gao,

Liang-Ying He,

Hong Bai

et al.

Environment International, Journal Year: 2023, Volume and Issue: 172, P. 107751 - 107751

Published: Jan. 13, 2023

Globally extensive use of antibiotics has accelerated antimicrobial resistance (AMR) in the environment. As one biggest antibiotic consumers, livestock farms are hotspots AMR prevalence, especially those atmosphere can transmit over long distances and pose inhalation risks to public. Here, we collected total suspended particulates swine ambient air an intensive farming area. Bacterial communities resistomes were analyzed using amplicon metagenomic sequencing approaches. exposure potential human-pathogenic antibiotic-resistant bacteria (HPARB) subsequently estimated with comparison reported hospital samples. The results show that shaped airborne bacterial community by increasing abundances, reducing diversities shifting compositions. Swine feces contributed 77% farm air, about 35% air. Airborne mainly conferred tetracyclines, aminoglycosides lincosamides, 48% originated from feces. Distinct Firmicutes dominant environments conditional pathogens including Clostridium, Streptococcus Aerococcus being major hosts genes (ARGs). Therein, genomes S. alactolyticus carrying (transposase/recombinase-associated) ARGs virulence factor retrieved metagenomes all samples, but they not detected any This suggests indication hazards human health. faced higher than intake HPARB a worker was three orders magnitude person who works hospital. Consequently, this study depicted atmospheric transmission

Language: Английский

Citations

32

Metagenomic surveillance of antibiotic resistome in influent and effluent of wastewater treatment plants located on the Qinghai-Tibetan Plateau DOI
Bin Shi, Renxin Zhao,

Guijin Su

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 870, P. 162031 - 162031

Published: Feb. 4, 2023

Language: Английский

Citations

28

Antibiotic-Induced Recruitment of Specific Algae-Associated Microbiome Enhances the Adaptability of Chlorella vulgaris to Antibiotic Stress and Incidence of Antibiotic Resistance DOI
Xue Xue,

Xiaoyue Su,

Linjun Zhou

et al.

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(36), P. 13336 - 13345

Published: Aug. 29, 2023

Insights into the symbiotic relation between eukaryotic hosts and their microbiome lift curtain on crucial roles of microbes in host fitness, behavior, ecology. However, it remains unclear whether how abiotic stress shapes further affects adaptability. This study first investigated effect antibiotic exposure behavior across varying algae taxa at community level. Chlorophyta, particular Chlorella vulgaris, exhibited remarkable adaptability to stress, leading dominance phytoplankton communities. Accordingly, we isolated C. vulgaris strains compared growth axenic nonaxenic ones under conditions. The positive antibiotics algal were apparent only presence bacteria. Results 16S rRNA sequencing revealed that challenges resulted recruitment specific bacterial consortia phycosphere, whose functions tightly linked promotion enhancement. In addition, phycosphere was characterized with 47-fold higher enrichment capability resistance genes (ARGs) than surrounding water. Under ARG profiles recruited presumably driven by assembly mobile genetic elements induced antibiotics. Moreover, even enhanced dissemination potential bacteria carrying ARGs from broader environmental niches. Overall, this provides an in-depth understanding functional significance antibiotic-mediated algae-associated for proliferation antibiotic-polluted waters.

Language: Английский

Citations

28

Dissemination of antibiotic resistance genes from aboveground sources to groundwater in livestock farms DOI

Liusheng Lei,

Nan Chen, Zeyou Chen

et al.

Water Research, Journal Year: 2024, Volume and Issue: 256, P. 121584 - 121584

Published: April 9, 2024

Language: Английский

Citations

10

Sources, compositions, spatio-temporal distributions, and human health risks of bioaerosols: A review DOI

Xinyuan Feng,

Xianghua Xu,

Xuewen Yao

et al.

Atmospheric Research, Journal Year: 2024, Volume and Issue: 305, P. 107453 - 107453

Published: April 30, 2024

Language: Английский

Citations

10

Airborne antibiotic resistome and microbiome in pharmaceutical factories DOI Creative Commons
Hong Bai,

Liang-Ying He,

Fang-Zhou Gao

et al.

Environment International, Journal Year: 2024, Volume and Issue: 186, P. 108639 - 108639

Published: April 1, 2024

Antimicrobial resistance is considered to be one of the biggest public health problems, and airborne transmission an important but under-appreciated pathway for spread antibiotic genes (ARGs) in environment. Previous research has shown pharmaceutical factories a major source ARGs resistant bacteria (ARB) surrounding receiving water soil environments. Pharmaceutical are hotspots resistance, atmospheric its environmental risk remain more concerns. Here, we conducted metagenomic investigation into microbiome resistome three China. Soil (average: 38.45 %) wastewater 28.53 were contributors resistome. (vanR/vanS, blaOXA, CfxA) conferring critically clinically used antibiotics identified air samples. The treatment area had significantly higher relative abundances 0.64 copies/16 s rRNA). Approximately 28.2 % detected found associated with plasmids, this increased about 50 area. We have compiled list high-risk factories. Moreover, A total 1,043 viral operational taxonomic units linked 47 family-group taxa. Different CRISPR-Cas immune systems been bacterial hosts response phage infection. Similarly, abundance 2451.70 PPM) was Our data provide insights gene profiles (bacterial non-bacterial) reveal potential role horizontal transfer ARGs, implications human animal health.

Language: Английский

Citations

8

Unveiling soil-borne antibiotic resistome and their associated risks: A comparative study of antibiotic and non-antibiotic pharmaceutical factories DOI

Liusheng Lei,

Jing Yu,

Linjia Liu

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 486, P. 137127 - 137127

Published: Jan. 5, 2025

Language: Английский

Citations

1