HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management

Nature Reviews Clinical Oncology, Год журнала: 2022, Номер 19(5), С. 306 - 327

Опубликована: Фев. 1, 2022

Язык: Английский

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NCCN Guidelines® Insights: Head and Neck Cancers, Version 1.2022

Journal of the National Comprehensive Cancer Network, Год журнала: 2022, Номер 20(3), С. 224 - 234

Опубликована: Март 1, 2022

The NCCN Guidelines for Head and Neck Cancers address tumors arising in the oral cavity (including mucosal lip), pharynx, larynx, paranasal sinuses. Occult primary cancer, salivary gland melanoma (MM) are also addressed. specific site of disease, stage, pathologic findings guide treatment (eg, appropriate surgical procedure, radiation targets, dose fractionation radiation, indications systemic therapy). Panel meets at least annually to review comments from reviewers within their institutions, examine relevant new data publications abstracts, reevaluate update recommendations. These Insights summarize panel's most recent recommendations regarding management HPV-positive oropharynx cancer ongoing research this area.

Язык: Английский

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Plasma Circulating Tumor HPV DNA for the Surveillance of Cancer Recurrence in HPV-Associated Oropharyngeal Cancer

Journal of Clinical Oncology, Год журнала: 2020, Номер 38(10), С. 1050 - 1058

Опубликована: Фев. 4, 2020

PURPOSE Plasma circulating tumor human papillomavirus DNA (ctHPVDNA) is a sensitive and specific biomarker of (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC). We investigated whether longitudinal monitoring ctHPVDNA during post-treatment surveillance could accurately detect clinical disease recurrence. METHODS AND MATERIALS A prospective trial was conducted among patients with nonmetastatic HPV-associated (p16-positive) OPSCC. All were treated curative-intent chemoradiotherapy (CRT). Patients underwent 3-month post-CRT positron emission tomography/computed tomography scan thereafter clinically evaluated every 2-4 months (years 1-2), then 6 3-5). Chest imaging performed months. Blood specimens collected 6-9 for analysis plasma using multianalyte digital polymerase chain reaction assay. The primary endpoint to estimate the negative predictive value (NPV) positive (PPV) surveillance. RESULTS Forty-five enrolled, 509 blood samples analyzed. After median follow-up time 19.2 (range, 14.1-30.6 months), 4 (9%) developed Thirty-seven had undetectable at all points, none recurrence (NPV, 100%; 95% CI, 91% 100%). Eight surveillance, whom diagnosed biopsy-proven Four 2 consecutively tests, Two tests PPV 100% (95% 51% Median lead between positivity 6.6 3.3-12.9 months). CONCLUSION Detection in two consecutive has high NPV identifying cancer may facilitate earlier initiation salvage therapy.

Язык: Английский

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Epidemiology and incidence of HPV‐related cancers of the head and neck

Journal of Surgical Oncology, Год журнала: 2021, Номер 124(6), С. 920 - 922

Опубликована: Сен. 23, 2021

Globally, 4.5% of cancers are due to the human papillomavirus (HPV). In United States, 80 million people infected with HPV, and incidence HPV oropharyngeal cancer has surpassed cervical cancer. The highest burden is seen in middle-aged increasingly older White men. vaccination promises change epidemiology this disease, but rates remain too low today reduce disease transmission.

Язык: Английский

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Epidemiology of HPV-associated cancers past, present and future: towards prevention and elimination

Nature Reviews Clinical Oncology, Год журнала: 2024, Номер 21(7), С. 522 - 538

Опубликована: Май 17, 2024

Язык: Английский

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A global epidemic increase of an HPV‐induced tonsil and tongue base cancer – potential benefit from a pan‐gender use of HPV vaccine

Journal of Internal Medicine, Год журнала: 2019, Номер 287(2), С. 134 - 152

Опубликована: Ноя. 16, 2019

In 2007, human papillomavirus (HPV) type 16 was finally recognized as a risk factor, besides smoking and alcohol, for oropharyngeal squamous cell carcinoma (OPSCC), including tonsillar (TSCC), by the International Agency Research against Cancer. Just before, in 2006, Food Drug Administration had approved Gardasil, first vaccine HPV16, 18, 6 11, preventive vaccination women cervical cancer. Concurrently, some Western countries, where decreasing, disclosed an epidemic increase incidence of OPSCC, especially TSCC base tongue cancer (BOTSCC), together accounting 80-90% all OPSCCs, mainly affecting men. The later revealed to be due rise HPV-positive cases, scientists field suggested HPV also boys. Globally, there are roughly 96 000 incident OPSCC cases/year which 20-24% caused HPV, thereby around 22 cases annually. Of these HPV16 infection would prevented with presently registered vaccines. such Sweden (with almost 400 BOTSCC per year) United States, prevalence is higher 70%. girls has been initiated many vaccines have efficient their side effects limited. boys has, however, exception, but should definitely not delayed any further. It benefit both directly, result better more robust herd immunity. Today, we possibility eliminate several high-risk types younger generations avoid than 600 annually worldwide, this embraced offering global pan-gender vaccination.

Язык: Английский

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Projected Association of Human Papillomavirus Vaccination With Oropharynx Cancer Incidence in the US, 2020-2045

JAMA Oncology, Год журнала: 2021, Номер 7(10), С. e212907 - e212907

Опубликована: Сен. 2, 2021

Oropharynx cancer (OPC) incidence has increased for several decades in the US. It is unclear when and how this trend will be affected by current HPV vaccination trends.To assess association of with future OPC US.This population-based age-period-cohort analysis obtained data from Surveillance, Epidemiology, End Results program 69 562 patients 34 to 83 years age diagnosed OPC. The were National Immunization Survey-Teen (60 124 participants) Health Interview Survey (16 904 participants). Data collected January 1, 1992, December 31, 2017. Age-period-cohort forecasting models projected expected 2018 2045 under a counterfactual scenario no levels vaccination, stratifying sex. analyses completed 2020.Age- sex-specific cumulative prevalence 2016 2017 forward.Projected number cases prevented vaccination.Under rates, between 2045, decrease younger individuals (36-45 age: 1.4 0.8 per 100 000 population; 46-55 8.7 7.2 population) but continue increase among older (70-83 16.8 29.0 population). overall through remain modest (no vs vaccination: 14.3 13.8 population 2045). By reduce 36 45 (men: 48.1%; women: 42.5%) 46 55 9.0%; 22.6%), those 56 or older, rates are not meaningfully reduced. Between total 6334 which 88.8% such occur (≤55 years) groups.According projections study, have limited because who yet been vaccinated at high risk However, reductions should young middle-aged adults, group lowest diagnosis. These findings forecast continued shift landscape an population.

Язык: Английский

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Cell-Free HPV DNA Provides an Accurate and Rapid Diagnosis of HPV-Associated Head and Neck Cancer

Clinical Cancer Research, Год журнала: 2021, Номер 28(4), С. 719 - 727

Опубликована: Ноя. 29, 2021

Abstract Purpose: HPV-associated head and neck squamous cell carcinoma (HPV+HNSCC) is the most common malignancy in United States continues to increase incidence. Current diagnostic approaches for HPV+HNSCC rely on tissue biopsy followed by histomorphologic assessment detection of HPV indirectly p16 IHC. Such are invasive have variable sensitivity. Experimental Design: We conducted a prospective observational study 140 subjects (70 cases 70 controls) test hypothesis that noninvasive approach would improved accuracy, lower cost, shorter interval compared with standard approaches. Blood was collected, processed circulating tumor DNA (ctHPVDNA), analyzed custom ddPCR assays genotypes 16, 18, 33, 35, 45. Diagnostic performance, were calculated clinical workup using ctHPVDNA combined cross-sectional imaging physical examination findings. Results: Sensitivity specificity detecting 98.4% 98.6%, respectively. composite imaging/physical 95.1% accuracy this significantly higher than care (Youden index 0.937 vs. 0.707, P = 0.0006). Costs 36% 38% less median 26 days less. Conclusions: A demonstrated reduced time diagnosis could be viable alternative future.

Язык: Английский

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Cell‐free human papillomavirus DNA kinetics after surgery for human papillomavirus–associated oropharyngeal cancer

Cancer, Год журнала: 2022, Номер 128(11), С. 2193 - 2204

Опубликована: Фев. 9, 2022

Background New ultrasensitive methods for detecting residual disease after surgery are needed in human papillomavirus–associated oropharyngeal squamous cell carcinoma (HPV+OPSCC). Methods To determine whether the clearance kinetics of circulating tumor papillomavirus DNA (ctHPVDNA) is associated with postoperative status, a prospective observational study was conducted 33 patients HPV+OPSCC undergoing surgery. Blood collected before surgery, days 1 (POD 1), 7, and 30 follow‐up. A subcohort 12 underwent frequent blood collections first 24 hours to define early kinetics. Plasma run on custom droplet digital polymerase chain reaction (ddPCR) assays HPV genotypes 16, 18, 33, 35, 45. Results In without pathologic risk factors recurrence who were observed ctHPVDNA rapidly decreased <1 copy/mL by POD (n = 8/8). macroscopic disease, markedly elevated (>350 copies/mL) remained until adjuvant treatment 3/3). Patients intermediate levels (1.2‐58.4 all possessed microscopic 9/9). higher known adverse such as extranodal extension >1 mm ( P .0481) increasing lymph nodes involved .0453) further received .0076). One had that detected 2 months earlier than clinical detection. Conclusions curative intent thus could be used personalized biomarker selecting future. Lay Summary Human (HPV+OPSCC) at epidemic proportions commonly treated This report describes results from examining (circulating [ctHPVDNA]) following surgical HPV+OPSCC. We found day These findings demonstrate potential utility

Язык: Английский

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Global epidemiologic patterns of oropharyngeal cancer incidence trends

JNCI Journal of the National Cancer Institute, Год журнала: 2023, Номер 115(12), С. 1544 - 1554

Опубликована: Авг. 21, 2023

Abstract Background The emergence of human papillomavirus (HPV)–positive oropharyngeal cancer and evolving tobacco use patterns have changed the landscape head neck epidemiology internationally. We investigated updated trends in incidence worldwide. Methods analyzed data between 1993 2012 from 42 countries using Cancer Incidence Five Continents database volumes V through XI. Trends were compared with oral cavity cancers lung squamous cell carcinomas log-linear regression age period–cohort modeling. Results In total, 156 567 cancer, 146 693 621 947 carcinoma patients included. Oropharyngeal increased (P &lt; .05) 19 23 men women, respectively. increasing male incidence, all but 1 had statistically significant decreases 2 decreasing or nonsignificant net drifts for cancer. Increased was observed both middle-aged (40-59 years) older (≥60 cohorts, strong nonlinear birth cohort effects. 20 where women analysis possible, 13 negative drifts, including 4 higher vs .05 comparisons). Conclusions Increasing is seen among an expanding array men, extending to groups, likely driven by papillomavirus–related more diverse observed, suggesting a complex interplay risks factors varying country, several female increases may be HPV.

Язык: Английский

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