RETRACTED: lncRNA UCA1 Promotes Gefitinib Resistance as a ceRNA to Target FOSL2 by Sponging miR-143 in Non-small Cell Lung Cancer DOI Creative Commons

Xiliu Chen,

Zhongliang Wang, Fan Tong

и другие.

Molecular Therapy — Nucleic Acids, Год журнала: 2019, Номер 19, С. 643 - 653

Опубликована: Ноя. 29, 2019

Exosomes could mediate cell-cell crosstalk in cancer progression by transferring long noncoding RNAs (lncRNAs). The aim of this study is to explore the roles exosomal lncRNA urothelial carcinoma-associated 1 (UCA1) on gefitinib resistance non-small cell lung (NSCLC). First, we detected expression UCA1 gefitinib-resistant and gefitinib-sensitive NSCLC quantitative real-time PCR; occurred tissues, lines, exosomes. Cell phenotypes animal experiments were performed determine effects UCA1. Furthermore, bioinformatics online programs luciferase reporter assay used validate association miR-143 cells. We observed that was increased both cells their secreted In vitro vivo demonstrated knockdown impaired proliferation promoted gefitinib-induced apoptosis. Then repressed expression, bind predicted binding site then dissected effect proved suppressive role miR-143. found displayed its via modulating FOSL2 expression. summary, our findings indicate may serve as a promising therapeutic target for treatment epidermal growth factor receptor-positive (EGFR+) patients.

Язык: Английский

Emerging role of exosome-derived long non-coding RNAs in tumor microenvironment DOI Creative Commons
Zhenqiang Sun,

Shuaixi Yang,

Quanbo Zhou

и другие.

Molecular Cancer, Год журнала: 2018, Номер 17(1)

Опубликована: Апрель 20, 2018

Exosomes are extracellular vesicles released by many cell types and have been attributed for their roles in diseases including cancer. secreted tumor cells stromal critical mediators of intercellular communication microenvironments. Long noncoding RNAs (lncRNAs) selectively sorted into exosomes can regulate cancer onset progression a variety ways. In this review, we summarize the characteristics exosomal lncRNAs dysregulation multiple We provide an overview current research on microenvironments, especially functions regulating biology. A deeper understanding role microenvironment may help new diagnostic prognostic markers

Язык: Английский

Процитировано

380
LncRNA—UCA1 enhances cell proliferation and 5-fluorouracil resistance in colorectal cancer by inhibiting miR-204-5p DOI Creative Commons
Zehua Bian,

Liugen Jin,

Jiwei Zhang

и другие.

Scientific Reports, Год журнала: 2016, Номер 6(1)

Опубликована: Апрель 5, 2016

Abstract Recent preliminary studies reported the in vitro tumor-promoting effects of long non-coding RNA urothelial carcinoma associated 1 (UCA1) colorectal cancer (CRC). However, vivo functions and molecular mechanism UCA1 CRC remain unclear. Therefore, we investigated detailed role CRC. We found that was up-regulated CRCs negatively correlated with survival time two cohorts. Functional assays revealed growth-promoting function can decrease sensitivity cells to 5-FU by attenuating apoptosis. Further mechanistic could sponge endogenous miR-204-5p inhibit its activity. also identified CREB1 as a new target miR-204-5p. The protein levels were significantly CRCs, positively expression. present work provides first evidence UCA1-miR-204-5p- / BCL2 RAB22A regulatory network reveals are potential oncogenes prognostic factors for

Язык: Английский

Процитировано

344
Hypoxic exosomes facilitate bladder tumor growth and development through transferring long non-coding RNA-UCA1 DOI Creative Commons
Mei Xue, Wei Chen, Xiang An

и другие.

Molecular Cancer, Год журнала: 2017, Номер 16(1)

Опубликована: Авг. 25, 2017

To overcome the hostile hypoxic microenvironment of solid tumors, tumor cells secrete a large number non-coding RNA-containing exosomes that facilitate development and metastasis. However, precise mechanisms cell-derived during hypoxia are unknown. Here, we aim to clarify whether affects growth progression by transferring long RNA-urothelial cancer-associated 1 (lncRNA-UCA1) enriched secreted from bladder cancer cells. We used 5637 with high expression lncRNA-UCA1 as exosome-generating UMUC2 low recipient Exosomes derived cultured under normoxic or conditions were isolated identified transmission electron microscopy, nanoparticle tracking analysis western blotting analysis. These co-cultured evaluate cell proliferation, migration invasion. further investigated roles exosomal xenograft models. The availability in serum-derived biomarker for was also assessed. found promoted invasion, RNAs could be internalized three lines. Importantly, exosomes. Compared exosomes, showed higher levels lncRNA-UCA1. Moreover, Hypoxic promote though epithelial-mesenchymal transition, vitro vivo. In addition, human patients than healthy controls. Together, our results demonstrate remodel secreting oncogenic lncRNA-UCA1-enriched serum has possibility diagnostic cancer.

Язык: Английский

Процитировано

309
Long non-coding RNA UCA1 promotes cisplatin/gemcitabine resistance through CREB modulating miR-196a-5p in bladder cancer cells DOI
Jingjing Pan, Xu Li, Wenjing Wu

и другие.

Cancer Letters, Год журнала: 2016, Номер 382(1), С. 64 - 76

Опубликована: Сен. 9, 2016

Язык: Английский

Процитировано

204
Epidermal growth factor receptor (EGFR): A rising star in the era of precision medicine of lung cancer DOI Open Access
Xiaomin Liu, Ping Wang, Caiyan Zhang

и другие.

Oncotarget, Год журнала: 2017, Номер 8(30), С. 50209 - 50220

Опубликована: Апрель 5, 2017

Lung cancer is a leading cause of mortality worldwide. In tumors, the important role noncoding RNA regulatory networks has been more and reveal. EGFR identified as an oncogenic driver NSCLC, especially activating mutations its inhibition with specific TKIs can generate dramatic tumor responses. Studies have shown that plays significant roles in progression NSCLC. Subset analysis small proportion patients EGFR-mutant lung showed disease-free survival benefit, but was underpowered to detect advantage. Herein, we highlight EGFR, RNA, their carcinogenesis. We also focus on anti-lung drug development EGFR-related resistance.

Язык: Английский

Процитировано

186
Long Non-Coding RNAs: Key Regulators of Epithelial-Mesenchymal Transition, Tumour Drug Resistance and Cancer Stem Cells DOI Open Access
Richard Heery, Stephen P. Finn,

Sinéad Cuffe

и другие.

Cancers, Год журнала: 2017, Номер 9(4), С. 38 - 38

Опубликована: Апрель 21, 2017

Epithelial mesenchymal transition (EMT), the adoption by epithelial cells of a mesenchymal-like phenotype, is process co-opted carcinoma in order to initiate invasion and metastasis. In addition, it becoming clear that instrumental both development drug resistance tumour generation maintenance cancer stem cells. EMT thus pivotal during progression poses major barrier successful treatment cancer. Non-coding RNAs (ncRNA) often utilize epigenetic programs regulate gene expression chromatin structure. One type ncRNA, called long non-coding (lncRNAs), has become increasingly recognized as being highly dysregulated play variety different roles tumourigenesis. Indeed, over last few years, lncRNAs have rapidly emerged key regulators this review, we discuss been associated with molecular mechanisms signalling pathways through which they EMT, finally how these EMT-regulating impact on anti-cancer cell phenotype.

Язык: Английский

Процитировано

183
Intrinsic Resistance to EGFR-Tyrosine Kinase Inhibitors in EGFR-Mutant Non-Small Cell Lung Cancer: Differences and Similarities with Acquired Resistance DOI Open Access
Eric Santoni‐Rugiu, Linea Cecilie Melchior, Edyta Maria Urbanska

и другие.

Cancers, Год журнала: 2019, Номер 11(7), С. 923 - 923

Опубликована: Июль 1, 2019

Activating mutations in the epidermal growth factor receptor gene occur as early cancer-driving clonal events a subset of patients with non-small cell lung cancer (NSCLC) and result increased sensitivity to EGFR-tyrosine-kinase-inhibitors (EGFR-TKIs). Despite very frequent often prolonged clinical response EGFR-TKIs, virtually all advanced EGFR-mutated (EGFRM+) NSCLCs inevitably acquire resistance mechanisms progress at some point during treatment. Additionally, 20–30% do not respond or for short time (<3 months) because intrinsic resistance. While several acquired EGFR-TKI-resistance have been determined by analyzing tumor specimens obtained disease progression, factors causing TKI-resistance are less understood. However, recent comprehensive molecular-pathological profiling EGFRM+ NSCLC baseline has illustrated co-existence multiple genetic, phenotypic, functional that may contribute progression cause TKI-resistance. Several these further corroborated preclinical experiments. Intrinsic can be caused inherent EGFR EGFR-independent processes, including phenotypic changes. This review describes identified connected differences similarities among clinically implemented EGFR-TKIs different generations. highlights need extensive pre-treatment molecular identifying inherently TKI-resistant cases designing potential combinatorial targeted strategies treat them.

Язык: Английский

Процитировано

147
Long non-coding RNAs in lung cancer: Unraveling the molecular modulators of MAPK signaling DOI
Md Sadique Hussain, Obaid Afzal, Gaurav Gupta

и другие.

Pathology - Research and Practice, Год журнала: 2023, Номер 249, С. 154738 - 154738

Опубликована: Авг. 6, 2023

Язык: Английский

Процитировано

68
Long noncoding RNAs: new insights into non-small cell lung cancer biology, diagnosis and therapy DOI
Biagio Ricciuti, Clelia Mencaroni,

Luca Paglialunga

и другие.

Medical Oncology, Год журнала: 2016, Номер 33(2)

Опубликована: Янв. 19, 2016

Язык: Английский

Процитировано

145
LncRNA UCA1 in anti-cancer drug resistance DOI Open Access
Haohao Wang,

Zhonghai Guan,

Kuifeng He

и другие.

Oncotarget, Год журнала: 2017, Номер 8(38), С. 64638 - 64650

Опубликована: Июнь 2, 2017

// Haohao Wang 1, 2 , Zhonghai Guan 1 Kuifeng He Jiong Qian Jiang Cao 3 and Lisong Teng Cancer Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, P.R. China Key Laboratory Precision Diagnosis Treatment for Hepatobiliary Pancreatic Tumor Province, Clinical Research Second Correspondence to: Teng, email: [email protected] Keywords: long non-coding RNA, UCA1, chemoresistance, cancer Received: February 28, 2017      Accepted: May 22, Published: June 02, 2017 ABSTRACT pivotal role the RNA (lncRNA) urothelial carcinoma associated (UCA1) in anti-cancer drug resistance has been confirmed many cancers. Overexpression lncRNA UCA1 correlates with to chemotherapeutics such as cisplatin, gemcitabine, 5-FU, tamoxifen, imatinib EGFR-TKIs, whereas knockdown restores sensitivity. These studies highlight potential a diagnostic prognostic biomarker, therapeutic target malignant tumors. In this review, we address discuss its future clinical applications.

Язык: Английский

Процитировано

138