Physical performance across the cognitive spectrum and between dementia subtypes in a population-based sample of older adults: The HUNT study

Archives of Gerontology and Geriatrics, Год журнала: 2021, Номер 95, С. 104400 - 104400

Опубликована: Март 24, 2021

Literature on physical performance in older adults across the cognitive spectrum remains inconclusive, and knowledge differences between dementia subtypes is lacking. We aim to identify distinct physical-performance deficits subtypes. 11,466 persons were included from 70-year-and-older cohort fourth wave of Trøndelag Health Study (HUNT4 70+). Physical was assessed with Short Performance Battery (SPPB), 4-meter gait speed, five-times-sit-to-stand (FTSS), grip strength one-leg-standing (OLS). Clinical experts diagnosed per DSM-5 criteria. Multiple linear logistic regression performed analyze groups. Age, sex, education, somatic comorbidity, activity smoking status used as covariates. Gait speed declined spectrum, beginning people subjective decline (SCD). Participants mild impairment (MCI) additionally showed reduced lower-limb muscle strength, balance strength. Those scored lowest all measures. Alzheimer's disease (AD) had a higher SPPB sum score faster than participants vascular (VaD) Lewy body (LBD); VaD LBD lower odds being able perform FTSS OLS AD. cognitively healthy SCD MCI dementia. AD better assessments except LBD. Stage subtype should guide exercise interventions prevent mobility dependency.

Язык: Английский

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Using hand grip strength to detect slow walking speed in older adults: the Yilan study

BMC Geriatrics, Год журнала: 2021, Номер 21(1)

Опубликована: Июль 16, 2021

Abstract Background Walking speed is an important health indicator in older adults, although its measurement can be challenging because of the functional decline due to aging and limited environment. The aim this study was examine whether hand grip strength a useful proxy for detecting slow walking population. Methods A cross-sectional conducted using cohort from Yilan Study Taiwan. Community-dwelling adults aged 65 years were included. Slow defined as 6-meter < 1.0 m/s, according 2019 Asian Working Group Sarcopenia diagnostic criteria. Stepwise multiple linear regression used determine most significant variables associated with speed. Receiver operating characteristic analysis optimal cutoff values Results total 301 participants average age 73.9 ± 6.8 included; 55.1 % women. In stepwise that included various variables, found explainable factor among all each sex. detection 19.73 kg (sensitivity: 55 %, specificity: 83 area under curve: 0.74, accuracy: 66.9 %), 35.10 men 92 42 0.70, 66.4 17.93 women 62 80 0.76, 67.9 %). Conclusions Hand identification adults.

Язык: Английский

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Association Between Grip Strength and Cognitive Function in US Older Adults of NHANES 2011–2014

Journal of Alzheimer s Disease, Год журнала: 2022, Номер 89(2), С. 427 - 436

Опубликована: Июль 22, 2022

The relationship between grip strength and cognitive function remains no consensus in the older adults.To investigate association of with performance different domains.Participants present cross-sectional study were from National Health Nutrition Examination Survey 2011-2014. Grip was measured by dynamometer, combined handgrip sum largest reading each hand. Four domains (immediate delayed memory, language, attention) assessed a set neuropsychological tests. subjective decline determined via self-report.Among 2,618 participants, positively associated scores on global domain after controlling for demographic characteristics, lifestyle factors, history disease. In addition, compared to those < 46.7 kg, participants strength≥75.3 kg had odds ratios 0.36 (95% CI: 0.21 0.63) poor function, 0.66 0.38 1.13) immediate 0.53 0.30 0.93) 0.48 0.27 0.86) language 0.20 0.11 0.35) attention, 0.18 0.73) fully adjusted model.Older adults higher significantly better cognition included various such as decline.

Язык: Английский

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Combination of gait speed and grip strength to predict cognitive decline and dementia

Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring, Год журнала: 2022, Номер 14(1)

Опубликована: Янв. 1, 2022

To determine whether slowed gait and weakened grip strength independently, or together, better identify risk of cognitive decline dementia.Time to walk 3 meters were measured in a randomized placebo-controlled clinical trial involving community-dwelling, initially cognitively healthy older adults (N = 19,114).Over median 4.7 years follow-up, slow weak at baseline independently associated with incident dementia (hazard ratio [HR] 1.44, 95% confidence interval [CI]: 1.19-1.73; 1.24, CI: 1.04-1.50, respectively) (HR 1.38, 1.26-1.51; 1.04, 0.95-1.14, when combined, 79% 43% increase decline, respectively. Annual declines over time showed similar results.Gait speed are low-cost markers that may be useful the setting help manage individuals greater risk, early signs, dementia, particularly together.Grip effective predictors dementia.Dementia is than grip.Decline speed, more so strength, predicts risk.Greater prediction results from combining speed.

Язык: Английский

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Functional outcomes and complications after treatment of distal radius fracture in patients sixty years and over: A systematic review and network meta-analysis

Injury, Год журнала: 2023, Номер 54(7), С. 110767 - 110767

Опубликована: Апрель 30, 2023

Язык: Английский

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Fine motor control improves in older adults after 1 year of piano lessons: Analysis of individual development and its coupling with cognition and brain structure

European Journal of Neuroscience, Год журнала: 2023, Номер 57(12), С. 2040 - 2061

Опубликована: Май 5, 2023

Musical training can improve fine motor skills and cognitive abilities induce macrostructural brain changes. However, it is not clear whether the changes in occur simultaneously with neurophysiological parameters. In this study, 156 healthy, musically naïve right-handed older adults were recruited randomly assigned to a piano or music listening group. Before, after 6 12 months, participants scanned using MRI assessed for skills, auditory working memory processing speed. A Bayesian multilevel modelling approach was used examine behavioural group differences. The relationships between parameters determined latent change score models. Compared listening, practicing resulted greater improvement probably memory. Only group, unimanual grey matter volume of contralateral M1 changed together during 6-12-month period. Additionally, co-developed ipsilateral putamen thalamus. Playing induced more prevalent coupling domains. there little evidence that control develops concurrently functions. an instrument promotes motor, neural development into age. During learning process, consolidation appears take place sensorimotor networks, enabling musicians perform untrained tasks higher acuity. Relationships acuity cognition bidirectional be explained by common cause as well shared resources compensatory mechanisms.

Язык: Английский

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Association of Motor Function With Cognitive Trajectories and Structural Brain Differences

Neurology, Год журнала: 2023, Номер 101(17)

Опубликована: Сен. 1, 2023

The association of motor function with cognitive health remains controversial, and the mechanisms underlying this relationship are unclear. We aimed to examine between long-term trajectories further explore using brain MRI.

Язык: Английский

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Sensory and motor deficits as contributors to early cognitive impairment

Alzheimer s & Dementia, Год журнала: 2024, Номер 20(4), С. 2653 - 2661

Опубликована: Фев. 20, 2024

Abstract INTRODUCTION Age‐related sensory and motor impairment are associated with risk of dementia. No study has examined the joint associations multiple measures on prevalence early cognitive (ECI). METHODS Six hundred fifty participants in Baltimore Longitudinal Study Aging completed function tests. The association between ECI was using structural equation modeling three latent factors corresponding to multisensory, fine motor, gross function. RESULTS fine, were all correlated ( r = 0.74 0.81). odds lower for each additional unit improvement multisensory (32%), (30%), (12%). DISCUSSION relationship emerging may guide future intervention studies aimed at preventing and/or treating ECI. Highlights Sensorimotor (ECI) assessed via modeling. degree is indicators also

Язык: Английский

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Identifying characteristics and clinical conditions associated with hand grip strength in adults: the Project Baseline Health Study

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Апрель 18, 2024

Low hand grip strength (HGS) is associated with several conditions, but its value outside of the older adult population unclear. We sought to identify most salient factors HGS from an extensive list candidate variables while stratifying by age and sex. used data initial visit Project Baseline Health Study (N = 2502) which captured detailed demographic, occupational, social, lifestyle, clinical data. applied MI-LASSO using group methods determine out 175 variables. performed analyses separately for sex (< 65 vs. ≥ years). Race was varying degrees across groups. Osteoporosis osteopenia were negatively in female study participants. Immune cell counts male participants (neutrophils) (≥ 65, monocytes; < lymphocytes). Most findings and/or group-specific; few common all Several each novel, others corroborate previous research. Our results support as a useful indicator variety characteristics; however, utility varies

Язык: Английский

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Exploring The Relationship Between Manual Dexterity and Cognition in People with Multiple Sclerosis: 9-Hole Peg and Multiple Cognitive Functions

Multiple Sclerosis and Related Disorders, Год журнала: 2024, Номер 88, С. 105696 - 105696

Опубликована: Май 27, 2024

Язык: Английский

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