Immunologic Research, Год журнала: 2021, Номер 69(3), С. 225 - 238
Опубликована: Май 13, 2021
Язык: Английский
The Lancet, Год журнала: 2023, Номер 402(10416), С. 2019 - 2033
Опубликована: Окт. 27, 2023
Язык: Английский
Процитировано
226
Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)
Опубликована: Фев. 17, 2023
Abstract Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease progression leads to joint deformity and associated loss of function, which significantly impacts the quality life for sufferers adds losses in labor force. In past few decades, RA has attracted increased attention from researchers, abnormal signaling pathways are a very important research field diagnosis treatment RA, provides evidence understanding this complex disease developing novel RA-linked intervention targets. The current review intends provide comprehensive overview including general introduction disease, historical events, epidemiology, risk factors, pathological process, highlight primary progress various molecular mechanisms, genetic epigenetic summarize most recent developments identifying new inhibitors treating RA. therapeutic interventions approved drugs, clinical pre-clinical cutting-edge technologies. These will hopefully drive strategically targeted therapies hope ideas options future.
Язык: Английский
Процитировано
203
Nature Reviews Rheumatology, Год журнала: 2020, Номер 17(1), С. 17 - 33
Опубликована: Дек. 8, 2020
Язык: Английский
Процитировано
188
Cells, Год журнала: 2021, Номер 10(11), С. 3017 - 3017
Опубликована: Ноя. 4, 2021
Rheumatoid arthritis (RA) is considered a chronic systemic, multi-factorial, inflammatory, and progressive autoimmune disease affecting many people worldwide. While patients show very individual courses of disease, with RA focusing on the musculoskeletal system, joints are often severely affected, leading to local inflammation, cartilage destruction, bone erosion. To prevent joint damage physical disability as one symptoms RA, early diagnosis critical. Auto-antibodies play pivotal clinical role in systemic RA. As biomarkers, they could help make more efficient diagnosis, prognosis, treatment decision. Besides auto-antibodies, several other factors involved progression such epigenetic alterations, post-translational modifications, glycosylation, autophagy, T-cells. Understanding interplay between these would contribute deeper insight into causes, mechanisms, progression, disease. In this review, latest research findings discussed better understand pathogenesis, finally, strategies for therapy presented, including both conventional approaches new methods that have been developed recent years or currently under investigation.
Язык: Английский
Процитировано
152
Frontiers in Medicine, Год журнала: 2021, Номер 8
Опубликована: Ноя. 26, 2021
Rheumatoid arthritis (RA) is the most common systemic inflammatory rheumatic disease. It associated with significant burden at patient and societal level. Extensive efforts have been devoted to identifying a potential cause for development of RA. Epidemiological studies thoroughly investigated association several factors risk course Although precise etiology remains elusive, current understanding that RA multifactorial disease, wherein complex interactions between host environmental determine overall disease susceptibility, persistence severity. Risk related may be divided into genetic; epigenetic; hormonal, reproductive neuroendocrine; comorbid factors. In turn, include smoking other airborne exposures; microbiota infectious agents; diet; socioeconomic present narrative review, aimed clinicians researchers in field RA, we provide state-of-the-art overview knowledge on this topic, focusing recent progresses improved our comprehension development.
Язык: Английский
Процитировано
117
Molecular and Cellular Biochemistry, Год журнала: 2022, Номер 478(1), С. 69 - 88
Опубликована: Июнь 21, 2022
Язык: Английский
Процитировано
107
ACS Nano, Год журнала: 2022, Номер 16(12), С. 19665 - 19690
Опубликована: Дек. 13, 2022
Joint diseases are one of the most common causes morbidity and disability worldwide. The main that affect joint cartilage osteoarthritis rheumatoid arthritis, which require chronic treatment focused on symptomatic relief. Conventional drugs administered through systemic or intra-articular routes have low accumulation and/or retention in articular cartilage, causing dose-limiting toxicities reduced efficacy. Therefore, there is an urgent need to develop improved strategies for drug delivery, particular, use micro- nanotechnology-based methods. Encapsulation therapeutic agents delivery systems reduces efflux from protects against rapid cellular enzymatic clearance following injection. Consequently, decreases side effects increases efficacy due enhanced space. Additionally, frequency administration reduced, as enable sustained release. This review summarizes various advanced systems, such nano- microcarriers, developed diseases.
Язык: Английский
Процитировано
87
Life Sciences, Год журнала: 2022, Номер 314, С. 121321 - 121321
Опубликована: Дек. 24, 2022
Язык: Английский
Процитировано
71
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(11), С. 9317 - 9317
Опубликована: Май 26, 2023
Baicalin is one of the most abundant flavonoids found in dried roots Scutellaria baicalensis Georgi (SBG) belonging to genus Scutellaria. While baicalin demonstrated have anti-inflammatory, antiviral, antitumor, antibacterial, anticonvulsant, antioxidant, hepatoprotective, and neuroprotective effects, its low hydrophilicity lipophilicity limit bioavailability pharmacological functions. Therefore, an in-depth study baicalin’s pharmacokinetics contributes laying theoretical foundation for applied research disease treatment. In this view, physicochemical properties anti-inflammatory activity are summarized terms bioavailability, drug interaction, inflammatory conditions.
Язык: Английский
Процитировано
56
Cells, Год журнала: 2019, Номер 8(9), С. 953 - 953
Опубликована: Авг. 22, 2019
Rheumatoid arthritis (RA) is a long-term autoimmune disease of unknown etiology that leads to progressive joint destruction and ultimately disability. RA affects as much 1% the population worldwide. To date, not curable disease, mechanisms responsible for development have yet been well understood. The more effective treatments improvements in early diagnosis direly needed increase patients’ functional capacity their quality life. As opposed genetic mutation, epigenetic changes, such DNA methylation, are reversible, making them good therapeutic candidates, modulating immune response or aggressive synovial fibroblasts (FLS—fibroblast-like synoviocytes) activity when it necessary. It has suggested methylation might contribute development, however, with insufficient conflicting results. Besides, recent studies shown circulating cell-free methylated (ccfDNA) blood offers very convenient, non-invasive, repeatable “liquid biopsy”, thus providing reliable template assessing molecular markers various diseases, including RA. Thus, therapies controlling autoimmunity systemic inflammation may find wider implications management In this review, we highlight current challenges associated treatment other diseases discuss how targeting improve diagnostic, prognostic, approaches.
Язык: Английский
Процитировано
97