Seminars in Cancer Biology, Год журнала: 2023, Номер 90, С. 73 - 100
Опубликована: Фев. 10, 2023
Язык: Английский
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Янв. 12, 2024
Abstract Although stem cell-based therapy has demonstrated considerable potential to manage certain diseases more successfully than conventional surgery, it nevertheless comes with inescapable drawbacks that might limit its clinical translation. Compared cells, cell-derived exosomes possess numerous advantages, such as non-immunogenicity, non-infusion toxicity, easy access, effortless preservation, and freedom from tumorigenic ethical issues. Exosomes can inherit similar therapeutic effects their parental cells embryonic adult through vertical delivery of pluripotency or multipotency. After a thorough search meticulous dissection relevant literature the last five years, we present this comprehensive, up-to-date, specialty-specific disease-oriented review highlight surgical application exosomes. derived (e.g., embryonic, induced pluripotent, hematopoietic, mesenchymal, neural, endothelial cells) are capable treating encountered in orthopedic neurosurgery, plastic general cardiothoracic urology, head neck ophthalmology, obstetrics gynecology. The diverse cells-derived hierarchical translation tissue-specific responses, cell-specific molecular signaling pathways. In review, viable potent alternative managing various conditions. We recommend future research combines wisdoms surgeons, nanomedicine practitioners, cell researchers intriguing area.
Язык: Английский
Процитировано
235
Inflammopharmacology, Год журнала: 2023, Номер 31(1), С. 145 - 169
Опубликована: Янв. 7, 2023
Язык: Английский
Процитировано
176
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Фев. 21, 2024
Abstract Inflammation-associated diseases encompass a range of infectious and non-infectious inflammatory diseases, which continuously pose one the most serious threats to human health, attributed factors such as emergence new pathogens, increasing drug resistance, changes in living environments lifestyles, aging population. Despite rapid advancements mechanistic research development for these current treatments often have limited efficacy notable side effects, necessitating more effective targeted anti-inflammatory therapies. In recent years, nanotechnology has provided crucial technological support prevention, treatment, detection inflammation-associated diseases. Various types nanoparticles (NPs) play significant roles, serving vaccine vehicles enhance immunogenicity carriers improve targeting bioavailability. NPs can also directly combat pathogens inflammation. addition, facilitated biosensors pathogen imaging techniques This review categorizes characterizes different NPs, summarizes their applications It discusses challenges associated with clinical translation this field explores latest developments prospects. conclusion, opens up possibilities comprehensive management
Язык: Английский
Процитировано
151
Vaccines, Год журнала: 2022, Номер 10(11), С. 1946 - 1946
Опубликована: Ноя. 17, 2022
Vaccination is still the most cost-effective way to combat infectious illnesses. Conventional vaccinations may have low immunogenicity and, in situations, only provide partial protection. A new class of nanoparticle-based has shown considerable promise addressing majority shortcomings traditional and subunit vaccines. This due recent breakthroughs chemical biological engineering, which allow for exact regulation nanoparticle size, shape, functionality, surface characteristics, resulting improved antigen presentation robust immunogenicity. blend physicochemical, immunological, toxicological experiments can be used accurately characterize nanovaccines. narrative review will an overview current scenario nanovaccine.
Язык: Английский
Процитировано
141
Biomaterials, Год журнала: 2022, Номер 293, С. 121949 - 121949
Опубликована: Дек. 8, 2022
Язык: Английский
Процитировано
125
Frontiers in Cell and Developmental Biology, Год журнала: 2022, Номер 10
Опубликована: Июнь 24, 2022
Extracellular vesicles (EVs) are with a lipid bilayer membrane on the outside, which widely found in various body fluids and contain biological macromolecules such as DNA, RNA, lipids proteins inside. EVs were once thought to be for removal of waste materials, but now known involved variety pathophysiological processes many diseases. This study examines advantage challenges associated their application. A more rational use advantageous properties composition specificity, specific targeting, circulatory stability, active penetration barriers, high efficient drug delivery vehicles anticancer vaccines, oxidative phosphorylation activity enzymatic activity, resolution shortcomings isolation purification methods, storage conditions pharmacokinetics biodistribution patterns during will facilitate clinical application EVs.
Язык: Английский
Процитировано
85
International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(14), С. 7986 - 7986
Опубликована: Июль 20, 2022
Extracellular vesicles (EVs) are minute with lipid bilayer membranes. EVs secreted by cells for intercellular communication. Recently, have received much attention, as they rich in biological components such nucleic acids, lipids, and proteins that play essential roles tissue regeneration disease modification. In addition, can be developed vaccines against cancer infectious diseases, the vesicle membrane has an abundance of antigenic determinants virulent factors. therapeutic applications typically collected from conditioned media cultured cells. However, number is limited. Thus, it critical to devise new strategies large-scale production EVs. Here, we discussed utilized researchers scalable Techniques bioreactors, mechanical stimulation, electrical thermal magnetic field topographic clue, hypoxia, serum deprivation, pH modification, exposure small molecules, nanoparticles, increasing intracellular calcium concentration, genetic modification been used improve secretion nitrogen cavitation, porous extrusion, sonication prepare EV-mimetic nanovesicles share many characteristics naturally Apart inducing EV production, these upscaling interventions also reported modify EVs' cargo thus their functionality potential. summary, imperative identify a reliable technique produce large quantities consistently. Ideally, produced should possess improved
Язык: Английский
Процитировано
78
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 167, С. 115597 - 115597
Опубликована: Сен. 30, 2023
The field of nanotechnology has revolutionised global attempts to prevent, treat, and eradicate infectious diseases in the foreseen future. Nanovaccines have proven be a valuable pawn this novel technology. are made up nanoparticles that associated with or prepared components can stimulate host's immune system. In addition their delivery capabilities, nanocarriers been demonstrated possess intrinsic adjuvant properties, working as cell stimulators. Thus, nanovaccines potential promote rapid well long-lasting humoral cellular immunity. several possible benefits, including site-specific antigen delivery, increased bioavailability, diminished adverse effect profile. To avail these nanoparticle-based vaccines being developed, virus-like particles, liposomes, polymeric nanoparticles, nanogels, lipid emulsion vaccines, exomes, inorganic nanoparticles. Inspired by distinctive researchers on development for variety applications, such cancer immunotherapy diseases. Although few challenges still need overcome, modulation nanoparticle pharmacokinetics avoid elimination from bloodstream reticuloendothelial system, future prospects technology also assuring, multiple options personalised needle-free formulations, combination promising candidates.
Язык: Английский
Процитировано
76
Extracellular Vesicle, Год журнала: 2023, Номер 3, С. 100032 - 100032
Опубликована: Дек. 9, 2023
Exosomes are nanovesicles released from cells due to pathophysiological events. These nanoparticles resistant metabolic destruction and can transcend the blood-brain barrier. Exosome therapy could be employed as precision medicine by targeting underlying etiology. This article briefly elucidates basic physiology of exosomes, their types, characteristics, cargo that for drug administration. It then delves into therapeutic applications, such oncology, neurological disorders, regenerative medicine. Exosome-based delivery using small molecules, nucleic acids, proteins is also demonstrated. Finally, global organizations successfully creating testing medicinal biomaterials highlighted.
Язык: Английский
Процитировано
53
Immunity, Год журнала: 2024, Номер 57(8), С. 1752 - 1768
Опубликована: Авг. 1, 2024
Язык: Английский
Процитировано
34