The Roles and Interactions of Porphyromonas gingivalis and Fusobacterium nucleatum in Oral and Gastrointestinal Carcinogenesis: A Narrative Review

Pathogens, Год журнала: 2024, Номер 13(1), С. 93 - 93

Опубликована: Янв. 20, 2024

Epidemiological studies have spotlighted the intricate relationship between individual oral bacteria and tumor occurrence. Porphyromonas gingivalis Fusobacteria nucleatum, which are known periodontal pathogens, emerged as extensively studied participants with potential pathogenic abilities in carcinogenesis. However, complex dynamics arising from interactions these two pathogens were less addressed. This narrative review aims to summarize current knowledge on prevalence mechanism implications of P. F. nucleatum carcinogenesis squamous cell carcinoma (OSCC), colorectal cancer (CRC), pancreatic ductal adenocarcinoma (PDAC). In particular, it explores clinical experimental evidence interplay affecting gastrointestinal recognized keystone or bridging bacteria, identified multiple simultaneously. The both species correlated development progression, emphasizing impact collaboration. Regrettably, there was insufficient demonstrate synergistic function. We further propose a hypothesis elucidate underlying mechanisms, offering promising avenue for future research this dynamic evolving field.

Язык: Английский

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Diversity and compositional differences in the oral microbiome of oral squamous cell carcinoma patients and healthy controls: a scoping review

Frontiers in Oral Health, Год журнала: 2024, Номер 5

Опубликована: Июнь 11, 2024

The human oral microbiome may play a role in the development of squamous cell carcinoma. aim this scoping review was to examine microbial diversity and differences composition between OSCC patients healthy controls.

Язык: Английский

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Intratumoral Microbiota as a Target for Advanced Cancer Therapeutics

Advanced Materials, Год журнала: 2024, Номер 36(38)

Опубликована: Июль 26, 2024

Abstract In recent years, advancements in microbial sequencing technology have sparked an increasing interest the bacteria residing within solid tumors and its distribution functions various tumors. Intratumoral critically modulate tumor oncogenesis development through DNA damage induction, chronic inflammation, epigenetic alterations, metabolic immune regulation, while also influencing cancer treatment efficacy by affecting drug metabolism. response to these discoveries, a variety of anti‐cancer therapies targeting microorganisms emerged. These approaches encompass oncolytic therapy utilizing tumor‐associated bacteria, design biomaterials based on intratumoral use bacterial components for delivery systems, comprehensive strategies aimed at eradication tumor‐promoting bacteria. Herein, this review article summarizes patterns different tumors, examines their impact evaluates current therapeutic centered Furthermore, challenges prospects developing drugs that target communities are explored, promising new directions treatment.

Язык: Английский

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State of the Art in the Diagnosis and Assessment of Oral Malignant and Potentially Malignant Disorders: Present Insights and Future Outlook—An Overview

Bioengineering, Год журнала: 2024, Номер 11(3), С. 228 - 228

Опубликована: Фев. 28, 2024

Oral Potentially Malignant Disorder (OPMD) is a significant concern for clinicians due to the risk of malignant transformation. Squamous Cell Carcinoma (OSCC) common type cancer with low survival rate, causing over 200,000 new cases globally each year. Despite advancements in diagnosis and treatment, five-year rate OSCC patients remains under 50%. Early can greatly improve chances survival. Therefore, understanding development transformation developing diagnostic methods crucial. The field oral medicine has been advanced by technological molecular innovations, leading integration medical technologies into dental practice. This study aims outline potential role non-invasive imaging techniques signatures early detection Disorders.

Язык: Английский

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The role of periodontitis in cancer development, with a focus on oral cancers

Molecular Biology Reports, Год журнала: 2024, Номер 51(1)

Опубликована: Июль 15, 2024

Язык: Английский

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A Narrative Review: Repurposing Metformin as a Potential Therapeutic Agent for Oral Cancer

Cancers, Год журнала: 2024, Номер 16(17), С. 3017 - 3017

Опубликована: Авг. 29, 2024

Oral cancer, particularly oral squamous cell carcinoma (OSCC), is a significant global health challenge because of its high incidence and limited treatment options. Major risk factors, including tobacco use, alcohol consumption, specific microbiota, contribute to the disease’s prevalence. Recently, compelling association between diabetes mellitus (DM) cancer has been identified, with metformin, widely used antidiabetic drug, emerging as potential therapeutic agent across various cancers, OSCC. This review explores both preclinical clinical studies understand mechanisms by which metformin may exert anticancer effects, such inhibiting proliferation, inducing apoptosis, enhancing efficacy existing treatments. Preclinical demonstrate that modulates crucial metabolic pathways, reduces inflammation, impacts cellular thereby potentially lowering improving patient outcomes. Additionally, metformin’s ability reverse epithelial-to-mesenchymal transition (EMT), regulate LIN28/let-7 axis, role in head neck (HNSCC) are examined through experimental models. In contexts, shows promise outcomes reducing recurrence rates, although challenges drug interactions, complex dosing regimens, risks vitamin B12 deficiency remain. Future research should focus on optimizing application, investigating synergistic effects other therapies, conducting rigorous trials validate OSCC treatment. dual exploration underscores play transformative management care, revolutionizing strategies.

Язык: Английский

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Current Evidence on the Relation Between Microbiota and Oral Cancer—The Role of Fusobacterium nucleatum—A Narrative Review

Cancers, Год журнала: 2025, Номер 17(2), С. 171 - 171

Опубликована: Янв. 7, 2025

Oral squamous cell carcinoma (OSCC) is one the most prevalent head and neck cancers represents a major cause of morbidity mortality worldwide. The main established risk factors for OSCC include tobacco alcohol consumption betel quid chewing, which may contribute alone or in combination with other environmental to carcinogenesis. oral microbiota emerging as key player establishment molecular cellular mechanisms that trigger promote carcinogenesis, including cavity. Among bacterial species found microbiota, Fusobacterium nucleatum, an anaerobic bacterium commonly biofilms periodontal pathogen, has gained attention due solid evidence implicating F. nucleatum colorectal cancer (CRC). been shown induce chronic inflammation, proliferation invasion while deploying immune evasion mechanisms. These experimental findings were first obtained vitro vivo models CRC are being confirmed studies on OSCC. In this review, we summarize recent role OSCC, discuss clinical implications terms prognosis provide overview involved. Moreover, identify research questions aspects require investigations clarify We anticipate field have significant impact diagnosis, management

Язык: Английский

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Microbiome-mediated immune modulation in tumor microenvironment

International review of cell and molecular biology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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The gut-oral microbiome axis: How systemic inflammation sparks oral cancer development

Medical Journal Armed Forces India, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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Parvimonas micra promotes oral squamous cell carcinoma metastasis through TmpC-CKAP4 axis

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Март 7, 2025

Parvimonas micra (P. micra), an opportunistic oral pathogen associated with multiple cancers, has limited research on its role in squamous cell carcinoma (OSCC). This study shows that P. is enriched OSCC tissues and positively correlated tumor metastasis stages. infection promotes by inducing hypoxia/HIF-1α, glycolysis, autophagy. Mechanistically, surface protein TmpC binds to CKAP4, a receptor overexpressed OSCC, facilitating bacterial attachment invasion. interaction activates HIF-1α autophagy via CKAP4-RanBP2 CKAP4-NBR1 pathways, driving metastasis. Targeting CKAP4 masitinib or antibodies impairs abolishes micra-promoted vitro vivo. Together, our findings identify as highlight TmpC-CKAP4 could be potential therapeutic target for OSCC. micra) frequently present lesions infections. Here, authors report regulation HIF-1α-induced glycolysis following binding receptor.

Язык: Английский

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