Ultrasound as a versatile tool for short- and long-term improvement and monitoring of brain function

Neuron, Год журнала: 2023, Номер 111(8), С. 1174 - 1190

Опубликована: Март 13, 2023

Язык: Английский

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Photoacoustic Imaging in Biomedicine and Life Sciences

Life, Год журнала: 2022, Номер 12(4), С. 588 - 588

Опубликована: Апрель 14, 2022

Photo-acoustic imaging, also known as opto-acoustic has become a widely popular modality for biomedical applications. This hybrid technique possesses the advantages of high optical contrast and ultrasonic resolution. Due to distinct absorption properties tissue compartments main chromophores, photo-acoustics is able non-invasively observe structural functional variations within biological tissues including oxygenation deoxygenation, blood vessels spatial melanin distribution. The detection acoustic waves produced by pulsed laser source yields scaling range, from organ level photo-acoustic tomography sub-cellular or even molecular imaging. review discusses significant novel technical solutions utilising their applications in fields biomedicine life sciences.

Язык: Английский

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Multimodal optoacoustic imaging: methods and contrast materials

Chemical Society Reviews, Год журнала: 2024, Номер 53(12), С. 6068 - 6099

Опубликована: Янв. 1, 2024

Combining optoacoustics with other imaging techniques helps bring its powerful label-free functional readings and molecular sensitivity into precise anatomical context while providing an essential cross-validation against established methods.

Язык: Английский

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Nanophotonic-enhanced photoacoustic imaging for brain tumor detection

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Март 5, 2025

Photoacoustic brain imaging (PABI) has emerged as a promising biomedical modality, combining high contrast of optical with deep tissue penetration ultrasound imaging. This review explores the application photoacoustic in tumor imaging, highlighting synergy between nanomaterials and state art techniques to achieve high-resolution deeper tissues. PABI leverages effect, where absorbed light energy causes thermoelastic expansion, generating waves that are detected converted into images. technique enables precise diagnosis, therapy monitoring, enhanced clinical screening, specifically management complex diseases such breast cancer, lymphatic disorder, neurological conditions. Despite integration agents radiation, providing comprehensive overview current methodologies, major obstacles treatment, future directions for improving diagnostic therapeutic outcomes. The underscores significance robust research tool medical method, potential revolutionize disease diagnosis treatment.

Язык: Английский

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Transfontanelle photoacoustic imaging: ultrasound transducer selection analysis

Biomedical Optics Express, Год журнала: 2022, Номер 13(2), С. 676 - 676

Опубликована: Янв. 3, 2022

Transfontanelle ultrasound imaging (TFUI) is the conventional approach for diagnosing brain injury in neonates. Despite being first stage modality, TFUI lacks accuracy determining at an early due to degraded sensitivity and specificity. Therefore, a modality like photoacoustic that combines advantages of both acoustic optical can overcome existing limitations. Even though variety transducers have been used TFUI, it essential identify transducer specification optimal transfontanelle using technique. In this study, we evaluated performance 6 commercially available arrays characteristics imaging. We focused on linear phased array probes with center frequencies ranging from 2.5MHz 8.5MHz which covers entire spectrum The were tested vitro ex vivo tissue, their terms resolution, size, penetration depth, sensitivity, signal noise ratio, amplification reconstructed image quality evaluated. analysis selected these areas allowed us determine imaging, based vasculature depth blood density tissue sheep brain. outcome evaluation identified two most suitable

Язык: Английский

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Near-infrared-II deep tissue fluorescence microscopy and application

Nano Research, Год журнала: 2022, Номер 16(1), С. 692 - 714

Опубликована: Сен. 27, 2022

Язык: Английский

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Nanotheranostics: Molecular Diagnostics and Nanotherapeutic Evaluation by Photoacoustic/Ultrasound Imaging in Small Animals

Molecular Pharmaceutics, Год журнала: 2023, Номер 20(12), С. 6010 - 6034

Опубликована: Ноя. 6, 2023

Nanotheranostics is a rapidly developing field that integrates nanotechnology, diagnostics, and therapy to provide novel methods for imaging treating wide categories of diseases. Targeted nanotheranostics offers platform the precise delivery theranostic agents, their therapeutic outcomes are monitored in real-time. Presently, vivo magnetic resonance imaging, fluorescence ultrasound photoacoustic (PAI), etc. noninvasive techniques preclinically available tracking small animals. Additionally, preclinical essential drug development, phenotyping, understanding disease stage progression its associated mechanisms. Small animal technique theranostics applications due merits being nonionizing, real-time, portable, able penetrate deep tissues. Recently, different types contrast agents have been explored, such as microbubbles, echogenic exosomes, gas-vesicles, nanoparticles-based agents. Moreover, an optical image obtained through creates ultrasonic waves when pulsed laser light used expose object picture tissue's distribution energy absorption on object. Contrast may be endogenous (hemoglobin, melanin, DNA/RNA) or exogenous (dyes nanomaterials-based agents). The integration with allows simultaneous treatment diseases animals, which provides information about response progression. In this review, we covered various imaging. discussed systems integrated application. Further, briefly current challenges

Язык: Английский

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Shedding light on ultrasound in action: Optical and optoacoustic monitoring of ultrasound brain interventions

Advanced Drug Delivery Reviews, Год журнала: 2024, Номер 205, С. 115177 - 115177

Опубликована: Янв. 5, 2024

Monitoring brain responses to ultrasonic interventions is becoming an important pillar of a growing number applications employing acoustic waves actuate and cure the brain. Optical interrogation living tissues provides unique means for retrieving functional molecular information related activity disease-specific biomarkers. The hybrid optoacoustic imaging methods have further enabled deep-tissue with optical contrast at high spatial temporal resolution. marriage between light sound thus brings together highly complementary advantages both modalities toward precision interrogation, stimulation, therapy strong impact in fields ultrasound neuromodulation, gene drug delivery, or noninvasive treatments neurological neurodegenerative disorders. In this review, we elaborate on current advances monitoring interventions. We describe main principles mechanisms underlying each method before diving into corresponding biomedical applications. identify areas improvement as well promising approaches clinical translation potential.

Язык: Английский

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A Comprehensive Review on Photoacoustic-Based Devices for Biomedical Applications

Sensors, Год журнала: 2022, Номер 22(23), С. 9541 - 9541

Опубликована: Дек. 6, 2022

The photoacoustic effect is an emerging technology that has sparked significant interest in the research field since acoustic wave can be produced simply by incidence of light on a material or tissue. This phenomenon been extensively investigated, not only to perform imaging but also develop highly miniaturized ultrasound probes provide biologically meaningful information. Therefore, this review aims outline materials and their fabrication process employed as targets, both biological non-biological, report main components' features achieve certain performance. When designing device, it utmost importance model at early stage for deeper understanding ease optimization process. As such, throughout article, different methods already implemented are introduced, well advantages drawbacks inherent each approach. However, some remaining challenges still faced when developing such system regarding its fabrication, modeling, characterization, which discussed.

Язык: Английский

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Broadband Model‐Based Optoacoustic Mesoscopy Enables Deep‐Tissue Imaging beyond the Acoustic Diffraction Limit

Laser & Photonics Review, Год журнала: 2022, Номер 16(5)

Опубликована: Апрель 3, 2022

Abstract Optoacoustic mesoscopy (OAM) retrieves anatomical and functional contrast in vivo at depths not resolvable with optical microscopy. Recent progress on reconstruction algorithms have further advanced its imaging performance to provide high lateral resolution ultimately limited by acoustic diffraction. In this work, a new broadband model‐based OAM (MB‐OAM) framework efficiently exploiting scanning symmetries for an enhanced is presented. By capitalizing the large detection bandwidth of spherical polyvinylidene difluoride film while accurately accounting spatial impulse response, approach significantly outperforms standard implementations terms resolution, as validated experiments mice human volunteers. Furthermore, L1‐norm regularization enables resolving structures separated less than theoretical diffraction‐limited resolution. This unique label‐free angiographic demonstrates general applicability MB‐OAM super‐resolution deep‐tissue method capable breaking through limits imposed

Язык: Английский

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