The Important Role of Zinc in Neurological Diseases

Biomolecules, Год журнала: 2022, Номер 13(1), С. 28 - 28

Опубликована: Дек. 23, 2022

Zinc is one of the most abundant metal ions in central nervous system (CNS), where it plays a crucial role both physiological and pathological brain functions. promotes antioxidant effects, neurogenesis, immune responses. From neonatal development to preservation control adult function, zinc vital homeostatic component CNS. Molecularly, regulates gene expression with transcription factors activates dozens enzymes involved neuronal metabolism. During adulthood, acts as regulator synaptic activity plasticity at cellular level. There are several neurological diseases that may be affected by changes status, these include stroke, neurodegenerative diseases, traumatic injuries, depression. Accordingly, deficiency result declines cognition learning an increase oxidative stress, while accumulation lead neurotoxicity cell death. In this review, we explore mechanisms balance, strategies affecting for prevention treatment diseases.

Язык: Английский

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Zinc in Cognitive Impairment and Aging

Biomolecules, Год журнала: 2022, Номер 12(7), С. 1000 - 1000

Опубликована: Июль 18, 2022

Zinc, an essential micronutrient for life, was first discovered in 1869 and later found to be indispensable the normal development of plants growth rats birds. Zinc plays important role many physiological pathological processes mammalian brain development, especially central nervous system. deficiency can lead neurodegenerative diseases, mental abnormalities, sleep disorders, tumors, vascular other conditions, which cause cognitive impairment premature aging. This study aimed review effects zinc zinc-associated proteins aging, reveal its molecular mechanism, highlight potential interventions aging impairments.

Язык: Английский

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PRDM16 Regulating Adipocyte Transformation and Thermogenesis: A Promising Therapeutic Target for Obesity and Diabetes

Frontiers in Pharmacology, Год журнала: 2022, Номер 13

Опубликована: Апрель 8, 2022

Given that obesity and diabetes have been major public health concerns disease morbidities rising continuously, effective treatment for these diseases is urgently needed. Because adipose tissue metabolism involved in the progression of diabetes, it might be efficient to target adipocyte metabolic pathways. Positive regulatory domain zinc finger region protein 16 (PRDM16), a transcription factor highly expressed adipocytes, plays key role metabolism, such as browning thermogenesis beigeing adipogenic differentiation myoblasts, conversion visceral adipocytes subcutaneous adipocytes. Furthermore, clinical basic studies shown expression PRDM16 associated with signaling participates two diseases. For example, metformin promotes alleviates by activating AMPK/αKG/PRDM16 pathway; rosiglitazone under synergistic effect PRDM16; resveratrol an antiobesity inducing liraglupeptide improves insulin resistance mulberry leaves play anti-inflammatory antidiabetes brown fat cell marker genes (including PRDM16). In this review, we summarize evidence involvement may promising therapy diabetes.

Язык: Английский

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From zinc homeostasis to disease progression: Unveiling the neurodegenerative puzzle

Pharmacological Research, Год журнала: 2023, Номер 199, С. 107039 - 107039

Опубликована: Дек. 19, 2023

Zinc is a crucial trace element in the human body, playing role various physiological processes such as oxidative stress, neurotransmission, protein synthesis, and DNA repair. The zinc transporters (ZnTs) family members are responsible for exporting intracellular zinc, while Zrt- Irt-like proteins (ZIPs) involved importing extracellular zinc. These essential maintaining cellular homeostasis. Imbalances metabolism have been linked to development of neurodegenerative diseases. Disruptions levels can impact survival activity neurons, thereby contributing progression diseases through mechanisms like cell apoptosis regulation, phase separation, ferroptosis, neuroinflammation. Therefore, conducting systematic review regulatory network investigating relationship between dysmetabolism enhance our understanding pathogenesis these Additionally, it may offer new insights approaches treatment

Язык: Английский

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Whole-genome sequencing analysis reveals new susceptibility loci and structural variants associated with progressive supranuclear palsy

Molecular Neurodegeneration, Год журнала: 2024, Номер 19(1)

Опубликована: Авг. 16, 2024

Abstract Background Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease characterized by the accumulation of aggregated tau proteins in astrocytes, neurons, and oligodendrocytes. Previous genome-wide association studies for PSP were based on genotype array, therefore, inadequate analysis variants as well larger mutations, such small insertions/deletions (indels) structural (SVs). Method In this study, we performed whole genome sequencing (WGS) conducted single nucleotide (SNVs), indels, SVs, cohort 1,718 cases 2,944 controls European ancestry. Of individuals, 1,441 autopsy-confirmed 277 clinically diagnosed. Results Our common SNVs indels confirmed known genetic loci at MAPT , MOBP S TX6 SLCO1A2 DUSP10 SP1 further uncovered novel signals APOE FCHO1/MAP1S, KIF13A, TRIM24, TNXB, ELOVL1 . Notably, contrast to Alzheimer’s (AD), observed ε2 allele be risk PSP. Analysis identified significant ZNF592 gene network module neuronal genes dysregulated Moreover, seven SVs associated with H1/H2 haplotype region (17q21.31) other loci, including IGH PCMT1 CYP2A13 SMCP region, there burden deletions duplications ( P = 6.73 × 10 –3 ) Conclusions Through WGS, significantly enhanced our understanding basis PSP, providing new targets exploring mechanisms therapeutic interventions.

Язык: Английский

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Chemical Proteomic Profiling of Protein Dopaminylation in Colorectal Cancer Cells

Journal of Proteome Research, Год журнала: 2024, Номер 23(7), С. 2651 - 2660

Опубликована: Июнь 5, 2024

Histone dopaminylation is a newly identified epigenetic mark that plays role in the regulation of gene transcription, where an isopeptide bond formed between fifth amino acid H3 (i.e., glutamine) and dopamine. Recently, we developed chemical probe to specifically label enrich histone via bioorthogonal chemistry. Given this powerful tool, found glutamine 5 (H3Q5dop) was highly enriched colorectal tumors, which could be attributed high expression level its regulator, transglutaminase 2 (TGM2), colon cancer cells. Due enzyme promiscuity TGM2, nonhistone proteins have also been as targets; however, dopaminylated proteome cells still remains elusive. Here, utilized our from manner performed proteomics analysis. Therefore, 425 were identified, many are involved nucleic metabolism transcription pathways. More importantly, number sites successful application probe. Overall, these findings shed light on significant association cellular protein development, further suggesting targeting pathways may become promising anticancer strategy.

Язык: Английский

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The Role of Zinc in Modulating Acid-Sensing Ion Channel Function

Biomolecules, Год журнала: 2023, Номер 13(2), С. 229 - 229

Опубликована: Янв. 24, 2023

Acid-sensing ion channels (ASICs) are proton-gated, voltage-independent sodium widely expressed throughout the central and peripheral nervous systems. They involved in synaptic plasticity, learning/memory, fear conditioning pain. Zinc, an important trace metal body, contributes to numerous physiological functions, with neurotransmission being of note. Zinc has been implicated modulation ASICs by binding specific sites on these exerting either stimulatory or inhibitory effects depending ASIC subtype. have linked several neurological psychological disorders, such as Alzheimer’s disease, Parkinson’s ischemic stroke, epilepsy cocaine addiction. Different isoforms contribute persistence each disorders. It is critical understand how various zinc concentrations can modulate subtypes regulation diseases. This review elucidates zinc’s structural interactions discusses potential therapeutic implications may diseases through targeting ASICs.

Язык: Английский

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Functional and biological activities of Edible Bird’s Nest (EBN) protein by proteomic and bioinformatic analyses

Journal of Food Measurement & Characterization, Год журнала: 2024, Номер 18(4), С. 3018 - 3031

Опубликована: Фев. 12, 2024

Язык: Английский

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The zinc finger protein560(ZNF560) functions as a novel oncogenic gene in osteosarcoma

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 2, 2025

Background: Abnormal expression of Zinc finger (ZNF) genes is commonly observed in osteosarcoma (OS), the most prevalent malignant bone tumor children and teenagers. This project focused on role ZNF560 progress OS. Methods: The published datasets including TCGA-SARC GSE99671 was utilized to screen out abnormal associated gene patterns sarcoma OS tissues. Prognosis value identified cohorts. In order manipulate HOS MG63 (OS) cells, genetic strategies such as shRNA constructs were utilized. analyzed through techniques immunohistochemistry, Western blotting, qRT-PCR. Results: By analyzing data from both GEO Cancer Genome Atlas (TCGA) databases, increased tissues verified, which significantly with poorer outcomes patients our own Additionally, downregulation resulted decreased cell viability, fewer colonies, induced apoptosis cells. Moreover, found be essential for migration human Conclusion: Collectively, these findings suggest that has potential serve a predictive biomarker osteosarcoma.

Язык: Английский

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Zinc Finger Proteins in the War on Gastric Cancer: Molecular Mechanism and Clinical Potential

Cells, Год журнала: 2023, Номер 12(9), С. 1314 - 1314

Опубликована: Май 4, 2023

According to the 2020 global cancer data released by World Cancer Research Fund (WCRF) International, gastric (GC) is fifth most common worldwide, with yearly increasing incidence and second-highest fatality rate in malignancies. Despite contemporary ambiguous molecular mechanisms GC pathogenesis, numerous in-depth studies have demonstrated that zinc finger proteins (ZFPs) are essential for development progression of GC. ZFPs a class transcription factors finger-like domains bind Zn2+ extensively participate gene replication, cell differentiation tumor development. In this review, we briefly outline roles, latest advances GC, including eight principal aspects, such as proliferation, epithelial–mesenchymal transition (EMT), invasion metastasis, inflammation immune infiltration, apoptosis, cycle, DNA methylation, stem cells (CSCs) drug resistance. Intriguingly, myeloid 1 (MZF1) possesses reversely dual roles promoting proliferation or impeding via apoptosis. Therefore, thorough understanding mechanism on will pave solid way screening potentially effective diagnostic indicators, prognostic biomarkers therapeutic targets

Язык: Английский

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