Bee Pollen Phytochemicals and Nutrients as Unequaled Pool of Epigenetic Regulators: Implications for Age-Related Diseases

Foods, Год журнала: 2025, Номер 14(3), С. 347 - 347

Опубликована: Янв. 21, 2025

Bee pollen is characterized by an exceptional diversity and abundance of micronutrients bioactive phytochemicals. This richness remains very sparsely investigated, but accumulating evidence strongly supports a promising future for bee in human nutrition medicine. Epigenetic regulation among the most compelling biomedical topics that remain completely untapped derivative research. In our current research, we identified numerous ubiquitous compounds are consistently present this matrix, regardless its botanical geographical origins, have been well studied documented as epigenetic regulators recent years. Given relative newness both research studies within nutritional, pharmaceutical, medical sciences, review aims to bridge these valuable fields advance related experimental investigations. To best knowledge, first work has aimed comprehensively investigate modulatory potential compounds. Our findings also unveiled several intriguing phenomena, such dual effect same compound depending on cellular context or some cross-generational heritability traits. Although whole extract still lacking, study clearly indicates avenue worth further We hope constitutes foundational cornerstone investigations

Язык: Английский

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Impact of micronutrients and nutraceuticals on cognitive function and performance in Alzheimer's disease

Ageing Research Reviews, Год журнала: 2024, Номер 95, С. 102210 - 102210

Опубликована: Фев. 1, 2024

Alzheimer's disease (AD) is a major global health problem today and the most common form of dementia. AD characterized by formation β-amyloid (Aβ) plaques neurofibrillary clusters, leading to decreased brain acetylcholine levels in brain. Another mechanism underlying pathogenesis abnormal phosphorylation tau protein that accumulates at level aggregates, areas affected this pathological process are usually cholinergic neurons cortical, subcortical, hippocampal areas. These effects result cognitive function, atrophy, neuronal death. Malnutrition weight loss frequent manifestations AD, these also associated with greater decline. Several studies have confirmed balanced low-calorie diet proper nutritional intake may be considered important factors counteracting or slowing progression whereas high-fat hypercholesterolemic predisposes an increased risk developing AD. Especially, fruits, vegetables, antioxidants, vitamins, polyunsaturated fatty acids, micronutrients supplementation exert positive on aging-related changes due their antioxidant, anti-inflammatory, radical scavenging properties. The purpose review summarize some possible contribute prevention understand role nutrition plays Aβ typical neurodegenerative disease, identify potential therapeutic strategies involve natural compounds, delaying disease.

Язык: Английский

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Association of PM_2.5 Components with Acceleration of Aging: Moderating Role of Sex Hormones

Environmental Science & Technology, Год журнала: 2023, Номер 57(9), С. 3772 - 3782

Опубликована: Фев. 22, 2023

Fine particulate matter (PM2.5) has been linked to aging risk, and a lack of knowledge about the relationships between PM2.5 components risk impeded development healthy aging. Participants were recruited through multicenter cross-sectional study in Beijing-Tianjin-Hebei region China. Middle-age older males menopausal women completed collection basic information, blood samples, clinical examinations. The biological age was estimated by Klemera-Doubal method (KDM) algorithms based on biomarkers. Multiple linear regression models applied quantify associations interactions while controlling for confounders, restricted cubic spline function corresponding dose-response curves relationships. Overall, KDM-biological acceleration associated with component exposure over preceding year both females, calcium [females: 0.795 (95% CI: 0.451, 1.138); males: 0.712 0.389, 1.034)], arsenic 0.770 0.641, 0.899); 0.661 0.532, 0.791)], copper 0.401 0.158, 0.644); 0.379 0.122, 0.636)] having greater estimates effect than total mass. Additionally, we observed that specific lower higher sex hormone scenario. Maintaining high levels hormones may be crucial barrier against component-related middle groups.

Язык: Английский

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Association between the Composite Dietary Antioxidant Index and Stroke: A cross-sectional Study

Biological Trace Element Research, Год журнала: 2023, Номер 202(10), С. 4335 - 4344

Опубликована: Дек. 28, 2023

Язык: Английский

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The Association between Dietary Nutrient Intake and Acceleration of Aging: Evidence from NHANES

Nutrients, Год журнала: 2024, Номер 16(11), С. 1635 - 1635

Опубликована: Май 27, 2024

The acceleration of aging is a risk factor for numerous diseases, and diet has been identified as an especially effective anti-aging method. Currently, research on the relationship between dietary nutrient intake accelerated remains limited, with existing studies focusing small number individual nutrients. Comprehensive single mixed effects nutrients not conducted. This study aimed to comprehensively explore intakes, both singly in combination, aging. Data this were extracted from 2015–2018 National Health Nutrition Examination Surveys (NHANES). was measured by phenotypic age acceleration. Linear regression (linear), restricted cubic spline (RCS) (nonlinear), weighted quantile sum (WQS) (mixed effect) models used association A total 4692 participants aged ≥ 20 included study. In fully adjusted models, intakes 16 negatively associated (protein, vitamin E, A, beta-carotene, B1, B2, B6, K, phosphorus, magnesium, iron, zinc, copper, potassium, fiber, alcohol). Intakes sugars, C, caffeine, alcohol showed significant nonlinear associations Additionally, Single well may mitigate Moderately increasing specific maintaining balance be key strategies prevent

Язык: Английский

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Administration of nicotinamide mononucleotide suppresses the progression of age-related hearing loss in mice

Hearing Research, Год журнала: 2025, Номер 457, С. 109182 - 109182

Опубликована: Янв. 5, 2025

Язык: Английский

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A Recent Review On: Effect of Nutrients On Brain Function and Development

Indus journal of bioscience research., Год журнала: 2025, Номер 3(1), С. 125 - 135

Опубликована: Янв. 16, 2025

Recent studies have demonstrated the important role that nutrition plays in maintaining cognitive health by highlighting substantial effects of different nutrients on brain growth and function. Research articles from Google scholar, scihub, PUBMED was searched for food development Important are connected to neurodevelopment, synaptic plasticity, general function include omega-3 fatty acids, B vitamins, antioxidants, vital minerals. The structure depend especially DHA, neurotransmitter production resilience supported vitamins. Vitamins E C examples antioxidants reduce oxidative stress support neurons. Cognitive deficits linked mineral shortages, those involving iron zinc. This review summarizes research relationship between long-term problems nutritional deficiencies, particularly during developmental stages. Additionally, diets high particular better mental outcomes lowers risks various illnesses caused neurodegeneration. Overall, this highlights how crucial a balanced diet is promoting throughout life.

Язык: Английский

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In vitro and In silico Anti-Alzheimer study of Rutin embedded with Zinc chloride loaded bovine serum albumin nanoparticles

Tissue and Cell, Год журнала: 2025, Номер 95, С. 102869 - 102869

Опубликована: Март 28, 2025

Язык: Английский

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Correlations of vascular cognitive impairment with brain-derived neurotrophic factor and trace elements

Revista română de medicină de laborator, Год журнала: 2025, Номер 33(1), С. 35 - 40

Опубликована: Янв. 1, 2025

Abstract Background Cognitive impairment has become one of the major public health problems due to population aging and increased morbidity associated with stroke. In this study, we aimed analyze correlations vascular cognitive (VCI) brain-derived neurotrophic factor (BDNF) trace elements. Methods Between January 2022 2024, a total 206 subjects were included in which 103 VCI patients treated our hospital (a group), volunteers undergoing physical examination control group). Comparisons conducted on levels BDNF elements (Cu, Fe, Zn, Ca, Mg, Se, As, Al) between two groups. Results comparison group, group had significantly reduced BDNF, Cu, Fe Zn (p<0.05), raised Al level decreases score Mini-Mental State Examination (MMSE) corrected Montreal Assessment (MoCA) (p<0.05). The MMSE MoCA positively correlated (p<0.05) negatively both groups <5.39 μg/L, Cu <10.87 μmol/L, <5.97 <77.32 >0.72 μmol/L risk factors for VCI. Conclusions have lower Zn) higher than those healthy populations. Excessively low an overly high harmful element are

Язык: Английский

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Maternal Treadmill Exercise and Zinc Supplementation Alleviate Prenatal Stress–Induced Cognitive Deficits and Restore Neurological Biomarkers in Offspring: A Study on Male Rats Aged 30 and 90 Days

Developmental Neurobiology, Год журнала: 2025, Номер 85(2)

Опубликована: Апрель 1, 2025

ABSTRACT The detrimental effects of prenatal stress (PS) on offspring's neurological and behavioral outcomes are well documented. However, strategies to mitigate these underexplored. This study examines whether zinc supplementation treadmill exercise can modulate PS‐induced cognitive impairments neurobiological markers in young adult male rat offspring, leveraging the established neuroprotective potential both physical activity zinc. Pregnant rats were divided into five groups: control, stress, + exercise, zinc, with all except control group subjected restraint (gestational days 15–19). groups underwent forced whereas those received oral sulfate throughout pregnancy. At postnatal 30 90, function offspring was evaluated using Morris water maze (MWM) test, hippocampal gene expression levels caspase‐3, brain‐derived neurotrophic factor (BDNF), glial fibrillary acidic protein (GFAP) measured reverse transcription–polymerase chain reaction (RT‐PCR). PS impaired functions, increased caspase‐3 expression, decreased BDNF GFAP rats. Prenatal found deficits primarily through enhancing improved mainly reduced expression. combined effect not additive functions biomarkers. Physical may alleviate by modulating astrocytic factors, exert its inhibiting apoptosis via a BDNF‐dependent pathway. Further targeted research is necessary confirm relationships.

Язык: Английский

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