Journal of Xenobiotics,
Journal Year:
2025,
Volume and Issue:
15(2), P. 47 - 47
Published: March 24, 2025
Numerous
epidemiological
studies
indicate
that
populations
exposed
to
environmental
toxicants
such
as
heavy
metals
have
a
higher
likelihood
of
developing
Alzheimer’s
disease
(AD)
compared
those
unexposed,
indicating
potential
association
between
exposure
and
AD.
The
aim
this
review
is
summarize
contemporary
mechanistic
research
exploring
the
associations
four
important
metals,
arsenic
(As),
manganese
(Mn),
lead
(Pb),
cadmium
(Cd),
with
AD
possible
pathways,
processes,
molecular
mechanisms
on
basis
data
from
most
recent
studies.
Primary
publications
published
during
last
decade
were
identified
via
search
PubMed
Database.
A
thorough
literature
final
screening
yielded
45
original
articles
for
review.
Of
articles,
6
pertain
As,
9
Mn,
21
Pb,
Cd
exposures
pathobiology.
Environmental
these
induces
wide
range
pathological
processes
intersect
well-known
leading
AD,
oxidative
stress,
mitochondrial
dysfunction,
protein
aggregation,
neuroinflammation,
autophagy
tau
hyperphosphorylation.
While
single
shares
some
affected
certain
effects
are
unique
specific
metals.
For
instance,
Pb
disrupts
blood–brain
barrier
(BBB)
functions
alters
AD-related
genes
epigenetically.
triggers
neuronal
senescence
p53/p21/Rb.
As
nitric
oxide
(NO)
signaling,
cortical,
synaptic
function.
Mn
causes
glutamate
excitotoxicity
dopamine
neuron
damage.
Our
provides
deeper
understanding
biological
showing
how
contribute
Information
regarding
metal-induced
toxicity
relevant
may
help
us
develop
effective
therapeutic
intervention,
treatment,
prevention.
Gut Microbes,
Journal Year:
2023,
Volume and Issue:
15(2)
Published: Nov. 7, 2023
The
advent
of
highthroughput
‘omics’
technologies
has
improved
our
knowledge
gut
microbiome
in
human
health
and
disease,
including
Alzheimer’s
disease
(AD),
a
neurodegenerative
disorder.
Frequent
bidirectional
communications
mutual
regulation
exist
between
the
gastrointestinal
tract
central
nervous
system
through
gut-brain
axis.
A
large
body
research
reported
close
association
microbiota
AD
development,
restoring
healthy
may
curb
or
even
improve
symptoms
progression.
Thus,
modulation
become
novel
paradigm
for
clinical
management
AD,
emerging
effort
focused
on
developing
potential
strategies
preventing
and/or
treating
disease.
In
this
review,
we
provide
an
overview
connection
causal
relationship
dysbiosis
mechanisms
driving
progression,
successes
challenges
implementing
available
microbiome-targeted
therapies
(including
probiotics,
prebiotics,
synbiotics,
postbiotics,
fecal
transplantation)
preventive
therapeutic
preclinical
intervention
studies
AD.
Finally,
discuss
future
directions
field.
Nutrition & Metabolism,
Journal Year:
2024,
Volume and Issue:
21(1)
Published: March 19, 2024
Abstract
Context
Resveratrol
(RV),
a
natural
compound
found
in
grapes,
berries,
and
peanuts,
has
been
extensively
studied
for
its
potential
treating
Alzheimer’s
disease
(AD).
RV
shown
promise
inhibiting
the
formation
of
beta-amyloid
plaques
(Aβ)
neurofibrillary
tangles
(NFTs),
protecting
against
neuronal
damage
oxidative
stress,
reducing
inflammation,
promoting
neuroprotection,
improving
function
blood–brain
barrier
(BBB).
However,
conflicting
results
have
reported,
necessitating
comprehensive
umbrella
review
systematic
reviews
to
provide
an
unbiased
conclusion
on
therapeutic
effectiveness
AD.
Objective
The
objective
this
study
was
systematically
synthesize
evaluate
meta-analysis
investigating
role
AD
using
data
from
both
human
animal
studies.
Data
sources
extraction
Of
34
examining
association
between
that
were
collected,
six
included
based
specific
selection
criteria.
To
identify
pertinent
studies,
search
conducted
English-language
peer-reviewed
journals
without
any
restrictions
publication
date
until
October
15,
2023.
carried
out
across
multiple
databases,
including
Embase,
MEDLINE
(PubMed),
Cochrane
Library,
Web
Science,
Google
Scholar,
utilizing
appropriate
terms
relevant
research
field.
AMSTAR-2
ROBIS
tools
also
used
quality
risk
bias
reviews,
respectively.
Two
researchers
independently
extracted
analyzed
data,
resolving
discrepancies
through
consensus.
note,
adhered
PRIOR
checklist.
analysis
This
presented
robust
evidence
supporting
positive
impacts
AD,
irrespective
mechanisms
involved.
It
indeed
indicated
all
unanimously
concluded
consumption
can
be
effective
treatment
Conclusion
exhibits
promising
benefiting
individuals
with
various
mechanisms.
observed
enhance
cognitive
function,
reduce
Aβ
accumulation,
protect
BBB,
support
mitochondrial
facilitate
synaptic
plasticity,
stabilize
tau
proteins,
mitigate
neuroinflammation
commonly
associated
Graphical
abstract
Neurosciences,
Journal Year:
2025,
Volume and Issue:
30(1), P. 5 - 19
Published: Jan. 1, 2025
The
hippocampus,
noted
as
(HC),
plays
a
crucial
role
in
the
processes
of
learning,
memory
formation,
and
spatial
navigation.
Recent
research
reveals
that
this
brain
region
can
undergo
structural
functional
changes
due
to
environmental
exposures,
including
stress,
noise
pollution,
sleep
deprivation,
microgravity.
This
review
synthesizes
findings
from
animal
human
studies,
emphasizing
HC's
plasticity
response
these
factors.
It
examines
volume,
architecture,
neurogenesis,
synaptic
plasticity,
gene
expression
highlights
critical
periods
vulnerability
influences
impacting
cognition
behavior.
also
investigates
underlying
mechanisms
such
glucocorticoid
signaling,
epigenetic
alterations,
neural
circuit
adaptations.
Understanding
how
HC
reacts
various
exposures
is
vital
for
developing
strategies
enhance
cognitive
resilience
mitigate
negative
effects
on
region.
Further
needed
identify
protective
risk
factors
create
effective
interventions.
Ageing Research Reviews,
Journal Year:
2024,
Volume and Issue:
95, P. 102210 - 102210
Published: Feb. 1, 2024
Alzheimer's
disease
(AD)
is
a
major
global
health
problem
today
and
the
most
common
form
of
dementia.
AD
characterized
by
formation
β-amyloid
(Aβ)
plaques
neurofibrillary
clusters,
leading
to
decreased
brain
acetylcholine
levels
in
brain.
Another
mechanism
underlying
pathogenesis
abnormal
phosphorylation
tau
protein
that
accumulates
at
level
aggregates,
areas
affected
this
pathological
process
are
usually
cholinergic
neurons
cortical,
subcortical,
hippocampal
areas.
These
effects
result
cognitive
function,
atrophy,
neuronal
death.
Malnutrition
weight
loss
frequent
manifestations
AD,
these
also
associated
with
greater
decline.
Several
studies
have
confirmed
balanced
low-calorie
diet
proper
nutritional
intake
may
be
considered
important
factors
counteracting
or
slowing
progression
whereas
high-fat
hypercholesterolemic
predisposes
an
increased
risk
developing
AD.
Especially,
fruits,
vegetables,
antioxidants,
vitamins,
polyunsaturated
fatty
acids,
micronutrients
supplementation
exert
positive
on
aging-related
changes
due
their
antioxidant,
anti-inflammatory,
radical
scavenging
properties.
The
purpose
review
summarize
some
possible
contribute
prevention
understand
role
nutrition
plays
Aβ
typical
neurodegenerative
disease,
identify
potential
therapeutic
strategies
involve
natural
compounds,
delaying
disease.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(5), P. 606 - 606
Published: May 15, 2024
Epigenetics
defines
changes
in
cell
function
without
involving
alterations
DNA
sequence.
Neuroepigenetics
bridges
neuroscience
and
epigenetics
by
regulating
gene
expression
the
nervous
system
its
impact
on
brain
function.
With
increase
research
recent
years,
it
was
observed
that
did
not
always
originate
from
genetic
sequence,
which
has
led
to
understanding
role
of
neurodegenerative
diseases
(NDDs)
including
Alzheimer's
disease
(AD)
Parkinson's
(PD).
Epigenetic
contribute
aberrant
genes
involved
neuroinflammation,
protein
aggregation,
neuronal
death.
Natural
phytochemicals
have
shown
promise
as
potential
therapeutic
agents
against
NDDs
because
their
antioxidant,
anti-inflammatory,
neuroprotective
effects
cellular
animal
models.
For
instance,
resveratrol
(grapes),
curcumin
(turmeric),
epigallocatechin
gallate
(EGCG;
green
tea)
exhibit
through
influence
methylation
patterns,
histone
acetylation,
non-coding
RNA
profiles.
Phytochemicals
also
aid
slowing
progression,
preserving
function,
enhancing
cognitive
motor
abilities.
The
present
review
focuses
various
epigenetic
modifications
pathology
NDDs,
AD
PD,
regulation
related
alterations,
specific
polyphenols
influencing
PD.
Aging Clinical and Experimental Research,
Journal Year:
2024,
Volume and Issue:
36(1)
Published: Aug. 20, 2024
Cognitive
impairment
is
projected
to
affect
a
preponderant
proportion
of
the
aging
population.
Lifelong
dietary
habits
have
been
hypothesized
play
role
in
preventing
cognitive
decline.
Among
most
studied
components,
fish
consumptionhas
extensively
for
its
potential
effects
on
human
brain.
Frontiers in Medicine,
Journal Year:
2024,
Volume and Issue:
11
Published: Dec. 16, 2024
Alzheimer's
disease
(AD)
is
a
chronic,
progressive
neurodegenerative
disorder
characterized
by
cognitive
decline,
memory
loss,
and
impaired
reasoning.
It
the
leading
cause
of
dementia
in
older
adults,
marked
pathological
accumulation
amyloid-beta
plaques
neurofibrillary
tangles.
These
changes
lead
to
widespread
neuronal
damage,
significantly
impacting
daily
functioning
quality
life.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(11), P. 1589 - 1589
Published: May 23, 2024
The
rhizomes
of
Acorus
tatarinowii
Schott
and
gramineus
Solander
are
widely
used
for
treating
amnesia
in
traditional
Chinese
medicine.
In
contrast,
their
leaves
usually
discarded
without
medicinal
properties
being
known.
Here,
we
found
that
the
hot
water
extract
improved
cognition
tau
pathology
model
mice
frontotemporal
dementia,
similar
to
or
even
better
than
rhizomes.
To
explore
optimal
method
processing,
made
three
preparations
from
dried
leaves:
extract,
extraction
residue,
non-extracted
simple
crush
powder.
Among
them,
powder
had
strongest
effect
on
tauopathy
mice.
also
ameliorated
Aβ
α-synuclein
pathologies
restored
mouse
models
Alzheimer’s
disease
dementia
with
Lewy
bodies.
These
findings
suggest
potential
tatarinowii/gramineus
as
a
dietary
source
prevention
reveal
crushing
is
way
maximize
efficacy.
