Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy

Cell Communication and Signaling, Год журнала: 2023, Номер 21(1)

Опубликована: Май 1, 2023

Abstract Cancer is a leading cause of death worldwide and involves an oxidative stress mechanism. The transcription factor Nrf2 has crucial role in cytoprotective response against stress, including cancer growth progression therapy resistance. For this reason, inhibitors are new targets to be studied. Traditional plant-based remedies rich phytochemicals have been used human cancers phenolic compounds known for their chemopreventive properties. This comprehensive review offers updated the as anticancer agents due action on inhibition. In addition, naturally-occurring bioactive covered clinical applications polyphenols inhibitors.

Язык: Английский

---

Camellia sinensis: Insights on its molecular mechanisms of action towards nutraceutical, anticancer potential and other therapeutic applications

Arabian Journal of Chemistry, Год журнала: 2023, Номер 16(5), С. 104680 - 104680

Опубликована: Фев. 15, 2023

The Camellia sinensis plant provides a wide diversity of black, green, oolong, yellow, brick dark, and white tea. Tea is one the majorly used beverages across globe, succeeds only in water for fitness pleasure. Generally, green tea has been preferred more as compared to other teas due its main constituent e.g. polyphenols which contribute various health benefits. aim this updated comprehensive review bring together latest data on phytochemistry pharmacological properties highlight therapeutic prospects bioactive compounds so that full medicinal potential can be realised. A published studies topic was performed by searching PubMed/MedLine, Scopus, Google scholar, Web Science databases from 1999 2022. results analysed showed are four prime flavonoids catechins: epigallocatechin gallate (EGCG), epicatechin (ECG), (EGC), (EC) along with beneficial biological broad heterogeneity disorders, including anticancer, neuroprotective, antibacterial, antiviral, antifungal, antiobesity, antidiabetes antiglaucoma activities. Poor absorption low bioavailability limiting aspects their use. More human clinical approaching nanoformulation techniques nanoparticles transport target phytochemical increase efficacy needed future.

Язык: Английский

---

Exploring the Therapeutic Potential of Bromelain: Applications, Benefits, and Mechanisms

Nutrients, Год журнала: 2024, Номер 16(13), С. 2060 - 2060

Опубликована: Июнь 28, 2024

Bromelain is a mixture of proteolytic enzymes primarily extracted from the fruit and stem pineapple plant (

Язык: Английский

---

Protective Effects of Bromelain in Testicular Torsion-Detorsion: Reducing Inflammation, Oxidative Stress, and Apoptosis While Enhancing Sperm Quality

Biomolecules, Год журнала: 2025, Номер 15(2), С. 292 - 292

Опубликована: Фев. 15, 2025

Inflammation and increased oxidative stress in testicular tissue are documented side effects of torsion the testicles. The preventive role Bromelain (Bro) against testicle torsion-induced ischemia/reperfusion (I/R) injury was investigated this research. Five groups six animals each were created: ischemia, Ischemia+Reperfusion (I+R), Ischemia+Reperfusion+Bromelain (I+R+Bro; 10 mg/kg), control (sham), (Bro; mg/kg). An I/R damage resulted from two hours 720° clockwise twisting left testis. Blood samples epididymal sperm collected after reperfusion to analyze parameters (recovery, motility, viability, morphology) cytokines that promote inflammation (IL-1β, IL-6, TNF-α). Using Western blotting, examined for histopathological alterations, antioxidant enzymes (GSH, SOD), lipid peroxidation (MDA), apoptosis, survival-related proteins (TLR4, Caspase-3, Bcl-2, NRF-2, HO-1, PI3K, mTOR, AKT-1). While raising activities GSH SOD, enzymes, Bro administration dramatically reduced MDA concentrations. I+R+Bro group had significantly amounts promoted compared I+R group. Bro's protective properties also attributed altered by it participate apoptosis survival cells. Sperm morphology, concentration notably improved bromelain-treated group, according spermatological examination. Testicular treated with bromelain showed less histological evaluations than untreated These findings imply has anti-inflammatory, anti-apoptotic, qualities. It effectively reduces modulating PI3K/Akt/mTOR NRF-2/HO-1 pathways, hence minimizing injury.

Язык: Английский

---

Bromelain: a review of its mechanisms, pharmacological effects and potential applications

Food & Function, Год журнала: 2023, Номер 14(18), С. 8101 - 8128

Опубликована: Янв. 1, 2023

Bromelain, an enzyme obtained from pineapple, has now been identified as having versatile pharmaceutical applications. The last decade witnessed a paradigm shift for bromelain food to potential drug candidate.

Язык: Английский

---

An updated overview of anticancer effects of alternariol and its derivatives: underlying molecular mechanisms

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Март 23, 2023

Alternariol is a toxic metabolite of Alternaria fungi and studies have shown multiple potential pharmacological effects. To outline the anticancer effects mechanisms alternariol its derivatives based on database reports, an updated search PubMed/MedLine, ScienceDirect, Web Science, Scopus databases was performed with relevant keywords for published articles. The found to suggest that this mycotoxin and/or in many preclinical test systems. Scientific reports indicate exhibit through several pathways, including cytotoxic, reactive oxygen species leading oxidative stress mitochondrial dysfunction-linked cytotoxic effect, anti-inflammatory, cell cycle arrest, apoptotic death, genotoxic mutagenic, anti-proliferative, autophagy, estrogenic clastogenic mechanisms. In light these results, may be one hopeful chemotherapeutic agents.

Язык: Английский

---

Reduction of Post-Surgical Facial Edema Following Bromelain and Coumarin Intake in Traumatology: A Prospective Study with 100 Patients

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(4), С. 922 - 922

Опубликована: Фев. 6, 2024

Background: Bromelain and coumarins are recognized as safe effective therapeutic agents, used by individuals to treat ailments such postoperative edema, inflammation other diseases. has been proven be well absorbed the body after oral administration, it no major side effects even prolonged use. The purpose of this study is evaluate effectiveness bromelain nutraceuticals in reducing post-surgical swelling, pain need anti-inflammatory drugs maxillofacial post-traumatic surgery. Methods: This prospective open-label was conducted on patients undergoing surgery for trauma area. One hundred were selected divided into two groups: one group who underwent therapy with bromelain, Aesculus hippocastanum Melilotus officinalis a control that not given drug therapy. Results: Patients experimental showed reduction edema first second weeks, faster complete facial lower maximum mouth opening needed less pain. Conclusions: These findings seem provide evidence Brovas® may improving outcomes surgical treatment fractures.

Язык: Английский

---

Nanocompartment-confined polymerization in living systems

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Авг. 26, 2023

Polymerization in living systems has become an effective strategy to regulate cell functions and behavior. However, the requirement of high concentrations monomers, existence complicated intracorporal interferences, demand for extra external stimulations hinder their further biological applications. Herein, a nanocompartment-confined that provides confined secluded environment monomer enrichment isolation is developed achieve polymerization efficiency, reduce interference from environment, realize broad-spectrum polymerizations systems. For exogenous photopolymerization, light-mediated free-radical sodium 4-styrenesulfonate induces 2.7-fold increase reaction rate with protection environment. endogenous hydrogen peroxide-responsive polymerization, p‑aminodiphenylamine hydrochloride embedded nanocompartment not only performs 6.4-fold higher than free but also activates second near-infrared photoacoustic imaging-guided photothermal immunotherapy at tumor sites. This breaks shackles conventional providing universal platform vivo synthesis polymers diverse structures functions.

Язык: Английский

---

A comprehensive review on traditional uses, phytochemistry and pharmacological properties of Paeonia emodi Wall. ex Royle: current landscape and future perspectives

Chinese Medicine, Год журнала: 2023, Номер 18(1)

Опубликована: Март 2, 2023

Abstract Paeonia emodi Wall. ex Royle is commonly known as Himalayan paeony has great importance a food and medicine. The practice of very ancient it conventionally used for wide range illnesses in the folk system medicine because its beneficial phytochemical profile. main purpose current review was synthesis recent data on botany, ethnopharmacology, phytochemistry potential pharmacological mechanisms action Royle, thus offering new prospects development adjuvant natural therapies. Using scientific databases such PubMed/MedLine, Scopus, Web Science, ScienceDirect, Google Scholar, Springer, Wiley, comprehensive literature search performed Royle. For searching, we next MeSH terms: “Biological Product/isolation purification”, Products/pharmacology”, “Drug Discovery/methods”, “Ethnopharmacology, Medicine”, “Traditional/methods”, “Paeonia/chemistry”, “Plant Extracts/pharmacology”, “Phytochemicals/chemistry”, “Phytochemicals/pharmacology”, “Plants, Medicinal”. results most studies were analyzed important summarized tables figures. Phytochemical research led to isolation triterpenes, monoterpenes, phenolic acids, fatty organic compounds, steroids, free radicals some other classes primary metabolites. In addition, diverse activities like antibacterial, antifungal, anticoagulant, airway relaxant lipoxygenase beta-glucuronidase inhibiting activity, radical scavenging phytotoxic insecticidal have been reported Different bioactive compounds proven their therapeutic modern biomedical cure numerous gastrointestinal nervous disorders. future, further vitro vivo are required identify action, pharmacokinetics studies, pharmaceutical formulations target transport possible interaction with allopathic drugs. Also, regarding quality evaluation, toxicity safety humans needed.

Язык: Английский

---

A review on the immobilization of bromelain

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 273, С. 133089 - 133089

Опубликована: Июнь 14, 2024

This review shows the endeavors performed to prepare immobilized formulations of bromelain extract, usually from pineapple, and their use in diverse applications. extract has a potent proteolytic component that is based on thiol proteases, which differ depending location fruit. Stem fruit are areas where higher activity found. The edible origin this enzyme one features determines applications more significant degree. been wide diversity supports via different strategies (covalent bonds, ion exchange), also forming ex novo solids (nanoflowers, CLEAs, trapping alginate beads, etc.). preexisting nanoparticles as immobilization relevant, facilitates main enzyme, therapeutic (as wound dressing healing components, antibacterial or anticancer, mucus mobility control, A curiosity spores probiotic microorganisms adsorption, order have perfect vivo compatibility. Other outstanding stabilization wine versus haze during storage, mainly when chitosan. Curiously, scarcely applied production bioactive peptides.

Язык: Английский

---