Polymers,
Год журнала:
2024,
Номер
16(2), С. 206 - 206
Опубликована: Янв. 10, 2024
Degradable
polymers
(both
biomacromolecules
and
several
synthetic
polymers)
for
biomedical
applications
have
been
promising
very
much
in
the
recent
past
due
to
their
low
cost,
biocompatibility,
flexibility,
minimal
side
effects.
Here,
we
present
an
overview
with
updated
information
on
natural
degradable
where
a
brief
account
different
polysaccharides,
proteins,
viz.
polyesters/polyamino
acids/polyanhydrides/polyphosphazenes/polyurethanes
relevant
has
provided.
The
various
approaches
transformation
of
these
by
physical/chemical
means
cross-linking,
as
polyblends,
nanocomposites/hybrid
composites,
interpenetrating
complexes,
interpolymer/polyion
functionalization,
polymer
conjugates,
block
graft
copolymers,
are
described.
degradation
mechanism,
drug
loading
profiles,
toxicological
aspects
polymeric
nanoparticles
formed
also
defined.
Biomedical
polymer-based
biomaterials
wound
dressing/healing,
biosensors,
delivery
systems,
tissue
engineering,
regenerative
medicine,
etc.,
highlighted.
In
addition,
use
such
nano
systems
solve
current
problems
is
briefly
reviewed.
Polymers,
Год журнала:
2022,
Номер
14(4), С. 687 - 687
Опубликована: Фев. 11, 2022
Reactive
oxygen
species
(ROS)-sensitive
drug
delivery
systems
(DDS)
specifically
responding
to
altered
levels
of
ROS
in
the
pathological
microenvironment
have
emerged
as
an
effective
means
enhance
pharmaceutical
efficacy
conventional
nanomedicines,
while
simultaneously
reducing
side
effects.
In
particular,
use
biocompatible,
biodegradable,
and
non-toxic
ROS-responsive
thioketal
(TK)
functional
group
design
smart
DDS
has
grown
exponentially
recent
years.
TK-based
DDS,
different
technological
uses
TK
been
proposed
overcome
major
limitations
counterparts
including
uncontrolled
release
off-target
This
review
will
focus
on
biomaterials
nanomedicines
by
using
it
a
linker
connect
surface
nanoparticles,
form
prodrugs,
core
component
directly
control
its
structure,
opening
drug-releasing
gates
or
change
conformation
nano-systems.
A
comprehensive
view
various
may
allow
researchers
exploit
this
reactive
more
consciously
designing
be
with
improved
disease-targeting
ability,
providing
novel
therapeutic
opportunities
treatment
many
diseases.
Abstract
Dynamic‐responsive
self‐assembly
is
the
process
of
ordered
supramolecular
structure
formation
or
reversible
decomposition
from
building
blocks.
This
driven
by
non‐covalent
interactions
based
on
complex
stimulus‐responsive
systems
comprising
different
components
within
a
microenvironment.
Furthermore,
stimuli‐responsive
assembly‐disassembly
an
intrinsic
interaction
in
organisms,
indispensable
maintaining
life
activities
and
functions.
However,
dynamic
between
dynamically
responsive
nano‐drug
(DRNSs)
biological
remain
unpredictable,
which
are
challenge
for
precisely
targeted
therapy
controlled
drug
release
DRNSs
vivo.
review
highlights
novel
self‐assembling
peptide‐based
their
interactions.
By
controlling
shape
size
self‐assembled
peptide
nanomaterials,
biologically
simulated
with
diverse
functions
precise
transport
at
subcellular
level
can
be
achieved.
We
have
also
summarized
limitations
challenges
nanomaterials
clinical
translation.
Additionally,
we
discussed
future
perspectives
therapeutics
using
signaling
molecule
gradient
concentrations
efficiencies
highlighted
direction
developing
clinically
translatable
smart
nanomedicines.
Pharmacology & Therapeutics,
Год журнала:
2024,
Номер
257, С. 108631 - 108631
Опубликована: Март 11, 2024
Mouse
models
of
disease
play
a
pivotal
role
at
all
stages
cancer
drug
development.
Cell-line
derived
subcutaneous
tumour
are
predominant
in
early
discovery,
but
there
is
growing
recognition
the
importance
more
complex
orthotopic
and
metastatic
for
understanding
both
target
biology
correct
tissue
context,
impact
microenvironment
immune
system
responses
to
treatment.
The
aim
this
review
highlight
value
that
bring
study
development
while
pointing
out
those
most
likely
be
encountered
literature.
Important
developments
models,
such
as
increasing
use
passage
patient
material
(PDXs,
organoids)
humanised
mouse
discussed,
these
approaches
have
potential
increase
predictive
preclinical
studies,
ultimately
improve
success
rate
anticancer
drugs
clinical
trials.
Nanomaterials,
Год журнала:
2022,
Номер
12(15), С. 2672 - 2672
Опубликована: Авг. 4, 2022
Cancer
therapies
have
advanced
tremendously
throughout
the
last
decade,
yet
multiple
factors
still
hinder
success
of
different
cancer
therapeutics.
The
traditional
therapeutic
approach
has
been
proven
insufficient
and
lacking
in
suppression
tumor
growth.
simultaneous
delivery
small-molecule
chemotherapeutic
drugs
genes
improves
effectiveness
each
treatment,
thus
optimizing
efficacy
improving
synergistic
effects.
Nanomedicines
integrating
inorganic,
lipid,
polymeric-based
nanoparticles
designed
to
regulate
spatiotemporal
release
encapsulated
drugs.
Multidrug-loaded
nanocarriers
are
a
potential
strategy
fight
incorporation
co-delivery
systems
as
feasible
treatment
method
projected
benefits
limited
undesirable
Moreover,
development
for
maximum
impact
necessitates
better
knowledge
appropriate
agent
ratio
well
inherent
heterogeneity
cells.
Co-delivery
can
simplify
clinical
processes
increase
patient
quality
life,
even
though
such
more
difficult
prepare
than
single
drug
systems.
This
review
highlights
progress
attained
design
nano
carrier-based
discusses
limitations,
challenges,
future
perspectives
fabrication
ACS Applied Materials & Interfaces,
Год журнала:
2023,
Номер
15(2), С. 2747 - 2759
Опубликована: Янв. 6, 2023
Bacteria-mediated
cancer
therapy
has
attracted
much
attention
in
recent
years.
However,
using
magnetotactic
bacteria
as
both
a
drug
carrier
and
for
never
been
reported.
Herein,
we
incorporated
photosensitizer
chlorin
e6
(Ce6)
into
the
M.
magneticum
strain
AMB-1
through
chemical
bond
or
physical
blending.
A
reaction
was
finally
selected
fabricating
AMB-1/Ce6
micromotors,
such
micromotors
exhibited
high
payload
normal
bacterial
activities.
An
interesting
finding
is
that
not
only
an
excellent
but
also
unique
could
inhibit
mouse
tumor
growth.
We
also,
first
time,
demonstrated
photosensitizer.
Under
laser
irradiation,
killed
cells
with
efficiency
due
to
high-level
reactive
oxygen
species
generated
by
micromotors.
Micromotors
target
hypoxic
normoxic
regions
vitro
via
active
swimming
of
external
magnetic
field
guidance.
showed
tumor-homing
ability
owing
above
double
targeting
mechanisms.
After
injection
followed
guidance
growth
tumors
significantly
inhibited
AMB-1-based
biotherapy
phototoxicity
Ce6.
This
micromotor-mediated
tumor-targeted
strategy
may
be
great
platform
treating
many
types
solid
tumors.
Bioactive Materials,
Год журнала:
2024,
Номер
36, С. 48 - 61
Опубликована: Фев. 26, 2024
Photosynthetic
bacteria
(PSB)
has
shown
significant
potential
as
a
drug
or
delivery
system
owing
to
their
photothermal
capabilities
and
antioxidant
properties.
Nevertheless,
the
actualization
of
is
impeded
by
inherent
constraints,
including
considerable
size,
heightened
immunogenicity
compromised
biosafety.
Conquering
these
obstacles
pursuing
more
effective
solutions
remains
top
priority.
Similar
extracellular
vesicles,
bacterial
outer
membrane
vesicles
(OMVs)
have
demonstrated
great
in
biomedical
applications.
OMVs
from
PSB
encapsulate
rich
array
bioactive
constituents,
proteins,
nucleic
acids,
lipids
inherited
parent
cells.
Consequently,
they
emerge
promising
practical
alternative.
Unfortunately,
suffered
low
yield
inconsistent
particle
sizes.
In
response,
bacteria-derived
nanovesicles
(BNVs),
created
through
controlled
extrusion,
adeptly
overcome
challenges
associated
with
OMVs.
However,
differences,
both
composition
subsequent
biological
effects,
between
BNVs
remain
enigmatic.
groundbreaking
endeavor,
our
study
meticulously
cultivates
PSB-derived
BNVs,
dissecting
nuances.
Despite
minimal
differences
morphology
size
latter
contains
higher
concentration
active
ingredients
metabolites.
Particularly
noteworthy
elevated
levels
lysophosphatidylcholine
(LPC)
found
known
for
its
ability
enhance
cell
proliferation
initiate
downstream
signaling
pathways
that
promote
angiogenesis
epithelialization.
Importantly,
results
indicate
can
accelerate
wound
closure
effectively
orchestrating
harmonious
balance
migration
within
NIH-3T3
cells,
while
also
activating
EGFR/AKT/PI3K
pathway.
contrast,
pronounced
aptitude
anti-cancer
efforts,
driving
macrophages
toward
M1
phenotype
promoting
release
inflammatory
cytokines.
Thus,
findings
not
only
provide
methodological
framework
but
establish
definitive
criterion
discerning
optimal
application
addressing
wide
range
medical
conditions.
