Frontiers in Immunology,
Год журнала:
2024,
Номер
14
Опубликована: Янв. 12, 2024
Programmed
cell
death
(PCD)
is
an
evolutionarily
conserved
mechanism
of
suicide
that
controlled
by
various
signaling
pathways.
PCD
plays
important
role
in
a
multitude
biological
processes,
such
as
turnover,
development,
tissue
homeostasis
and
immunity.
Some
forms
PCD,
including
apoptosis,
autophagy-dependent
death,
pyroptosis,
ferroptosis
necroptosis,
contribute
to
carcinogenesis
cancer
thus
have
attracted
increasing
attention
the
field
oncology.
Recently,
research-based
evidence
has
demonstrated
acts
critical
modulator
tumor
can
affect
function
innate
adaptive
immune
cells,
which
leads
distinct
immunological
consequences,
priming
tumor-specific
T
immunosuppression
evasion.
Targeting
alone
or
combination
with
conventional
immunotherapy
may
provide
new
options
enhance
clinical
efficacy
anticancer
therapeutics.
In
this
review,
we
introduce
characteristics
mechanisms
ubiquitous
pathways
(e.g.,
pyroptosis
ferroptosis)
explore
complex
interaction
between
these
immunity
based
on
currently
available
evidence.
We
also
discuss
therapeutic
potential
PCD-based
approaches
outlining
trials
targeting
treatment.
Elucidating
immune-related
effects
pathogenesis
will
likely
improved
understanding
oncoimmunology
allow
be
exploited
for
Carbon
dots
were
synthesised
from
spent
coffee
grounds
via
a
novel
acetone
precipitation
approach,
featuring
superior
physico-chemical
properties
for
potential
biomedical
applications.
Created
in
BioRender.
Zhou,
Y.
(2025)
https://BioRender.com/m82x982.
The
research
and
development
of
non-viral
gene
therapy
has
been
extensive
over
the
past
decade
received
a
big
push
thanks
to
recent
successful
approval
nucleic
acid
products.
Despite
these
developments,
applications
in
cancer
have
limited.
One
main
causes
this
imbalance
delivery
vectors
as
compared
with
sophisticated
payloads,
such
siRNA,
mRNA,
etc.
This
paper
reviews
that
can
be
used
deliver
acids
for
treatment.
It
discusses
various
types
highlights
their
current
applications.
Additionally,
it
perspective
on
regulatory
landscape
facilitate
commercial
translation
therapy.
International Journal of Nanomedicine,
Год журнала:
2023,
Номер
Volume 18, С. 2589 - 2621
Опубликована: Май 1, 2023
Abstract:
Zein
is
a
type
of
prolamine
protein
that
derived
from
corn,
and
it
has
been
recognized
by
the
US
FDA
as
one
safest
biological
materials
available.
possesses
valuable
characteristics
have
made
popular
choice
for
preparation
drug
carriers,
which
can
be
administered
through
various
routes
to
improve
therapeutic
effect
antitumor
drugs.
Additionally,
zein
contains
free
hydroxyl
amino
groups
offer
numerous
modification
sites,
enabling
hybridized
with
other
create
functionalized
delivery
systems.
However,
despite
its
potential,
clinical
translation
drug-loaded
zein-based
carriers
remains
challenging
due
insufficient
basic
research
relatively
strong
hydrophobicity.
In
this
paper,
we
aim
systematically
introduce
main
interactions
between
loaded
drugs
zein,
administration
routes,
functionalization
systems,
in
order
demonstrate
development
potential
promote
their
further
application.
We
also
provide
perspectives
future
directions
promising
area
research.
Graphical
Keywords:
nanomedicine,
delivery,
Journal of Materials Chemistry B,
Год журнала:
2023,
Номер
12(4), С. 872 - 894
Опубликована: Дек. 11, 2023
This
review
delves
into
the
potential
of
zeolitic
imidazolate
framework-8
(ZIF-8)
nanoparticles
in
augmenting
efficacy
cancer
immunotherapy,
with
a
special
focus
on
delivery
programmed
cell
death
receptor
1
(PD-1)
inhibitors.
The
multifunctional
nature
ZIF-8
as
drug
carriers
is
emphasized,
their
ability
to
encapsulate
range
therapeutic
agents,
including
PD-1
inhibitors,
and
facilitate
targeted
tumor
locations.
By
manipulating
pore
size
surface
characteristics
nanoparticles,
controlled
release
can
be
realized.
strategic
use
deliver
inhibitors
presents
precise
modality
for
treatment,
reducing
off-target
impacts
enhancing
effectiveness.
combined
strategy
addresses
existing
challenges
constraints
current
immunotherapy
techniques,
ultimate
goal
patient
outcomes
therapy.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
14(4)
Опубликована: Ноя. 6, 2024
Cancer
remains
one
of
the
most
challenging
health
issues
globally,
demanding
innovative
therapeutic
approaches
for
effective
treatment.
Nanoparticles,
particularly
those
composed
gold,
silver,
and
iron
oxide,
have
emerged
as
promising
candidates
changing
cancer
therapy.
This
comprehensive
review
demonstrates
landscape
nanoparticle-based
oncological
interventions,
focusing
on
remarkable
advancements
potentials
oxide
nanoparticles.
Gold
nanoparticles
garnered
significant
attention
their
exceptional
biocompatibility,
tunable
surface
chemistry,
distinctive
optical
properties,
rendering
them
ideal
various
diagnostic
strategies.
Silver
nanoparticles,
renowned
antimicrobial
exhibit
potential
in
therapy
through
multiple
mechanisms,
including
apoptosis
induction,
angiogenesis
inhibition,
drug
delivery
enhancement.
With
magnetic
properties
offer
unique
diagnosis
targeted
opportunities.
critically
examines
recent
synthesis,
functionalization,
biomedical
applications
these
Moreover,
challenges
are
discussed,
toxicity
concerns,
immunogenicity,
translational
barriers,
ongoing
efforts
to
overcome
hurdles
highlighted.
Finally,
insights
into
future
directions
regulatory
considerations,
provided
aiming
accelerate
translation
technologies
from
bench
bedside.
Polymers,
Год журнала:
2024,
Номер
16(9), С. 1182 - 1182
Опубликована: Апрель 23, 2024
Polymers
derived
from
natural
biomass
have
emerged
as
a
valuable
resource
in
the
field
of
biomedicine
due
to
their
versatility.
Polysaccharides,
peptides,
proteins,
and
lignin
demonstrated
promising
results
various
applications,
including
drug
delivery
design.
However,
several
challenges
need
be
addressed
realize
full
potential
these
polymers.
The
current
paper
provides
comprehensive
overview
latest
research
perspectives
this
area,
with
particular
focus
on
developing
effective
methods
efficient
systems.
This
review
aims
offer
insights
into
opportunities
associated
use
polymers
provide
roadmap
for
future
field.
