Acta Pharmacologica Sinica, Год журнала: 2025, Номер unknown
Опубликована: Апрель 9, 2025
Язык: Английский
Molecular Biology Reports, Год журнала: 2025, Номер 52(1)
Опубликована: Фев. 17, 2025
Язык: Английский
Процитировано
1
Cancer Letters, Год журнала: 2024, Номер 588, С. 216738 - 216738
Опубликована: Фев. 23, 2024
Язык: Английский
Процитировано
7
Phytotherapy Research, Год журнала: 2024, Номер 38(4), С. 2041 - 2076
Опубликована: Фев. 23, 2024
Abstract In recent years, heightened interest surrounds the exploration of natural phenols as potential agents for cancer therapy, specifically by inducing ferroptosis, a unique form regulated cell death characterized iron‐dependent lipid peroxidation. This review delves into roles key phenols, flavonoids, phenolic acids, curcumin, and stilbenes, in modulating ferroptosis their underlying mechanisms. Emphasizing significance amino acid, lipid, iron metabolism, study elucidates diverse pathways through which these regulate ferroptosis. Notably, well‐known polyphenol, exhibits multifaceted interactions with cellular components involved regulation, providing distinctive therapeutic avenue. Stilbenes, another class, demonstrate promising influencing metabolism processes, contributing to ferroptotic death. Understanding intricate interplay between not only illuminates complex regulatory networks but also unveils avenues novel therapies. Exploring compounds inducers presents strategy targeted treatment, capitalizing on delicate balance article synthesizes current knowledge, aiming stimulate further research context ferroptosis‐mediated therapy.
Язык: Английский
Процитировано
7
Molecular and Cellular Biochemistry, Год журнала: 2024, Номер unknown
Опубликована: Апрель 26, 2024
Язык: Английский
Процитировано
7
Anti-Cancer Drugs, Год журнала: 2025, Номер unknown
Опубликована: Март 12, 2025
Pancreatic cancer is one of the most common malignant tumors digestive system, with majority patients not succumbing to primary tumor but rather metastasis. Epithelial-mesenchymal transition (EMT) abnormally activated in numerous cancers, whereby it promotes cell migration and invasion. Yes-associated protein 1 (YAP1) commonly overexpressed various types plays an oncogenic role. We demonstrated that FV-429, a derivative natural flavonoid wogonin, inhibited invasion metastasis pancreatic cells by modulating EMT-related proteins. FV-429 enhances expression p-LATS1, thereby promoting conversion YAP1 p-YAP1. Meanwhile, suppresses nuclear translocation YAP1, affecting E-cadherin snail1, which, turn, impacts EMT. The Hippo-signaling pathway inhibitor TDI-011536 was used validate these results. In vivo , mouse model lung established using PANC02 antimetastatic effect which confirmed its action through Hippo/YAP1 pathway. addition, high safety low toxicity. conclusion, we inhibits migration, invasion, human pathway, suggesting has potential be novel therapeutic agent for cancer.
Язык: Английский
Процитировано
1
Antioxidants, Год журнала: 2024, Номер 13(3), С. 334 - 334
Опубликована: Март 10, 2024
Ferroptosis is a recently discovered type of programmed cell death that mechanistically different from other types such as apoptosis, necroptosis, and autophagy. It characterized by the accumulation intracellular iron, overproduction reactive oxygen species, depletion glutathione, extensive lipid peroxidation lipids in membrane. was ferroptosis interconnected with many diseases, neurodegenerative ischemia/reperfusion injury, cancer, chronic kidney disease. Polyphenols, plant secondary metabolites known for bioactivities, are being extensively researched context their influence on which resulted great number publications showing need systematic review. In this review, an literature search performed. Databases (Scopus, Web Science, PubMed, ScienceDirect, Springer) were searched time span 2017 to November 2023, using keyword “ferroptosis” alone combination “flavonoid”, “phenolic acid”, “stilbene”, “coumarin”, “anthraquinone”, “chalcone”; after selection studies, we had 311 papers 143 phenolic compounds. total, 53 compounds showed ability induce ferroptosis, 110 able inhibit out those compounds, 20 both abilities depending model system. The most shikonin, curcumin, quercetin, resveratrol, baicalin. common modes action modulation Nrf2/GPX4 Nrf2/HO-1 axis iron metabolism.
Язык: Английский
Процитировано
6
Antioxidants, Год журнала: 2024, Номер 13(6), С. 696 - 696
Опубликована: Июнь 6, 2024
The transcription factor nuclear erythroid 2-related 2 (Nrf2) represents the master regulator of cellular antioxidant response and plays a critical role in tumorigenesis. This includes preventive effect Nrf2 on cell death through ferroptosis, which an essential mechanism therapy resistance malignant tumors, such as pancreatic ductal adenocarcinoma (PDAC) one most aggressive still incurable tumors. Addressing this issue, we provide overview mediated with particular emphasis its mitochondria organelle responsible for execution ferroptosis. We further outline how deregulated adds to progression PDAC, especially respect ferroptosis anti-cancer drug killing is impaired by resistance. Our review discusses recent approaches inhibition natural synthetic compounds overcome based enhanced Finally, outlook therapeutic strategies combined inducing drugs.
Язык: Английский
Процитировано
6
Journal of Biological Chemistry, Год журнала: 2024, Номер 300(8), С. 107583 - 107583
Опубликована: Июль 16, 2024
Ferroptosis is an iron-dependent cell death mechanism that may be important to prevent tumor formation and useful as a target for new cancer therapies. Transcriptional networks play crucial role in shaping ferroptosis sensitivity by regulating the expression of transporters, metabolic enzymes, other proteins. The Cap'n'collar (CNC) protein nuclear factor erythroid 2 like (NFE2L2, also known NRF2) key regulator many cells contexts. Emerging evidence indicates related CNC family members BTB homology 1 (BACH1) (NFE2L1) have non-redundant roles regulation. Here, we comprehensively review transcription factors governing cellular ferroptosis. We describe how regulate through modulation iron, lipid, redox metabolism. use examples regulation proteins illustrate flexible highly context-dependent nature between conditions.
Язык: Английский
Процитировано
5
Separation Science and Technology, Год журнала: 2024, Номер 59(1), С. 151 - 192
Опубликована: Янв. 2, 2024
With the requirement to increase safety and sustainability of separation processes, there has been a shift toward utilization green solvents in extraction processes. Deep eutectic (DESs) are neoteric with several advantages over conventional organic or ionic liquids (ILs). They nontoxic, nonflammable, biodegradable, less costly. Moreover, they can be regenerated reused process repeated cycles. The yield using DESs improved through employment ultrasound-assisted (UAE), microwave-assisted (MAE), ultrahigh pressure (UHPE), negative cavitation (NPCE). These techniques not only shorten processing time but also intensify mass transfer facilitate diffusion bioactive ingredients. raised interest purification polyphenol saponin compounds therapeutic properties, have found their applications as alternative solvents. This review aims highlight recent for flavonoids, curcuminoids, saponins from plant sources discuss compare factors that should considered enhancing efficiency these discussed works lay foundations further development processes
Язык: Английский
Процитировано
4
Current Nutrition Reports, Год журнала: 2024, Номер 13(3), С. 566 - 581
Опубликована: Май 3, 2024
Язык: Английский
Процитировано
4