AIP conference proceedings, Journal Year: 2025, Volume and Issue: 3270, P. 020110 - 020110
Published: Jan. 1, 2025
Language: Английский
Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)
Published: Feb. 17, 2025
Language: Английский
Citations
1
Cancer Letters, Journal Year: 2024, Volume and Issue: 588, P. 216738 - 216738
Published: Feb. 23, 2024
Language: Английский
Citations
7
Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(4), P. 2041 - 2076
Published: Feb. 23, 2024
Abstract In recent years, heightened interest surrounds the exploration of natural phenols as potential agents for cancer therapy, specifically by inducing ferroptosis, a unique form regulated cell death characterized iron‐dependent lipid peroxidation. This review delves into roles key phenols, flavonoids, phenolic acids, curcumin, and stilbenes, in modulating ferroptosis their underlying mechanisms. Emphasizing significance amino acid, lipid, iron metabolism, study elucidates diverse pathways through which these regulate ferroptosis. Notably, well‐known polyphenol, exhibits multifaceted interactions with cellular components involved regulation, providing distinctive therapeutic avenue. Stilbenes, another class, demonstrate promising influencing metabolism processes, contributing to ferroptotic death. Understanding intricate interplay between not only illuminates complex regulatory networks but also unveils avenues novel therapies. Exploring compounds inducers presents strategy targeted treatment, capitalizing on delicate balance article synthesizes current knowledge, aiming stimulate further research context ferroptosis‐mediated therapy.
Language: Английский
Citations
7
Antioxidants, Journal Year: 2024, Volume and Issue: 13(3), P. 334 - 334
Published: March 10, 2024
Ferroptosis is a recently discovered type of programmed cell death that mechanistically different from other types such as apoptosis, necroptosis, and autophagy. It characterized by the accumulation intracellular iron, overproduction reactive oxygen species, depletion glutathione, extensive lipid peroxidation lipids in membrane. was ferroptosis interconnected with many diseases, neurodegenerative ischemia/reperfusion injury, cancer, chronic kidney disease. Polyphenols, plant secondary metabolites known for bioactivities, are being extensively researched context their influence on which resulted great number publications showing need systematic review. In this review, an literature search performed. Databases (Scopus, Web Science, PubMed, ScienceDirect, Springer) were searched time span 2017 to November 2023, using keyword “ferroptosis” alone combination “flavonoid”, “phenolic acid”, “stilbene”, “coumarin”, “anthraquinone”, “chalcone”; after selection studies, we had 311 papers 143 phenolic compounds. total, 53 compounds showed ability induce ferroptosis, 110 able inhibit out those compounds, 20 both abilities depending model system. The most shikonin, curcumin, quercetin, resveratrol, baicalin. common modes action modulation Nrf2/GPX4 Nrf2/HO-1 axis iron metabolism.
Language: Английский
Citations
6
Molecular and Cellular Biochemistry, Journal Year: 2024, Volume and Issue: unknown
Published: April 26, 2024
Language: Английский
Citations
6
Antioxidants, Journal Year: 2024, Volume and Issue: 13(6), P. 696 - 696
Published: June 6, 2024
The transcription factor nuclear erythroid 2-related 2 (Nrf2) represents the master regulator of cellular antioxidant response and plays a critical role in tumorigenesis. This includes preventive effect Nrf2 on cell death through ferroptosis, which an essential mechanism therapy resistance malignant tumors, such as pancreatic ductal adenocarcinoma (PDAC) one most aggressive still incurable tumors. Addressing this issue, we provide overview mediated with particular emphasis its mitochondria organelle responsible for execution ferroptosis. We further outline how deregulated adds to progression PDAC, especially respect ferroptosis anti-cancer drug killing is impaired by resistance. Our review discusses recent approaches inhibition natural synthetic compounds overcome based enhanced Finally, outlook therapeutic strategies combined inducing drugs.
Language: Английский
Citations
6
Journal of Biological Chemistry, Journal Year: 2024, Volume and Issue: 300(8), P. 107583 - 107583
Published: July 16, 2024
Ferroptosis is an iron-dependent cell death mechanism that may be important to prevent tumor formation and useful as a target for new cancer therapies. Transcriptional networks play crucial role in shaping ferroptosis sensitivity by regulating the expression of transporters, metabolic enzymes, other proteins. The Cap'n'collar (CNC) protein nuclear factor erythroid 2 like (NFE2L2, also known NRF2) key regulator many cells contexts. Emerging evidence indicates related CNC family members BTB homology 1 (BACH1) (NFE2L1) have non-redundant roles regulation. Here, we comprehensively review transcription factors governing cellular ferroptosis. We describe how regulate through modulation iron, lipid, redox metabolism. use examples regulation proteins illustrate flexible highly context-dependent nature between conditions.
Language: Английский
Citations
5
Separation Science and Technology, Journal Year: 2024, Volume and Issue: 59(1), P. 151 - 192
Published: Jan. 2, 2024
With the requirement to increase safety and sustainability of separation processes, there has been a shift toward utilization green solvents in extraction processes. Deep eutectic (DESs) are neoteric with several advantages over conventional organic or ionic liquids (ILs). They nontoxic, nonflammable, biodegradable, less costly. Moreover, they can be regenerated reused process repeated cycles. The yield using DESs improved through employment ultrasound-assisted (UAE), microwave-assisted (MAE), ultrahigh pressure (UHPE), negative cavitation (NPCE). These techniques not only shorten processing time but also intensify mass transfer facilitate diffusion bioactive ingredients. raised interest purification polyphenol saponin compounds therapeutic properties, have found their applications as alternative solvents. This review aims highlight recent for flavonoids, curcuminoids, saponins from plant sources discuss compare factors that should considered enhancing efficiency these discussed works lay foundations further development processes
Language: Английский
Citations
4
Current Nutrition Reports, Journal Year: 2024, Volume and Issue: 13(3), P. 566 - 581
Published: May 3, 2024
Language: Английский
Citations
4
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: May 9, 2024
Lung cancer has high metastasis and drug resistance. The prognosis of lung patients is poor the patients’ survival chances are easily neglected. Ferroptosis a programmed cell death proposed in 2012, which differs from apoptosis, necrosis autophagy. novel type regulated driven by iron-dependent lipid peroxidation subsequent plasma membrane ruptures. It broad prospects field tumor disease treatment. At present, multiple studies have shown that biological compounds can induce ferroptosis cells, exhibits significant anti-cancer effects, they advantages safety, minimal side less possibility to In this review, we summarize used for treatment focusing on its mechanism. addition, systematically review current research status combining nanotechnology with treatment, shed new light targeting pathways applying compounds-based therapies.
Language: Английский
Citations
4