European Journal of Clinical Microbiology & Infectious Diseases, Год журнала: 2025, Номер unknown
Опубликована: Апрель 5, 2025
Язык: Английский
Journal of Epidemiology and Global Health, Год журнала: 2023, Номер 13(4), С. 725 - 739
Опубликована: Сен. 1, 2023
Asia's inflammatory bowel disease (IBD) burden has rapidly increased recently, but the epidemiological trends in Asia remain unclear. We report IBD's incidence, prevalence, mortality, and Disability-Adjusted Life Years (DALY) 52 Asian countries from 1990 to 2019.Data Global Burden of Disease 2019 were analyzed for IBD across countries, using metrics like mortality rates, DALY. The trend was assessed with Joinpoint APC methods. Decomposition frontier analyses examined factors behind case death changes. NORPRED forecasted morbidity 2044.From 2019, incidence prevalence Asia, while DALY decreased. East had highest increase burden. among 30-34 age group, peaking 45-49 group. In high-income regions, peak shifted younger groups. Decompose analysis showed population growth as primary factor increasing cases Asia. NORDPRED model predicted a continued over next 25 years.Between ASIR ASPR increased, ASMR ASDR Due aging, is expected rise years, particularly
Язык: Английский
Процитировано
29
Alimentary Pharmacology & Therapeutics, Год журнала: 2024, Номер 60(3), С. 378 - 388
Опубликована: Июнь 3, 2024
Summary Background and Aims The objective of the study was to analyse prevalence, incidence, death alcohol‐associated liver disease (ALD) among adolescents young adults globally, continentally, nationally, focusing on trends over time. Methods analysed data from Global Burden Disease (GBD) between 2000 2019. It examined ALD's in aged 15–29, segmented by region, nation, sociodemographic index. analysis utilised Joinpoint regression modelling calculate annual per cent change (APC) rate these parameters Results In 2019, there were 281,450 ALD prevalences, 18,930 incidences, 3190 deaths globally. From age‐adjusted prevalence 100,000 increased 25–29 age group (APC: +0.6%, p = 0.003), remained stable ages 20–24 ( 0.302) 15–19 0.160). Prevalence significantly (19‐fold increase) (2.5‐fold increase). rates all groups Africa Eastern Mediterranean region. Around three‐quarters countries territories experienced an increase incidence adults. Conclusion Over two decades, burden has emphasises importance public health policies aimed at reducing alcohol consumption preventing younger populations.
Язык: Английский
Процитировано
16
International Journal of Colorectal Disease, Год журнала: 2024, Номер 39(1)
Опубликована: Сен. 7, 2024
Язык: Английский
Процитировано
15
Frontiers in Public Health, Год журнала: 2025, Номер 12
Опубликована: Янв. 21, 2025
Objectives This study aims to analyze the global burden of otitis media and predict future trends using data from Global Burden Disease 2021 (GBD 2021). Study design A cross-sectional analysis GBD results was conducted. Methods Age-standardized incidence rates (ASIR), age-standardized prevalence (ASPR), disability-adjusted life years (DALYs) (ASDR) were calculated. Trend conducted estimated annual percentage change (EAPC), Joinpoint regression, age-period-cohort, decomposition analyses. Future projections generated Bayesian age-period-cohort (BAPC) auto-regressive integrated moving average (ARIMA) models. Results The rose 322.1 million cases in 1992 391.3 2021, with ASIR increasing slightly 5345.09 5529.1 per 100,000 (EAPC: 0.11%). Despite this increase, ASPR decreased 1786.56 1593.74 -0.43%). DALYs increased 2.16 2.48 million; however, ASDR declined 37.68 32.54 −0.51%). Notably, low low-middle SDI regions showed significant disparities, higher ASIRs (up 5315.08 for males) but declining ASPR. Regionally, East Asia exhibited most substantial decline (−1.14%) (−1.22%), while Central Sub-Saharan Africa demonstrated stable ASDR. indicate a rising through 2036. Conclusion shows regional rate. Public health interventions have been effective regions, targeted efforts are needed further reduce media.
Язык: Английский
Процитировано
1
Frontiers in Public Health, Год журнала: 2022, Номер 10
Опубликована: Окт. 25, 2022
This study aims to explore the epidemiological trends of inflammatory bowel disease (IBD) over past three decades in China and further predict IBD next 25 years.The prevalence, incidence, mortality, years life lived with disability (YLDs), lost (YLLs), disability-adjusted (DALYs), annual percentage changes above metrics from 1990 2019 were extracted Global Burden Disease Study 2019. The corresponding predicted.From 2019, cases raised 484 thousand [95% uncertainty interval (UI) 411-571] 427 (366-498) among males females, respectively. age-standardized incidence rate increased 1.72 per 100,000 population (1.44-2.05) 3.35 (2.88-3.88) 1.20 (1.02-1.42) 2.65 (2.29-3.08) females. highest occurred people aged 35-39 years. total YLDs attributed significantly increased, but YLLs showed a decreasing trend, resulting minor alterations DALYs. In years, would continue increase until plateau by 2030, IBD-related deaths also about 7.57 2044 despite mortality rate. Similar observed for both sexes, slight male predominance.Although is still low-endemic area IBD, prevalence dramatically decades. burden expected grow continuously due large base severe aging problem. estimated enter Compounding Prevalence stage around 2030.
Язык: Английский
Процитировано
25
Food Reviews International, Год журнала: 2023, Номер 40(1), С. 336 - 369
Опубликована: Фев. 8, 2023
Inflammatory Bowel Diseases (IBD) are inflammatory conditions characterized by bowel disruption and the involvement of immune system can be associated with development colorectal cancer. Conventional therapeutic approaches based on administering drugs capable modulating response; however, many patients irresponsive to conventional therapies. Grapes largely used in producing wine, juice, jam, other products. However, waste from production process represents an environmental problem. On hand, grape by-products rich bioactive compounds such as proanthocyanidins, anthocyanins, phenolic acids, stilbenes, flavonols. These help prevention or treatment several IBD Grape promote remarkable effects reducing pro-inflammatory, pro-oxidative, proliferative actions CRC both vivo vitro. related improvement epithelial integrity, reduction Disease Activity Index, mucosal barrier reinforcement, induction strong chemopreventive actions, tumor incidence, cell proliferation.
Язык: Английский
Процитировано
12
Nutrients, Год журнала: 2023, Номер 15(13), С. 3054 - 3054
Опубликована: Июль 6, 2023
Ulcerative colitis (UC) is evolving into a global burden with substantially increasing incidence in developing countries. It characterized by inflammation confined to mucosa and recognized as an intestinal barrier disease. The microbiota plays crucial role UC pathogenesis. N. commune has long been appreciated healthy food supplement worldwide polysaccharides account for 60%. Here, we examined the amelioration of against acute mice induced DSS assessed mediating gut microbiota. An integrated analysis microbiome, metabolomics, transcriptomics fully elaborated it markedly enhanced mucosal function, including: relative abundance Akkermansia muciniphila, uncultured_bacterium_g__norank_f__Muribaculaceae, unclassified_g__norank_f__norank_o__Clostridia_UCG-014; decreasing microbiota-derived phosphatidylcholines thromboxane 2 levels mapped arachidonic acid metabolism; improving mucin2 biosynthesis secretion; enhancing ZO-1 occludin expression; reducing neutrophil infiltration; regulating level colitis-related inflammatory cytokines; involving immune function-associated signaling pathways. Further, mediation effect was evaluated administering cocktail antibiotics. In conclusion, our results demonstrated that predominantly reinforced microbiota-mediated confer protection exhibited dramatic prebiotic-like functions, providing alternative or complementary treatment UC.
Язык: Английский
Процитировано
12
RMD Open, Год журнала: 2023, Номер 9(4), С. e003650 - e003650
Опубликована: Дек. 1, 2023
This study aims to evaluate the long-term trend of prevalence and DALY (disability-adjusted life-year) rate on age, period cohort (APC) BRICS (Brazil, Russia, India, China South Africa) country for autoimmune diseases (rheumatoid arthritis (RA), inflammatory bowel disease (IBD), multiple sclerosis (MS) psoriasis).The data are sourced from Global Burden Disease Study 2019, it uses Joinpoint regression model estimate time trends 1990 2019. Additionally, employs Age-Period-Cohort period, effects 2019.For ASPR (age-standardised rate) IBD increased significantly Africa, decreased Brazil, Russian. The Russian MS demonstrated a decreasing (average annual percent change=-0.5%, 95% CI -0.6 -0.5), with most occurring in Brazil at 2009-2014. effect rates Psoriasis displayed an ongoing 1929-1933 birth 1999-2003 cohort. Specifically, five countries relative risk values (RRs) DALYs due RA by 7.98, 16.07, 5.98, 3.19, 9.13 times, 20 24 age group 65 69 group.The population accounts more than 40% global population. And we found that various is heavily influenced ageing.
Язык: Английский
Процитировано
10
Nutrients, Год журнала: 2024, Номер 16(9), С. 1347 - 1347
Опубликована: Апрель 29, 2024
Inflammatory bowel disease (IBD) is a chronic inflammatory intestinal disorder, and its complex etiology makes prevention treatment challenging. Research on new drugs strategies currently focal point. Phenolic acids are widely present in plant-based diets have demonstrated the potential to alleviate colitis due their powerful antioxidant anti-inflammatory properties. In this review, we provide an overview of structures main dietary sources phenolic acids, encompassing benzoic acid cinnamic acid. Additionally, explore as nutritional therapy for preventing treating IBD. animal cell experiments, effectively IBD induced by drug exposure or genetic defects. The mechanisms include improving mucosal barrier function, reducing oxidative stress, inhibiting excessive activation immune response, regulating balance microbiota. Our observation points towards need additional basic clinical investigations derivatives novel therapeutic agents
Язык: Английский
Процитировано
4
Nutrients, Год журнала: 2024, Номер 16(14), С. 2302 - 2302
Опубликована: Июль 17, 2024
Inflammatory bowel disease (IBD), a complex chronic inflammatory disorder that includes Crohn’s (CD) and Ulcerative Colitis (UC), has become globally increasing health concern. Nutrition, as an important factor influencing the occurrence development of IBD, attracted more attention. As most nutrient, protein can not only provide energy nutrition required by patients, but also help repair damaged intestinal tissue, enhance immunity, thus alleviate inflammation. Numerous studies have shown nutritional support plays significant role in treatment remission IBD. This article presents comprehensive review pathogenesis IBD analyzes summarizes potential mechanisms Additionally, it provides overview clinical effects its impact on complications. Research findings reveal demonstrates benefits improving symptoms, reducing risk complications, quality life patients. Therefore, is expected to new approach for
Язык: Английский
Процитировано
4