GeroScience,
Год журнала:
2022,
Номер
44(6), С. 2585 - 2609
Опубликована: Ноя. 17, 2022
Abstract
Advancing
age
is
associated
with
chronic
diseases
which
are
the
largest
cause
of
death
and
disability
in
developed
countries.
With
increasing
life
expectancy
an
ageing
population,
there
a
need
to
conduct
trials
extend
healthy
ageing,
including
targeting
biological
processes,
prevent
ageing-related
diseases.
The
main
objectives
study
as
follows:
(i)
review
outcome
measures
utilised
focusing
on
pharmacological
therapies,
nutritional
supplements
medical
devices;
(ii)
summarise
views
key
stakeholders
selection
for
trials.
An
analysis
records
from
Clinicaltrials.gov
database
pertaining
inception
May
2022
was
conducted.
In
addition,
findings
workshop
attended
by
at
annual
UKSPINE
conference
were
qualitatively
analysed.
Substantial
heterogeneity
found
interventions
evaluated
outcomes
included
studies.
Recruitment
participants
diverse
backgrounds
confounding
effects
multi-morbidity
older
adults
identified
challenges
measuring
participants.
development
core
set
can
aid
comparability
across
within
different
settings.
provided
important
platform
garner
range
perspectives
this
setting.
It
critical
initiate
such
discussions
progress
field
provide
practical
answers
how
designed
structured
future.
Microorganisms,
Год журнала:
2024,
Номер
12(4), С. 775 - 775
Опубликована: Апрель 11, 2024
Immune
system
aging
is
becoming
a
field
of
increasing
public
health
interest
because
prolonged
life
expectancy,
which
not
paralleled
by
an
increase
in
expectancy.
As
age
progresses,
innate
and
adaptive
immune
systems
undergo
changes,
are
defined,
respectively,
as
inflammaging
senescence.
A
wealth
available
data
demonstrates
that
these
two
conditions
closely
linked,
leading
to
greater
vulnerability
elderly
subjects
viral,
bacterial,
opportunistic
infections
well
lower
post-vaccination
protection.
To
face
this
novel
scenario,
in-depth
assessment
the
players
involved
changing
epidemiology
demanded
regarding
individual
concerted
involvement
cells
mediators
within
endogenous
exogenous
factors
co-morbidities.
This
review
provides
overall
updated
description
changes
affecting
system,
may
be
help
understanding
underlying
mechanisms
associated
with
main
age-associated
infectious
diseases.
Aging
|
doi:10.18632/aging.206135.
Yu-Xuan
Lyu,
Qiang
Fu,
Dominika
Wilczok,
Kejun
Ying,
Aaron
King,
Adam
Antebi,
Aleksandar
Vojta,
Alexandra
Stolzing,
Alexey
Moskalev,
Anastasia
Georgievskaya,
Andrea
B.
Maier,
Olsen,
Anja
Groth,
Anna
Katharina
Simon,
Anne
Brunet,
Aisyah
Jamil,
Anton
Kulaga,
Asif
Bhatti,
Benjamin
Yaden,
Bente
Klarlund
Pedersen,
Björn
Schumacher,
Boris
Djordjevic,
Brian
Kennedy,
Chieh
Chen,
Christine
Yuan
Huang,
Christoph
U.
Correll,
Coleen
T.
Murphy,
Collin
Y.
Ewald,
Danica
Dario
Riccardo
Valenzano,
Dariusz
Sołdacki,
David
Erritzoe,
Meyer,
A.
Sinclair,
Eduardo
Nunes
Chini,
Emma
C.
Teeling,
Eric
Morgen,
Verdin,
Erik
Vernet,
Estefano
Pinilla,
Evandro
F.
Fang,
Evelyne
Bischof,
Evi
M.
Mercken,
Fabian
Finger,
Folkert
Kuipers,
Frank
W.
Pun,
Gabor
Gyülveszi,
Gabriele
Civiletto,
Garri
Zmudze,
Gil
Blander,
Harold
Pincus,
Joshua
McClure,
James
L.
Kirkland,
Peyer,
Jamie
N.
Justice,
Jan
Vijg,
Jennifer
R.
Gruhn,
Jerry
McLaughlin,
Joan
Mannick,
João
Passos,
Joseph
Baur,
Joe
Betts-LaCroix,
John
Sedivy,
Speakman,
Jordan
Shlain,
Julia
von
Maltzahn,
Katrin
I.
Andreasson,
Kelsey
Moody,
Konstantinos
Palikaras,
Kristen
Fortney,
Laura
J.
Niedernhofer,
Lene
Juel
Rasmussen,
Liesbeth
Veenhoff,
Lisa
Melton,
Luigi
Ferrucci,
Marco
Quarta,
Maria
Koval,
Marinova,
Mark
Hamalainen,
Maximilian
Unfried,
Michael
S.
Ringel,
Milos
Filipovic,
Mourad
Topors,
Natalia
Mitin,
Nawal
Roy,
Nika
Pintar,
Nir
Barzilai,
Paolo
Binetti,
Parminder
Singh,
Paul
Kohlhaas,
D.
Robbins,
Rubin,
Peter
O.
Fedichev,
Petrina
Kamya,
Pura
Muñoz-Canoves,
Rafael
de
Cabo,
Richard
G.
Faragher,
Rob
Konrad,
Roberto
Ripa,
Robin
Mansukhani,
Sabrina
Büttner,
Sara
Wickström,
Sebastian
Brunemeier,
Sergey
Jakimov,
Shan
Luo,
Sharon
Rosenzweig-Lipson,
Shih-Yin
Tsai,
Stefanie
Dimmeler,
Thomas
Rando,
Tim
Peterson,
Tina
Woods,
Tony
Wyss-Coray,
Toren
Finkel,
Tzipora
Strauss,
Vadim
Gladyshev,
Valter
Longo,
Varun
Dwaraka,
Vera
Gorbunova,
Victoria
Acosta-Rodríguez,
Vincenzo
Sorrentino,
Vittorio
Sebastiano,
Wenbin
Li,
Yousin
Suh,
Alex
Zhavoronkov,
Morten
Scheibye-Knudsen,
Daniela
Bakula
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2022,
Номер
unknown
Опубликована: Фев. 9, 2022
We
analyze
aging
signatures
of
DNA
methylation
and
longitudinal
electronic
medical
records
from
the
UK
Biobank
datasets
observe
that
is
driven
by
a
large
number
independent
infrequent
transitions
between
metastable
states
in
vast
configuration
space.
The
compound
effect
changes
can
be
captured
single
stochastic
variable,
thermodynamic
biological
age
(tBA),
tracking
entropy
produced,
hence
information
lost
during
aging.
show
tBA
increases
with
age,
causes
linear
irreversible
drift
physiological
state
variables,
reduces
resilience,
drives
exponential
acceleration
chronic
disease
incidence
death
risks.
entropic
character
sets
severe
constraints
on
possibilities
reversal.
However,
we
highlight
universal
features
transitions,
suggest
practical
ways
suppressing
rate
humans,
speculate
possibility
achieving
negligible
senescence.
In
medicines
development,
the
progress
in
science
and
technology
is
accelerating.
Awareness
of
these
developments
their
associated
challenges
opportunities
essential
for
regulators
others
to
translate
them
into
benefits
society.
this
context,
European
Medicines
Agency
uses
horizon
scanning
shine
a
light
on
early
signals
relevant
innovation
technological
trends
with
impact
medicinal
products.
This
article
provides
results
systematic
exercises
conducted
by
Agency,
collaboration
World
Health
Organization
(WHO)
Commission's
Joint
Research
Centre's
(DG
JRC).
These
collaborative
aim
inform
policy-makers
new
increase
preparedness
responding
them.
A
subset
25
trends,
divided
three
clusters
were
selected
reviewed
from
perspective
regulators.
For
each
expected
adoption
are
discussed,
along
recommendations
developers,
policy
makers.
Frontiers in Medicine,
Год журнала:
2024,
Номер
11
Опубликована: Окт. 18, 2024
The
most
recognizable
implications
of
tissue
aging
manifest
themselves
on
the
skin.
Skin
laxity,
roughness,
pigmentation
disorders,
age
spots,
wrinkles,
telangiectasia
or
hair
graying
are
symptoms
physiological
aging.
Development
senescent
phenotype
depends
interaction
between
cells
and
remodeling
skin’s
extracellular
matrix
(ECM)
that
contains
collagen
elastic
fiber.
Aging
changes
occur
due
to
combination
both
endogenous
(gene
mutation,
cellular
metabolism
hormonal
agents)
exogenous
factors
(ultraviolet
light,
environmental
pollutants,
unsuitable
diet).
However,
overproduction
mitochondrial
reactive
oxygen
species
(ROS)
is
a
key
factor
driving
senescence.
theories
have
disclosed
range
diverse
molecular
mechanisms
associated
with
senescence
body.
Theories
best
supported
by
evidence
include
protein
glycation,
oxidative
stress,
telomere
shortening,
cell
cycle
arrest,
limited
number
divisions.
Accumulation
ECM
damage
suggested
be
in
skin
Every
indicates
functional
morphological
change
may
used
as
biomarker
Senescence-associated
β
-galactosidase
(SA-β-gal),
inhibitors
(p16INK4a,
p21CIP1,
p27,
p53),
DNA
segments
chromatin
alterations
reinforcing
(DNA-SCARS),
senescence-associated
heterochromatin
foci
(SAHF),
shortening
telomeres
downregulation
lamina
B1
constitute
just
an
example
biomarkers
known
so
far.
also
assessed
non-invasively
through
measuring
fluorescence
advanced
glycation
end-products
(AGEs).
This
review
summarizes
recent
knowledge
pathogenesis
clinical
conditions
well
International Journal of Cosmetic Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 15, 2025
Abstract
Possible
sustainable
resources
of
beneficial
compounds
for
various
applications
are
agricultural
crop
and
food
production
residues
(ACFPR),
which
supported
by
considerable
efforts
to
characterize
their
compositions
biological
activities.
This
knowledge
can
be
utilized
the
rational
selection
residue
extracts
components
possible
use
in
development
value‐added
products,
such
as
anti‐ageing
cosmetics.
The
appearance
wrinkles,
pigmentation,
a
reduction
skin
elasticity
typical
signs
ageing
that
often
alleviated
natural
product‐based
preparations.
Here,
we
silico
approaches
identify
from
with
potential
alleviate
symptoms
or
reverse
process.
Target
predictions
combined
extensive
database
literature
searches
were
present
ACR
proteins
linked
ageing.
binding
affinity
products
selected
using
molecular
docking
respective
intermolecular
interaction
analyses
predicted
provide
an
indicative
measure
compounds'
activity.
A
number
interact
protein
targets
collagenase,
elastase,
hyaluronidase
identified.
In
addition
findings,
cytotoxicity
assays
conducted
rose
hip
seed
against
Hs294T
(human
metastatic
melanoma,
ATCC
HTB‐140)
MRC‐5
(normal
fetal
lung
fibroblasts,
CCL
171),
demonstrating
selective
cytotoxicity.
ELISA
revealed
induced
significant
increase
SIRT1
levels
(160%
control)
TGF‐β
(80%
control).
These
experimental
results
support
modulating
key
involved
ageing,
reinforcing
viability
ingredients
cosmetic
formulations.
An
analysis
relationships
pathways
organic
substances
sources
affect
offers
developing
formulations
rejuvenation
synergistic
effects
utilizing
design
innovative
skincare
laying
framework
more
effective
screening
different
applications.
