Foods, Год журнала: 2023, Номер 12(13), С. 2529 - 2529
Опубликована: Июнь 29, 2023
Ergosterol is an important sterol commonly found in edible mushrooms, and it has nutritional value pharmacological activity. a provitamin. It been well established that mushrooms are excellent food source of vitamin D2 because ergosterol precursor converted to under ultraviolet radiation. The effects ergosterol, which include antimicrobial, antioxidant, anticancer, antidiabetic, anti-neurodegenerative, other activities, have also reported. This review aims provide overview the available evidence regarding its underlying mechanisms action. Their potential benefits applications discussed.
Язык: Английский
Процитировано
47The neuroprotective effects of targeting key factors of neuronal cell death in neurodegenerative diseases: The role of ER stress, oxidative stress, and neuroinflammation
Frontiers in Cellular Neuroscience, Год журнала: 2023, Номер 17
Опубликована: Март 6, 2023
Neuronal loss is one of the striking causes various central nervous system (CNS) disorders, including major neurodegenerative diseases, such as Alzheimer’s disease (AD), Parkinson’s (PD), Huntington’s (HD), and Amyotrophic lateral sclerosis (ALS). Although these diseases have different features clinical manifestations, they share some common mechanisms pathology. Progressive regional neurons in patients responsible for motor, memory, cognitive dysfunctions, leading to disabilities death. cell death linked pathways conditions. Protein misfolding aggregation, mitochondrial dysfunction, generation reactive oxygen species (ROS), activation innate immune response are most critical hallmarks diseases. Thus, endoplasmic reticulum (ER) stress, oxidative neuroinflammation pathological factors neuronal Even though exact not fully discovered, notable role mentioned well known. On this basis, researchers been prompted investigate neuroprotective effects targeting underlying determine a promising therapeutic approach treatment. This review provides an overview ER death, mainly discussing or molecules involved factors.
Язык: Английский
Процитировано
46PPAR agonists for the treatment of neuroinflammatory diseases
Trends in Pharmacological Sciences, Год журнала: 2023, Номер 45(1), С. 9 - 23
Опубликована: Дек. 7, 2023
Язык: Английский
Процитировано
29Prenylated flavonoids from Hypericum perforatum L. and their anti-neuroinflammatory and neuroprotective activities
Industrial Crops and Products, Год журнала: 2024, Номер 216, С. 118792 - 118792
Опубликована: Май 21, 2024
Язык: Английский
Процитировано
6The shift in the fatty acid composition of the circulating lipidome in Alzheimer's disease
Alzheimer s & Dementia, Год журнала: 2024, Номер 20(5), С. 3322 - 3333
Опубликована: Март 27, 2024
Fatty acids (FAs) are the building blocks of complex lipids and signaling compounds; role lipidome fatty acid profile (LFA) in AD progression remains unclear.
Язык: Английский
Процитировано
5From Inhalation to Neurodegeneration: Air Pollution as a Modifiable Risk Factor for Alzheimer’s Disease
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(13), С. 6928 - 6928
Опубликована: Июнь 25, 2024
Air pollution, a growing concern for public health, has been linked to various respiratory and cardiovascular diseases. Emerging evidence also suggests link between exposure air pollutants neurodegenerative diseases, particularly Alzheimer's disease (AD). This review explores the composition sources of pollutants, including particulate matter, gases, persistent organic heavy metals. The pathophysiology AD is briefly discussed, highlighting role beta-amyloid plaques, neurofibrillary tangles, genetic factors. article examines how reach brain exert their detrimental effects, delving into neurotoxicity pollutants. molecular mechanisms linking pollution neurodegeneration are explored in detail, focusing on oxidative stress, neuroinflammation, protein aggregation. Preclinical studies, vitro experiments animal models, provide direct effects neuronal cells, glial blood-brain barrier. Epidemiological studies have reported associations an increased risk cognitive decline. body supporting as modifiable factor underscores importance considering environmental factors etiology progression face worsening global quality.
Язык: Английский
Процитировано
5The complex effects of miR-146a in the pathogenesis of Alzheimer’s disease
Neural Regeneration Research, Год журнала: 2024, Номер 20(5), С. 1309 - 1323
Опубликована: Июнь 3, 2024
Alzheimer’s disease is a neurodegenerative disorder characterized by cognitive dysfunction and behavioral abnormalities. Neuroinflammatory plaques formed through the extracellular deposition of amyloid-β proteins, as well neurofibrillary tangles intracellular hyperphosphorylated tau comprise two typical pathological features disease. Besides symptomatic treatment, there are no effective therapies for delaying progression. MicroRNAs (miR) small, non-coding RNAs that negatively regulate gene expression at transcriptional translational levels play important roles in multiple physiological processes. Indeed, miR-146a , NF-κB-regulated gene, has been extensively implicated development several pathways. Research demonstrated substantial dysregulation both during initial phases throughout progression this disorder. MiR-146a believed to reduce protein hyperphosphorylation TLR/IRAK1/TRAF6 pathway; however, also evidence supporting it can promote these processes many other pathways, thus exacerbating manifestations It widely reported mediates synaptic dysfunction, mitochondrial neuronal death targeting mRNAs encoding synaptic-related mitochondrial-related membrane mRNAs. Regarding impact on glial cells, exhibits differential effects. On one hand, causes widespread sustained inflammation certain while reverse polarization astrocytes microglia, alleviate neuroinflammation, oligodendrocyte progenitor cell differentiation, maintaining normal function myelin sheath exerting protective effect neurons. In review, we provide comprehensive analysis involvement pathogenesis We aim elucidate relationship between key disease, such deposition, hyperphosphorylation, death, summarize recent relevant studies have highlighted potential clinical diagnostic marker therapeutic target
Язык: Английский
Процитировано
5In situ biosensing for cell viability and drug evaluation in 3D extracellular matrix cultures: Applications in cytoprotection of oxidative stress injury
Talanta, Год журнала: 2025, Номер 287, С. 127588 - 127588
Опубликована: Янв. 13, 2025
Язык: Английский
Процитировано
0Health risk assessment of methyl mercury from fish consumption in a sample of adult Qatari residents
Environmental Monitoring and Assessment, Год журнала: 2023, Номер 195(5)
Опубликована: Апрель 27, 2023
Abstract Fish constitutes an essential source of high-quality protein and is, at the same time, exposure to many hazardous contaminants, namely mercury methyl (MeHg). This study aims assessing risk that MeHg poses health adult Qatari residents through fish consumption. Data on consumption were collected using a self-administered online survey composed three sections information about fish-eating patterns participants. The species reported be consumed by ≥ 3% respondents sampled analyzed for their total (T-Hg) content levels. concentrations derived from T-Hg levels scenario-based approach. Disaggregated contamination data combined deterministic approach estimate intakes. average, 75th, 95th percentiles intake estimates determined compared tolerable weekly (TWI) set European Food Safety Agency (EFSA) (1.3 μg·kg −1 ·w ). All samples contained ˂ 0.3–0.5 µg/g with mean value 0.077 µg/g. population had average 736.0 g/week. estimated intakes exceeded TWI some consumers including females childbearing age those following high-protein diet. Our highlights need establish regulatory guidelines dietary advice based risk/benefit ratio.
Язык: Английский
Процитировано
9Modulating Effects of Zingiberaceae Phenolic Compounds on Neurotrophic Factors and Their Potential as Neuroprotectants in Brain Disorders and Age-Associated Neurodegenerative Disorders: A Review
Nutrients, Год журнала: 2023, Номер 15(11), С. 2564 - 2564
Опубликована: Май 30, 2023
The Zingiberaceae family possess various phenolic compounds that have significant systemic bioactivities in the brain, including age-related neurodegenerative diseases. Neurotrophins are growth factors protect neurons from oxidative stress, and dysregulation of neurotrophic system may result neurocognitive disease. Phenolic been used traditional complementary medicine (TCM) to improve cognitive functions. These affect expression agents, but their underlying molecular mechanisms require further investigation. Therefore, goal this review is determine functional roles brain disorders disorders. While previous studies proposed for neuroprotective activity these compounds, precise mechanism action remains complex poorly understood. Despite some promising findings, there still shortcomings therapeutic use herbs, current interventions involving appear be clinically insufficient. This article aims summarize recent discoveries several members as neuroprotectants provide first evidence-linked bioactive ingredients prominent family.
Язык: Английский
Процитировано
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