Therapeutic promise of carotenoids as antioxidants and anti-inflammatory agents in neurodegenerative disorders

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 146, С. 112610 - 112610

Опубликована: Янв. 4, 2022

Neurodegenerative disorders (NDs) including Alzheimer's disease, Parkinson's amyotrophic lateral sclerosis, Huntington's and multiple sclerosis have various disease-specific causal factors pathological features. A very common characteristic of NDs is oxidative stress (OS), which takes place due to the elevated generation reactive oxygen species during progression NDs. Furthermore, condition an increased level protein aggregates can further lead chronic inflammation because microglial activation. Carotenoids (CTs) are naturally occurring pigments that play a significant role in averting brain disorders. More than 750 CTs present nature, they widely available plants, microorganisms, animals. accountable for red, yellow, orange several animals these colors usually indicate types CTs. exert bioactive properties its structure, anti-inflammatory antioxidant properties. Due protective CTs, levels human body been markedly linked with prevention treatment diseases In this review, we summarized relationship between OS, neuroinflammation, addition, also particularly focused on antioxidants management

Язык: Английский

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Polyphenols in Metabolic Diseases

Molecules, Год журнала: 2022, Номер 27(19), С. 6280 - 6280

Опубликована: Сен. 23, 2022

Polyphenols (PPs) are a large group of phytochemicals containing phenolic rings with two or more hydroxyl groups. They possess powerful antioxidant properties, multiple therapeutic effects, and possible health benefits in vivo vitro, as well reported clinical studies. Considering their free-radical scavenging anti-inflammatory these substances can be used to treat different kinds conditions associated metabolic disorders. Many symptoms syndrome (MtS), including obesity, dyslipidemia, atherosclerosis, elevated blood sugar, accelerating aging, liver intoxication, hypertension, cancer neurodegenerative disorders, substantially relieved by dietary PPs. The present study explores the bioprotective properties underlying mechanisms A detailed understanding natural compounds will open up new opportunities for producing unique PP-rich medicinal plans, ultimately affirming benefits.

Язык: Английский

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Food protein aggregation and its application

Food Research International, Год журнала: 2022, Номер 160, С. 111725 - 111725

Опубликована: Июль 21, 2022

Язык: Английский

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A conceptual review on classification, extraction, bioactive potential and role of phytochemicals in human health

Future Foods, Год журнала: 2024, Номер 9, С. 100313 - 100313

Опубликована: Фев. 9, 2024

Natural substances present in plants called phytochemicals are essential for fostering favourable human health outcomes. These bioactive compounds support general via a variety of processes. Phytochemicals have strong antioxidant qualities that aid scavenging dangerous free radicals from the body. This activity can promote cellular by lowering oxidative stress, major contributor to ageing and onset chronic diseases. exhibit dosage-dependent effect, which either beneficial or detrimental outcome. Several vivo vitro studies been conducted strongly supports health-promoting properties diets. A diet is rich derived fruits, vegetables, nuts, legumes, whole grains has linked lower incidence lipid peroxidation, cardiovascular disorders, cancer, other illnesses. Compounds such as β-glucans echinacea stimulate immune responses, enhancing body's ability defend against infections The study expanded understanding biochemical diversity their potential applications various fields life, including food nutrition, pharmaceuticals, cosmetics, agriculture. review deals with significance varieties used enhance nutrition overall health.

Язык: Английский

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Nutritional Aspects of Ecologically Relevant Phytochemicals in Ruminant Production

Frontiers in Veterinary Science, Год журнала: 2021, Номер 8

Опубликована: Март 5, 2021

This review provides an update of ecologically relevant phytochemicals for ruminant production, focusing on their contribution to advancing nutrition. Phytochemicals embody a broad spectrum chemical components that influence resource competence and biological advantage in determining plant species' distribution density different ecosystems. These natural compounds also often act as defensive chemicals against predatorial microbes, insects, herbivores. They may modulate or exacerbate microbial transactions the gastrointestinal tract physiological responses microbiomes. To harness production-enhancing characteristics, have been actively researched feed additives manipulate ruminal fermentation establish other phytochemoprophylactic (prevent animal diseases) phytochemotherapeutic (treat roles. However, phytochemical-host interactions, exact mechanism action, effects require more profound elucidation provide definitive recommendations production. The majority nutritional pharmacological interest are typically classified flavonoids (9%), terpenoids (55%), alkaloids (36%). Within flavonoids, polyphenolics (e.g., hydrolyzable condensed tannins) many benefits ruminants, including reducing methane (CH 4 ) emission, nematode parasitism, proteolysis. terpenoids, saponins essential oils mitigate CH but triterpenoid rich biochemical structures with clinical humans. anti-methanogenic property ruminants is variable because simultaneous targeting several pathways. explain saponin-containing forages' relative safety long-term use describe associated molecular interactions all metabolism phases. Alkaloids N-containing vast properties currently used treat humans, phytochemical usage has yet be exploited they ghost alongside known importance. We discussed strategic support sustainable such replacements antibiotics anthelmintics. Topics merit further examination include role fresh forages vis-à-vis processed feeds confined operations. Applications humankind fully understood utilized. Scientific explorations provided promising results, pending thorough vetting before primetime use, academic commercial interests technology adopted.

Язык: Английский

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Neuroprotective Effects of Agri-Food By-Products Rich in Phenolic Compounds

Nutrients, Год журнала: 2023, Номер 15(2), С. 449 - 449

Опубликована: Янв. 14, 2023

Neurodegenerative diseases are known for their wide range of harmful conditions related to progressive cell damage, nervous system connections and neuronal death. These pathologies promote the loss essential motor cognitive functions, such as mobility, learning sensation. Neurodegeneration affects millions people worldwide, no integral cure has been created yet. Here, bioactive compounds have proven exert numerous beneficial effects due remarkable bioactivity, so they could be considered great options development new neuroprotective strategies. Phenolic bioactives reported found in edible part plants; however, over last years, a large amount research focused on phenolic richness that plant by-products possess, which sometimes even exceeds content pulp. Thus, possible application an emergent technique also optimal strategy revalorize these agricultural residues (those originated from processing). This review aims summarize main triggers neurodegeneration, revise state art extracts role avoiding neurodegeneration discuss how effects. For this purpose, diverse search studies conducted, gathering number papers where were used strong sources properties. Finally, although lack investigation is quite greatly limits use compounds, phenolics remain attractive into multifactorial anti-neurodegenerative nutraceuticals.

Язык: Английский

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Plant‐derived exosomes extracted from Lycium barbarum L. loaded with isoliquiritigenin to promote spinal cord injury repair based on 3D printed bionic scaffold

Bioengineering & Translational Medicine, Год журнала: 2024, Номер 9(4)

Опубликована: Янв. 30, 2024

Abstract Plant‐derived exosomes (PEs) possess an array of therapeutic properties, including antitumor, antiviral, and anti‐inflammatory capabilities. They are also implicated in defensive responses to pathogenic attacks. Spinal cord injuries (SCIs) regeneration represents a global medical challenge, with appropriate research concentration on three pivotal domains: neural promotion, inflammation inhibition, innovation application regenerative scaffolds. Unfortunately, the utilization PE SCI therapy remains unexplored. Herein, we isolated from traditional Chinese medicinal herb, Lycium barbarum L. discovered their inflammatory inhibition neuronal differentiation promotion Compared derived ectomesenchymal stem cells (EMSCs), demonstrated substantial enhancement differentiation. We encapsulated isoliquiritigenin (ISL)‐loaded plant‐derived (ISL@PE) within 3D‐printed bionic scaffold. The intricate construct modulated response following SCI, facilitating restoration damaged axons culminating ameliorated neurological function. This pioneering investigation proposes novel potential route for insoluble drug delivery via plant exosomes, as well repair. institutional animal care use committee number is UJS‐IACUC‐2020121602.

Язык: Английский

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Glutathione and Related Molecules in Parkinsonism

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(16), С. 8689 - 8689

Опубликована: Авг. 13, 2021

Glutathione (GSH) is the most abundant intrinsic antioxidant in central nervous system, and its substrate cysteine readily becomes oxidized dimeric cystine. Since neurons lack a cystine transport neuronal GSH synthesis depends on uptake via cystine/glutamate exchange transporter (xCT), synthesis, release in/from surrounding astrocytes. Transcription factor nuclear erythroid 2-related 2 (Nrf2), detoxifying master transcription factor, expressed mainly astrocytes activates gene expression of various phase II drug-metabolizing enzymes or antioxidants including GSH-related molecules metallothionein by binding to response element (ARE) these genes. Accumulating evidence has shown involvement dysfunction antioxidative related pathogenesis Parkinson's disease (PD) parkinsonian models. Furthermore, we found several agents targeting that protect nigrostriatal dopaminergic loss PD In this article, neuroprotective effects supplementation enhancement pathology are reviewed, along with introducing new experimental findings, especially xCT-GSH synthetic system Nrf2-ARE pathway

Язык: Английский

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Exploring the anti-amyloid potential of salvianolic acid A against the ALS-associated mutant SOD1: insights from molecular docking and molecular dynamic simulations

Molecular Simulation, Год журнала: 2024, Номер 50(13), С. 899 - 917

Опубликована: Июнь 14, 2024

A central feature of a variety related neurological disorders, including amyotrophic lateral sclerosis (ALS), is the deposition misfolded protein aggregates in key regions human brain. Hence, targeting aggregation-prone SOD1 with small molecules can be used to design strategies inhibit its aggregation. Based on molecular docking and dynamics (MD) simulation, this study suggested that plant flavonoids act as potent anti-amyloidogenic polyphenol against Initial screening identified Rosmarinic acid Salvianolic promising drug leads effectively pathogenic behaviour. Our results showed reduces β-sheet content increases structural stability, hydrophobicity, flexibility, significantly lost hydrogen bonds mutant compared other compounds. Besides, we revealed changes free energy landscape (FEL) WT-SOD1 states (unbound/bound) differentiate We deduced above-mentioned deviation behaviour D124 V mutant. Among them, greatest therapeutic potential could serve candidate for highly efficient inhibitors reducing fatal irreversible ALS.

Язык: Английский

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Dietary Polyphenols in Metabolic and Neurodegenerative Diseases: Molecular Targets in Autophagy and Biological Effects

Antioxidants, Год журнала: 2021, Номер 10(2), С. 142 - 142

Опубликована: Янв. 20, 2021

Polyphenols represent a group of secondary metabolites plants which have been analyzed as potent regulators multiple biological processes, including cell proliferation, apoptosis, and autophagy, among others. These natural compounds exhibit beneficial effects protection against inflammation, oxidative stress, related injuries metabolic diseases, such cardiovascular damage, obesity diabetes, neurodegeneration. This review aims to summarize the mechanisms action polyphenols in relation activation stimulation mitochondrial function antioxidant defenses, attenuation reduction may be responsible health promoting properties these compounds.

Язык: Английский

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