Neuroinflammation and neurodegeneration in Huntington’s disease: genetic hallmarks, role of metals and organophosphates

Neurogenetics, Год журнала: 2025, Номер 26(1)

Опубликована: Янв. 17, 2025

Язык: Английский

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Cholesterol metabolism in the regulation of inflammatory responses

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Янв. 20, 2023

The importance of biologically active lipid mediators, such as prostanoids, leukotrienes, and specialized pro-resolving in the regulation inflammation is well established. While relevance cholesterol context atherosclerosis also widely accepted, role its biosynthetic precursors on inflammatory processes less comprehensively described. In present mini-review, we summarize current understanding inflammation-regulatory properties relevant intermediates taking into account implications different subcellular distributions. Finally, discuss effect homeostasis SARS-CoV-2 infections.

Язык: Английский

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Hydroxytyrosol Reduces Foam Cell Formation and Endothelial Inflammation Regulating the PPARγ/LXRα/ABCA1 Pathway

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(3), С. 2057 - 2057

Опубликована: Янв. 20, 2023

Cholesterol accumulation in macrophages leads to the formation of foam cells and increases risk developing atherosclerosis. We have verified whether hydroxytyrosol (HT), a phenolic compound with anti-inflammatory antioxidant properties, can reduce cholesterol build up THP-1 macrophage-derived cells. also investigated potential mechanisms. Oil Red O staining high-performance liquid chromatography (HPLC) assays were utilized detect cellular lipid content, respectively, treated HT. The impact HT on metabolism-related molecules (SR-A1, CD36, LOX-1, ABCA1, ABCG1, PPARγ LRX-α) was assessed using real-time PCR (RT-qPCR) Western blot analyses. Finally, effect adhesion monocytes human vascular endothelial (HUVEC) analyzed study activation. found that activates PPARγ/LXRα pathway upregulate ABCA1 expression, reducing Moreover, significantly inhibited monocyte reduced levels factors (ICAM-1 VCAM-1) pro-inflammatory (IL-6 TNF-α) LPS-induced Taken together, our findings suggest HT, its ability interfere import export cholesterol, could represent new therapeutic strategy for treatment atherosclerotic disease.

Язык: Английский

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Lymphatic-derived oxysterols promote anti-tumor immunity and response to immunotherapy in melanoma

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 31, 2025

Язык: Английский

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Cytoprotective activities of representative nutrients from the Mediterranean diet and of Mediterranean oils against 7-ketocholesterol- and 7β-hydroxycholesterol-induced cytotoxicity: Application to age-related diseases and civilization diseases

Steroids, Год журнала: 2022, Номер 187, С. 109093 - 109093

Опубликована: Авг. 24, 2022

Язык: Английский

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Tspan6 stimulates the chemoattractive potential of breast cancer cells for B cells in an EV- and LXR-dependent manner

Cell Reports, Год журнала: 2023, Номер 42(3), С. 112207 - 112207

Опубликована: Март 1, 2023

The immune microenvironment in breast cancer (BCa) is controlled by a complex network of communication between various cell types. Here, we find that recruitment B lymphocytes to BCa tissues via mechanisms associated with cell-derived extracellular vesicles (CCD-EVs). Gene expression profiling identifies the Liver X receptor (LXR)-dependent transcriptional as key pathway controls both CCD-EVs-induced migration cells and accumulation tissues. increased oxysterol ligands for LXR (i.e., 25-hydroxycholesterol 27-hydroxycholesterol) CCD-EVs regulated tetraspanin 6 (Tspan6). Tspan6 stimulates chemoattractive potential an EV- LXR-dependent manner. These results demonstrate tetraspanins control intercellular trafficking oxysterols CCD-EVs. Furthermore, tetraspanin-dependent changes composition signaling axis play role specific tumor microenvironment.

Язык: Английский

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Immune Implications of Cholesterol-Containing Lipid Nanoparticles

ACS Nano, Год журнала: 2024, Номер 18(42), С. 28480 - 28501

Опубликована: Окт. 10, 2024

The majority of clinically approved nanoparticle-mediated therapeutics are lipid nanoparticles (LNPs), and most these LNPs liposomes containing cholesterol. LNP formulations significantly alter the drug pharmacokinetics (PK) due to propensity for uptake by macrophages. In addition readily engulfing LNPs, high expression cholesterol hydroxylases reactive oxygen species (ROS) in macrophages suggests that they will produce oxysterols from LNP-associated Oxysterols a heterogeneous group oxidation products have potent immune modulatory effects. implicated pathogenesis atherosclerosis certain malignancies; also been found commercial liposome preparations. Yet,

Язык: Английский

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Unravelling the complexities of non-alcoholic steatohepatitis: The role of metabolism, transporters, and herb-drug interactions

Life Sciences, Год журнала: 2024, Номер 351, С. 122806 - 122806

Опубликована: Июнь 7, 2024

Язык: Английский

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Si-Ni-San alleviates intestinal and liver damage in ulcerative colitis mice by regulating cholesterol metabolism

Journal of Ethnopharmacology, Год журнала: 2024, Номер 336, С. 118715 - 118715

Опубликована: Авг. 22, 2024

Язык: Английский

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Mechanisms of lipid homeostasis in the Coxiella Containing Vacuole

Biochemical Society Transactions, Год журнала: 2025, Номер 00(00)

Опубликована: Янв. 22, 2025

Coxiella burnetii, the causative agent of human Q fever, is an obligate intracellular bacterial pathogen that replicates in a large, membrane-bound vacuole known as Containing Vacuole (CCV). The CCV unique, phagolysosome-derived with sterol-rich membrane containing host and proteins. itself serves barrier to protect bacteria from host’s innate immune response, lipid protein content directly influence both luminal environment interactions between trafficking pathways. cholesterol critical regulating pH, while phosphatidylinositol phosphate species fusion events dynamics. C. burnetii proteins target metabolism regulate generate source lipids support replication or response. This review provides overview diverse repertoire involved formation maintenance, highlighting pathogen-driven strategies modify homeostasis.

Язык: Английский

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