The Importance of “Negative” Results: Lipid Lessons in Coronavirus Biology DOI Creative Commons
Sarah R. Leist, Jason R. Mock

American Journal of Respiratory Cell and Molecular Biology, Journal Year: 2023, Volume and Issue: 69(6), P. 610 - 611

Published: Sept. 6, 2023

"The Importance of "Negative" Results – Lipid Lessons in Coronavirus Biology." American Journal Respiratory Cell and Molecular Biology, 0(ja), pp.

Language: Английский

Neuroinflammation and neurodegeneration in Huntington’s disease: genetic hallmarks, role of metals and organophosphates DOI

Omkar Kumar Kunwar,

Shamsher Singh

Neurogenetics, Journal Year: 2025, Volume and Issue: 26(1)

Published: Jan. 17, 2025

Language: Английский

Citations

2
Lymphatic-derived oxysterols promote anti-tumor immunity and response to immunotherapy in melanoma DOI Creative Commons

Mengzhu Sun,

Laure Garnier, Robert L. Chevalier

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 31, 2025

Language: Английский

Citations

1
Cholesterol metabolism in the regulation of inflammatory responses DOI Creative Commons
Rebekka Bauer, Bernhard Brüne, Tobias Schmid

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Jan. 20, 2023

The importance of biologically active lipid mediators, such as prostanoids, leukotrienes, and specialized pro-resolving in the regulation inflammation is well established. While relevance cholesterol context atherosclerosis also widely accepted, role its biosynthetic precursors on inflammatory processes less comprehensively described. In present mini-review, we summarize current understanding inflammation-regulatory properties relevant intermediates taking into account implications different subcellular distributions. Finally, discuss effect homeostasis SARS-CoV-2 infections.

Language: Английский

Citations

21
Hydroxytyrosol Reduces Foam Cell Formation and Endothelial Inflammation Regulating the PPARγ/LXRα/ABCA1 Pathway DOI Open Access
Sara Franceschelli,

Federica De Cecco,

Mirko Pesce

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2057 - 2057

Published: Jan. 20, 2023

Cholesterol accumulation in macrophages leads to the formation of foam cells and increases risk developing atherosclerosis. We have verified whether hydroxytyrosol (HT), a phenolic compound with anti-inflammatory antioxidant properties, can reduce cholesterol build up THP-1 macrophage-derived cells. also investigated potential mechanisms. Oil Red O staining high-performance liquid chromatography (HPLC) assays were utilized detect cellular lipid content, respectively, treated HT. The impact HT on metabolism-related molecules (SR-A1, CD36, LOX-1, ABCA1, ABCG1, PPARγ LRX-α) was assessed using real-time PCR (RT-qPCR) Western blot analyses. Finally, effect adhesion monocytes human vascular endothelial (HUVEC) analyzed study activation. found that activates PPARγ/LXRα pathway upregulate ABCA1 expression, reducing Moreover, significantly inhibited monocyte reduced levels factors (ICAM-1 VCAM-1) pro-inflammatory (IL-6 TNF-α) LPS-induced Taken together, our findings suggest HT, its ability interfere import export cholesterol, could represent new therapeutic strategy for treatment atherosclerotic disease.

Language: Английский

Citations

19
Cytoprotective activities of representative nutrients from the Mediterranean diet and of Mediterranean oils against 7-ketocholesterol- and 7β-hydroxycholesterol-induced cytotoxicity: Application to age-related diseases and civilization diseases DOI
Leila Rezig, Imen Ghzaiel, Mohamed Ksila

et al.

Steroids, Journal Year: 2022, Volume and Issue: 187, P. 109093 - 109093

Published: Aug. 24, 2022

Language: Английский

Citations

24
Tspan6 stimulates the chemoattractive potential of breast cancer cells for B cells in an EV- and LXR-dependent manner DOI Creative Commons

Guerman Molostvov,

Mariam Gachechiladze, Abeer M. Shaaban

et al.

Cell Reports, Journal Year: 2023, Volume and Issue: 42(3), P. 112207 - 112207

Published: March 1, 2023

The immune microenvironment in breast cancer (BCa) is controlled by a complex network of communication between various cell types. Here, we find that recruitment B lymphocytes to BCa tissues via mechanisms associated with cell-derived extracellular vesicles (CCD-EVs). Gene expression profiling identifies the Liver X receptor (LXR)-dependent transcriptional as key pathway controls both CCD-EVs-induced migration cells and accumulation tissues. increased oxysterol ligands for LXR (i.e., 25-hydroxycholesterol 27-hydroxycholesterol) CCD-EVs regulated tetraspanin 6 (Tspan6). Tspan6 stimulates chemoattractive potential an EV- LXR-dependent manner. These results demonstrate tetraspanins control intercellular trafficking oxysterols CCD-EVs. Furthermore, tetraspanin-dependent changes composition signaling axis play role specific tumor microenvironment.

Language: Английский

Citations

13
Immune Implications of Cholesterol-Containing Lipid Nanoparticles DOI
Patrícia Inês Back, Minzhi Yu, Shadan Modaresahmadi

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(42), P. 28480 - 28501

Published: Oct. 10, 2024

The majority of clinically approved nanoparticle-mediated therapeutics are lipid nanoparticles (LNPs), and most these LNPs liposomes containing cholesterol. LNP formulations significantly alter the drug pharmacokinetics (PK) due to propensity for uptake by macrophages. In addition readily engulfing LNPs, high expression cholesterol hydroxylases reactive oxygen species (ROS) in macrophages suggests that they will produce oxysterols from LNP-associated Oxysterols a heterogeneous group oxidation products have potent immune modulatory effects. implicated pathogenesis atherosclerosis certain malignancies; also been found commercial liposome preparations. Yet,

Language: Английский

Citations

4
Unravelling the complexities of non-alcoholic steatohepatitis: The role of metabolism, transporters, and herb-drug interactions DOI
Ravi Adinarayan Somabattini,

Sahla Sherin,

Brian Siva

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 351, P. 122806 - 122806

Published: June 7, 2024

Language: Английский

Citations

3
Si-Ni-San alleviates intestinal and liver damage in ulcerative colitis mice by regulating cholesterol metabolism DOI
Anhui Wang, Xue Yang,

Jia‐Chun Lin

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 336, P. 118715 - 118715

Published: Aug. 22, 2024

Language: Английский

Citations

3
Mechanisms of lipid homeostasis in the Coxiella Containing Vacuole DOI
Rajendra Kumar Angara, Peyton E. VanWinkle, Stacey D. Gilk

et al.

Biochemical Society Transactions, Journal Year: 2025, Volume and Issue: 00(00)

Published: Jan. 22, 2025

Coxiella burnetii, the causative agent of human Q fever, is an obligate intracellular bacterial pathogen that replicates in a large, membrane-bound vacuole known as Containing Vacuole (CCV). The CCV unique, phagolysosome-derived with sterol-rich membrane containing host and proteins. itself serves barrier to protect bacteria from host’s innate immune response, lipid protein content directly influence both luminal environment interactions between trafficking pathways. cholesterol critical regulating pH, while phosphatidylinositol phosphate species fusion events dynamics. C. burnetii proteins target metabolism regulate generate source lipids support replication or response. This review provides overview diverse repertoire involved formation maintenance, highlighting pathogen-driven strategies modify homeostasis.

Language: Английский

Citations

0