Beneficial effects of Lactobacillus plantarum on growth performance, immune status, antioxidant function and intestinal microbiota in broilers DOI Creative Commons
Xiao Xiao, Tiantian Cui, Songke Qin

и другие.

Poultry Science, Год журнала: 2024, Номер 103(12), С. 104280 - 104280

Опубликована: Сен. 1, 2024

Lactobacillus plantarum (L. plantarum) has been globally regarded as antibiotic alternative in animal farming the past few years. However, potential function of L. broilers not systemically explored. In this study, a total 560 one-day-old yellow-feathered were randomly divided into 3 groups, fed with basal diet and drank HJZW08 (LP) at concentration 0 (CON), 1000 × 10^5 (LP1000), 2000 CFU/L (LP2000) for 70 d. Results showed that body weight (BW), average daily gain (ADG), feed intake (ADFI), immunoglobulin A (IgA), IgY, anti-inflammatory interleukin 10 (IL-10) markedly improved (P < 0.05), while levels pro-inflammatory IL-2, IL-1β, IL-6, tumor necrosis factor-α (TNF-α) serum decreased 0.05) LP2000 group comparing CON group. Besides, LP treatment groups prominently increased activities antioxidant enzymes content malondialdehyde (MDA). Additionally, isobutyric acid LP1000 isovaleric significantly improved. More importantly, α-diversity microbial structure intestinal microbiota pronounced altered by supplementation. The results only relative abundance Actinobacteriota was group, 6 kinds bacteria on genus level changed. For further validation, linear discriminant analysis effect size (LEfSe) plots revealed 8 amplicon sequence variants (ASVs) predominant Bacteroides other beneficial species such Lactimicrobium massiliense (ASV4 ASV36), Intestinimonas butyriciproducens (ASV71), Barnesiella viscericola (ASV152 ASV571) enriched groups. Taken together, dietary supplementation obviously enhanced immune status, capacity, stabilized cecal SCFAs, contributing to improvement growth performance broilers. Our study laid good foundation application probiotic industry future.

Язык: Английский

From Liver to Brain: How MAFLD/MASLD Impacts Cognitive Function DOI Open Access
David Medina‐Julio, Mariana M. Ramírez-Mejía, Jacqueline Córdova‐Gallardo

и другие.

Medical Science Monitor, Год журнала: 2024, Номер 30

Опубликована: Янв. 16, 2024

Metabolic dysfunction-associated fatty liver disease or metabolic steatotic (MAFLD/MASLD), is a common chronic condition affecting substantial global population. Beyond its primary impact on function, MAFLD/MASLD associated with myriad of extrahepatic manifestations, including cognitive impairment. The scope impairment within the realm matter escalating concern. Positioned as an intermediate stage between normal aging process and onset dementia, manifests challenge this condition. Insights from studies underscore presence compromised executive function decline in capabilities among individuals identified being at risk progressing to fibrosis. Importantly, transcends mere association factors, delving deep into intricate pathophysiology characterizing MAFLD/MASLD. multifaceted nature context underlined by spectrum prominently featuring insulin resistance, lipotoxicity, systemic inflammation pivotal contributors. These factors interplay landscape MAFLD/MASLD, fostering nuanced understanding links hepatic health function. By synthesizing available evidence, exploring potential mechanisms, assessing clinical implications, overarching aim review contribute more complete

Язык: Английский

Процитировано

14
The central role of the gut microbiota in the pathophysiology and management of type 2 diabetes DOI

Daniel P Baars,

Marcos F. Fondevila, Abraham S. Meijnikman

и другие.

Cell Host & Microbe, Год журнала: 2024, Номер 32(8), С. 1280 - 1300

Опубликована: Авг. 1, 2024

Язык: Английский

Процитировано

14
Immunology of bile acids regulated receptors DOI
Stefano Fiorucci, Silvia Marchianò,

Ginevra Urbani

и другие.

Progress in Lipid Research, Год журнала: 2024, Номер 95, С. 101291 - 101291

Опубликована: Июль 1, 2024

Язык: Английский

Процитировано

13
Underlying Mechanisms behind the Brain–Gut–Liver Axis and Metabolic-Associated Fatty Liver Disease (MAFLD): An Update DOI Open Access

Júlia Pauli De Cól,

Enzo Pereira de Lima,

Fernanda Moris Pompeu

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(7), С. 3694 - 3694

Опубликована: Март 26, 2024

Metabolic-associated fatty liver disease (MAFLD) includes several metabolic dysfunctions caused by dysregulation in the brain–gut–liver axis and, consequently, increases cardiovascular risks and dysfunction. In MAFLD, type 2 diabetes mellitus, obesity, syndrome are frequently present; these conditions related to lipogenesis systemic inflammation. This study aimed review connection between MAFLD. The inflammatory process, cellular alterations hepatocytes stellate cells, hypercaloric diet, sedentarism aggravate prognosis of patients with Thus, understand modulation physiopathology it is necessary include organokines involved this process (adipokines, myokines, osteokines, hepatokines) their clinical relevance project future perspectives condition bring light new possibilities therapeutic approaches. Adipokines responsible for activation distinct signaling different tissues, such as insulin pro-inflammatory cytokines, which important balancing substances avoid MAFLD its progression. Myokines improve quantity quality adipose contributing avoiding development Finally, hepatokines decisive improving or not progression through regulation anti-inflammatory organokines.

Язык: Английский

Процитировано

12
Ginsenoside CK Alleviates DSS-Induced IBD in Mice by Regulating Tryptophan Metabolism and Activating Aryl Hydrocarbon Receptor via Gut Microbiota Modulation DOI
Yuan Liu, Xue Bai,

Huanyan Wu

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(17), С. 9867 - 9879

Опубликована: Апрель 11, 2024

Dysbiosis of gut microbiota is believed to be associated with inflammatory bowel disease (IBD). Ginsenoside compound K (CK), the main metabolite Panax ginseng ginsenoside, has proven effective as an anti-inflammatory agent in IBD. However, mechanisms by which CK modulates ameliorate IBD remain poorly understood. Herein, demonstrated potential suppress release proinflammatory cytokines modulation. Notably, supplementation promoted restoration a harmonious balance microbiota, primarily enhancing populations Lactobacillus and Akkermansia. Furthermore, considerably elevated concentrations tryptophan metabolites derived from that could activate aryl hydrocarbon receptor. Overall, promising alleviative efficacy stemmed promotion growth production metabolites, suggesting should regarded prospective prebiotic for future.

Язык: Английский

Процитировано

11
Bacterial extracellular vesicles: Vital contributors to physiology from bacteria to host DOI

Xinke Nie,

Qiqiong Li, Xinyang Chen

и другие.

Microbiological Research, Год журнала: 2024, Номер 284, С. 127733 - 127733

Опубликована: Апрель 25, 2024

Язык: Английский

Процитировано

11
Shaoyao decoction improves damp-heat colitis by activating the AHR/IL-22/STAT3 pathway through tryptophan metabolism driven by gut microbiota DOI
Yahui Zhang,

Luoxia Han,

Jiaqi Dong

и другие.

Journal of Ethnopharmacology, Год журнала: 2024, Номер 326, С. 117874 - 117874

Опубликована: Фев. 9, 2024

Язык: Английский

Процитировано

10
Mendelian randomization analysis reveals an independent causal relationship between four gut microbes and acne vulgaris DOI Creative Commons
Yujia Wu, Xiaoyun Wang, Wenjuan Wu

и другие.

Frontiers in Microbiology, Год журнала: 2024, Номер 15

Опубликована: Фев. 2, 2024

Numerous studies have suggested a correlation between gut microbiota and acne vulgaris; however, no specific causal link has been explored. To investigate the possible relationship vulgaris, this study employed large-scale genome-wide association (GWAS) summary statistic. Initially, two-sample Mendelian randomization (MR) analysis was utilized to identify microflora responsible for vulgaris. We used Inverse Variance Weighted (IVW) method as main MR method. Additionally, we assessed heterogeneity horizontal pleiotropy, while also examining potential influence of individual single-nucleotide polymorphisms (SNPs) on results. In order eliminate with reverse associations, conducted analysis. Multivariate (MVMR) then verify independence associations. Finally, performed SNP annotation instrumental variables independent vulgaris determine genes where these genetic variations are located. explored biological functions through enrichment The IVW forward identified nine microbes (p < 0.05). findings from sensitivity demonstrate absence or leave-one-out indicates that results not driven by single SNP. Reverse excluded two reverse-correlated pathogenic microbes. And then, MVMR analyze seven microbes, it found Cyanobacterium Family XIII were risk factors Ruminococcus1 Ruminiclostridium5 protective After conducting annotation, six (PLA2G4A, FADS2, TIMP17, ADAMTS9, ZC3H3, CPSF4L) may be associated patients. indicate PLA2G4A/FADS2 is fatty acid metabolism pathways. Our relationships four revealed patients microbiota. Consider preventing treating interfering relative content

Язык: Английский

Процитировано

9
Gut microbiota and its metabolic products in acute respiratory distress syndrome DOI Creative Commons
Dongwei Zhang,

Jiali Lu,

Bi-Ying Dong

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Фев. 16, 2024

The prevalence rate of acute respiratory distress syndrome (ARDS) is estimated at approximately 10% in critically ill patients worldwide, with the mortality ranging from 17% to 39%. Currently, ARDS usually higher COVID-19, giving another challenge for treatment. However, treatment efficacy far satisfactory. relationship between gut microbiota and has been substantiated by relevant scientific studies. not only changes distribution microbiota, but also influences intestinal mucosal barrier through alteration microbiota. modulation can impact onset progression triggering dysfunctions inflammatory response immune cells, oxidative stress, cell apoptosis, autophagy, pyroptosis, ferroptosis mechanisms. Meanwhile, may influence metabolic products In this review, we focus on how further function, cellular functions related signaling pathways during ARDS. roles microbiota-derived metabolites development occurrence are discussed.

Язык: Английский

Процитировано

9
The microbiota-gut-brain-immune interface in the pathogenesis of neuroinflammatory diseases: a narrative review of the emerging literature DOI Creative Commons
Alison Warren, Yvonne Nyavor,

Nikkia Zarabian

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Май 16, 2024

Importance Research is beginning to elucidate the sophisticated mechanisms underlying microbiota-gut-brain-immune interface, moving from primarily animal models human studies. Findings support dynamic relationships between gut microbiota as an ecosystem (microbiome) within (host) and its intersection with host immune nervous systems. Adding this effects on epigenetic regulation of gene expression further complicates strengthens response. At heart inflammation, which manifests in a variety pathologies including neurodegenerative diseases such Alzheimer’s disease, Parkinson’s Multiple Sclerosis (MS). Observations Generally, research date limited has focused bacteria, likely due simplicity cost-effectiveness 16s rRNA sequencing, despite lower resolution inability determine functional ability/alterations. However, omits all other fungi, viruses, phages, are emerging key members microbiome. Much been done pre-clinical and/or small studies more developed parts world. The observed promising but cannot be considered reliable or generalizable at time. Specifically, causal determined currently. More followed by then little MS. data for MS encouraging this. Conclusions relevance While still nascent, interface may missing link, hampered our progress understanding, let alone preventing, managing, putting into remission diseases. Relationships must first established humans, have shown poorly translate complex physiology environments, especially when investigating microbiome where often overly simplistic. Only can robust conducted humans using mechanistic model

Язык: Английский

Процитировано

9