Beneficial effects of Lactobacillus plantarum on growth performance, immune status, antioxidant function and intestinal microbiota in broilers DOI Creative Commons
Xiao Xiao, Tiantian Cui, Songke Qin

et al.

Poultry Science, Journal Year: 2024, Volume and Issue: 103(12), P. 104280 - 104280

Published: Sept. 1, 2024

Lactobacillus plantarum (L. plantarum) has been globally regarded as antibiotic alternative in animal farming the past few years. However, potential function of L. broilers not systemically explored. In this study, a total 560 one-day-old yellow-feathered were randomly divided into 3 groups, fed with basal diet and drank HJZW08 (LP) at concentration 0 (CON), 1000 × 10^5 (LP1000), 2000 CFU/L (LP2000) for 70 d. Results showed that body weight (BW), average daily gain (ADG), feed intake (ADFI), immunoglobulin A (IgA), IgY, anti-inflammatory interleukin 10 (IL-10) markedly improved (P < 0.05), while levels pro-inflammatory IL-2, IL-1β, IL-6, tumor necrosis factor-α (TNF-α) serum decreased 0.05) LP2000 group comparing CON group. Besides, LP treatment groups prominently increased activities antioxidant enzymes content malondialdehyde (MDA). Additionally, isobutyric acid LP1000 isovaleric significantly improved. More importantly, α-diversity microbial structure intestinal microbiota pronounced altered by supplementation. The results only relative abundance Actinobacteriota was group, 6 kinds bacteria on genus level changed. For further validation, linear discriminant analysis effect size (LEfSe) plots revealed 8 amplicon sequence variants (ASVs) predominant Bacteroides other beneficial species such Lactimicrobium massiliense (ASV4 ASV36), Intestinimonas butyriciproducens (ASV71), Barnesiella viscericola (ASV152 ASV571) enriched groups. Taken together, dietary supplementation obviously enhanced immune status, capacity, stabilized cecal SCFAs, contributing to improvement growth performance broilers. Our study laid good foundation application probiotic industry future.

Language: Английский

Short-chain fatty acids in nonalcoholic fatty liver disease: New prospects for short-chain fatty acids as therapeutic targets DOI Creative Commons
Xinyu Li, Maozhang He,

Xinrui Yi

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(5), P. e26991 - e26991

Published: Feb. 27, 2024

Nonalcoholic fatty liver disease (NAFLD) is a stress-induced injury related to heredity, environmental exposure and the gut microbiome metabolism. Short-chain acids (SCFAs), metabolites of microbiota (GM), participate in regulation hepatic steatosis inflammation through gut-liver axis, which play an important role alleviation NAFLD. However, little progress has been made systematically elucidating mechanism how SCFAs improve NAFLD, especially epigenetic mechanisms potential therapeutic application as clinical treatment for Herein, we adopted PubMed Medline search relevant keywords such 'SCFAs', 'NAFLD', 'gut microbiota', 'Epigenetic', 'diet', 'prebiotic effect' review latest research on NAFLD up November 2023. In this review, firstly, specifically discussed production function SCFAs, well their crosstalk coordination axis. Secondly, provided updated summary intensive discussion affect alleviate from perspective genetic epigenetic. Thirdly, paid attention pharmacological physiological characteristics proposed promising future direction adopt alone or combination with prebiotics drugs prevent treat Together, aimed elucidate provide new insights prospects target

Language: Английский

Citations

15
The central role of the gut microbiota in the pathophysiology and management of type 2 diabetes DOI

Daniel P Baars,

Marcos F. Fondevila, Abraham S. Meijnikman

et al.

Cell Host & Microbe, Journal Year: 2024, Volume and Issue: 32(8), P. 1280 - 1300

Published: Aug. 1, 2024

Language: Английский

Citations

15
From Liver to Brain: How MAFLD/MASLD Impacts Cognitive Function DOI Open Access
David Medina‐Julio, Mariana M. Ramírez-Mejía, Jacqueline Córdova‐Gallardo

et al.

Medical Science Monitor, Journal Year: 2024, Volume and Issue: 30

Published: Jan. 16, 2024

Metabolic dysfunction-associated fatty liver disease or metabolic steatotic (MAFLD/MASLD), is a common chronic condition affecting substantial global population. Beyond its primary impact on function, MAFLD/MASLD associated with myriad of extrahepatic manifestations, including cognitive impairment. The scope impairment within the realm matter escalating concern. Positioned as an intermediate stage between normal aging process and onset dementia, manifests challenge this condition. Insights from studies underscore presence compromised executive function decline in capabilities among individuals identified being at risk progressing to fibrosis. Importantly, transcends mere association factors, delving deep into intricate pathophysiology characterizing MAFLD/MASLD. multifaceted nature context underlined by spectrum prominently featuring insulin resistance, lipotoxicity, systemic inflammation pivotal contributors. These factors interplay landscape MAFLD/MASLD, fostering nuanced understanding links hepatic health function. By synthesizing available evidence, exploring potential mechanisms, assessing clinical implications, overarching aim review contribute more complete

Language: Английский

Citations

14
Immunology of bile acids regulated receptors DOI
Stefano Fiorucci, Silvia Marchianò,

Ginevra Urbani

et al.

Progress in Lipid Research, Journal Year: 2024, Volume and Issue: 95, P. 101291 - 101291

Published: July 1, 2024

Language: Английский

Citations

13
Underlying Mechanisms behind the Brain–Gut–Liver Axis and Metabolic-Associated Fatty Liver Disease (MAFLD): An Update DOI Open Access

Júlia Pauli De Cól,

Enzo Pereira de Lima,

Fernanda Moris Pompeu

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3694 - 3694

Published: March 26, 2024

Metabolic-associated fatty liver disease (MAFLD) includes several metabolic dysfunctions caused by dysregulation in the brain–gut–liver axis and, consequently, increases cardiovascular risks and dysfunction. In MAFLD, type 2 diabetes mellitus, obesity, syndrome are frequently present; these conditions related to lipogenesis systemic inflammation. This study aimed review connection between MAFLD. The inflammatory process, cellular alterations hepatocytes stellate cells, hypercaloric diet, sedentarism aggravate prognosis of patients with Thus, understand modulation physiopathology it is necessary include organokines involved this process (adipokines, myokines, osteokines, hepatokines) their clinical relevance project future perspectives condition bring light new possibilities therapeutic approaches. Adipokines responsible for activation distinct signaling different tissues, such as insulin pro-inflammatory cytokines, which important balancing substances avoid MAFLD its progression. Myokines improve quantity quality adipose contributing avoiding development Finally, hepatokines decisive improving or not progression through regulation anti-inflammatory organokines.

Language: Английский

Citations

12
Ginsenoside CK Alleviates DSS-Induced IBD in Mice by Regulating Tryptophan Metabolism and Activating Aryl Hydrocarbon Receptor via Gut Microbiota Modulation DOI
Yuan Liu, Xue Bai,

Huanyan Wu

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(17), P. 9867 - 9879

Published: April 11, 2024

Dysbiosis of gut microbiota is believed to be associated with inflammatory bowel disease (IBD). Ginsenoside compound K (CK), the main metabolite Panax ginseng ginsenoside, has proven effective as an anti-inflammatory agent in IBD. However, mechanisms by which CK modulates ameliorate IBD remain poorly understood. Herein, demonstrated potential suppress release proinflammatory cytokines modulation. Notably, supplementation promoted restoration a harmonious balance microbiota, primarily enhancing populations Lactobacillus and Akkermansia. Furthermore, considerably elevated concentrations tryptophan metabolites derived from that could activate aryl hydrocarbon receptor. Overall, promising alleviative efficacy stemmed promotion growth production metabolites, suggesting should regarded prospective prebiotic for future.

Language: Английский

Citations

11
Bacterial extracellular vesicles: Vital contributors to physiology from bacteria to host DOI

Xinke Nie,

Qiqiong Li, Xinyang Chen

et al.

Microbiological Research, Journal Year: 2024, Volume and Issue: 284, P. 127733 - 127733

Published: April 25, 2024

Language: Английский

Citations

11
Shaoyao decoction improves damp-heat colitis by activating the AHR/IL-22/STAT3 pathway through tryptophan metabolism driven by gut microbiota DOI
Yahui Zhang,

Luoxia Han,

Jiaqi Dong

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 326, P. 117874 - 117874

Published: Feb. 9, 2024

Language: Английский

Citations

10
Short-chain fatty acids reverses gut microbiota dysbiosis-promoted progression of glioblastoma by up-regulating M1 polarization in the tumor microenvironment DOI
Mengnan Zhou,

Jianqi Wu,

Yang Shao

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 141, P. 112881 - 112881

Published: Aug. 18, 2024

Language: Английский

Citations

10
Mendelian randomization analysis reveals an independent causal relationship between four gut microbes and acne vulgaris DOI Creative Commons
Yujia Wu, Xiaoyun Wang, Wenjuan Wu

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 2, 2024

Numerous studies have suggested a correlation between gut microbiota and acne vulgaris; however, no specific causal link has been explored. To investigate the possible relationship vulgaris, this study employed large-scale genome-wide association (GWAS) summary statistic. Initially, two-sample Mendelian randomization (MR) analysis was utilized to identify microflora responsible for vulgaris. We used Inverse Variance Weighted (IVW) method as main MR method. Additionally, we assessed heterogeneity horizontal pleiotropy, while also examining potential influence of individual single-nucleotide polymorphisms (SNPs) on results. In order eliminate with reverse associations, conducted analysis. Multivariate (MVMR) then verify independence associations. Finally, performed SNP annotation instrumental variables independent vulgaris determine genes where these genetic variations are located. explored biological functions through enrichment The IVW forward identified nine microbes (p < 0.05). findings from sensitivity demonstrate absence or leave-one-out indicates that results not driven by single SNP. Reverse excluded two reverse-correlated pathogenic microbes. And then, MVMR analyze seven microbes, it found Cyanobacterium Family XIII were risk factors Ruminococcus1 Ruminiclostridium5 protective After conducting annotation, six (PLA2G4A, FADS2, TIMP17, ADAMTS9, ZC3H3, CPSF4L) may be associated patients. indicate PLA2G4A/FADS2 is fatty acid metabolism pathways. Our relationships four revealed patients microbiota. Consider preventing treating interfering relative content

Language: Английский

Citations

9