Revue Roumaine de Chimie,
Год журнала:
2023,
Номер
68(5-6), С. 285 - 295
Опубликована: Май 12, 2023
Peptide-based
hydrogels
have
become
an
area
of
intense
investigation
due
to
their
easy
design,
possibility
make
a
large
range
hierarchical
nanostructures
and
high
biocompatibility
biodegradability.
Here,
we
investigated
by
mass
spectrometry
(MS)
few
synthetic
gel-forming
peptides
having
different
amino
acid
sequences.
Four
were
selected
for
MS
measurements:
EEE-OH,
FFFFF-OH,
FESNF-NH2,
LWMRFA-OH.
Our
data
show
that
can
be
used
get
detailed
information
on
structure,
molecular
weight,
chemical
bond
energies
as
well
assess
purity
stability.
Fourier
transform
infrared
spectroscopy
(FTIR)
theoretical
studies
carried
out
using
GPMAW
ChemDraw
Ultra
computer
programs
confirmed
the
data.
The
peptide
tendency
aggregate,
process
observed
in
case
EEE
polar
environment,
was
also
theoretically
modeling.
European journal of medical research,
Год журнала:
2025,
Номер
30(1)
Опубликована: Фев. 4, 2025
Abstract
Brain
tumor
treatment
remains
a
significant
challenge
due
to
their
high
mortality
and
resistance
current
therapies.
This
paper
discusses
the
promising
potential
of
hydrogel-based
nanoparticles
as
innovative
drug
delivery
systems
for
brain
therapy.
Extensive
characterization
techniques
reveal
ability
these
Nano-systems
demonstrate
prolonged
blood
circulation
targeted
delivery,
leading
improved
survival
rates.
Designed
with
optimized
physicochemical
characteristics,
effectively
cross
blood–brain
barrier,
circumventing
major
impediment
brain.
By
delivering
drugs
directly
bed,
enhance
therapeutic
outcomes
minimize
adverse
effects.
In
addition,
this
review
investigates
characterizing,
visualizing,
modifying
nanoparticles,
well
standing
challenges
research
avenues
clinical
application.
Further
investigations
are
encouraged
by
investigate
advancements
in
nanoparticle
approaches
tumors.
includes
investigating
tailored
hydrogels,
hybrid
systems,
computational
modeling,
integration
gene
therapy
immunotherapy
techniques.
The
study
also
addresses
need
enhanced
synthesis
techniques,
stability,
scalability,
cost-cutting
measures
overcome
obstacles
advance
use
treating
Graphical
abstract
Hydrogels
are
widely
used
in
wound
dressings
due
to
their
moisturizing
properties
and
biocompatibility.
However,
traditional
hydrogel
cannot
monitor
wounds
provide
accurate
treatment.
Recent
advancements
focus
on
with
integrated
monitoring
treatment
functions,
using
sensors
or
intelligent
materials
detect
changes
the
microenvironment.
These
enable
responsive
promote
healing.
They
can
carry
out
dynamic
time
effectively
there
is
still
a
lack
of
comprehensive
reviews
that
incorporate
both
micro-environment
functions.
Therefore,
this
review
categorizes
according
types
examines
current
status,
progress,
challenges,
future
trends.
It
discusses
various
types,
including
infected
wounds,
burns,
diabetic
pressure
ulcers,
explores
healing
process.
The
presents
conditions
tailored
treatment,
such
as
pH-sensitive,
temperature-sensitive,
glucose-sensitive,
pressure-sensitive,
nano-composite
dressings.
Challenges
include
developing
meet
standards
excellent
biocompatibility,
improving
accuracy
sensitivity,
overcoming
obstacles
production
commercialization.
Furthermore,
it
provides
trends
field,
aiming
give
clear
view
its
past,
present,
future.
Gels,
Год журнала:
2024,
Номер
10(4), С. 260 - 260
Опубликована: Апрель 11, 2024
Many
efforts
are
continuously
undertaken
to
develop
glucose-sensitive
biomaterials
able
of
controlling
glucose
levels
in
the
body
and
self-regulating
insulin
delivery.
Hydrogels
that
swell
or
shrink
as
a
function
environmental
free
content
suitable
systems
for
monitoring
blood
glucose,
delivering
doses
adapted
concentration.
In
this
context,
development
sensors
based
on
reversible
binding
molecules
represents
continuous
challenge.
Concanavalin
A
(Con
A)
is
bioactive
protein
isolated
from
sword
bean
plants
(Canavalia
ensiformis)
contains
four
sugar-binding
sites.
The
high
affinity
reversibly
specifically
mannose
makes
Con
natural
receptor
smart
glucose-responsive
materials.
During
last
few
years,
was
used
materials,
such
hydrogels,
microgels,
nanoparticles
films,
producing
biosensors
drug
delivery
devices.
This
review
focused
A-based
materials
diagnosis
therapeutics
diabetes.
brief
outlook
glucose-derived
theranostics
cancer
also
presented.
Abstract
This
article
presents
a
thorough
overview
of
gel-based
cleaning
methods
used
in
art
conservation.
It
covers
the
evolution
traditional
approaches
and
development
advanced
gel
systems.
The
paper
examines
structure,
characterization,
classification
gels,
as
well
their
mechanical
properties,
which
are
crucial
Various
types
including
hydrogels,
organogels,
xerogels,
semi-IPNs,
microgels,
discussed
detail,
highlighting
unique
properties
suitability
for
specific
conservation
applications.
advantages,
limitations,
applications
both
natural
synthesized
polymers
that
form
basis
these
gels
also
analyzed.
Case
studies
presented
to
demonstrate
practicality
effectiveness
different
materials
such
paper,
paintings,
metals,
textiles.
These
case
showcase
successful
removal
stains,
pollutants,
unwanted
layers
while
preserving
integrity
aesthetic
value
artworks.
By
contributing
existing
knowledge
on
conservation,
this
comprehensive
review
establishes
foundation
future
research
field.
concludes
with
discussion
challenges
potential
directions
optimization
Overall,
is
valuable
resource
researchers,
conservators,
students
field
providing
essential
information
insights
into
use
effective
safe
agents.
Thermoresponsive
Pluronic®
F127
(PL)
gels
in
water
were
investigated
through
rheological
tests
different
shear
conditions.
The
gel
strength
was
tuned
with
the
addition
of
1%
polysaccharide
solution.
In
presence
xanthan
gum
(XG),
viscoelastic
behavior
PL-based
hydrogels
improved
aqueous
environment,
but
less
changed
XG
PBS
solutions,
whereas
0.1
M
NaCl,
parameters
decreased.
PL
micellar
networks
exhibited
a
self-healing
ability,
recovering
their
initial
structure
after
applying
cycles
high
strain.
characteristics
hydrogel
polysaccharides
(xanthan
gum,
alginate,
κ-carrageenan,
gellan,
or
chitosan).
PL/polysaccharide
systems
form
temperature-responsive
thinning
behavior,
yield
stress,
and
being
considered
versatile
platform
for
injectable
biomaterials
bioinks.
Thus,
medium,
strain
(the
values
elastic
modulus
increased).
other
natural
polymers
induced
specific
behaviors.
Good
performances
observed
gellan
strain,
ability
to
recover
A
modest
chitosan
dissolved
NaCl
Abstract
Polysaccharides,
also
known
as
glycans,
are
biological
macromolecules
consisting
of
many
monosaccharide
units.
Alongside
proteins,
nucleic
acids,
and
lipids,
they
constitute
the
four
fundamental
substances
crucial
for
life
activities
essential
growth
development
living
organisms.
As
natural
products
with
inherent
activity,
polysaccharides
widely
available,
nontoxic,
possess
numerous
functional
properties,
holding
immense
potential
advancement
in
food,
medicine,
cosmetics.
Furthermore,
exploration
polysaccharide‐based
drugs,
an
alternative
to
conventional
therapies,
emerges
a
promising
avenue
addressing
future
disease
challenges.
This
article
comprehensively
reviews
sources,
structural
characteristics,
synthesis,
degradation,
functions,
applications
polysaccharides.
The
pharmacological
applications,
antitumor,
antiaging,
antioxidant,
hypoglycemic,
anti‐inflammatory,
antiviral,
anticoagulant
is
summarized.
Additionally,
role
environmental
protection
discussed.
It
anticipated
that
this
review
will
offer
innovative
strategic
insights,
serving
theoretical
foundation
inspiration
subsequent
research
on
healthcare.
The
Development
of
bioresponsive
extrudable
hydrogels
for
3D
bioprinting
is
imperative
to
address
the
growing
demand
scaffold
design
as
well
efficient
and
reliable
methods
tissue
engineering
regenerative
medicine.
This
study
proposed
genipin
(5
mg)
cross-linked
gelatin
(1
1.5
g)-hyaluronic
acid
(0.3
g)
hydrogel
bioink
(20
mL)
tailored
bioprinting.
focus
on
high
cell
loading
a
less
artificial
extra-cellular
matrix
(ECM)
effect,
exploring
their
potential
applications
in
engineering.
bioresponsiveness
these
scaffolds
was
successfully
evaluated
at
37
°C
room
temperature
(at
pH
2.5,
7.4,
9).
rheological
mechanical
properties
(more
than
three
times)
increased
with
increase
content
hydrogel;
however,
least
amount
showed
best
extrusion
capability.
optimized
hydrogel’s
ability
post-printing
shape
fidelity
were
evident
from
four-axis
printing
complex
structures
such
hollow
tubes,
stars,
pyramids,
zigzag
porous
tubular
(four-axis)
(printed
90
kPa
pressure,
70
mm/s
speed,
22G
needle,
fourth
axis
rotation
4
rpm).
3
million/mL
MC3T3-E1
mouse
osteoblast
cells
used
preparing
bioprinted
samples.
vitro
culture
studies
have
been
carried
out
CO2
incubator
°C,
5%
CO2).
In
cytocompatibility
study,
almost
times
more
viability
observed
days
compared
day
1
control,
proving
non-toxicity
cell-supportiveness
hydrogels.
High
cell-to-cell
interactions
end
using
this
moderately
stable
exhibit
precise
delivery
modes
The
growing
impact
of
infections
and
the
rapid
emergence
antibiotic
resistance
represent
a
public
health
concern
worldwide.
exponential
development
in
field
biomaterials
its
multiple
applications
can
offer
solution
to
problems
that
derive
from
these
situations.
In
this
sense,
antimicrobial
hydrogels
promising
opportunity
with
translational
expectations
medical
management
infectious
diseases
due
their
unique
physicochemical
biological
properties
as
well
for
drug
delivery
specific
areas.
Hydrogels
are
three-dimensional
cross-linked
networks
hydrophilic
polymers
absorb
retain
large
amounts
water
or
fluids.
Moreover,
(AMH)
present
good
biocompatibility,
low
toxicity,
availability,
viscoelasticity,
biodegradability,
properties.
review,
we
collect
discuss
most
strategies
AMH,
which
divided
into
inherent
activity
agent-loaded
based
on
composition.
Then,
an
overview
main
applications:
wound
healing,
tissue
engineering
regeneration,
systems,
contact
lenses,
3D
printing,
biosensing,
purification.
