Personalised screening tool for early detection of sarcopenia in stroke patients: a machine learning-based comparative study

Aging Clinical and Experimental Research, Год журнала: 2025, Номер 37(1)

Опубликована: Фев. 20, 2025

Sarcopenia is a common complication in patients with stroke, adversely affecting recovery and increasing mortality risk. However, no standardised tool exists for its screening this population. This study aims to identify factors influencing sarcopenia develop risk prediction model evaluate predictive performance. Data from 794 stroke were analysed assess demographic clinical characteristics. Variable selection was performed using least absolute shrinkage operator (LASSO) regression, followed by multivariate regression analysis. Logistic (LR), random forest (RF) XGBoost algorithms used construct models, the optimal subjected external validation. Internal validation conducted via bootstrap resampling, involved an additional cohort of 159 stroke. Model performance assessed area under curve (AUC), calibration curves decision analysis (DCA). Seven variables identified through LASSO The LR achieved highest AUC (0.805), outperforming RF (0.796) (0.780) models. Additionally, exhibited superior accuracy, precision, recall, specificity F1-score. External confirmed model's robustness, 0.816. Calibration DCA demonstrated their accuracy applicability. A model, presented as nomogram online calculator, developed Early may facilitate timely interventions improve patient outcomes.

Язык: Английский

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The current state and development trends of frailty research in diabetic patients: a bibliometric analysis

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Март 11, 2025

Background Diabetes mellitus is a global public health issue, often leading to organ damage, complications, and disabilities. Frailty an age-related syndrome characterized by reduced physiological reserve increased vulnerability stressors, significantly affecting the prognosis of older diabetic patients. The prevalence frailty notably higher in adults with diabetes than those without. Therefore, bibliometric analysis research on diabetes-related can provide deeper insights into current state this field inform future directions. Methods This study retrieved English-language publications from Web Science Core Collection (WOS) database, covering period 2005 2023. A total 403 articles were included analysis. Statistical data visualization conducted using Microsoft Excel, R Studio, VOS viewer, Cite Space 6.3.R1. emphasized journals, authors, keywords, country collaborations, institutional references elucidate trends knowledge structures within research. Results number has been steadily increasing each year, predominantly focused developed countries, particularly United States Europe. University London emerged as institution highest volume publications, while Alan J. Sinclair recognized significant contributor field. Key hotspots include complications associated frailty, epidemiology, quality life. Additionally, timeline suggests that nephropathy currently at forefront area. Conclusion comprehensive underscores necessity for improved international collaboration further investigate mechanisms underlying devise more effective prevention treatment strategies. Future should emphasize relationship between well development personalized intervention programs tailored frail

Язык: Английский

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More comprehensive relationship between eGDR and sarcopenia in China: a nationwide cohort study with national representation

Diabetology & Metabolic Syndrome, Год журнала: 2025, Номер 17(1)

Опубликована: Март 24, 2025

Although studies had shown that Insulin resistance (IR) was correlated with the occurrence of sarcopenia, there were still many controversial conclusions. Therefore, we conducted a more comprehensive study on relationship between estimated glucose disposal rate (eGDR), an alternative indicator IR, and risk muscle mass, strength to clarify their interactions. The Study included individuals from China Health Retirement Longitudinal (CHARLS) who complete eGDR data at baseline did not develop low mass strength. divided into four subgroups based quartile (Q) eGDR. lowest (Q1) used as reference. Logistic regression linear evaluate sarcopenia (low strength, possible sarcopenia) related features (ASM/Ht2, grip, RMS), respectively. In addition, further evaluated nonlinear using smooth curve fitting threshold effect analysis. results showed after adjusting for confounders, negatively associated positively characteristics. men significant reduction in likelihood compared women. But levels rise, women gain ASM/Ht2. Further analysis revealed inverse correlation ASM/Ht2 inflection point 15.3893. Besides that, grip (7.1862) RMS (11.1042) before point. found higher lower developing sarcopenia. However, effects need be considered comprehensively. For it is recommended maintain below 15.3893, 7.1862, potential benefits early warning

Язык: Английский

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Evaluating the Efficacy of a Sedentary Behavior Intervention on Self-Efficacy, Step Count, and frailty in Elderly Patients with Type 2 Diabetes Mellitus of Nursing Home

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Апрель 17, 2025

Background: This study aimed to explore the effects of interventions on improving self-efficacy, increasing physical activity, and reducing frailty associated with sedentary behavior in older people type 2 diabetes (OPT2DM). Methods: The convenient sampling method was employed select OPT2DM from six nursing homes Zhengzhou City, China, between July 2023 January 2024. Participants were randomly assigned control experimental groups. Prior intervention protocol, as well 8 weeks 16 post-intervention, subjects assessed using a general data questionnaire, Measure time (MOS), Self-efficacy for (SED), Frail-NH Debilitation Scale, step counts, Body Mass Index (BMI). Results: A total 92 cases included study, comprising 43 group 44 group. scores SED showed statistically significant improvement after (P < 0.05). counts steps taken exhibited differences both Additionally, demonstrated at 16-week mark broad estimation equation analysis indicated that intervention, groups significant, highlighting inter-group effects, interaction Conclusion: reduced among OPT2DM. These not only enhanced self-efficacy regarding management but also increased activity levels, ultimately overall well-being these participants.

Язык: Английский

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Possible sarcopenia and risk of new-onset type 2 diabetes mellitus in older adults in China: a 7-year longitudinal cohort study

BMC Geriatrics, Год журнала: 2023, Номер 23(1)

Опубликована: Июль 3, 2023

Previous studies have shown that type 2 diabetes mellitus (T2DM) can cause sarcopenia; however, these conditions may a bidirectional association. This study aimed to explore the longitudinal association between possible sarcopenia and new-onset T2DM.We conducted population-based cohort using nationally representative data from China Health Retirement Longitudinal Study (CHARLS). included participants aged ≥ 60 years who were free of during baseline survey CHARLS (2011 2012) followed up until 2018. Possible status was defined according Asian Working Group for Sarcopenia 2019 criteria. Cox proportional hazards regression models used evaluate effect on T2DM.In total, 3,707 individuals enrolled in this study, with median age 66 years; prevalence 45.1%. During 7-year follow-up, 575 cases (15.5%) incident identified. Participants more likely T2DM than those without (hazard ratio: 1.27, 95% confidence interval: 1.07-1.50; p = 0.006). In subgroup analysis, we found significant < 75 or BMI 24 kg/m². However, not kg/m².Possible is associated an increased risk older adults, especially are overweight younger.

Язык: Английский

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Associations between thyroid hormones and appendicular skeletal muscle index, and hand grip strength in people with diabetes: The KAMOGAWA-A study

Diabetes Research and Clinical Practice, Год журнала: 2024, Номер 209, С. 111573 - 111573

Опубликована: Фев. 10, 2024

Язык: Английский

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Holistic and Personalized Strategies for Managing in Elderly Type 2 Diabetes Patients

Diabetes & Metabolism Journal, Год журнала: 2024, Номер 48(4), С. 531 - 545

Опубликована: Июль 29, 2024

Due to increased life expectancy and lifestyle changes, the prevalence of diabetes among elderly in Korea is continuously rising, as associated public health burden. Diabetes management patients complicated by age-related physiological sarcopenia characterized loss muscle mass function, comorbidities, varying levels functional, cognitive, mobility abilities that lead frailty. Moreover, with frequently face multiple chronic conditions elevate their risk cardiovascular diseases, cancer, mortality; they are also prone complications such hyperglycemic hyperosmolar state, diabetic ketoacidosis, severe hypoglycemia. This review examines characteristics approaches for elderly, advocates a comprehensive yet personalized strategy.

Язык: Английский

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Joint effects of physical frailty and traditional cardiovascular risk factor control on cardiovascular disease in patients with diabetes

The journal of nutrition health & aging, Год журнала: 2024, Номер 28(10), С. 100342 - 100342

Опубликована: Авг. 24, 2024

Physical frailty has been found to increase the risk of multiple adverse outcomes including cardiovascular disease (CVD) in diabetic patients, but whether this could be modified by traditional factor control remains unknown. We aimed explore joint and interaction effects on CVD.

Язык: Английский

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Management of Glucose-Lowering Therapy in Older Adults with Type 2 Diabetes: Challenges and Opportunities

Clinical Interventions in Aging, Год журнала: 2023, Номер Volume 18, С. 1687 - 1703

Опубликована: Окт. 1, 2023

Abstract: The population of older adults (≥ 65 years) with type 2 diabetes mellitus (T2DM) is diverse, encompassing individuals varying functional capabilities, living arrangements, concomitant medical conditions, and life expectancies. Hence, their categorization into different patient profiles (ie, good health, intermediate poor health) may aid in clinical decision-making when establishing glycemic goals pharmacological treatment strategies. Further granularity assessing each profile through interdisciplinary collaboration also add precision to therapeutic monitoring decisions. In this review, we discuss a multidisciplinary approach how deliver the best benefit from advanced therapies technologies T2DM according profile. There remain however several areas that deserve further research T2DM, including efficacy safety continuous glucose automated insulin delivery systems, switch once-weekly insulin, effectiveness care models, use supported telemedicine remote blood oldest-old 85 who particularly require assistance others. Keywords: diabetes, adults, profiles, management

Язык: Английский

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Pathophysiological interactions between sarcopenia and type 2 diabetes: A two‐way street influencing diagnosis and therapeutic options

Diabetes Obesity and Metabolism, Год журнала: 2023, Номер 26(2), С. 407 - 416

Опубликована: Окт. 18, 2023

Abstract This review will try to elucidate the interconnected pathophysiology of sarcopenia and type 2 diabetes (T2D) identify a common pathway explain their development. To this end, PubMed Scopus databases were searched for articles published about underlying pathophysiology, diagnosis treatment both T2D. The medical subject heading (MeSH) terms ‘sarcopenia’ AND ‘diabetes mellitus’ (‘physiopathology’ OR ‘diagnosis’ ‘therapeutics’ ‘aetiology’ ‘causality’) used. After screening, 32 papers included. It was evident that T2D share multiple pathophysiological mechanisms. Common changes in muscle architecture consist shift myocyte composition, increased myosteatosis decreased capacity regeneration. Further, diseases are linked an imbalance myokine sex hormone production. Chronic low‐grade inflammation levels oxidative stress also known contributors. In future, research efforts should be directed towards discovering checkpoints development as possible shared therapeutic targets diseases. Current with biguanides, incretins insulin may already convey protective effect on sarcopenia. Furthermore, attention given early within population people T2D, sizeable physical burden it encompasses. A combination simple diagnostic techniques could used at regular check‐ups stage start lifestyle modifications soon possible.

Язык: Английский

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