Long COVID: a clinical update

The Lancet, Год журнала: 2024, Номер 404(10453), С. 707 - 724

Опубликована: Июль 31, 2024

Язык: Английский

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Clinical phenotypes and quality of life to define post-COVID-19 syndrome: a cluster analysis of the multinational, prospective ORCHESTRA cohort

EClinicalMedicine, Год журнала: 2023, Номер 62, С. 102107 - 102107

Опубликована: Июль 21, 2023

Lack of specific definitions clinical characteristics, disease severity, and risk preventive factors post-COVID-19 syndrome (PCS) severely impacts research discovery new therapeutics drugs.This prospective multicenter cohort study was conducted from February 2020 to June 2022 in 5 countries, enrolling SARS-CoV-2 out- in-patients followed at 3-, 6-, 12-month diagnosis, with assessment biochemical features, antibody (Ab) response, Variant Concern (VoC), physical mental quality life (QoL). Outcome interest identification protective PCS by phenotype, setting, severity disease, treatment, vaccination status. We used SF-36 questionnaire assess evolution QoL index during follow-up unsupervised machine learning algorithms (principal component analysis, PCA) explore symptom clusters. Severity defined phenotype QoL. also generalized linear models analyse the impact on associated factors. CT registration number: NCT05097677.Among 1796 patients enrolled, 1030 (57%) suffered least one 12-month. PCA identified 4 phenotypes: chronic fatigue-like (CFs: fatigue, headache memory loss, 757 patients, 42%), respiratory (REs: cough dyspnoea, 502, 23%); pain (CPs: arthralgia myalgia, 399, 22%); neurosensorial (NSs: alteration taste smell, 197, 11%). Determinants phenotypes were different (all comparisons p < 0.05): being female increased CPs, NSs, CFs; pulmonary diseases REs; neurological symptoms diagnosis REs, oxygen therapy CFs gastrointestinal CFs. Early treatment infection monoclonal Ab phenotypes), corticosteroids for mild/severe cases (NSs), (CPs) less likely be 0.05). Highest reduction detected REs CPs (43.57 43.86 vs 57.32 PCS-negative controls, 0.001). Female sex (p 0.001), = 0.034) renal complications 0.002) acute increase severe (QoL <50). Vaccination early reduced 0.01 0.03, respectively).Our provides evidence suggesting that can classified QoL, underlying possible pathogenic mechanisms. each PCS. These results might help designing pathogenesis studies selecting high-risk inclusion therapeutic management trials.The received funding Horizon ORCHESTRA project, grant 101016167; Netherlands Organisation Health Research Development (ZonMw), 10430012010023; Inserm, REACTing (REsearch & ACtion emergING infectious diseases) consortium French Ministry Health, PHRC 20-0424.

Язык: Английский

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Oxidative Damage and Post-COVID Syndrome: A Cross-Sectional Study in a Cohort of Italian Workers

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(8), С. 7445 - 7445

Опубликована: Апрель 18, 2023

In addition to the acute symptoms after infection, patients and society are also being challenged by long-term effects of COVID-19, known as long COVID. Oxidative stress, a pivotal point in pathophysiology could potentially be involved development post-COVID syndrome. The aim present study was evaluate relationship between changes oxidative status persistence long-COVID workers with previous mild COVID-19 infection. A cross-sectional conducted among 127 employees an Italian university (80 47 healthy subjects). TBARS assay used detect malondialdehyde serum levels (MDA), while total hydroperoxide (TH) production measured d-ROMs kit. significant difference mean MDA values found previously infected subjects controls (4.9 µm vs. 2.8 µm, respectively). Receiver–operating characteristic (ROC) curves showed high specificity good sensibility (78.7% 67.5%, respectively) for levels. random forest classifier identified hematocrit value, levels, IgG titer against SARS-CoV-2 features highest predictive value distinguishing 34 from 46 asymptomatic subjects. damage persists suggesting possible role stress mediators pathogenesis

Язык: Английский

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Long-term symptom profiles after COVID-19 vs other acute respiratory infections: an analysis of data from the COVIDENCE UK study

EClinicalMedicine, Год журнала: 2023, Номер 65, С. 102251 - 102251

Опубликована: Окт. 6, 2023

Язык: Английский

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Post-covid-19 conditions in adults: systematic review and meta-analysis of health outcomes in controlled studies

BMJ Medicine, Год журнала: 2024, Номер 3(1), С. e000723 - e000723

Опубликована: Янв. 1, 2024

To assess the impact of post-covid-19 conditions among adults.

Язык: Английский

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Clustering Analysis Identified Three Long COVID Phenotypes and Their Association with General Health Status and Working Ability

Journal of Clinical Medicine, Год журнала: 2023, Номер 12(11), С. 3617 - 3617

Опубликована: Май 23, 2023

Background/aim: This study aimed to distinguish different phenotypes of long COVID through the post-COVID syndrome (PCS) score based on long-term persistent symptoms following COVID-19 and evaluate whether these affect general health work ability. In addition, identified predictors for severe COVID. Method: cluster analysis included cross-sectional data from three cohorts patients after COVID-19: non-hospitalized (n = 401), hospitalized 98) those enrolled at outpatient’s clinic 85). All subjects responded survey sociodemographic clinical factors. K-Means ordinal logistic regression were used create PCS scores that patients’ phenotypes. Results: 506 with complete divided into distinct phenotypes: none/mild (59%), moderate (22%) (19%). The phenotype, predominating fatigue, cognitive impairment depression, had most reduced status Smoking, snuff, body mass index (BMI), diabetes, chronic pain symptom severity onset factors predicting phenotype. Conclusion: suggested COVID, where was associated highest impact working knowledge could be by clinicians support their medical decisions regarding prioritizing more detailed follow-up some patient groups.

Язык: Английский

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A systematic review of quantitative EEG findings in Fibromyalgia, Chronic Fatigue Syndrome and Long COVID

Clinical Neurophysiology, Год журнала: 2024, Номер 163, С. 209 - 222

Опубликована: Май 6, 2024

Fibromyalgia Syndrome (FMS), Myalgic Encephalomyelitis/Chronic Fatigue (ME/CFS) and Long COVID (LC) are similar multisymptom clinical syndromes but with difference in dominant symptoms each individual. There is existing emerging literature on possible functional alterations of the central nervous system these conditions. This review aims to synthesise appraise resting-state qEEG FMS, ME/CFS LC, drawing previous research FMS help understand neuropathophysiology new condition LC. A systematic search MEDLINE, Embase, CINHAL, PsycINFO Web Science databases for articles published between December 1994 September 2023 was performed. Out initial 2510 studies identified, 17 were retrieved that met all predetermined selection criteria, particularly assessing changes one three conditions compared healthy controls. All scored moderate high quality Newcastle-Ottawa scale. a general trend decreased low-frequency EEG band activity (delta, theta, alpha) increased high-frequency beta differing found ME/CFS. The limited LC included this focused mainly cognitive impairments showed mixed findings not consistent patterns observed Our suggest different brainwave Further required explore whether there phenotypes within have signatures or could inform identification reliable diagnostic markers targets neuromodulation therapies tailored syndrome.

Язык: Английский

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Long COVID: Pathophysiological and immunological dynamics

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 585 - 597

Опубликована: Янв. 1, 2025

Язык: Английский

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SARS-CoV-2 infection is associated with self-reported post-acute neuropsychological symptoms within six months of follow-up

PLoS ONE, Год журнала: 2024, Номер 19(4), С. e0297481 - e0297481

Опубликована: Апрель 16, 2024

Background Chronic neuropsychological sequelae following SARS-CoV-2 infection, including depression, anxiety, fatigue, and general cognitive difficulties, are a major public health concern. Given the potential impact of long-term impairment, it is important to characterize frequency predictors this post-infection phenotype. Methods The Epidemiology, Immunology, Clinical Characteristics Emerging Infectious Diseases with Pandemic Potential (EPICC) study longitudinal assessing infection in U.S. Military Healthcare System (MHS) beneficiaries, i.e. those eligible for care MHS active duty servicemembers, dependents, retirees. Four broad areas symptoms were assessed cross-sectionally among subjects 1–6 months post-infection/enrollment, including: depression (Patient Health Questionnaire-9), anxiety (General Anxiety Disorder-7), fatigue (PROMIS® Fatigue 7a), function Cognitive Function 8a PROMIS® abilities 8a). Multivariable Poisson regression models compared participants without history on these measures, adjusting sex, ethnicity, active-duty status, age, post-first positive or enrollment questionnaire completion (MPFP/E); also adjusted scores. Results population included 2383 who completed all five instruments within six MPFP/E, whom 687 (28.8%) had at least one test. Compared never tested SARS-CoV-2, group was more likely meet instrument-based criteria (15.4% vs 10.3%, p<0.001), (20.1% 8.0%, impaired (15.7% 8.6%, (24.3% 16.3%, p<0.001). In multivariable models, participants, an average 2.7 after increased risk moderate severe (RR: 1.44, 95% CI 1.12–1.84), 2.07, 1.62–2.65), 1.64, 1.27–2.11), 1.41, 1.15–1.71); MPFP/E not significant. Conclusions Participants up twice as report impairment prior infection. These findings underscore continued importance preventing while time since infection/enrollment significant through 6 follow-up, highlights need additional research into impacts COVID-19 mitigate reverse outcomes.

Язык: Английский

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Clinical-based phenotypes in children with pediatric post-COVID-19 condition

World Journal of Pediatrics, Год журнала: 2024, Номер 20(7), С. 682 - 691

Опубликована: Апрель 25, 2024

Abstract Background Pediatric post coronavirus disease 2019 (COVID-19) condition (PPCC) is a heterogeneous syndrome, which can significantly affect the daily lives of children. This study aimed to identify clinically meaningful phenotypes in children with PPCC, better characterize and treat this condition. Methods Participants were physician-diagnosed referred academic hospital Amsterdam UMC Netherlands between November 2021 March 2023. Demographic factors information on post-COVID symptoms, comorbidities, impact life collected. Clinical clusters identified using an unsupervised unbiased approach for mixed data types. Results Analysis 111 patients (aged 3–18 years) revealed three distinct within PPCC. Cluster 1 ( n = 62, median age 15 predominantly consisted girls (74.2%). These suffered relatively more from exercise intolerance, dyspnea, smell disorders. 2 33, 13 contained even gender distribution (51.5% girls). They sleep problems, memory loss, gastrointestinal arthralgia. 3 16, 11 had higher proportion boys (75.0%), fever, fewer symptoms (median 5 compared 8 10 respectively), experienced lower life. Conclusions clinical PPCC phenotypes, variations sex, age, symptom patterns, findings highlight need further research understand potentially diverse underlying mechanisms contributing Graphical abstract

Язык: Английский

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