Immune system, Год журнала: 2024, Номер unknown, С. 293 - 322
Опубликована: Ноя. 8, 2024
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(16), С. 13012 - 13012
Опубликована: Авг. 21, 2023
PTSD is associated with disturbed hepatic morphology and metabolism. Neuronal mitochondrial dysfunction considered a subcellular determinant of PTSD, but link between damage in has not been demonstrated. Thus, the effects experimental on livers high anxiety (HA) low (LA) rats were compared, determinants underlying difference their investigated. Rats exposed to predator stress for 10 days. Then, 14 days post-stress, evaluated an elevated plus maze assigned HA LA groups according index. Experimental caused dystrophic changes hepatocytes hepatocellular evident by increased plasma ALT AST activities. Mitochondrial was as predominance small-size mitochondria rats, which positively correlated index, activities transaminases, lipids, negatively glycogen. In contrast, had medium-sized mitochondria. we show links dysfunction, damage, heightened rats. These results will provide foundation future research role pathogenesis.
Язык: Английский
Процитировано
9
Molecules, Год журнала: 2023, Номер 28(23), С. 7935 - 7935
Опубликована: Дек. 4, 2023
Neurological-related disorders are diseases that affect the body’s neurons or peripheral nerve tissue, such as Parkinson’s disease (PD) and Alzheimer’s (AD). The development of neurological can cause serious harm to quality life functioning patient. use traditional therapeutic agents dopamine-promoting drugs, anticholinergic cholinesterase inhibitors, NMDA receptor antagonists is often accompanied by a series side effects drug resistance, cardiac arrhythmia, liver function abnormalities, blurred vision. Therefore, there an urgent need find with high safety profile few effects. Herbal medicines rich in active ingredients natural macromolecules. Ginsenoside main ingredient ginseng, which has variety pharmacological considered have potential value treatment human diseases. Modern studies shown ginsenosides Rg2 Rh1 strong activities nervous system, protective on cells, improved resistance neuronal injury, modulation neural activity, cerebral ischemia/reperfusion improvement brain damage after eclampsia hemorrhage, memory cognitive deficits, AD vascular dementia, alleviation anxiety, pain, inhibition ionic-like behavior. In this article, we searched research literature field diseases, summarized latest progress two ginsenosides, reviewed mechanisms Rh1, provided new way thinking for ginseng anti-neurological drugs.
Язык: Английский
Процитировано
9
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(6), С. 3529 - 3529
Опубликована: Март 20, 2024
Post-traumatic stress disorder (PTSD) is a highly disabling mental arising after traumatism exposure, often revealing critical and complex courses when comorbidity with bipolar (BD) occurs. To search for PTSD or depression biomarkers that would help clinicians define BD presentations, this study aimed at preliminarily evaluating circulating brain-derived-neurotrophic factor (BDNF) levels in subjects experiencing major depressive episode versus controls. Two bloodstream BDNF components were specifically investigated, the storage (intraplatelet) released (plasma) ones, both as adaptogenic/repair signals during neuroendocrine response dynamics. Bipolar patients (n = 20) rigorously recruited together unrelated healthy controls 24) subsequently examined by psychiatric questionnaires blood samplings. Platelet-poor plasma (PPP) intraplatelet (PLT) measured ELISA assays. The results showed markedly higher vs. BDNF, confirming platelets' role neurotrophin transport/storage. No between-group PPP-BDNF difference was reported, whereas PLT-BDNF significantly reduced depressed patients. negatively correlated mood scores but not items like PPP-BDNF, which instead displayed opposite correlation trends manic severity. Present findings highlight more reliable detecting than BD, encouraging further into variability contextually immune-inflammatory parameters wider cohorts of differentially symptomatic
Язык: Английский
Процитировано
3
Опубликована: Март 31, 2023
Post-traumatic stress disorder (PTSD) is a chronic psychiatric that occurs following exposure to traumatic events. The prevalence of PTSD estimated be 5-10% worldwide, and it associated with significant distress disability. Recent evidence suggests may risk factor for the development subsequent neurodegenerative disorders, including Alzheimer’s dementia Parkinson’s disease. Identification biomarkers known neurodegeneration in patients would shed light on pathophysiological mechanisms linking these also help preventive approaches aimed at reducing disorders PTSD. In current review, PubMed Scopus databases were searched studies identifying genetic, biochemical, neuroimaging or behavioral markers Out total 342 citations retrieved, 29 relevant identified inclusion review. results suggest several potentially biological markers, cerebral cortical thinning, disrupted white matter integrity, specific genetic polymorphisms, immune-inflammatory alterations, vitamin D deficiency, metabolic syndrome parasomnias, an increased Though many need replication, they highlight number pathways plausibly link valuable avenues prevention early intervention this patient population.
Язык: Английский
Процитировано
8
Biology, Год журнала: 2023, Номер 12(8), С. 1050 - 1050
Опубликована: Июль 26, 2023
Post-traumatic stress disorder (PTSD) is a complex psychological that develops following exposure to traumatic events. PTSD influenced by catalytic factors such as dysregulated hypothalamic-pituitary-adrenal (HPA) axis, neurotransmitter imbalances, and oxidative stress. Genetic variations may act important catalysts, impacting neurochemical signaling, synaptic plasticity, response systems. Understanding the intricate gene networks their interactions vital for comprehending underlying mechanisms of PTSD. Focusing on essential because they provide valuable insights into disorder. By understanding these interplay, researchers uncover potential targets interventions therapies, leading more effective personalized treatments individuals with The aforementioned networks, composed specific genes associated disorder, comprehensive view molecular pathways regulatory involved in Through this study disorder’s opening avenues treatments, interventions, development biomarkers early detection monitoring are provided.
Язык: Английский
Процитировано
8
Актуальні проблеми сучасної медицини Вісник Української медичної стоматологічної академії, Год журнала: 2023, Номер 23(3), С. 137 - 142
Опубликована: Ноя. 3, 2023
In an experiment on 42 white rats, the mechanisms of oxidative-nitrosative stress in liver tissues under conditions surgical trauma reproduced background post-traumatic disorder were studied. It has been shown that reproduction experimental model posttraumatic (single prolonged stress) causes development rat tissues: it increases rate superoxide anion radical generation by microsomes, mitochondria and leukocyte NADPH oxidase, NO-synthase activity activating inducible isoform, reduces conjugation constitutive NO-synthases, which is accompanied increase concentration peroxynitrites alkaline alkaline-earth metals. On 7th day after laparotomy against disorder, indicators tissues, such as production microsomes oxidase total metals, significantly exceed their values a single sham operation simulated stress.
Язык: Английский
Процитировано
8
Frontiers in Physiology, Год журнала: 2023, Номер 14
Опубликована: Окт. 24, 2023
Post-traumatic stress disorder (PTSD) is a neuropsychiatric that occurs in approximately 15% of people as result some traumatic events. The main symptoms are re-experiencing and avoidance everything related to this event hyperarousal. component the pathophysiology PTSD an imbalance functioning hypothalamic-pituitary-adrenal axis (HPA) development neuroinflammation. In parallel with this, mitochondrial dysfunction observed, many other diseases. review, we focus on question how mitochondria may be involved neuroinflammation its maintaining at PTSD. First, describe differences operation neuro-endocrine system during versus We then show changes activity/expression proteins they can affect levels hormones development, well damage/pathogen-associated molecule patterns (DAMPs/PAMPs) trigger inflammation. addition, examine possibility treating PTSD-related inflammation using target.
Язык: Английский
Процитировано
7
European journal of medical research, Год журнала: 2024, Номер 29(1)
Опубликована: Янв. 11, 2024
Abstract Background Post-traumatic stress disorder (PTSD), a disease state that has an unclear pathogenesis, imposes substantial burden on individuals and society. Traumatic brain injury (TBI) is one of the most significant triggers PTSD. Identifying biomarkers associated with TBI-related PTSD will help researchers to uncover underlying mechanism drives development. Furthermore, it remains be confirmed whether different types traumas share common action. Methods For this study, we screened eligible data sets from Gene Expression Omnibus (GEO) database, obtained differentially expressed genes (DEGs) through analysis, conducted functional enrichment analysis DEGs in order understand their molecular mechanisms, constructed PPI network, used various algorithms obtain hub genes, finally evaluated, validated, analyzed diagnostic performance genes. Results A total 430 upregulated 992 down-regulated were extracted TBI set. 1919 851 Functional revealed had biological functions linked regulation, cell signaling transduction, metabolic immune response. After constructing network introducing algorithm identified as VNN1, SERPINB2, ETFDH, FLT3LG, DYRK1A, DCN, FKBP8. In addition, by comparing patients other trauma, was showed processes are under influence trauma characteristics responses. Conclusions By exploring role during pathogenesis PTSD, its possible mechanisms have been revealed, providing vital information for understanding complex pathways The study important implications design development new therapeutic methods needed treat manage
Язык: Английский
Процитировано
2
Current Issues in Molecular Biology, Год журнала: 2024, Номер 46(6), С. 5530 - 5549
Опубликована: Май 31, 2024
A large portion of patients with Human Immunodeficiency Virus (HIV) have neurologic sequelae. Those better-controlled HIV via antiretroviral therapies generally less severe symptoms. However, for many patients, antiretrovirals do not adequately resolve Since much the pathogenesis HIV/AIDS (Autoimmune Deficiency Syndrome) involves oxidative stress either directly, through viral interaction, or indirectly, inflammatory mechanisms, we reviewed relevant trials glutathione supplementation in each HIV-associated neurocognitive diseases and found disease-specific results. For which been completed, predicted responses to are made based on mechanisms seen literature. It is sufficient conclude that all disorders (HAND) will benefit from antioxidant effects supplementation. The potential HAND likely differ specific disease.
Язык: Английский
Процитировано
2
Brain Behavior and Immunity Integrative, Год журнала: 2023, Номер 4, С. 100031 - 100031
Опубликована: Окт. 27, 2023
Lifetime prevalence of post-traumatic stress disorder (PTSD) is double among veterans compared to civilians and women men. Inflammatory factors are increasingly implicated in symptoms PTSD. Yoga shows promise reduce psychological PTSD positively impact inflammatory responses. The present study aimed examine the effectiveness yoga depression addition investigating treatment on markers with secondary military sexual trauma. We collected dried blood spot samples, self-report clinician administered measures PTSD, self-reported at baseline, 2 weeks, 3 months post-intervention from a subset diagnosed (N = 27) who were randomized either Trauma Center Trauma-Sensitive (TCTSY; movement therapy) or cognitive processing therapy (CPT; talk as part larger multisite RCT. Concentrations interleukin (IL)-6, IL-10, C-reactive protein (CRP) measured using multiplex bead-based immunoassay baseline (2 weeks months). Generalized estimating equations examined changes depression, over time. hypothesized decreases IL-6 CRP increases IL-10 TCTSY participants CPT that would improve time both groups. From post-intervention, (β 0.10, p < 0.05), 0.68, 0.77, 0.05) increased relative those CPT. reduced groups (CAPS-5 β −3.96, PCL-5 −4.66, BDI-II −2.70, all 0.05); did not differ magnitude symptom reduction. Findings indicate has potential alter markers. findings limited by our sample size immune we examined. Future directions for related research benefit measuring wider array response components.
Язык: Английский
Процитировано
5