Experimental Eye Research, Год журнала: 2020, Номер 199, С. 108198 - 108198
Опубликована: Авг. 21, 2020
Язык: Английский
The EPMA Journal, Год журнала: 2021, Номер 12(4), С. 449 - 475
Опубликована: Дек. 1, 2021
Abstract Over the last two decades, a large number of non-communicable/chronic disorders reached an epidemic level on global scale such as diabetes mellitus type 2, cardio-vascular disease, several types malignancies, neurological and eye pathologies—all exerted system’s enormous socio-economic burden to primary, secondary, tertiary healthcare. The paradigm change from reactive predictive, preventive, personalized medicine (3PM/PPPM) has been declared essential transformation overall healthcare approach benefit patient society at large. To this end, specific biomarker panels are instrumental for cost-effective predictive individualized prevention treatments tailored person. source biomarkers is crucial specificity reliability diagnostic tests treatment targets. Furthermore, any preferentially should be noninvasive increase availability biomaterial, decrease risks potential complications well concomitant costs. These requirements clearly fulfilled by tear fluid, which represents precious panels. well-justified principle “sick in sick body” makes comprehensive fluid profiling highly relevant not only diagnostics pathologies but also prediction, prognosis, monitoring systemic diseases. One prominent example Sicca syndrome linked cascade severe that include dry eye, neurologic, oncologic In review, protein profiles highlighted corresponding exemplified pathologies, including diabetic retinopathy, cancers, disorders. Corresponding analytical approaches sample pre-processing, differential proteomics, electrophoretic techniques, high-performance liquid chromatography (HPLC), enzyme-linked immuno-sorbent assay (ELISA), microarrays, mass spectrometry (MS) methodology detailed. Consequently, we proposed strategies based application 3P practice. context medicine, pathways considered predict disease development, target preventive measures, create algorithms individual profiles.
Язык: Английский
Процитировано
96
Contact Lens and Anterior Eye, Год журнала: 2021, Номер 44(2), С. 132 - 156
Опубликована: Март 25, 2021
Язык: Английский
Процитировано
67
Experimental Eye Research, Год журнала: 2022, Номер 220, С. 109101 - 109101
Опубликована: Май 1, 2022
Язык: Английский
Процитировано
49
Chemical Engineering Journal, Год журнала: 2023, Номер 479, С. 147590 - 147590
Опубликована: Ноя. 22, 2023
Язык: Английский
Процитировано
22
Expert Opinion on Drug Metabolism & Toxicology, Год журнала: 2020, Номер 16(10), С. 885 - 906
Опубликована: Июль 30, 2020
Ocular barriers hinder drug delivery and reduce bioavailability. This article focuses on enhancing absorption across the corneal conjunctival epithelium. Both, transporter targeted prodrug formulations nanomicellar strategy is proven to enhance permeation of therapeutic agents various ocular barriers. These strategies can increase aqueous solubility stability many hydrophobic drugs for topical ophthalmic formulations.The discusses barriers, influx, efflux transporters. It elaborates used absorption. Along with this, also describes formulation, its characteristic advantages, applications in anterior posterior segment delivery.Prodrugs provide an effective improving bioavailability will be exciting see efficacy nanomicelles treating back eye disorders after their application. considered as a holy grail due dynamic static restricting entry topically applied formulations.
Язык: Английский
Процитировано
54
The EPMA Journal, Год журнала: 2023, Номер 14(1), С. 53 - 71
Опубликована: Фев. 17, 2023
Abstract Metabolomics refers to the high-through untargeted or targeted screening of metabolites in biofluids, cells, and tissues. Metabolome reflects functional states cells organs an individual, influenced by genes, RNA, proteins, environment. Metabolomic analyses help understand interaction between metabolism phenotype reveal biomarkers for diseases. Advanced ocular diseases can lead vision loss blindness, reducing patients’ quality life aggravating socio-economic burden. Contextually, transition from reactive medicine predictive, preventive, personalized (PPPM / 3P) is needed. Clinicians researchers dedicate a lot efforts explore effective ways disease prevention, prediction, treatments, taking advantages metabolomics. In this way, metabolomics has great clinical utility primary secondary care. review, we summarized much progress achieved applying pointed out potential metabolic pathways involved promote 3P approach healthcare.
Язык: Английский
Процитировано
21
Journal of Controlled Release, Год журнала: 2023, Номер 365, С. 1 - 15
Опубликована: Ноя. 18, 2023
Язык: Английский
Процитировано
21
Biomedicines, Год журнала: 2024, Номер 12(6), С. 1303 - 1303
Опубликована: Июнь 12, 2024
Diabetes mellitus (DM) is a chronic metabolic disorder marked by hyperglycemia due to defects in insulin secretion, action, or both, with global prevalence that has tripled recent decades. This condition poses significant public health challenges, affecting individuals, healthcare systems, and economies worldwide. Among its numerous complications, ocular surface disease (OSD) concern, yet understanding pathophysiology, diagnosis, management remains challenging. review aims explore the epidemiology, clinical manifestations, diagnostic approaches, strategies of diabetes-related OSD. The surface, including cornea, conjunctiva, associated structures, vital for maintaining eye health, lacrimal functional unit (LFU) playing crucial role tear film regulation. In DM, changes glycosaminoglycan metabolism, collagen synthesis, oxygen consumption, LFU dysfunction contribute complications. Persistent leads expression cytokines, chemokines, cell adhesion molecules, resulting neuropathy, abnormalities, epithelial lesions. Recent advances molecular research therapeutic modalities, such as gene stem therapies, show promise managing diabetic Future should focus on pathogenetically oriented therapies neuropathy keratopathy, transitioning from animal models trials improve patient outcomes.
Язык: Английский
Процитировано
6
Lab on a Chip, Год журнала: 2021, Номер 21(7), С. 1269 - 1286
Опубликована: Янв. 1, 2021
Eyes have remarkable potential as biological sensing sites for various physical factors and biomarkers, which makes contact lens sensors a promising platform wearable point-of-care device monitoring diagnosis of diseases.
Язык: Английский
Процитировано
37
Applied Materials Today, Год журнала: 2022, Номер 27, С. 101411 - 101411
Опубликована: Фев. 7, 2022
Язык: Английский
Процитировано
26