Journal of Fungi,
Год журнала:
2023,
Номер
9(1), С. 80 - 80
Опубликована: Янв. 5, 2023
Candida
parapsilosis
is
the
second
most
common
species
isolated
in
Asia,
Southern
Europe,
and
Latin
America
often
involved
invasive
infections
that
seriously
impact
human
health.
This
pathogen
part
of
psilosis
complex,
which
also
includes
orthopsilosis
metapsilosis.
C.
are
particularly
prevalent
among
neonates
with
low
birth
weights,
individuals
who
immunocompromised,
patients
require
prolonged
use
a
central
venous
catheter
or
other
indwelling
devices,
whose
surfaces
exhibits
an
enhanced
capacity
to
adhere
form
biofilms.
Despite
this
well-acknowledged
prevalence,
biology
has
not
been
as
extensively
explored
albicans.
In
paper,
we
describe
molecular
mechanistic
pathways
virulence
show
how
they
differ
from
those
We
mode
action
antifungal
drugs
used
for
treatment
infections,
namely,
polyenes,
echinocandins,
azoles,
well
resistance
mechanisms
developed
by
overcome
them.
Finally,
stress
importance
ongoing
search
species-specific
features
may
aid
development
effective
control
strategies
thus
reduce
burden
on
healthcare
costs.
Micromachines,
Год журнала:
2023,
Номер
14(1), С. 209 - 209
Опубликована: Янв. 14, 2023
The
high
occurrence
of
mycological
resistance
to
conventional
antifungal
agents
results
in
significant
illness
and
death
rates
among
immunodeficient
patients.
In
addition,
the
underprivileged
therapeutic
agents,
besides
potential
toxicity
resulting
from
long
term
therapy
necessitate
fabrication
efficient
antimicrobial
combinations.
Hence,
objective
present
investigation
is
synthesize,
characterize
investigate
anticandidal
action
green
zinc
oxide
nanoparticles
(ZnO-NPs)
formulated
using
Camellia
sinensis
leaf
extract
against
three
candidal
pathogens.
eco-friendly
synthesized
ZnO-NPs
were
characterized
utilizing
different
physicochemical
methods
their
potency
was
tested
a
disk
diffusion
assay.
this
setting,
size
biofabricated
detected
transmission
electron
microscope
(TEM)
micrographs,
recording
an
average
particle
19.380
±
2.14
nm.
zeta
analysis
revealed
that
surface
charge
−4.72
mV.
biogenic
reveal
highest
activity
C.
tropicalis
strain,
demonstrating
relative
suppressive
zones
measured
at
35.16
0.13
37.87
0.24
mm
diameter
for
concentrations
50
100
μg/disk,
respectively.
Excitingly,
Candida
glabrata
showed
susceptibility
ZnO
nanomaterials
both
ZnO-NPs’
(50
μg/disk)
compared
control.
Moreover,
biosynthesized
synergistic
effectiveness
with
nystatin
terbinafine
concerned
strains.
maximum
efficiency
noticed
percentages
23.02
45.9%,
no
hemolytic
human
erythrocytes
revealing
biosafety
hemocompatibility.
Finally,
pathogens,
as
well
patterns
such
terbinafine,
emphasize
prospective
application
these
combinations
biocompatible
highly
agents.
Journal of Fungi,
Год журнала:
2022,
Номер
9(1), С. 11 - 11
Опубликована: Дек. 21, 2022
Fungal
infections
caused
by
Candida
species
have
become
a
constant
threat
to
public
health,
especially
for
immunocompromised
patients,
who
are
considered
susceptible
this
type
of
opportunistic
infections.
albicans
is
known
as
the
most
common
etiological
agent
candidiasis;
however,
other
species,
such
tropicalis,
parapsilosis,
Nakaseomyces
glabrata
(previously
glabrata),
auris,
guilliermondii,
and
Pichia
kudriavzevii
named
krusei),
also
gained
great
importance
in
recent
years.
The
increasing
frequency
isolation
non-albicans
associated
with
different
factors,
exposure
antifungal
drugs,
use
catheters
hospitalized
cancer,
age,
geographic
distribution.
main
concerns
control
these
pathogens
include
their
ability
evade
mechanisms
action
thus
developing
resistance
it
has
been
shown
that
some
manage
host's
immunity.
These
biological
traits
make
candidiasis
treatment
challenging
task.
In
review
manuscript,
detailed
update
literature
on
six
relevant
provided,
focusing
immune
response,
evasion
mechanisms,
new
plant-derived
compounds
properties.
Candida
tropicalis
is
a
notable
species
of
the
genus
representing
an
impressive
epidemiology
in
tropical
regions,
especially
South
America
and
Asia,
where
India
already
presents
as
first
epidemiology.
has
also
shown
worrying
antifungal
resistance
profile
recent
years.
It
essential
to
highlight
that
each
pathogenic
particular
biology;
however,
virulence
factors
are
almost
entirely
based
on
studies
with
C.
albicans.
The
intrinsic
krusei
some
azoles,
osmotolerance
tropicalis,
multidrug
auris
just
few
examples
how
biology
unique.
Despite
being
phylogenetically
close
species,
can
support
15%
NaCl,
antagonistically
metabolize
signal
N-acetylglucosamine,
encode
16
reported
ALS
genes,
other
specificities
discussed
here
compared
clarify
details
infectious
process,
including
identifying
participating
secreted
enzyme(s),
responsible
for
tissue
damage,
mechanisms
underlying
morphogenesis
tolerance
signaling
pathways.
In
this
review,
we
thoroughly
assembled
what
known
about
main
highlighting
missing
pieces
stimulate
further
research
non-Candida
albicans
species.
Journal of Umm Al-Qura University for Applied Sciences,
Год журнала:
2023,
Номер
9(3), С. 360 - 377
Опубликована: Май 10, 2023
Abstract
Fungal
infections
(mycoses)
represent
a
major
health
issue
in
humans.
They
have
emerged
as
global
concern
for
medical
professionals
by
causing
high
morbidity
and
mortality.
approximately
impact
one
billion
individuals
per
annum
account
1.6
million
deaths.
The
diagnosis
of
Candida
is
challenging
task.
Laboratory-based
species
identification
techniques
(molecular,
commercial,
conventional)
been
reviewed
summarized.
This
review
aims
to
discuss
the
mycoses
history,
taxonomy,
pathogenicity,
virulence
characteristics.
Microorganisms,
Год журнала:
2023,
Номер
11(6), С. 1476 - 1476
Опубликована: Июнь 1, 2023
Candida
albicans
is
a
commensal
fungal
species
that
commonly
colonizes
the
human
body,
but
it
also
pervasive
opportunistic
pathogen
in
patients
with
malignant
diseases.
A
growing
body
of
evidence
suggests
this
fungus
not
only
coincidental
oncology
patients,
may
play
an
active
role
development
cancer.
More
specifically,
several
studies
have
investigated
potential
association
between
C.
and
various
types
cancer,
including
oral,
esophageal,
colorectal
possible
skin
cancer
as
well.
The
proposed
mechanisms
include
production
carcinogenic
metabolites,
modulation
immune
response,
changes
cell
morphology,
microbiome
alterations,
biofilm
production,
activation
oncogenic
signaling
pathways,
induction
chronic
inflammation.
These
act
together
or
independently
to
promote
development.
Although
more
research
needed
fully
grasp
carcinogenesis,
available
be
contributor
underscores
importance
considering
impact
on
pathogenesis.
In
narrative
review,
we
aimed
summarize
current
state
offer
some
insights
into
mechanisms.
Oral
candidiasis
(OC),
a
prevalent
opportunistic
infection
of
the
oral
mucosa,
presents
considerable
health
challenge,
particularly
in
individuals
with
compromised
immune
responses,
advanced
age,
and
local
predisposing
conditions.
A
part
population
carries
Candida
cavity,
but
only
few
develop
OC.
Therefore,
pathogenesis
OC
may
depend
on
factors
other
than
attributes
fungus,
such
as
host
factors.
Mucosal
trauma
inflammation
compromise
epithelial
integrity,
fostering
conducive
environment
for
fungal
invasion.
Molecular
insights
into
immunocompromised
state
reveal
dysregulation
innate
adaptive
immunity,
creating
permissive
proliferation.
Detailed
examination
species
(spp.)
their
virulence
uncovers
nuanced
understanding
beyond
traditional
C.
albicans
focus,
which
embrace
diverse
spp.
strategies,
influencing
adhesion,
invasion,
evasion,
biofilm
formation.
Understanding
pathophysiological
microenvironments
is
crucial
development
targeted
therapeutic
interventions.
This
review
aims
to
unravel
focusing
microbial,
host,
factors,
considers
resistance
antifungal
therapy.
The
comprehensive
approach
offers
refined
perspective
OC,
seeking
briefly
identify
potential
targets
future
effective
management.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2023,
Номер
13
Опубликована: Окт. 13, 2023
-mediated
vulvovaginal
candidiasis
(VVC)
is
a
significant
challenge
in
clinical
settings,
owing
to
the
inefficacy
of
current
antifungals
modulating
virulence,
development
resistance,
and
poor
penetration
into
biofilm
matrix.
Various
predisposition
factors
are
molecular
drivers
that
lead
dysbiosis
normal
microflora
vagina,
upregulation
central
metabolic
pathways,
morphogenesis,
hyphal
extension,
adhesion,
invasion,
formation
leading
chronic
infection
recurrence.
Hence,
it
crucial
understand
mechanism
behind
virulence
pathways
driven
by
those
decode
drug
targets.
Finding
innovative
solutions
targeting
fungal
virulence/biofilm
may
potentiate
at
low
concentrations
without
affecting
recurrence
resistance.
With
this
background,
present
review
details
critical
associated
network
possible
targets,
target-specific
inhibitors,
probable
mode
delivery
cross
preclinical
phase
appropriate
