Modulation of NRF2/KEAP1 Signaling in Preeclampsia

Cells, Год журнала: 2023, Номер 12(11), С. 1545 - 1545

Опубликована: Июнь 4, 2023

Placentation is a key and tightly regulated process that ensures the normal development of placenta fetal growth. Preeclampsia (PE) hypertensive pregnancy-related disorder involving about 5–8% all pregnancies clinically characterized by de novo maternal hypertension proteinuria. In addition, PE are also increased oxidative stress inflammation. The NRF2/KEAP1 signaling pathway plays an important role in protecting cells against damage due to reactive oxygen species (ROS) levels. ROS activate NRF2, allowing its binding antioxidant response element (ARE) region present promoter several genes such as heme oxygenase, catalase, glutathione peroxidase superoxide dismutase neutralize ROS, damages. this review, we analyze current literature regarding preeclamptic pregnancies, discussing main cellular modulators pathway. Moreover, discuss natural synthetic compounds can regulate vivo vitro models.

Язык: Английский

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Molecular and Cellular Mechanisms of Osteoporosis

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(21), С. 15772 - 15772

Опубликована: Окт. 30, 2023

Osteoporosis is a widespread systemic disease characterized by decrease in bone mass and an imbalance of the microarchitecture tissue. Experimental clinical studies devoted to investigating main pathogenetic mechanisms osteoporosis revealed important role estrogen deficiency, inflammation, oxidative stress, cellular senescence, epigenetic factors development resorption due osteoclastogenesis, decreased mineralization tissue formation reduced function osteoblasts caused apoptosis age-depended differentiation osteoblast precursors into adipocytes. The current review was conducted describe basic at molecular levels elucidate most promising therapeutic strategies therapy based on articles cited PubMed up September 2023.

Язык: Английский

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Insights and implications of sexual dimorphism in osteoporosis

Bone Research, Год журнала: 2024, Номер 12(1)

Опубликована: Фев. 18, 2024

Osteoporosis, a metabolic bone disease characterized by low mineral density and deterioration of microarchitecture, has led to high risk fatal osteoporotic fractures worldwide. Accumulating evidence revealed that sexual dimorphism is notable feature osteoporosis, with sex-specific differences in epidemiology pathogenesis. Specifically, females are more susceptible than males while prone disability or death from the disease. To date, sex chromosome abnormalities steroid hormones have been proven contribute greatly osteoporosis regulating functions cells. Understanding its related complications essential for improving treatment strategies tailored women men. This literature review focuses on mechanisms underlying mainly population aging patients, chronic glucocorticoid administration, diabetes. Moreover, we highlight implications developing therapeutics preventive screening approaches Additionally, challenges translating bench research bedside treatments future directions overcome these obstacles will be discussed.

Язык: Английский

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Association of systemic inflammatory response index with bone mineral density, osteoporosis, and future fracture risk in elderly hypertensive patients

Postgraduate Medicine, Год журнала: 2024, Номер 136(4), С. 406 - 416

Опубликована: Май 16, 2024

This study sought to investigate the relationship between systemic inflammatory response index (SIRI) and bone mineral density (BMD), osteoporosis, future fracture risk in elderly hypertensive patients.

Язык: Английский

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Anthocyanins from a new hybrid sweet potato peel cultivated in Northern Thailand mitigate LPS-induced inflammation and RANKL-induced osteoporosis by regulating ROS-mediated pathways

Inflammopharmacology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 13, 2025

Maejo 341 Sweet potato (MSP) is a new purple sweet variety cultivated in Northern Thailand, but its health benefits are unknown. This study aimed to investigate antioxidant, anti-inflammatory, and anti-osteoporotic activities, as well anthocyanin content. The peel flesh of MSP were extracted with ethanol water. Compared the extracts, extracts presented greater antioxidant capacity rich phenolics, flavonoids, anthocyanins, namely, cyanidin-3-O-glucoside, peonidin-3-O-glucoside, pelargonidin-3-O-glucoside, cyanidin, peonidin. suppressed lipopolysaccharide-induced inflammation by inhibiting secretion proinflammatory cytokines enzymes, including TNF-α, IL-1β, IL-6, COX-2, iNOS, reducing nitric oxide matrix metalloproteinase-9 secretion. inhibited RANKL-induced NF-κB MAPK pathways downregulated osteoclastogenic marker expression. Under LPS RANKL treatment, notably reduced reactive oxygen species production while increasing gene Furthermore, they increased osteoblast viability slightly raise alkaline phosphatase activity. These findings suggest that could be used functional food alleviate oxidative stress inflammation-related osteoporosis.

Язык: Английский

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Anti-inflammatory and antioxidant traditional Chinese Medicine in treatment and prevention of osteoporosis

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Июнь 27, 2023

A metabolic bone disorder called osteoporosis is characterized by decreased mass and compromised microarchitecture. This condition can deteriorate bones raise the risk of fractures. The two main causes are an increase in osteoclast activity or quantity a decrease osteoblast viability. Numerous mechanisms, including estrogen shortage, aging, chemical agents, mechanical loads, have been linked to osteoporosis. Inflammation oxidative stress recently osteoporosis, according increasing number studies. primary medications used treat at moment bisphosphonates selective receptor modulators (SERMs). These work well for brought on aging deprivation, however, they do not target inflammation stress-induced In addition, these drugs some limitations that attributed various side effects overcome. Traditional Chinese medicine (TCM) has applied many years high safety profile. Therefore, this review, literature related botanical effect was searched for. Moreover, pharmacologically active ingredients herbs pathways were discussed may contribute discovery more safe effective treatment

Язык: Английский

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ROS-scavenging bioactive scaffold orchestrates bone regeneration for osteoporotic bone defect repair

Composites Part B Engineering, Год журнала: 2024, Номер 281, С. 111528 - 111528

Опубликована: Май 4, 2024

Язык: Английский

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Picein alleviates oxidative stress and promotes bone regeneration in osteoporotic bone defect by inhibiting ferroptosis via Nrf2/HO‐1/GPX4 pathway

Environmental Toxicology, Год журнала: 2024, Номер 39(7), С. 4066 - 4085

Опубликована: Май 10, 2024

Abstract Osteoporosis (OP) can result in slower bone regeneration than the normal condition due to abnormal oxidative stress and high levels of reactive oxygen species (ROS), a detrimental for formation, making OP‐related healing significant clinical challenge. As osteogenic differentiation ability marrow mesenchymal stem cells (BMSCs) is closely related regeneration; currently, this study assessed effects Picein on BMSCs vitro osteoporotic defect vivo. Cell viability was determined by CCK‐8 assay. The production malonaldehyde, superoxide dismutase activities, glutathione evaluated using commercially available kits, flow cytometry analysis adopted detect macrophage polarization. Osteogenic capacity alkaline phosphatase (ALP) activity, ALP staining, Alizarin red S staining. expression osteogenic‐related proteins (OPN, Runx‐2, OCN) genes (ALP, BMP‐4, COL‐1, Osterix) were Western blotting real‐time PCR (RT‐PCR). In addition, proliferation, migration ability, angiogenic human umbilical vein endothelial (HUVECs) EdU scratch test, transwell assay, tube formation respectively. Angiogenic‐related (VEGF, vWF, CD31) also RT‐PCR. Results showed that alleviated erastin‐induced stress, enhanced BMSCs, angiogenesis HUVECs, protects against ferroptosis through Nrf2/HO‐1/GPX4 axis. Moreover, regulate immune microenvironment promoting polarization M2 macrophages vitro. reduce inflammation promotes OP rat models Altogether, these results suggested promote alleviate via pathway, offering as novel antioxidant agent treating defect.

Язык: Английский

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Multifunctional scaffolds for bone repair following age-related biological decline: Promising prospects for smart biomaterial-driven technologies

Biomaterials, Год журнала: 2024, Номер 311, С. 122683 - 122683

Опубликована: Июнь 28, 2024

Язык: Английский

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The Therapeutic Potential of Two Egyptian Plant Extracts for Mitigating Dexamethasone-Induced Osteoporosis in Rats: Nrf2/HO-1 and RANK/RANKL/OPG Signals

Antioxidants, Год журнала: 2024, Номер 13(1), С. 66 - 66

Опубликована: Янв. 1, 2024

The prolonged use of exogenous glucocorticoids, such as dexamethasone (Dex), is the most prevalent secondary cause osteoporosis, known glucocorticoid-induced osteoporosis (GIO). current study examined preventative and synergistic effect aqueous chicory extract (ACE) ethanolic purslane (EPE) on GIO compared with Alendronate (ALN). phytochemical contents, elemental analysis, antioxidant scavenging activity, ACE EPE combination index were evaluated. Rats randomly divided into control, ACE, EPE, ACE/EPE MIX groups (100 mg/kg orally), Dex group (received 1.5 mg Dex/kg, Sc), four treated received MIX, ALN Dex. bone mineral density content, index, growth, turnover, oxidative stress measured. molecular analysis RANK/RANKL/OPG Nrf2/HO-1 pathways also causes by increasing stress, decreasing markers, reducing growth markers (OPG OCN), turnover resorption (NFATc1, RANKL, ACP, ALP, IL-6, TNF-α). In contrast, showed a prophylactic against Dex-induced modulating measured parameters histopathological architecture. conclusion, exerts powerful mode action different from ALN.

Язык: Английский

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