This
research
note
explores
the
potential
of
Semaglutide,
a
GLP-1
agonist
similar
to
Ozempic,
as
preventive
anti-cancer
agent.
It
discusses
shared
pathophysiological
features
between
cancer
and
diabetes,
including
insulin
resistance,
inflammation,
oxidative
stress,
adipokine
imbalance.
The
highlights
GLP-1's
role
in
diabetes
prevention,
its
mechanisms,
ongoing
research.
also
touches
upon
promising
relationship
receptor
agonists
treatment,
focusing
on
their
impact
cell
proliferation,
apoptosis,
angiogenesis
regulation.
Finally,
it
emphasizes
importance
establishing
optimal
dosages
for
address
both
prevention.
Abstract
Diabesity
is
a
condition
where
an
individual
has
both
diabetes
and
obesity,
which
can
lead
to
severe
complications
including
cardiovascular
disease,
leading
cause
of
mortality.
Recently,
cancer
become
excess
hospitalizations,
obesity
are
associated
with
higher
risk
developing
several
types
cancer.
In
this
review,
we
propose
that
chronic
stress
significantly
increases
association.
Managing
challenging
as
they
significant
distress.
The
relationship
between
interconnected,
anxiety
depression
being
common
in
patients.
Cancer
diagnosis
treatment
lasting
changes
the
body’s
neuroendocrine
system,
causing
excessive
release
catecholamines
prostaglandins
patients
undergoing
surgery,
promotes
spread
other
parts
body.
Furthermore,
could
increase
diabetes,
or
both.
Neuroscience & Biobehavioral Reviews,
Год журнала:
2024,
Номер
165, С. 105848 - 105848
Опубликована: Авг. 13, 2024
Microglia,
as
immune
cells
in
the
central
nervous
system,
are
closely
related
to
cognitive
impairment
associated
with
type
2
diabetes
(T2D).
Preliminary
explorations
have
investigated
relationship
between
T2D-related
and
activation
polarization
of
microglia.
This
review
summarizes
potential
mechanisms
microglial
context
T2D.
It
discusses
inflammatory
responses,
neuronal
apoptosis,
amyloid-β
deposition,
abnormal
phosphorylation
Tau
protein
mediated
by
polarization,
exploring
connections
from
multiple
perspectives.
Additionally,
this
provides
references
for
future
treatment
targeting
microglia
clinical
translation.
Heca Journal of Applied Sciences,
Год журнала:
2025,
Номер
3(1), С. 1 - 16
Опубликована: Фев. 26, 2025
Prostate
cancer
is
a
leading
malignancy
in
men,
ranking
fourth
globally
and
fifth
Indonesia
(GLOBOCAN
2020).
Conventional
therapies,
though
available,
are
limited
by
high
costs,
side
effects,
resistance,
highlighting
the
need
for
accessible
alternatives.
Broccoli
microgreens,
rich
bioactive
compounds,
have
shown
potential
preventing
treating
various
cancers.
This
study
hypothesized
that
compounds
broccoli
microgreens
interact
with
molecular
targets
involved
prostate
progression.
To
test
this
hypothesis,
we
employed
network
pharmacology-based
silico
approach
to
systematically
explore
these
interactions
identify
therapeutic
mechanisms.
Bioactive
were
identified
using
liquid
chromatography-mass
spectrometry
(LC-MS)
analyzed
via
PubChem
database.
The
biological
activities
of
predicted
PASS
Online,
focusing
on
their
capacity
modulate
TP53
gene
expression.
Pharmacokinetic
toxicity
evaluations
performed
ADMETLab
3.0
Protox
assess
safety
drug-like
properties.
Target
proteins
through
SwissTargetPrediction
GeneCards,
while
protein-protein
interaction
networks
constructed
STRING.
pharmacological
was
visualized
Cytoscape
elucidate
mechanisms
action.
analysis
528
relevant
target
proteins,
key
roles
attributed
SRC
EGFR,
both
critical
resistance
EGFR
tyrosine
kinase
inhibitors
regulating
processes
such
as
cell
proliferation,
apoptosis
metastatic
potential.
Through
pharmacology,
kaempferol
polydatin
targets,
demonstrating
ability
pathways
essential
In
conclusion,
contain
relevance
cancer,
particularly
pathways,
warranting
further
experimental
validation.
Endocrine,
Год журнала:
2024,
Номер
85(2), С. 520 - 531
Опубликована: Март 20, 2024
Abstract
Purpose
Neuroendocrine
neoplasms
(NENs)
are
a
heterogeneous
group
of
malignancies
originating
from
cells
with
neuroendocrine
phenotype.
The
complex
relationship
between
lipid
metabolism
and
cancer
is
gaining
interest
potential
anti-cancer
effect
lowering
agents
being
considered.
This
review
aims
to
discuss
the
current
understanding
treatment
dyslipidaemia
in
NENs,
focusing
on
role
agents,
including
new
therapeutic
approaches,
future
perspectives
as
possible
tool
prevention
tumor-growth
control.
Methods
We
performed
an
electronic-based
search
using
PubMed
updated
until
December
2023,
summarizing
available
evidence
both
basic
clinical
research
about
NENs.
Results
Dyslipidemia
important
aspect
be
considered
NENs
management,
although
randomized
studies
specifically
addressing
this
topic
lacking,
unlike
other
types.
Available
data
mainly
regard
statins,
vitro
have
demonstrated
direct
antitumor
effects,
antiproliferative
effects
some
cancers,
supporting
pleiotropic
also
but
remain
conflicting.
Ezetimibe,
omega
3-fatty
acids,
fibrates
inhibitors
proprotein
convertase
subtilisin/kexin
type
9
(PCSK9)
may
enhance
regulation
homeostasis,
cancers.
Conclusions
Targeting
dyslipidemia
should
part
multidisciplinary
management
integrated
approach
best
option
for
metabolic
tumor
Whether
directly
contribute
control
remains
confirmed
specific
studies,
association
risk,
disease
stage
primary
site.
Intelligent Pharmacy,
Год журнала:
2024,
Номер
2(4), С. 456 - 466
Опубликована: Май 16, 2024
Cowhide
collagen
hydrolysates
(CCHs)
are
peptides
and
amino
acids
obtained
from
the
partial
hydrolysis
of
collagen.
These
have
numerous
potential
applications
in
food,
biomedical,
pharmaceutical
industries.
The
study
analyzed
physicochemical,
antioxidant,
anti-atherosclerosis
properties
cowhide
using
silico
methods.
Proteins
were
identified
based
on
their
molecular
weights
origin
protein
database
(UniProtKB).
Using
bioinformatics
tools,
physicochemical
(toxicity
acid
composition)
determined.
proteins
subsequently
subjected
to
an
enzymatic
pepsin,
thermolysin,
proteinase
K.
characterized.
Molecular
docking
was
conducted
between
generated
three
target
enzymes
(3-Hydroxy-3-Methylglutaryl-CoA
(HMG-CoA)
reductase,
cyclooxygenase-2,
Nicotinamide
Adenine
Dinucleotide
Phosphate
(NADPH)
oxidase).
Two
collagens
identified,
F1MJQ6
G3MZI7,
with
172,076
184,867
Dalton,
respectively.
A
compositional
analysis
G3MZI7
revealed
significant
presence
glycine
residues
at
25%
23%,
proline
16%
18%,
exhibited
a
high
concentration
both
essential
semi-essential
acids.
results
indicate
that
antioxidant
ADF,
PHF,
LW
(novel
released
by
K)
most
promising
candidates
for
further
development
as
inhibitors
HMG-CoA
cyclo-oxygenase-2,
NADPH
oxidase.
In
particularly
properties.
Journal of Nutrition and Metabolism,
Год журнала:
2024,
Номер
2024, С. 1 - 10
Опубликована: Фев. 21, 2024
Insulin
resistance
(IR)
is
associated
with
increased
cardiovascular
disease
risk,
and
all-cause,
cardiovascular,
cancer
mortality.
A
number
of
surrogate
markers
are
used
in
clinical
practice
to
diagnose
IR.
The
aim
this
study
was
investigate
the
discriminatory
power
a
routinely
available
anthropometric
biochemical
variables
predicting
IR
determine
their
optimal
cutoffs.
We
performed
cross-sectional
cohort
middle-aged
individuals.
receiver
operator
characteristics
(ROC)
analyses
order
parameters
interest
detecting
IR,
which
defined
as
homeostatic
model
assessment-insulin
≥2.5.
Both
lipid
accumulation
product
(LAP)
visceral
adiposity
index
(VAI)
exhibited
good
detect
both
males
females.
cutoffs
were
42.5
1.44,
respectively,
36.2
1.41,
Serum
triglycerides
(TG)
waist
circumference
(WC)
similarly
demonstrated
sexes.
for
serum
TG
WC
1.35
mmol/L
96.5
cm,
men
1.33
82
women.
On
other
hand,
systolic
diastolic
blood
pressure,
liver
transaminases,
high-density
lipoprotein
cholesterol,
uric
acid,
ferritin,
waist-hip
ratio,
"A"
body
shape,
thigh
circumference,
weight-adjusted
all
had
poor
power.
Our
data
show
that
LAP,
VAI,
TG,
have
lower
than
those
currently
recommended
Replication
studies
required
different
subpopulations
ethnicities
be
able
update
current
cut
points
ones
reflect
contemporary
population
well
evaluate
longitudinal
relationship
longer-term
cardiometabolic
outcomes.
Abstract
Mechanical
forces
are
of
major
importance
in
regulating
vascular
homeostasis
by
influencing
endothelial
cell
behavior
and
functions.
Adherens
junctions
critical
sites
for
mechanotransduction
cells.
β-catenin,
a
component
adherens
the
canonical
Wnt
signaling
pathway,
plays
role
mechanoactivation.
Evidence
suggests
that
β-catenin
is
involved
flow
sensing
responds
to
tensional
forces,
impacting
junction
dynamics.
The
mechanoregulation
context-dependent,
influenced
type
duration
mechanical
loads.
In
cells,
β-catenin’s
nuclear
translocation
shear
stress
strain,
affecting
permeability.
study
investigates
how
stress,
surface
topography
impact
dynamics,
regulate
localization,
influence
barrier
properties.
Insight
box
loads
potent
regulators
functions
through
not
completely
elucidated
mechanisms.
Surface
topography,
wall
cyclic
deformation
contribute
overlapping
stimuli
which
monolayer
respond
adapt
maintain
use
custom
developed
chamber
bioreactor
allows
quantifying
response
mature
human
well-defined
gradients
strain.
Here,
substrate
stretch
analyzed
linked
control
Current Issues in Molecular Biology,
Год журнала:
2023,
Номер
45(11), С. 8780 - 8815
Опубликована: Ноя. 1, 2023
A
strong
relationship
exists
between
immune
dysfunction
and
cardiovascular
disease.
Immune
dysregulation
can
promote
the
development
of
diseases
as
well
exacerbate
their
course.
The
disorders
may
occur
due
to
presence
primary
defects
(currently
known
inborn
errors
immunity)
more
common
secondary
deficiencies.
Secondary
deficiencies
be
caused
by
certain
chronic
conditions
(such
diabetes,
kidney
disease,
obesity,
autoimmune
diseases,
or
cancer),
nutritional
(including
both
lack
nutrients
bioactive
non-nutrient
compounds),
medical
treatments
addictive
substances.
This
article
unravels
molecular
linkage
aforementioned
system
atherosclerosis.
Cell & Cellular Life Sciences Journal,
Год журнала:
2024,
Номер
9(1), С. 1 - 4
Опубликована: Янв. 1, 2024
This
research
note
explores
the
potential
of
Semaglutide,
a
GLP-1
agonist
similar
to
Ozempic,
as
preventive
anti-cancer
agent.
It
discusses
shared
pathophysiological
features
between
cancer
and
diabetes,
including
insulin
resistance,
inflammation,
oxidative
stress,
adipokine
imbalance.
The
highlights
GLP-1's
role
in
diabetes
prevention,
its
mechanisms,
ongoing
research.
also
touches
upon
promising
relationship
receptor
agonists
treatment,
focusing
on
their
impact
cell
proliferation,
apoptosis,
angiogenesis
regulation.
Finally,
it
emphasizes
importance
establishing
optimal
dosages
for
address
both
prevention.
