Role of microRNAs in Immune Regulation with Translational and Clinical Applications
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(3), С. 1942 - 1942
Опубликована: Фев. 5, 2024
MicroRNAs
(miRNAs)
are
19-23
nucleotide
long,
evolutionarily
conserved
noncoding
RNA
molecules
that
regulate
gene
expression
at
the
post-transcriptional
level.
In
this
review,
involvement
of
miRNAs
is
summarized
in
differentiation
and
function
immune
cells,
anti-infective
responses,
immunodeficiencies
autoimmune
diseases.
Roles
anticancer
immunity
transplantation
solid
organs
hematopoietic
stem
cells
also
discussed.
Major
focus
put
on
translational
clinical
applications
miRNAs,
including
establishment
noninvasive
biomarkers
for
differential
diagnosis
prediction
prognosis.
Patient
selection
response
to
biological
therapy
one
most
promising
fields
application.
Replacement
or
inhibition
has
enormous
therapeutic
potential,
with
constantly
expanding
possibilities.
Although
important
challenges
still
await
solutions,
evaluation
miRNA
fingerprints
may
contribute
an
increasingly
personalized
management
dysregulation
a
remarkable
reduction
toxicity
treatment
side
effects.
More
detailed
knowledge
molecular
effects
physical
exercise
nutrition
system
facilitate
self-tailored
lifestyle
recommendations
advances
prevention.
Язык: Английский
Understanding exososmes: Part 3—therapeutic + diagnostic potential in dentistry
Periodontology 2000,
Год журнала:
2024,
Номер
94(1), С. 415 - 482
Опубликована: Фев. 1, 2024
Abstract
Exosomes
are
the
smallest
subset
of
extracellular
signaling
vesicles
secreted
by
most
cells
with
ability
to
communicate
other
tissues
and
cell
types
over
long
distances.
Their
use
in
regenerative
medicine
has
gained
tremendous
momentum
recently
due
their
be
utilized
as
therapeutic
options
for
a
wide
array
various
diseases.
Over
5000
publications
currently
being
published
on
this
topic
yearly,
many
which
dental
space.
This
extensive
review
article
is
first
scoping
aimed
at
summarizing
all
uses
exosomes
dentistry.
A
total
944
articles
were
identified
using
field
either
regenerative/therapeutic
potential
or
diagnostic
purposes
derived
from
oral
cavity.
In
total,
113
research
selected
(102
vitro,
60
vivo,
50
studies
included
both).
Therapeutic
commonly
pulps,
periodontal
ligament
cells,
gingival
fibroblasts,
stem
exfoliated
deciduous
teeth,
apical
papilla
have
been
shown
facilitate
number
including
bone,
cementum,
ligament,
nerves,
aid
orthodontic
tooth
movement,
relieve
temporomandibular
joint
disorders,
among
others.
Results
demonstrate
that
led
positive
outcomes
100%
studies.
bone
field,
found
perform
equally
well
better
than
rhBMP2
while
significantly
reducing
inflammation.
Periodontitis
animal
models
treated
simple
injections
benefits
even
observed
when
administered
intravenously.
much
more
stable
growth
factors
far
resistant
against
degradation
pathogens
routinely
periodontitis
environment.
Comparative
regeneration
compared
native
parent
cells.
47
revealed
role
salivary/crevicular
fluid
diagnosis
birth
defects,
cardiovascular
disease,
diabetes,
recession
detection,
gingivitis,
irritable
bowel
syndrome,
neurodegenerative
lichen
planus,
squamous
carcinoma,
oropharyngeal
cancer
root
resorption,
pancreatic
cancer,
periodontitis,
peri‐implantitis,
Sjögren
systemic
Hence,
we
characterize
possessing
“remarkable”
potential,
serving
valuable
tool
clinicians
significant
advantages.
Язык: Английский
Extracellular vesicles in dry eye disease and Sjogren syndrome: A systematic review on their diagnostic and therapeutic role
Survey of Ophthalmology,
Год журнала:
2025,
Номер
70(3), С. 499 - 515
Опубликована: Янв. 14, 2025
Язык: Английский
An Overview of the Dry Eye Disease in Sjögren’s Syndrome Using Our Current Molecular Understanding
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(2), С. 1580 - 1580
Опубликована: Янв. 13, 2023
Sjögren's
syndrome
is
a
chronic
and
insidious
auto-immune
disease
characterized
by
lymphocyte
infiltration
of
exocrine
glands.
The
patients
typically
present
with
ocular
surface
diseases
related
to
dry
eye
other
systemic
manifestations.
However,
due
the
high
prevalence
lack
objective
clinically
reliable
diagnostic
tools,
discriminating
(SSDE)
from
non-Sjögren's
(NSSDE)
remains
challenge
for
clinicians.
Diagnosing
SS
important
improve
quality
life
through
timely
referral
workups,
as
associated
serious
complications
such
lymphoma
autoimmune
diseases.
purpose
this
article
describe
current
molecular
understanding
its
implications
novel
modalities
on
horizon.
A
literature
review
pre-clinical
clinical
studies
published
between
2016
2022
was
conducted.
SSDE
pathophysiology
immunology
pathways
have
become
better
understood
in
recent
years.
Novel
modalities,
tear
saliva
proteomics
well
exosomal
biomarkers,
provide
hope
Язык: Английский
Advances in Sjögren’s Syndrome Dry Eye Diagnostics: Biomarkers and Biomolecules beyond Clinical Symptoms
Biomolecules,
Год журнала:
2024,
Номер
14(1), С. 80 - 80
Опубликована: Янв. 8, 2024
Sjögren’s
syndrome
dry
eye
(SSDE)
is
a
subset
of
marked
by
symptoms
that
distinct
from
non-Sjögren’s
(NSSDE).
As
SSDE
can
lead
to
severe
complications,
its
early
detection
imperative.
However,
the
differentiation
between
and
NSSDE
remains
challenging
due
overlapping
clinical
manifestations.
This
review
endeavors
give
concise
overview
classification,
pathophysiology,
features
presentation,
ocular
systemic
diagnosis,
management
SSDE.
Despite
advancements,
limitations
in
current
diagnostic
methods
underscore
need
for
novel
modalities.
Thus,
examines
various
biomarkers
utilized
identification,
encompassing
serum,
salivary,
tear
analyses.
Recent
advancements
proteomic
research
exosomal
offer
promising
potential.
Through
comprehensive
literature
spanning
2016
2023,
we
highlight
molecular
insights
advanced
modalities
have
potential
enhance
our
understanding
diagnosis
Язык: Английский
Predicting autoimmune diseases: A comprehensive review of classic biomarkers and advances in artificial intelligence
Autoimmunity Reviews,
Год журнала:
2024,
Номер
23(9), С. 103611 - 103611
Опубликована: Авг. 28, 2024
Язык: Английский
Extracellular vesicles as a new horizon in the diagnosis and treatment of inflammatory eye diseases: A narrative review of the literature
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Март 9, 2023
Extracellular
vesicles
include
exosomes,
microvesicles,
and
apoptotic
bodies.
Their
cargos
contain
a
diverse
variety
of
lipids,
proteins,
nucleic
acids
that
are
involved
in
both
normal
physiology
pathology
the
ocular
system.
Thus,
studying
extracellular
may
lead
to
more
comprehensive
understanding
pathogenesis,
diagnosis,
even
potential
treatments
for
various
diseases.
The
roles
inflammatory
eye
disorders
have
been
widely
investigated
recent
years.
term
“inflammatory
diseases”
refers
conditions
such
as
inflammation-related
diseases,
degenerative
with
remarkable
components,
neuropathy,
tumors.
This
study
presents
an
overview
vesicles’
exosomes’
pathogenic,
diagnostic,
therapeutic
values
well
existing
challenges.
Язык: Английский
Exosome-based engineering strategies for the diagnosis and treatment of oral and maxillofacial diseases
Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Дек. 21, 2023
Oral
and
maxillofacial
diseases
are
one
of
the
most
prevalent
in
world,
which
not
only
seriously
affect
health
patients'
oral
tissues,
but
also
bring
serious
economic
psychological
burdens
to
patients.
Therefore,
require
effective
treatment.
Traditional
treatments
have
limited
effects.
In
recent
years,
nature
exosomes
attracted
increasing
attention
due
their
ability
diagnose
treat
diseases.
However,
application
is
low
yield,
high
impurities,
lack
targeting,
cost.
Engineered
can
be
endowed
with
better
comprehensive
therapeutic
properties
by
modifying
parent
cells
or
directly
exosomes,
biomaterial
loading
exosomes.
Compared
natural
these
engineered
achieve
more
diagnosis
treatment
maxillary
system
diseases,
provide
reference
guidance
for
clinical
application.
This
paper
reviews
engineering
modification
methods
looks
forward
future
research
directions.
Язык: Английский