Exosome-based engineering strategies for the diagnosis and treatment of oral and maxillofacial diseases DOI Creative Commons

Jianing Ren,

Xuan Jing, Yingyu Liu

et al.

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Dec. 21, 2023

Oral and maxillofacial diseases are one of the most prevalent in world, which not only seriously affect health patients' oral tissues, but also bring serious economic psychological burdens to patients. Therefore, require effective treatment. Traditional treatments have limited effects. In recent years, nature exosomes attracted increasing attention due their ability diagnose treat diseases. However, application is low yield, high impurities, lack targeting, cost. Engineered can be endowed with better comprehensive therapeutic properties by modifying parent cells or directly exosomes, biomaterial loading exosomes. Compared natural these engineered achieve more diagnosis treatment maxillary system diseases, provide reference guidance for clinical application. This paper reviews engineering modification methods looks forward future research directions.

Language: Английский

Role of microRNAs in Immune Regulation with Translational and Clinical Applications DOI Open Access
Zsuzsanna Gaál

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1942 - 1942

Published: Feb. 5, 2024

MicroRNAs (miRNAs) are 19-23 nucleotide long, evolutionarily conserved noncoding RNA molecules that regulate gene expression at the post-transcriptional level. In this review, involvement of miRNAs is summarized in differentiation and function immune cells, anti-infective responses, immunodeficiencies autoimmune diseases. Roles anticancer immunity transplantation solid organs hematopoietic stem cells also discussed. Major focus put on translational clinical applications miRNAs, including establishment noninvasive biomarkers for differential diagnosis prediction prognosis. Patient selection response to biological therapy one most promising fields application. Replacement or inhibition has enormous therapeutic potential, with constantly expanding possibilities. Although important challenges still await solutions, evaluation miRNA fingerprints may contribute an increasingly personalized management dysregulation a remarkable reduction toxicity treatment side effects. More detailed knowledge molecular effects physical exercise nutrition system facilitate self-tailored lifestyle recommendations advances prevention.

Language: Английский

Citations

15
Understanding exososmes: Part 3—therapeutic + diagnostic potential in dentistry DOI Creative Commons
Richard J. Miron, Nathan E. Estrin, Anton Sculean

et al.

Periodontology 2000, Journal Year: 2024, Volume and Issue: 94(1), P. 415 - 482

Published: Feb. 1, 2024

Abstract Exosomes are the smallest subset of extracellular signaling vesicles secreted by most cells with ability to communicate other tissues and cell types over long distances. Their use in regenerative medicine has gained tremendous momentum recently due their be utilized as therapeutic options for a wide array various diseases. Over 5000 publications currently being published on this topic yearly, many which dental space. This extensive review article is first scoping aimed at summarizing all uses exosomes dentistry. A total 944 articles were identified using field either regenerative/therapeutic potential or diagnostic purposes derived from oral cavity. In total, 113 research selected (102 vitro, 60 vivo, 50 studies included both). Therapeutic commonly pulps, periodontal ligament cells, gingival fibroblasts, stem exfoliated deciduous teeth, apical papilla have been shown facilitate number including bone, cementum, ligament, nerves, aid orthodontic tooth movement, relieve temporomandibular joint disorders, among others. Results demonstrate that led positive outcomes 100% studies. bone field, found perform equally well better than rhBMP2 while significantly reducing inflammation. Periodontitis animal models treated simple injections benefits even observed when administered intravenously. much more stable growth factors far resistant against degradation pathogens routinely periodontitis environment. Comparative regeneration compared native parent cells. 47 revealed role salivary/crevicular fluid diagnosis birth defects, cardiovascular disease, diabetes, recession detection, gingivitis, irritable bowel syndrome, neurodegenerative lichen planus, squamous carcinoma, oropharyngeal cancer root resorption, pancreatic cancer, periodontitis, peri‐implantitis, Sjögren systemic Hence, we characterize possessing “remarkable” potential, serving valuable tool clinicians significant advantages.

Language: Английский

Citations

8
Extracellular vesicles in dry eye disease and Sjogren syndrome: A systematic review on their diagnostic and therapeutic role DOI Creative Commons
Prakshi Chopra,

Asra Fatima,

Sonali Mohapatra

et al.

Survey of Ophthalmology, Journal Year: 2025, Volume and Issue: 70(3), P. 499 - 515

Published: Jan. 14, 2025

Language: Английский

Citations

1
An Overview of the Dry Eye Disease in Sjögren’s Syndrome Using Our Current Molecular Understanding DOI Open Access
Kevin Y. Wu, Merve Kulbay, Cristina Tănăsescu

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(2), P. 1580 - 1580

Published: Jan. 13, 2023

Sjögren's syndrome is a chronic and insidious auto-immune disease characterized by lymphocyte infiltration of exocrine glands. The patients typically present with ocular surface diseases related to dry eye other systemic manifestations. However, due the high prevalence lack objective clinically reliable diagnostic tools, discriminating (SSDE) from non-Sjögren's (NSSDE) remains challenge for clinicians. Diagnosing SS important improve quality life through timely referral workups, as associated serious complications such lymphoma autoimmune diseases. purpose this article describe current molecular understanding its implications novel modalities on horizon. A literature review pre-clinical clinical studies published between 2016 2022 was conducted. SSDE pathophysiology immunology pathways have become better understood in recent years. Novel modalities, tear saliva proteomics well exosomal biomarkers, provide hope

Language: Английский

Citations

21
Advances in Sjögren’s Syndrome Dry Eye Diagnostics: Biomarkers and Biomolecules beyond Clinical Symptoms DOI Creative Commons
Kevin Y. Wu,

Olivia Serhan,

Anne Faucher

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(1), P. 80 - 80

Published: Jan. 8, 2024

Sjögren’s syndrome dry eye (SSDE) is a subset of marked by symptoms that distinct from non-Sjögren’s (NSSDE). As SSDE can lead to severe complications, its early detection imperative. However, the differentiation between and NSSDE remains challenging due overlapping clinical manifestations. This review endeavors give concise overview classification, pathophysiology, features presentation, ocular systemic diagnosis, management SSDE. Despite advancements, limitations in current diagnostic methods underscore need for novel modalities. Thus, examines various biomarkers utilized identification, encompassing serum, salivary, tear analyses. Recent advancements proteomic research exosomal offer promising potential. Through comprehensive literature spanning 2016 2023, we highlight molecular insights advanced modalities have potential enhance our understanding diagnosis

Language: Английский

Citations

4
Predicting autoimmune diseases: A comprehensive review of classic biomarkers and advances in artificial intelligence DOI
Álvaro J. Vivas,

Synda Boumediene,

Gabriel J. Tobón

et al.

Autoimmunity Reviews, Journal Year: 2024, Volume and Issue: 23(9), P. 103611 - 103611

Published: Aug. 28, 2024

Language: Английский

Citations

3
Extracellular vesicles as a new horizon in the diagnosis and treatment of inflammatory eye diseases: A narrative review of the literature DOI Creative Commons

Azam Habibi,

Zeinab Zarei‐Behjani, Kimia Falamarzi

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: March 9, 2023

Extracellular vesicles include exosomes, microvesicles, and apoptotic bodies. Their cargos contain a diverse variety of lipids, proteins, nucleic acids that are involved in both normal physiology pathology the ocular system. Thus, studying extracellular may lead to more comprehensive understanding pathogenesis, diagnosis, even potential treatments for various diseases. The roles inflammatory eye disorders have been widely investigated recent years. term “inflammatory diseases” refers conditions such as inflammation-related diseases, degenerative with remarkable components, neuropathy, tumors. This study presents an overview vesicles’ exosomes’ pathogenic, diagnostic, therapeutic values well existing challenges.

Language: Английский

Citations

4
Exosome-based engineering strategies for the diagnosis and treatment of oral and maxillofacial diseases DOI Creative Commons

Jianing Ren,

Xuan Jing, Yingyu Liu

et al.

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Dec. 21, 2023

Oral and maxillofacial diseases are one of the most prevalent in world, which not only seriously affect health patients' oral tissues, but also bring serious economic psychological burdens to patients. Therefore, require effective treatment. Traditional treatments have limited effects. In recent years, nature exosomes attracted increasing attention due their ability diagnose treat diseases. However, application is low yield, high impurities, lack targeting, cost. Engineered can be endowed with better comprehensive therapeutic properties by modifying parent cells or directly exosomes, biomaterial loading exosomes. Compared natural these engineered achieve more diagnosis treatment maxillary system diseases, provide reference guidance for clinical application. This paper reviews engineering modification methods looks forward future research directions.

Language: Английский

Citations

3