Research in Pharmaceutical Sciences,
Год журнала:
2023,
Номер
18(3), С. 279 - 291
Опубликована: Март 11, 2023
The
GC-MS
analysis
reported
n-hexadecanoic
acid
or
palmitic
as
a
major
component
of
the
ethanolic
extract
Halymenia
durvillei
(HDET).
This
compound
shows
cytotoxic
effects
against
various
human
cancer
cells.
present
study
investigated
effect
HDET
on
viability
and
proliferation
MDA-MB-231,
triple-negative
breast
(TNBC)
cell
line.Cell
cycle
were
determined
by
flow
cytometry
regulatory
protein
expression
levels
then
Western
blotting.
presence
reactive
oxygen
species
(ROS)
was
evaluated
dichlorofluorescein,
followed
analyzing
changes
in
gene
antioxidant
enzymes
using
real-time
polymerase
chain
reaction.HDET
dose-dependently
reduced
with
50%
inhibitory
concentration
(IC50)
269.4
±
31.2
µg/mL
at
24
h.
assays
showed
increased
succinimidyl
ester
fluorescent
intensity
after
treatment
≥
100
HDET,
indicating
inhibition
proliferation.
Cell
propidium
iodide
staining
an
percentage
cells
G2/M
phase.
also
decreased
proteins
including
cyclin
D1
level
p21.
promoted
oxidative
stress
increasing
ROS
along
reduction
catalase
expression.
However,
did
not
induce
apoptosis
caspase
activation
TNBC
cells.These
findings
suggest
that
which
is
rich
may
serve
potential
therapeutic
agent
to
target
via
arrest
progression
Medical Sciences,
Год журнала:
2024,
Номер
12(4), С. 55 - 55
Опубликована: Окт. 13, 2024
The
prevalence
of
overweight
and
obesity
is
increasing
worldwide.
Common
comorbidities
related
to
obesity,
significantly
polygenic
disorders,
cardiovascular
disease,
heart
conditions
affect
social
monetary
systems.
Over
the
past
decade,
research
in
drug
discovery
development
has
opened
new
paths
for
alternative
conventional
medicine.
With
a
deeper
comprehension
its
underlying
mechanisms,
now
recognized
more
as
chronic
condition
rather
than
merely
result
lifestyle
choices.
Nonetheless,
addressing
it
solely
through
changes
challenging
due
intricate
nature
energy
regulation
dysfunction.
Federal
Drug
Administration
(FDA)
approved
six
medications
management
obesity.
Seaweed
are
plants
algae
that
grow
oceans,
rivers,
lakes.
Studies
have
shown
seaweed
therapeutic
potential
body
weight
compounds
such
carotenoids,
xanthophyll,
astaxanthin,
fucoidans,
fucoxanthin
been
demonstrated
bioactive
components
treatment
abundance
natural
explored
their
treating
Keeping
this
view,
review
covered
latest
developments
varied
anti-obese
World Development Sustainability,
Год журнала:
2024,
Номер
4, С. 100141 - 100141
Опубликована: Март 19, 2024
Food
security
is
a
significant
global
concern
as
result
of
the
burden
that
fast-expanding
population
has
placed
on
finite
resources,
such
arable
land
for
farming.
Additionally,
hunt
more
nutritious
food
alternatives
been
prompted
by
growing
understanding
health,
nutrition,
and
diet.
Seaweeds
are
simple-to-grow
aquatic
plants
underused
medicine.
Recent
studies
have
focused
gaining
access
to
using
these
readily
available
natural
resources
nutrition
medicinal
objectives.
This
review
systematically
evaluated
trends
recent
research
seaweed,
therapeutic
possibilities
product
development.
After
examining
several
documents,
this
analysis
discovered
seaweeds
incredibly
beneficial
algae
both
medicine,
may
be
further
explored
in
innovative
products,
meeting
increasing
need
food.
Polymers,
Год журнала:
2022,
Номер
14(22), С. 4993 - 4993
Опубликована: Ноя. 18, 2022
In
the
gastric
mucosa,
chronic
inflammation
due
to
Helicobacter
pylori
infection
promotes
gastrocarcinogenesis.
Polysaccharides
of
Caulerpa
lentillifera
are
well-characterized
by
broad
antimicrobial
activity
and
anti-inflammatory
potentials.
The
present
study
was
undertaken
investigate
whether
low
molecular
sulfate
polysaccharides
C.
(CLCP)
exhibit
any
anti-adhesive
against
H.
pylori.
After
a
hot
water
extraction
purification
process,
two
purified
polysaccharide
fractions
(CLCP-1
CLCP2)
were
studied
based
on
structural
characterization
bioactivity
determination.
results
implied
that
except
for
molar
ratio,
CLCP-1
CLCP-2
contain
high
sulfate,
mannose,
galactose,
xylose,
glucose
levels,
protein
levels.
weight
Fourier
transform
infrared
spectroscopy
(FT-IR)
assays
confirmed
with
an
average
(Mw)
963.15
648.42
kDa,
respectively.
addition,
exhibited
stronger
antibacterial
could
significantly
promote
macrophage
proliferation
decrease
production
nitric
oxide
(NO)
through
downregulated
expression
inducible
synthase
(iNOS).
Meanwhile,
in
this
showed
efficiently
protected
adenocarcinoma
(AGS)
cells
inhibition
IL-8/NF-κB
axis.
These
findings
suggested
effect
adhesion,
potential
supply
nutrients
eradication
therapy
reduction
cell
count
inflammation.
Scientific Reports,
Год журнала:
2023,
Номер
13(1)
Опубликована: Сен. 7, 2023
Seaweed
aquaculture
has
become
a
profitable
and
an
attractive
alternative
of
cultivation
thanks
to
its
quick
biomass
production
for
food,
feed,
other
non-food
applications.
In
addition,
the
ecosystem
services
generated
by
seaweed
towards
carbon
fixation
represents
more
sustainable
solution
ocean's
acidification.
The
growth
elkhorn
sea
moss
(Kappaphycus
alvarezii)
was
evaluated
in
three
plots
with
200
propagules
during
period
70
days
floating
raft
system
covered
fishing
net
underneath.
Initial
weight
159.3
±
12.74
g
wet
15.3
1.43
dry
were
sampled
up
19
(in
lag
phase;
I),
33
exponential
II)
stationarity
III).
variations
surface
water
temperature,
salinity,
turbidity
(Secchi
depth),
total
ammonium,
nitrites,
nitrates,
phosphate
determined.
increase
evident
phase
II
when
28.0
2.48
(1153.3
6.25
mass)
reached,
than
7
times
average
daily
rate
15.2%
g.day-1.
carrying
capacity
zone
estimated
at
86.2%
area
where
53
units
would
be
projected.
economic
analysis
presented
financial
feasibility
profit
19%
over
projected
income
IRR
16.5%,
recovering
investment
4.3
years.
We
recommend
continue
larger-scale
studies
optimize
K.
alvarezii
study
area.
Journal of Aquatic Food Product Technology,
Год журнала:
2024,
Номер
33(7), С. 553 - 572
Опубликована: Июль 24, 2024
This
review
explores
the
versatility
of
K.
alvarezii
in
various
food
applications,
including
bakery,
meat,
snacks,
jams,
and
prebiotics.
Abundant
vitamins,
minerals,
antioxidants,
bioactives,
seaweed
enhances
texture,
reduces
fat,
provides
nutritional
benefits.
In
meat
products,
acts
as
a
gelling
binding
agent,
improving
moisture
retention,
allowing
for
salt
fat
reduction.
Seaweed
snacks
offer
both
health
benefits
pleasant
aroma,
while
alvarezii's
prebiotics
support
gut
by
promoting
beneficial
bacteria.
Additionally,
serves
natural
stabilizing
jam
jelly
textures,
exhibits
promise
sustainable
packaging
through
edible
films.
One
of
the
most
underutilized
biological
resources
in
world
is
marine
environment,
which
makes
up
nearly
three-quarters
Earth's
surface.
A
variety
organisms
with
unique
systems
and
features
can
be
found
environment.
They
have
evolved
special
characteristics
that
allow
them
to
survive
a
hostile
environments.
By
applying
wide
screening
tools,
extracts
purified
compounds
these
studied
for
food
processing,
activities,
bioenergy
production.
Biomolecules
derived
from
range
applications
industry,
including
colorants,
preservatives,
flavor
enhancers.
Some
useful
marine-derived
ingredients
are
pigments,
polyunsaturated
fatty
acids,
sterols,
polysaccharides,
proteins,
enzymes.
Among
therapeutics,
more
than
60
%
active
pharmaceutical
formulations
come
natural
products
or
their
derivatives,
been
reported
possess
activities
(anticancer,
anti-inflammatory,
antioxidant,
antimicrobial,
etc.).
Using
produce
biodiesel
one
hottest
areas
renewable
energy.
International
cooperation,
novel
biotechnological
mass
production
organisms,
integration
biotechnology
other
sectors,
etc.,
will
necessary
fully
explore
potential
sources.
Marine Drugs,
Год журнала:
2022,
Номер
21(1), С. 31 - 31
Опубликована: Дек. 29, 2022
A
novel
strain,
isolate
5K15T,
which
belongs
to
difficult-to-cultivate
phylum
Verrucomicrobiota,
was
recovered
from
kelp
collected
Li
Island,
Rongcheng,
China.
The
genome
sequence
of
the
strain
(genome
size
3.95
Mbp)
showed
presence
four
putative
biosynthetic
gene
clusters
(BGCs),
namely,
two
terpene
clusters,
one
aryl
polyene
cluster,
and
type
III
PKS
cluster.
Genomic
analysis
revealed
79
sulfatase-encoded
genes,
24
sulfatase-like
hydrolase/transferase-encoded
25
arylsulfatase-encoded
indicated
great
potential
5K15T
degrade
sulfated
polysaccharides.
Comparative
16S
rRNA
that
most
closely
related
Oceaniferula
marina
N1E253T
(96.4%).
On
basis
evidence
a
polyphasic
study,
it
is
proposed
(=
KCTC
82748T
=
MCCC
1H00442T
SDUM
810003T)
be
classified
as
flavus
sp.
nov.
has
ability
carbohydrate
transport
metabolism.
This
allows
survive
in
carbohydrate-rich
materials
such
kelp.
It
used
marine
drug
industry
using
seaweed.
Exploration of Neuroprotective Therapy,
Год журнала:
2023,
Номер
unknown, С. 409 - 428
Опубликована: Ноя. 17, 2023
Recent
investigations
have
shed
light
on
the
potential
of
seaweed,
an
abundant
source
bioactive
compounds,
to
mitigate
and
combat
neurodegenerative
diseases.
In
this
comprehensive
review,
accumulating
evidence
supporting
neuroprotective
properties
seaweed-derived
compounds
is
evaluated
their
putative
mechanisms
action
are
elucidated.
The
background
review
encompasses
general
understanding
diseases
as
debilitating
conditions
characterized
by
progressive
loss
nerve
cell
function
viability
in
central
nervous
system.
Furthermore,
global
prevalence
these
diseases,
encompassing
Alzheimer’s
disease,
Parkinson’s
Huntington’s
persistent
absence
effective
treatments
emphasized.
To
address
critical
issue,
innovative
avenue
research
explored
investigating
seaweed
its
diverse
array
compounds.
By
examining
available
literature,
effects
consolidated.
These
constituents
exhibit
promising
preventing
mitigating
neurodegeneration.
Mechanistically,
actions
involve
intricate
pathways
that
contribute
neuronal
survival,
reduction
oxidative
stress,
inhibition
neuroinflammation,
modulation
protein
aggregation
processes.
This
provides
a
analysis
underlying
conclusion,
highlights
valuable
underscores
advancements
made
burgeoning
field.
identification
elucidation
through
which
exert
hold
promise
for
development
novel
therapeutic
interventions.
findings
transcend
disciplinary
boundaries,
offering
insight
into
application
resource
combating
across
scientific
domains.