Phenomics, Год журнала: 2025, Номер unknown
Опубликована: Фев. 14, 2025
Язык: Английский
Medicine, Год журнала: 2024, Номер 103(5), С. e37114 - e37114
Опубликована: Фев. 2, 2024
The gastrointestinal tract is embedded with microorganisms of numerous genera, referred to as gut microbiota. Gut microbiota has multiple effects on many body organs, including the brain. There a bidirectional connection between and brain called gut-brain-axis, these connections are formed through immunological, neuronal, neuroendocrine pathways. In addition, modulates synthesis functioning neurotransmitters. Therefore, disruption in composition or function, which known dysbiosis, associated pathogenesis mental disorders, such schizophrenia, depression, other psychiatric disorders. This review aims summarize modulation role 4 prominent neurotransmitters (tryptophan serotonergic system, dopamine, gamma-aminobutyric acid, glutamate), well its association disorders (schizophrenia, anxiety autism spectrum disorder). More future research required develop efficient gut-microbiota-based therapies for illnesses.
Язык: Английский
Процитировано
34
Nutrients, Год журнала: 2024, Номер 16(3), С. 400 - 400
Опубликована: Янв. 30, 2024
The infant gut microbiome plays a key role in the healthy development of human organism and appears to be influenced by dietary practices through multiple pathways. First, maternal diet during pregnancy nutrition significantly influence microbiota. Moreover, breastfeeding fosters proliferation beneficial bacteria, while formula feeding increases microbial diversity. timing introducing solid foods also influences microbiota composition. In preterm infants is factors, including time since birth intake breast milk, interventions such as probiotics prebiotics supplementation show promising results reducing morbidity mortality this population. These findings underscore need for future research understand long-term health impacts these further strategies enrich formula-fed infants.
Язык: Английский
Процитировано
24
Industrial Crops and Products, Год журнала: 2023, Номер 205, С. 117556 - 117556
Опубликована: Сен. 25, 2023
Язык: Английский
Процитировано
29
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(15), С. 8250 - 8250
Опубликована: Июль 28, 2024
The intricate relationship between the gastrointestinal (GI) microbiome and progression of chronic non-communicable diseases underscores significance developing strategies to modulate GI microbiota for promoting human health. administration probiotics prebiotics represents a good strategy that enhances population beneficial bacteria in intestinal lumen post-consumption, which has positive impact on In addition, dietary fibers serve as significant energy source inhabiting cecum colon. Research articles reviews sourced from various global databases were systematically analyzed using specific phrases keywords investigate these relationships. There is clear association fiber intake improved colon function, gut motility, reduced colorectal cancer (CRC) risk. Moreover, state health reflected reciprocal bidirectional relationships among food, antioxidants, inflammation, body composition. They are known their antioxidant properties ability inhibit angiogenesis, metastasis, cell proliferation. Additionally, they promote survival, immune inflammatory responses, inactivate pro-carcinogens. These actions collectively contribute role prevention. different investigations, supplements containing vitamins have been shown lower risk types. contrast, some evidence suggests taking can increase cancer. Ultimately, collaborative efforts immunologists, clinicians, nutritionists, dietitians imperative designing well-structured nutritional trials corroborate clinical efficacy therapy managing inflammation preventing carcinogenesis. This review seeks explore interrelationships fiber, microbiome, with particular focus potential implications
Язык: Английский
Процитировано
9
PLoS ONE, Год журнала: 2024, Номер 19(3), С. e0298602 - e0298602
Опубликована: Март 1, 2024
The objectives were 1) to characterize a Göttingen Minipig model of metabolic syndrome regarding its colon microbiota and circulating microbial products, 2) assess whether ovariectomized female castrated male minipigs show similar phenotypes. Twenty-four nine-week-old Minipigs allocated four groups based on sex diet: females males fed either chow or high-fat diet (HFD) for 12 weeks. At study end, body composition plasma biomarkers measured, mixed meal tolerance test (MMT) an intravenous glucose (IVGTT) performed. HFD had significantly higher weight gain, fat percentage, fasting insulin glucagon compared the groups. Homeostatic assessment resistance index (HOMA-IR) was increased effectiveness derived from IVGTT Matsuda´s sensitivity MMT decreased in displayed dyslipidemia, with total-, LDL- HDL-cholesterol, HDL/non-HDL cholesterol ratio. clearly differed lean controls (GuniFrac distance matrix). main bacteria families driving this separation Clostridiaceae , Fibrobacteraceae Flavobacteriaceae Porphyromonadaceae . Moreover, species richness by HFD. In addition, level short chain fatty acids beneficial metabolites hippuric acid, xanthine trigonelline, while increasing branched amino acids. Six nine metabolically relevant genes differentially expressed between chow-fed HFD-fed animals liver omental adipose tissue, respectively. pigs presented syndrome, gut dysbiosis marked decrease healthy products thus parallels human obesity resistance. therefore represents animal studying host-microbiota interactions. No significant differences observed.
Язык: Английский
Процитировано
8
Biomedicines, Год журнала: 2025, Номер 13(1), С. 179 - 179
Опубликована: Янв. 13, 2025
In the current era, malnutrition is seen as both undernutrition and overweight obesity; conditions are caused by nutrient deficiency or excess improper use imbalance in intake of macro micronutrients. Recent evidence suggests that alters intestinal microbiota, known dysbiosis. Secretory immunoglobulin A (sIgA) plays an important role maintaining increasing beneficial microbiota populations protecting against pathogenic species. Depletion bacterial throughout life also conditioned malnutrition. This review aims to synthesize establishes interrelationship between diet, malnutrition, changes flora, sIgA levels. Targeted nutritional therapies combined with prebiotic, probiotic, postbiotic administration can restore immune response intestine host’s homeostasis.
Язык: Английский
Процитировано
1
Critical Reviews in Food Science and Nutrition, Год журнала: 2025, Номер unknown, С. 1 - 19
Опубликована: Янв. 16, 2025
Quantity and source of dietary protein intakes impact the gut microbiota differently. However, these effects have not been systematically studied. This review aimed to investigate whilst controlling for fiber intake. Seven databases were searched, with 50 15 randomized controlled trials selected systematic network meta-analysis respectively. Most microbiota-related outcomes showed no significant differences between different intake combinations. Compared Normal Protein, High Fiber intakes, Low (HPLF) greater fecal valerate (SMD = 0.79, 95% CrI: 0.35, 1.24) plasma trimethylamine N-oxide (TMAO) 2.90, 0.16, 5.65) levels. HPLF also propionate 0.49, 0.02, 1.07) 0.31, 1.28) levels compared intakes. Greater TMAO observed animal Overall, quantity do generally alter composition, although can influence function via modulations in proteolytic fermentation. Both should be considered when assessing on microbiota. trial was registered at PROSPERO (CRD42023391270).
Язык: Английский
Процитировано
1
Medicina, Год журнала: 2025, Номер 61(2), С. 192 - 192
Опубликована: Янв. 22, 2025
The purpose of this article is to present selected food additives as disruptors normal intestinal homeostasis with a potential impact on the development metabolic dysfunction-associated steatotic liver disease (MASLD). A comprehensive literature search was conducted in three major electronic databases: PubMed, ScienceDirect, and Google Scholar. MASLD prevalent condition that closely related global rise obesity. Its pathogenesis multifactorial, genetic, environmental, factors playing key role. “multiple-hit” hypothesis suggests Western-style diet, rich ultra-processed foods, saturated fats, additives, combined low physical activity, contributes obesity, which promotes lipid accumulation liver. Recent studies underscore role impaired MASLD. Food including preservatives, emulsifiers, sweeteners, affect gut health function. Selected preservatives inhibit pathogenic microorganisms but disrupt microbiota, leading changes permeability dysfunction. Some emulsifiers thickeners can cause inflammation alter microbiome, contributing steatosis. Furthermore, use sweeteners such sucralose aspartame has been linked metabolism microbial composition, turn disorders.
Язык: Английский
Процитировано
1
Food Research International, Год журнала: 2025, Номер 206, С. 115843 - 115843
Опубликована: Фев. 1, 2025
Despite evolving definitions, dietary fibre classifications remain simplistic, often reduced to soluble and insoluble types. This binary system overlooks the complexity of structures their diverse health effects. Indeed, is not just but has important qualities such as fermentability, attenuating insulin secretion, lowering serum cholesterol. However, this limited classification fails account for diversity predict full range physiological article proposes a holistic framework that accounts different types can be used accurately infer outcomes. proposed comprises five constituents: backbone structure, water-holding-capacity, structural charge, matrix fermentation rate. model more captures functional fibres, offering refined approach predicting benefits.
Язык: Английский
Процитировано
1
Human Genomics, Год журнала: 2023, Номер 17(1)
Опубликована: Дек. 8, 2023
Abstract The unique physiological and genetic characteristics of individuals influence their reactions to different dietary constituents nutrients. This notion is the foundation personalized nutrition. field nutrigenetics has witnessed significant progress in understanding impact variants on macronutrient micronutrient levels individual's responsiveness intake. These hold value facilitating development nutritional interventions, thereby enabling effective translation from conventional guidelines genome-guided Nevertheless, certain obstacles could impede extensive implementation individualized nutrition, which still its infancy, such as polygenic nature nutrition-related pathologies. Consequently, many disorders are susceptible collective multiple genes environmental interplay, wherein each gene exerts a moderate modest effect. Furthermore, it widely accepted that diseases emerge because intricate interplay between predisposition external influences. In context this specific paradigm, utilization advanced "omic" technologies, including epigenomics, transcriptomics, proteomics, metabolomics, microbiome analysis, conjunction with comprehensive phenotyping, potential unveil hitherto undisclosed hereditary elements interactions environment. review aims provide up-to-date information regarding fundamentals specifically emphasizing complex triangulation among microbiota, metabolites, genes. highlights intestinal microbiota's makeup, nutrigenomics, tailoring suggestions. Finally, article provides an overview genotyping versus microbiomics, focusing investigating applications knowledge tailored plans aim improve human well-being overall health.
Язык: Английский
Процитировано
21