Discovery of plant-derived anti-tumor natural products: Potential leads for anti-tumor drug discovery

Bioorganic Chemistry, Год журнала: 2023, Номер 142, С. 106957 - 106957

Опубликована: Ноя. 5, 2023

Язык: Английский

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Nature’s magic: how natural products work hand in hand with mitochondria to treat stroke

Frontiers in Pharmacology, Год журнала: 2025, Номер 15

Опубликована: Янв. 7, 2025

Mitochondria, as the energy factories of cells, are involved in a wide range vital activities, including cell differentiation, signal transduction, cycle, and apoptosis, while also regulating growth. However, current pharmacological treatments for stroke challenged by issues such drug resistance side effects, necessitating exploration new therapeutic strategies. This review aims to summarize regulatory effects natural compounds targeting mitochondria on neuronal mitochondrial function metabolism, providing perspectives treatment. Numerous vitro vivo studies have shown that products berberine, ginsenosides, baicalein protect reduce stroke-induced damage through multiple mechanisms. These apoptosis modulating expression mitochondrial-associated apoptotic proteins. They inhibit activation permeability transition pore (mPTP), thereby decreasing ROS production cytochrome C release, which helps preserve function. Additionally, they regulate ferroptosis, fission, promote autophagy trafficking, further enhancing protection. As multi-target chemical agents, offer high efficacy with fewer present promising potential innovative therapies. Future research should investigate effectiveness safety these clinical applications, advancing their development strategy stroke.

Язык: Английский

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Natural product/diet-based regulation of macrophage polarization: Implications in treatment of inflammatory-related diseases and cancer

The Journal of Nutritional Biochemistry, Год журнала: 2024, Номер 130, С. 109647 - 109647

Опубликована: Апрель 10, 2024

Язык: Английский

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Paeoniflorin Induces ER Stress-Mediated Apoptotic Cell Death by Generating Nox4-Derived ROS under Radiation in Gastric Cancer

Nutrients, Год журнала: 2023, Номер 15(24), С. 5092 - 5092

Опубликована: Дек. 13, 2023

Gastric cancer is one of the most prevalent types worldwide, and its resistance to therapies, such as chemotherapy radiotherapy, has made treating it a major challenge. Paeoniflorin (PF) potential pharmacological treatment derived from paeony root. However, in cancer, molecular mechanisms biological functions PF are still unclear. In present study, we found that exerts anti-tumor effects vivo vitro induces apoptotic cell death through ER stress, calcium (Ca2+), reactive oxygen species (ROS) release gastric cells. ROS inhibition by DPI NAC blocks PERK signaling pathway via reduction Nox4. Moreover, triggers synergistic inhibitory effect epithelial-mesenchymal transition (EMT) process under radiation exposure radiation-resistant These findings indicate PF-induced Ca2+ overcomes radioresistance stress Therefore, PF, combination with radiation, may be powerful strategy for therapy.

Язык: Английский

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Targeting programmed cell death in inflammatory bowel disease through natural products: New insights from molecular mechanisms to targeted therapies

Phytotherapy Research, Год журнала: 2024, Номер unknown

Опубликована: Май 5, 2024

Abstract Inflammatory bowel disease (IBD) is an autoimmune disorder primarily characterized by intestinal inflammation and recurrent ulceration, leading to a compromised barrier inflammatory infiltration. This disorder's pathogenesis mainly attributed extensive damage or death of epithelial cells, along with abnormal activation impaired regulation immune cells the release various factors, which contribute environment in intestines. Thus, maintaining homeostasis hinges on balancing survival functionality cell types. Programmed (PCD) pathways, including apoptosis, pyroptosis, autophagy, ferroptosis, necroptosis, neutrophil extracellular traps, are integral IBD mediating cells. Natural products derived from plants, fruits, vegetables have shown potential regulating PCD, offering preventive therapeutic avenues for IBD. article reviews role natural treatment focusing targeting PCD opening new clinical management.

Язык: Английский

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Bufotalin enhances apoptosis and TMZ chemosensitivity of glioblastoma cells by promoting mitochondrial dysfunction via AKT signaling pathway

Aging, Год журнала: 2024, Номер unknown

Опубликована: Май 28, 2024

Glioblastoma multiforme (GBM) is the most prevalent and lethal primary intracranial neoplasm in adult population, with treatments of limited efficacy. Recently, bufotalin has been shown to have anti-cancer activity a variety cancers. This investigation aims investigate effect on GBM elucidate its potential underlying mechanism. Our results show that not only inhibits proliferation epithelial-mesenchymal transition (EMT) but also triggers apoptosis cells. The result RNA-seq indicated could induce mitochondrial dysfunction. Moreover, our observations indicate induces an excessive accumulation intracellular reactive oxygen species (ROS) cells, leading dysfunction dephosphorylation AKT. improved TMZ sensitivity cells

Язык: Английский

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Discovery of Cinnamoyl–Flavonoid Hybrid Derivatives as Inhibitors of SARS-CoV-2 Mpro and Anti-inflammatory Agents: Experimental and In Silico Insights into their Efficacy against Lipopolysaccharide-Induced Lung Injury

European Journal of Pharmacology, Год журнала: 2025, Номер unknown, С. 177636 - 177636

Опубликована: Апрель 1, 2025

The chemical structures of the parental compounds flavonoids from Boesenbergia rotunda were modified by conjugation with cinnamic acid to form cinnamoyl-flavonoid hybrid derivatives enhanced anti-inflammatory and SARS-CoV-2 Mpro-inhibitory properties. Cinnamoyl-flavonoid 6 10 showed potential inhibit Mpro IC50 values 52.49 22.62 μM. Compounds lower cytotoxicity in human lung cell lines MRC-5 A549 at concentrations greater than 50 effects on viability studied a 3D co-culture model treated lipopolysaccharide (LPS) observed through confocal microscopy. downregulated p65 mRNA expression, resulting reduction pro-inflammatory cytokines, including Interleukin 8 (IL-8) Monocyte Chemoattractant Protein-1 (MCP-1/CCL2), leading an response Nuclear factor kappa-light-chain-enhancer activated B cells (NF-κB) signalling pathways. Compound activity, downregulating Bcl-2 Associated X gene (BAX), which resulted inhibition apoptotic death when compared compound 10. In silico molecular dynamic simulation shed light how these interact myeloid differentiation 2 (MD-2), is involved inflammatory response. Our findings suggest that show as drugs anti-SARS-CoV-2 drugs.

Язык: Английский

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Aptamers for the Delivery of Plant-Based Compounds: A Review

Pharmaceutics, Год журнала: 2024, Номер 16(4), С. 541 - 541

Опубликована: Апрель 14, 2024

Natural compounds have a high potential for the treatment of various conditions, including infections, inflammatory diseases, and cancer. However, they usually present poor pharmacokinetics, low specificity, even toxicity, which limits their use. Therefore, targeted drug delivery systems, typically composed carrier targeting ligand, can enhance natural product selectivity effectiveness. Notably, aptamers—short RNA or single-stranded DNA molecules—have gained attention as promising ligands in since are simple to synthesize modify, tissue permeability, stability, wide array available targets. The combination products, namely plant-based compounds, with system utilizing aptamers agents represents an emerging strategy that has broaden its applications. This review discusses well new trends developments utilization field medicine.

Язык: Английский

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Discovery of a Hybrid Molecule with Phytotoxic Activity by Genome Mining, Heterologous Expression, and OSMAC Strategy

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(33), С. 18520 - 18527

Опубликована: Авг. 6, 2024

Genome mining in association with the OSMAC (one strain, many compounds) approach provides a feasible strategy to extend chemical diversity and novelty of natural products. In this study, we identified biosynthetic gene cluster (BGC) restricticin, promising antifungal agent featuring reactive primary amine, from fungus

Язык: Английский

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Novel Oleanolic Acid-Phtalimidines Tethered 1,2,3 Triazole Hybrids as Promising Antibacterial Agents: Design, Synthesis, In Vitro Experiments and In Silico Docking Studies

Molecules, Год журнала: 2023, Номер 28(12), С. 4655 - 4655

Опубликована: Июнь 8, 2023

As part of the valorization agricultural waste into bioactive compounds, a series structurally novel oleanolic acid ((3β-hydroxyolean-12-en-28-oic acid, OA-1)-phtalimidines (isoindolinones) conjugates 18a-u bearing 1,2,3-triazole moieties were designed and synthesized by treating an azide 4 previously prepared from OA-1 isolated olive pomace (Olea europaea L.) with wide range propargylated phtalimidines using Cu(I)-catalyzed click chemistry approach. its newly analogues, 18a-u, screened in vitro for their antibacterial activity against two Gram-positive bacteria, Staphylococcus aureus Listeria monocytogenes, Gram-negative Salmonella thyphimurium Pseudomonas aeruginosa. Attractive results obtained, notably L. monocytogenes. Compounds 18d, 18g, 18h exhibited highest when compared other compounds tested pathogenic bacterial strains. A molecular docking study was performed to explore binding mode most active derivatives site ABC substrate-binding protein Lmo0181 Results showed importance both hydrogen bonding hydrophobic interactions target are favor experimental data.

Язык: Английский

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