Nutrients,
Год журнала:
2023,
Номер
15(23), С. 4917 - 4917
Опубликована: Ноя. 25, 2023
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
one
of
the
leading
causes
chronic
and
represents
a
public
health
issue
in
Western
industrialized
countries
[...].
Metabolites,
Год журнала:
2024,
Номер
14(7), С. 366 - 366
Опубликована: Июнь 28, 2024
Nonalcoholic
fatty
liver
disease
(NAFLD)
poses
an
emerging
threat
topublic
health.
steatohepatitis
(NASH)
is
reported
to
be
the
most
rapidly
rising
cause
of
hepatocellular
carcinoma
in
western
world.
Recently,
a
new
term
has
been
proposed:
metabolic
dysfunction-associated
steatotic
(MASLD).
The
introduction
this
terminology
sparked
debate
about
interchangeability
these
terms.
pathogenesis
NAFLD/MASLD
thought
multifactorial,
involving
both
genetic
and
environmental
factors.
Among
factors,
alterations
gut
microbiota
dysbiosis
have
recently
garnered
significant
attention.
In
context,
review
will
further
discuss
gut-liver
axis,
which
refers
bidirectional
interaction
between
human
liver.
Additionally,
therapeutic
potential
probiotics,
particularly
next-generation
probiotics
genetically
engineered
bacteria,
explored.
Moreover,
role
prebiotics,
synbiotics,
postbiotics,
phages
as
well
fecal
transplantation
analyzed.
Particularly
for
lean
patients
with
NAFLD/MASLD,
who
limited
treatment
options,
approaches
that
modify
diversity
composition
may
hold
promise.
However,
due
ongoing
safety
concerns
modulate
microbiota,
large-scale
studies
are
necessary
better
assess
their
efficacy
treating
NAFLD/MASLD.
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
unknown, С. 138855 - 138855
Опубликована: Дек. 1, 2024
Plant-derived
bioactive
polysaccharides
(PDBPs),
versatile
polymers
originating
from
various
botanical
sources,
exhibit
a
spectrum
of
biological
functionalities
crucial
for
human
health.
This
review
delves
into
the
multifaceted
roles
these
compounds,
elucidating
their
immune-boosting
properties,
antioxidant
prowess,
anti-inflammatory
capabilities,
and
contributions
to
gut
Amidst
pivotal
roles,
efficiency
PDBPs
delivery
bioavailability
in
system
stands
as
central
determinant
efficacy
utilization.
paper
extensively
systematically
examines
diverse
activities,
such
immunomodulatory
effects,
mechanisms
like
microencapsulation,
promising
applications
within
realms
both
food
(functional
foods
nutraceuticals)
pharmaceutical
(antimicrobial
agents
drugs)
sectors.
Additionally,
it
offers
comprehensive
overview
classification,
structural
diversity
polysaccharides,
highlighting
identification
techniques
rheological
considerations.
Moreover,
addresses
critical
safety
regulatory
concerns
alongside
global
legislation
about
plant
envisaging
broader
landscape
Through
this
synthesis,
we
aim
underscore
holistic
significance
potential
revolutionize
nutritional
therapeutic
paradigms.
Molecular Nutrition & Food Research,
Год журнала:
2024,
Номер
68(7)
Опубликована: Март 20, 2024
Abstract
Obesity
is
a
global
health
issue
characterized
by
the
excessive
fat
accumulation,
leading
to
an
increased
risk
of
chronic
noncommunicable
diseases
(NCDs),
including
metabolic
dysfunction‐associated
fatty
liver
disease
(MAFLD),
which
can
progress
from
simple
steatosis
steatohepatitis,
fibrosis,
cirrhosis,
and
hepatocellular
carcinoma.
Currently,
there
are
no
approved
pharmacological
protocols
for
prevention/treatment
MAFLD,
due
complexity
lying
beneath
these
mechanisms,
monotherapies
unlikely
be
efficacious.
This
review
article
analyzes
possibility
that
NCDs
prevented
or
attenuated
combination
bioactive
substances,
as
they
could
promote
higher
response
rates,
maximum
reaction
results,
additive
synergistic
effects
compounds
having
similar
different
mechanisms
action
and/or
refraining
possible
side
effects,
related
use
lower
doses
exposures
times
than
monotherapies.
Accordingly,
prevention
mouse
MAFLD
observed
with
omega‐3
docosahexaenoic
acid
antioxidant
hydroxytyrosol,
whereas
attenuation
mild
cognitive
impairment
attained
folic
plus
cobalamin
in
elderly
patients.
The
existence
several
drawbacks
underlying
published
combined
trials,
opens
space
adequate
stricter
experimental
clinical
tryouts
achieve
meaningful
outcomes
human
applicability.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Янв. 25, 2024
The
pathogenesis
of
age-related
macular
degeneration
(AMD),
a
degenerative
retinopathy,
remains
unclear.
Administration
anti-vascular
endothelial
growth
factor
agents,
antioxidants,
fundus
lasers,
photodynamic
therapy,
and
transpupillary
warming
has
proven
effective
in
alleviating
symptoms;
however,
these
interventions
cannot
prevent
or
reverse
AMD.
Increasing
evidence
suggests
that
AMD
risk
is
linked
to
changes
the
composition,
abundance,
diversity
gut
microbiota
(GM).
Activation
multiple
signaling
pathways
by
GM
metabolites,
including
lipopolysaccharides,
oxysterols,
short-chain
fatty
acids
(SCFAs),
bile
(BAs),
influences
retinal
physiology.
Traditional
Chinese
medicine
(TCM),
known
for
its
multi-component
multi-target
advantages,
can
help
treat
altering
composition
regulating
levels
certain
substances,
such
as
reducing
increasing
SCFA
BA
contents.
This
review
explores
correlation
between
two
provide
new
perspectives
on
treating
with
TCM.
Foods,
Год журнала:
2024,
Номер
13(11), С. 1630 - 1630
Опубликована: Май 23, 2024
Ulva
rigida
green
macroalgae
contain
a
variety
of
polysaccharides.
A
recent
study
investigated
the
optimum
concentration
and
yield
polysaccharide
extraction
from
oven-dried
U.
biomass
using
water-soluble
method
that
adhered
to
safety
standards.
This
utilised
complete
factorial
experiments
examine
effects
varying
factors
on
extraction.
Results
showed
positive
correlation
between
increased
levels
all
higher
yield.
also
found
main
their
interaction
had
significant
impact
extracted
polysaccharides
rigida.
The
highest
content
were
9.5
mg/mL
189
mg/g,
respectively.
Water-soluble
demonstrated
presence
reducing
sugar
(8
mg/g),
phenolics
(0.69
mg/g)
flavonoids
(1.42
exhibited
antioxidant
properties.
revealed
freeze-dried
powders
primarily
composed
monosaccharide
rhamnose.
Preliminary
results
effect
these
probiotics
supplementation
promoted
viable
Lactobacillus
rhamnosus
ATCC
53103
growth
during
cultivation.
discovery
has
potential
revolutionise
human
food
industry
promote
development
functional
ingredients
for
novel
future
products,
with
numerous
applications
in
nutraceutical
pharmaceutical
industries.
Molecules,
Год журнала:
2024,
Номер
29(5), С. 976 - 976
Опубликована: Фев. 23, 2024
Metabolism-associated
fatty
liver
disease
(MAFLD),
a
growing
health
problem
worldwide,
is
one
of
the
major
risks
for
development
cirrhosis
and
cancer.
Oral
administration
nobiletin
(NOB),
natural
citrus
flavonoid,
modulates
gut
microbes
their
metabolites
in
mice.
In
present
study,
we
established
mouse
model
MAFLD
by
subjecting
mice
to
high-fat
diet
(HFD)
12
weeks.
Throughout
this
timeframe,
NOB
was
administered
investigate
its
potential
benefits
on
microbial
balance
bile
acid
(BA)
metabolism
using
various
techniques,
including
16S
rRNA
sequencing,
targeted
metabolomics
BA,
biological
assays.
effectively
slowed
progression
reducing
serum
lipid
levels,
blood
glucose
LPS
hepatic
IL-1β
TNF-α
levels.
Furthermore,
reinstated
diversity
within
community,
increasing
population
bacteria
that
produce
salt
hydrolase
(BSH)
enhance
BA
excretion.
By
exploring
further,
found
downregulated
expression
farnesoid
X
receptor
(FXR)
associated
small
heterodimer
partner
(SHP),
it
increased
downstream
enzymes,
cholesterol
7α-hydroxylase
(CYP7A1)
cytochrome
P450
27A1
(CYP27A1).
This
acceleration
conversion
contributes
mitigating
MAFLD.
The
findings
underscore
significant
role
regulating
metabolism,
revealing
long-term
intake
plays
beneficial
roles
prevention
or
intervention
Food Science & Nutrition,
Год журнала:
2024,
Номер
12(9), С. 6442 - 6460
Опубликована: Июнь 18, 2024
Abstract
Nonalcoholic
fatty
liver
disease
(NAFLD)
is
a
common
chronic
disease,
but
there
currently
no
effective
treatment
method.
Probiotics
have
been
used
as
an
adjunct
therapy
for
NAFLD,
the
mechanism
not
clear.
This
study
Bifidobacterium
longum
BL19
(BL‐19)
to
treat
NAFLD
mice
induced
by
high‐fat
diet,
and
explored
through
gut
microbiota
serum
metabolomics
techniques.
We
found
that
BL‐19
effectively
prevented
rapid
weight
gain
in
reduced
their
overall
food
energy
intake,
decreased
inflammatory
factors
expressions,
increased
bile
acid
synthetase
enzyme
CYP7A1
superoxide
dismutase.
After
treatment,
abundances
of
butyric
bacteria
(
Oscillospira
Coprococcus
)
feces
significantly,
concentration
also
significantly.
believe
promotes
production
butyrate
intestines,
which
turn
regulates
activity
synthesis,
ultimately
treating
inflammation
lipid
accumulation
mice.
Serum
results
indicated
affected
multiple
pathways
related
metabolism
These
findings
suggest
shows
promise
it
can
significantly
improve
oxidative
stress,
reduce
liver,
decrease
accumulation.