Journal of Pharmaceutical Investigation, Год журнала: 2023, Номер 53(6), С. 781 - 801
Опубликована: Окт. 30, 2023
Язык: Английский
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 266, С. 131207 - 131207
Опубликована: Март 28, 2024
Язык: Английский
Процитировано
26
Advanced Drug Delivery Reviews, Год журнала: 2024, Номер 207, С. 115217 - 115217
Опубликована: Фев. 27, 2024
Язык: Английский
Процитировано
22
Gels, Год журнала: 2025, Номер 11(2), С. 123 - 123
Опубликована: Фев. 7, 2025
Recent advancements in wound dressing materials have significantly improved acute and chronic management by addressing challenges such as infection control, moisture balance, enhanced healing. Important progress has been made, especially with hydrogels, foams, antimicrobial for creating optimized dressings. Hydrogels are known maintaining optimal levels, while foam dressings excellent exudate absorbents. Meanwhile, incorporates various agents to reduce risks. These options healing time focusing on customized patient needs. Therefore, this review highlights the newest research prototypes applications, emphasizing their particular benefits clinical importance. Innovations stimuli-responsive hydrogels hybrid bioengineered composites discussed relation properties, including responsiveness pH, temperature, glucose, or enzymes drug delivery precision. Moreover, ongoing trials included, demonstrating potential of emerging solutions be soon translated from laboratory settings. By discussing interdisciplinary approaches that integrate advanced materials, nanotechnology, biological insights, work provides a contemporary framework patient-centric, efficient care strategies.
Язык: Английский
Процитировано
7
Molecules, Год журнала: 2025, Номер 30(3), С. 686 - 686
Опубликована: Фев. 4, 2025
Chronic wounds pose a substantial healthcare concern due to their prevalence and cost burden. This paper presents detailed overview of chronic emphasizes the critical need for novel therapeutic solutions. The pathophysiology wound healing is discussed, including stages factors contributing chronicity. focus on diverse types wounds, such as diabetic foot necrosis, pressure ulcers, venous leg highlighting etiology, consequences, issues they provide. Further, modern care solutions, particularly hydrogels, are highlighted tackling challenges management. Hydrogels characterized multipurpose materials that possess vital characteristics like capacity retain moisture, biocompatibility, incorporation active drugs. Hydrogels’ effectiveness in applications demonstrated by how support healing, preserving ideal moisture levels, promoting cellular migration, possessing antibacterial properties. Thus, this hydrogel technology’s latest developments, emphasizing drug-loaded stimuli-responsive underscoring these advanced formulations greatly improve therapy outcomes enabling dynamic focused reactions environment. Future directions research promote development customized treatments digital health tools treatment wounds.
Язык: Английский
Процитировано
5
Deleted Journal, Год журнала: 2023, Номер 5(1)
Опубликована: Окт. 23, 2023
Abstract The skin plays a fundamental role in regulating the body’s internal balance and protecting against external traumas. A broad variety of environmental risk factors frequently result acute wounds, whose inappropriate treatments would lead to chronic wounds that are difficult heal. Traditional dressings have been widely used repair however their drawbacks such as insufficient hemostatic efficacy non-moist environment severely limited clinical applications. As principal component skin, collagen has always research hotspot field due its advantages low antigenicity, high biocompatibility superior bioactivity. Collagen-based increasingly developed heal during past decades, arising from capability decreasing protein electrolyte losses wound exudate, preventing bacterial contamination, permitting less painful dressing changes, improving healing quality. This review overviews recent progress for healing. Various commonly management first introduced. Collagen categorized films, sponges, hydrogels, nanofibers, powders, compared. critical functions healing, stopping bleeding, shortening inflammation, promoting angiogenesis, stimulating tissue regeneration elaborated. applications different types thoroughly summarized. comprehensive list commercialized updated, an outlook finally speculated. Graphical
Язык: Английский
Процитировано
33
Materials Horizons, Год журнала: 2023, Номер 10(9), С. 3237 - 3256
Опубликована: Янв. 1, 2023
This work highlights the animal tissue-derived biomaterials in wound treatment field based on an evaluation of their critical properties, advanced design strategies and latest applications.
Язык: Английский
Процитировано
28
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(4), С. 3893 - 3893
Опубликована: Фев. 15, 2023
The present research aims to describe a new methodology obtain biocompatible hydrogels based on Aloe vera used for wound healing applications. properties of two (differing in concentration, AV5 and AV10) prepared by an all-green synthesis method from raw, natural, renewable bioavailable materials such as salicylic acid, allantoin xanthan gum were investigated. morphology the hydrogel biomaterials was studied SEM analysis. rheological hydrogels, well their cell viability, biocompatibility cytotoxicity, determined. antibacterial activity evaluated both Gram-positive, Staphylococcus aureus Gram-negative, Pseudomonas aeruginosa strains. obtained novel green showed good properties. In vitro scratch assay demonstrated capacity AV10 accelerate proliferation migration induce closure wounded area. A corroboration all morphological, rheological, cytocompatibility viability results indicates that this may be suitable
Язык: Английский
Процитировано
27
Pharmaceutics, Год журнала: 2024, Номер 16(2), С. 155 - 155
Опубликована: Янв. 23, 2024
Wound infection due to bacterial invasion at the wound site is one of primary challenges associated with delayed healing. Microorganisms tend form biofilms that protect them from harm, leading their multidrug resistance. The alarming increase in antibiotic resistance poses a threat Hence, urgent need for novel dressing materials capable managing crucial expediting recovery. There considerable interest polymeric dressings embedded bioactive substances, such as metal-based nanoparticles, potential solutions treating microbially infected wounds. Metal-based nanoparticles have been widely used management wounds broad antimicrobial efficacy. This review focuses on polymer-based and loaded like silver, gold, magnesium oxide, or zinc oxide. When compared, oxide-loaded exhibited higher antibacterial activity against Gram-positive strains silver nanoparticle-loaded gram-negative strains. However, infused both displayed synergistic effect bacteria. Furthermore, these antibiofilm generation reactive oxygen species while accelerating closure vitro vivo.
Язык: Английский
Процитировано
13
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 266, С. 130989 - 130989
Опубликована: Март 18, 2024
Язык: Английский
Процитировано
12
Journal of Nanomaterials, Год журнала: 2024, Номер 2024, С. 1 - 23
Опубликована: Янв. 8, 2024
Chronic wounds, which include venous leg ulcers, diabetic foot and pressure are a global health issue that affects between 1% 2% of the developed world’s population. wound healing necessitates extensive medical intervention at costly healthcare expenses. Wound care management is mainly dependent on discovery new appropriate chronic dressing materials, it remains focus research in care. Biocompatible metallic nanoparticle-loaded offers novel opportunity for effectively overcoming inherent drawbacks traditional particularly nonhealing wounds due to their clinical complexity, example, infections, irritation, trauma, persistence foreign body or bacterial proteins, ischemia. In this review, we will primarily advancements nanoparticle-based antibacterial antioxidant materials (e.g., hydrogels, electrospun scaffolds, sponges, films) treatment overcome limitations dressings.
Язык: Английский
Процитировано
9