Viruses,
Год журнала:
2024,
Номер
16(5), С. 673 - 673
Опубликована: Апрель 25, 2024
Viral
co-infections,
in
which
a
host
is
infected
with
multiple
viruses
simultaneously,
are
common
the
human
population.
Human
viral
co-infections
can
lead
to
complex
interactions
between
and
immune
system,
affecting
clinical
outcome
posing
challenges
for
treatment.
Understanding
types,
mechanisms,
impacts,
identification
methods
of
crucial
prevention
control
diseases.
In
this
review,
we
first
introduce
significance
studying
summarize
current
research
progress
gaps
field.
We
then
classify
into
four
types
based
on
pathogenic
properties
species
involved.
Next,
discuss
molecular
mechanisms
focusing
virus–virus
interactions,
responses,
manifestations.
also
experimental
computational
emphasizing
latest
advances
high-throughput
sequencing
bioinformatics
approaches.
Finally,
highlight
future
directions
co-infection
research,
aiming
provide
new
insights
strategies
prevention,
control,
diagnosis,
treatment
This
review
provides
comprehensive
overview
knowledge
perspectives
underscores
need
interdisciplinary
collaboration
address
important
topic.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(3), С. 2264 - 2264
Опубликована: Янв. 23, 2023
The
first
2
years
of
the
COVID-19
pandemic
were
mainly
characterized
by
recurrent
mutations
SARS-CoV-2
Spike
protein
at
residues
K417,
L452,
E484,
N501
and
P681
emerging
independently
across
different
variants
concern
(Alpha,
Beta,
Gamma,
Delta).
Such
homoplasy
is
a
marker
convergent
evolution.
Since
Spring
2022
third
year
pandemic,
with
advent
Omicron
its
sublineages,
evolution
has
led
to
observation
lineages
acquiring
an
additional
group
amino
acid
residues,
namely
R346,
K444,
N450,
N460,
F486,
F490,
Q493,
S494.
Mutations
these
have
become
increasingly
prevalent
during
Summer
Autumn
2022,
combinations
showing
increased
fitness.
most
likely
reason
for
this
convergence
selective
pressure
exerted
previous
infection-
or
vaccine-elicited
immunity.
accelerated
caused
failure
all
anti-Spike
monoclonal
antibodies,
including
bebtelovimab
cilgavimab.
While
we
are
learning
how
fast
coronaviruses
can
mutate
recombine,
should
reconsider
opportunities
economically
sustainable
escape-proof
combination
therapies,
refocus
antibody-mediated
therapeutic
efforts
on
polyclonal
preparations
that
less
allow
viral
immune
escape.
Infection Genetics and Evolution,
Год журнала:
2023,
Номер
108, С. 105405 - 105405
Опубликована: Янв. 18, 2023
The
COVID-19
pandemic
has
brought
significant
challenges
for
genomic
surveillance
strategies
in
public
health
systems
worldwide.
During
the
past
thirty-four
months,
many
countries
faced
several
epidemic
waves
of
SARS-CoV-2
infections,
driven
mainly
by
emergence
and
spread
novel
variants.
In
that
line,
been
a
crucial
toolkit
to
study
real-time
evolution,
assessment
optimization
diagnostic
assays,
improve
efficacy
existing
vaccines.
pandemic,
identification
emerging
lineages
carrying
lineage-specific
mutations
(particularly
those
Receptor
Binding
domain)
showed
how
these
might
significantly
impact
viral
transmissibility,
protection
from
reinfection
vaccination.
So
far,
an
unprecedented
number
genomes
released
databases
(i.e.,
GISAID,
NCBI),
achieving
14
million
genome
sequences
available
as
early-November
2022.
present
review,
we
summarise
global
landscape
during
first
months
circulation
evolution.
It
demonstrates
urgency
importance
sustained
investment
timely
identify
any
potential
pathogen
or
associated
variants,
which
turn
is
key
preparedness.
Journal of Medical Virology,
Год журнала:
2023,
Номер
95(3)
Опубликована: Фев. 28, 2023
Abstract
Recombination
is
the
main
contributor
to
RNA
virus
evolution,
and
SARS‐CoV‐2
during
pandemic
produced
several
recombinants.
The
most
recent
recombinant
lineage
labeled
XBB,
also
known
as
Gryphon,
which
arose
from
BJ.1
BM.1.1.1.
Here
we
performed
a
genome‐based
survey
aimed
compare
new
with
its
parental
lineages
that
never
became
dominant.
Genetic
analyses
indicated
XBB
first
descendant
XBB.1
show
an
evolutionary
condition
typical
of
blind
background
no
further
epidemiologically
relevant
descendant.
variability
expansion
capabilities
are
slightly
higher
than
lineages.
Bayesian
Skyline
Plot
indicates
reached
plateau
around
October
6,
2022
after
initial
rapid
growth
viral
population
size
did
not
expand,
November
10,
levels
genetic
decreased.
Simultaneously
reduction
size,
increase
sub‐lineage
occurred,
in
turn
9,
showing
kind
vicariance
direct
progenitors.
Structure
analysis
affinity
for
ACE2
surface
XBB/XBB.1
RBDs
weaker
BA.2
RBD.
In
conclusion,
at
present
do
evidence
about
particular
danger
or
high
capability.
Genome‐based
monitoring
must
continue
uninterrupted
individuate
if
mutations
can
make
more
dangerous
generate
subvariants
different
International Journal of Medical Sciences,
Год журнала:
2023,
Номер
20(1), С. 151 - 162
Опубликована: Янв. 1, 2023
The
SARS-CoV-2
Omicron
is
currently
the
predominant
circulating
variant
in
COVID-19
pandemic.
dominating
sublineages
respond
to
host
immune
pressure
and
develop
advantageous
mutations
or
genetic
recombination,
which
result
variants
that
are
more
contagious
better
at
escaping
responses
response
previous
infection
vaccination.
Meanwhile,
multiple
recombination
events
have
been
reported
coinfection
cases,
majority
of
resulted
from
between
co-circulating
BA.1
(or
BA.1.1)
Delta
BA.2.
Here,
we
review
knowledge
characterization
for
population
level,
provide
an
update
on
occurrence
newly
sublineages,
discuss
effectiveness
novel
vaccines/therapeutic
drugs
against
variant.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2024,
Номер
13
Опубликована: Янв. 5, 2024
Lung
infections
in
Influenza-Like
Illness
(ILI)
are
triggered
by
a
variety
of
respiratory
viruses.
All
human
pandemics
have
been
caused
the
members
two
major
virus
families,
namely
Orthomyxoviridae
(influenza
A
viruses
(IAVs);
subtypes
H1N1,
H2N2,
and
H3N2)
Coronaviridae
(severe
acute
syndrome
coronavirus
2,
SARS−CoV−2).
These
acquired
some
adaptive
changes
known
intermediate
host
including
domestic
birds
(IAVs)
or
unknown
(SARS-CoV-2)
following
transmission
from
their
natural
reservoirs
(e.g.
migratory
bats,
respectively).
Verily,
these
substitutions
facilitated
crossing
species
barriers
to
infect
humans
phenomenon
that
is
as
zoonosis.
Besides,
aided
variant
strain
transmit
horizontally
other
contact
non-human
animal
pets
wild
animals
(zooanthroponosis).
Herein
we
discuss
main
zoonotic
reverse-zoonosis
events
occurred
during
last
influenza
A/H1N1
SARS-CoV-2.
We
also
highlight
impact
interspecies
pandemic
on
evolution
possible
prophylactic
therapeutic
interventions.
Based
information
available
presented
this
review
article,
it
important
close
monitoring
viral
zoonosis
reverse
strains
within
One-Health
One-World
approach
mitigate
unforeseen
risks,
such
resistance
limited
