Deleted Journal, Год журнала: 2025, Номер 2(1), С. 100057 - 100057
Опубликована: Янв. 30, 2025
Язык: Английский
Asian Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер 19(3), С. 100911 - 100911
Опубликована: Апрель 14, 2024
Precision therapy has become the preferred choice attributed to optimal drug concentration in target sites, increased therapeutic efficacy, and reduced adverse effects. Over past few years, sprayable or injectable thermosensitive hydrogels have exhibited high potential. These can be applied as cell-growing scaffolds drug-releasing reservoirs by simply mixing a free-flowing sol phase at room temperature. Inspired their unique properties, been widely delivery treatment platforms for precision medicine. In this review, state-of-the-art developments are investigated, which covers from thermo-gelling mechanisms main components biomedical applications, including wound healing, anti-tumor activity, osteogenesis, periodontal, sinonasal ophthalmic diseases. The most promising applications trends of also discussed light features.
Язык: Английский
Процитировано
10
Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12
Опубликована: Май 28, 2024
The repair of irregular bone tissue suffers severe clinical problems due to the scarcity an appropriate therapeutic carrier that can match dynamic and complex damage. Fortunately, stimuli-responsive in situ hydrogel systems are triggered by a special microenvironment could be ideal method regenerating because injectability, gelatin, spatiotemporally tunable drug release. Herein, we introduce two main stimulus-response approaches, exogenous endogenous, forming hydrogels engineering. First, summarize specific distinct responses extensive range external stimuli (e.g., ultraviolet, near-infrared, ultrasound, etc.) form created from biocompatible materials modified various functional groups or hybrid nanoparticles. Furthermore, “smart” hydrogels, which respond endogenous physiological environmental temperature, pH, enzyme, etc.), achieve gelation one injection vivo without additional intervention. Moreover, mild chemistry response-mediated also offer fascinating prospects engineering, such as Diels–Alder, Michael addition, thiol-Michael Schiff reactions, etc. recent developments challenges smart their application administration engineering discussed this review. It is anticipated advanced strategies innovative ideas will exploited field increase quality life for patients with
Язык: Английский
Процитировано
10
Polymers, Год журнала: 2024, Номер 16(2), С. 281 - 281
Опубликована: Янв. 19, 2024
Infected bone defects represent a common clinical condition involving tissue, often necessitating surgical intervention and antibiotic therapy. However, conventional treatment methods face obstacles such as resistance susceptibility to postoperative infections. Hydrogels show great potential for application in the field of tissue engineering due their advantageous biocompatibility, unique mechanical properties, exceptional processability, degradability. Recent interest has surged employing hydrogels novel therapeutic infected repair. This article aims comprehensively review existing literature on anti-microbial osteogenic approaches utilized by repairing bones, encompassing fabrication techniques, antimicrobial efficacy, biological activities. Additionally, opportunities practical implementation will be explored. Lastly, limitations presently encountered prospective avenues further investigation realm hydrogel materials management deliberated. provides theoretical foundation advanced design strategies defects.
Язык: Английский
Процитировано
9
Research, Год журнала: 2023, Номер 6
Опубликована: Янв. 1, 2023
The limitations of autologous bone grafts necessitate the development advanced biomimetic biomaterials for efficient cranial defect restoration. bones are typical flat with sandwich structures, consisting a diploe in middle region and 2 outer compact tables. In this study, we originally developed types flat-bone-mimetic β-tricalcium phosphate bioceramic scaffolds (Gyr-Comp Gyr-Tub) by high-precision vat-photopolymerization-based 3-dimensional printing. Both had layers an inner layer gyroid pores mimicking structure. Gyr-Comp simulated low porosity tables, while those Gyr-Tub mimicked tubular pore structure tables bones. possessed higher compressive strength noticeably promoted vitro cell proliferation, osteogenic differentiation, angiogenic activities compared conventional cross-hatch structures. After implantation into rabbit defects 12 weeks, achieved best repairing effects accelerating generation tissues blood vessels. This work provides strategy to prepare that fit structural functional needs efficacious regeneration.
Язык: Английский
Процитировано
17
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(19)
Опубликована: Март 1, 2024
Abstract Exosomes, nanoparticles secreted by various cells, composed of a bilayer lipid membrane, and containing bioactive substances such as proteins, nucleic acids, metabolites, etc., have been intensively investigated in tissue engineering owing to their high biocompatibility versatile biofunction. However, there is still lack high‐quality review on bone defect regeneration potentiated exosomes. In this review, the biogenesis isolation methods exosomes are first introduced. More importantly, engineered current state knowledge discussed review. Afterward, biomaterial carriers mechanisms repair elucidated compelling evidence presented. Thus, future perspectives concerns revealed help devise advanced modalities based overcome challenges regeneration. It totally believed will attract special attention from clinicians provide promising ideas for works.
Язык: Английский
Процитировано
8
Materials Horizons, Год журнала: 2024, Номер 11(18), С. 4367 - 4377
Опубликована: Янв. 1, 2024
The degradability of hydrogels plays a pivotal role in bone regeneration, yet its precise effects on the repair process remain poorly understood. Traditional studies have been limited by use with insufficient variation degradation properties for thorough comparative analysis. Addressing this gap, our study introduces development matrix metalloproteinase (MMP)-responsive engineered tunable rate, specifically designed regeneration applications. These innovative are synthesized integrating MMP-sensitive peptides, which exhibit chirality-transferred amino acids, norbornene (NB)-modified 8-arm polyethylene glycol (PEG) macromers to form hydrogel network. behavior these is manipulated through chirality incorporated resulting classification into L, LD, and D hydrogels. Remarkably, L variant shows significantly enhanced both
Язык: Английский
Процитировано
8
Bioactive Materials, Год журнала: 2024, Номер 43, С. 240 - 254
Опубликована: Сен. 25, 2024
Язык: Английский
Процитировано
7
Chemical Engineering Journal, Год журнала: 2024, Номер 497, С. 154433 - 154433
Опубликована: Июль 31, 2024
Язык: Английский
Процитировано
6
Chemical Engineering Journal, Год журнала: 2024, Номер 499, С. 156554 - 156554
Опубликована: Окт. 12, 2024
Язык: Английский
Процитировано
6
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Ноя. 6, 2024
Organoids are "mini-organs" that self-organize and differentiate from stem cells under in vitro 3D culture conditions, mimicking the spatial structure function of tissues vivo. Extracellular vesicles (EVs) nanoscale phospholipid bilayer secreted by living cells, rich bioactive molecules, with excellent biocompatibility low immunogenicity. Compared to EVs, organoid-derived EVs (OEVs) exhibit higher yield enhanced biological functions. possess cell characteristics, OEVs capable delivering active substances, making both highly promising for medical applications. In this review, we provide an overview fundamental principles organoids OEVs, discuss their current applications disease treatment. We then focus on differences between traditional EVs. Subsequently, present methods engineering modification OEVs. Finally, critically summarize advantages challenges conclusion, believe a deeper understanding will innovative solutions complex diseases.
Язык: Английский
Процитировано
6