International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(18), С. 9758 - 9758
Опубликована: Сен. 10, 2024
The
role
of
ferroptosis
and
iron
metabolism
dysregulation
in
the
pathophysiology
cardiovascular
diseases
is
increasingly
recognized.
Conditions
such
as
hypertension,
cardiomyopathy,
atherosclerosis,
myocardial
ischemia/reperfusion
injury,
heart
failure,
complications
associated
with
COVID-19
have
been
linked
to
these
processes.
Inflammation
central
conditions,
prompting
exploration
into
inflammatory
immunoregulatory
molecular
pathways
that
mediate
its
contribution
disease
progression.
Notably,
emerging
evidence
highlights
interleukin-37
a
protective
cytokine
ability
activate
nuclear
factor
erythroid
2-related
2
pathway,
inhibit
macrophage
ferroptosis,
attenuate
atherosclerosis
progression
murine
models.
However,
comprehensive
review
focusing
on
against
CVD
currently
lacking.
This
aims
fill
this
gap
by
summarizing
existing
knowledge
interleukin-37,
including
regulatory
functions
impact
conditions
infarction.
We
also
explore
experimental
strategies
propose
targeting
modulate
presents
promising
therapeutic
approach
for
prevention
treatment
diseases.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Май 31, 2024
Abstract
The
immune
response
holds
a
pivotal
role
in
cardiovascular
disease
development.
As
multifunctional
cells
of
the
innate
system,
macrophages
play
an
essential
initial
inflammatory
that
occurs
following
injury,
thereby
inducing
subsequent
damage
while
also
facilitating
recovery.
Meanwhile,
diverse
phenotypes
and
phenotypic
alterations
strongly
associate
with
distinct
types
severity
diseases,
including
coronary
heart
disease,
valvular
myocarditis,
cardiomyopathy,
failure,
atherosclerosis
aneurysm,
which
underscores
importance
investigating
macrophage
regulatory
mechanisms
within
context
specific
diseases.
Besides,
recent
strides
single-cell
sequencing
technologies
have
revealed
heterogeneity,
cell–cell
interactions,
downstream
therapeutic
targets
at
higher
resolution,
brings
new
perspectives
into
macrophage-mediated
potential
Remarkably,
myocardial
fibrosis,
prevalent
characteristic
most
cardiac
remains
formidable
clinical
challenge,
necessitating
profound
investigation
impact
on
fibrosis
In
this
review,
we
systematically
summarize
functional
plasticity
diseases
unprecedented
insights
introduced
by
technologies,
focus
different
causes
characteristics
especially
relationship
between
inflammation
(myocardial
infarction,
pressure
overload,
dilated
diabetic
cardiomyopathy
aging)
vascular
injury
(atherosclerosis
aneurysm).
Finally,
highlight
preclinical/clinical
targeting
strategies
translational
implications.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Март 20, 2024
Macrophages
are
highly
plastic
cells
ubiquitous
in
various
tissues,
where
they
perform
diverse
functions.
They
participate
the
response
to
pathogen
invasion
and
inflammation
resolution
following
immune
response,
as
well
maintenance
of
homeostasis
proper
tissue
generally
considered
long-lived
with
relatively
strong
resistance
numerous
cytotoxic
factors.
On
other
hand,
their
death
seems
be
one
principal
mechanisms
by
which
macrophages
physiological
functions
or
can
contribute
development
certain
diseases.
In
this
review,
we
scrutinize
three
distinct
pro-inflammatory
programmed
cell
pathways
-
pyroptosis,
necroptosis,
ferroptosis
occurring
under
specific
circumstances,
explain
how
these
appear
undergo
dynamic
yet
not
always
final
changes
before
ultimately
dying.
We
achieve
that
examining
interconnectivity
types,
seem
create
a
coordinated
flexible
system
responding
microenvironment.
Finally,
discuss
complexity
consequences
pyroptotic,
necroptotic,
ferroptotic
pathway
induction
two
pathological
conditions
atherosclerosis
cancer.
summarize
damage-associated
molecular
patterns
(DAMPs)
along
microenvironmental
factors,
macrophage
polarization
states,
associated
general
outcomes,
such
comprehensive
look
at
correlations
may
point
out
methodologies
potential
therapeutic
approaches.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
173, С. 116356 - 116356
Опубликована: Фев. 29, 2024
Aging,
an
inevitable
aspect
of
human
existence,
serves
as
one
the
predominant
risk
factors
for
vascular
diseases.
Delving
into
mystery
disease's
pathophysiology,
profound
involvement
programmed
cell
death
(PCD)
has
been
extensively
demonstrated.
PCD
is
a
fundamental
biological
process
that
plays
crucial
role
in
both
normal
physiology
and
pathology,
including
recently
discovered
form,
ferroptosis.
Ferroptosis
characterized
by
its
reliance
on
iron
lipid
peroxidation,
significant
disease
pathophysiology
increasingly
acknowledged.
This
phenomenon
not
only
offers
promising
therapeutic
target
but
also
deepens
our
understanding
complex
relationship
between
ferroptosis
age-related
Consequently,
this
article
aims
to
thoroughly
review
mechanisms
enable
effective
control
inhibition
It
focuses
genetic
pharmacological
interventions,
with
goal
developing
innovative
strategies
combat
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
178, С. 117183 - 117183
Опубликована: Июль 30, 2024
Atherosclerosis,
characterized
by
the
accumulation
of
plaque
within
arterial
walls,
is
an
intricate
cardiovascular
disease
that
often
results
in
severe
health
issues.
Recent
studies
have
emphasized
importance
ferroptosis,
a
controlled
type
cell
death
dependent
on
iron,
as
critical
factor
this
state.
Ferroptosis,
distinguished
its
reliance
iron
and
lipid
hydroperoxides,
offers
unique
insight
into
pathology
atherosclerotic
lesions.
This
summary
encapsulates
current
knowledge
role
ferroptosis
plays
onset
progression
atherosclerosis.
It
explores
molecular
processes
through
which
peroxidation
metabolism
contribute
to
development
atheromatous
plaques
evaluates
possibility
utilizing
novel
treatment
approach
for
By
illuminating
relationship
between
ferroptosis-related
atherosclerosis,
review
paves
way
future
clinical
applications
personalized
medicine
approaches
aimed
at
alleviating
effects
Journal of Inflammation Research,
Год журнала:
2024,
Номер
Volume 17, С. 4001 - 4016
Опубликована: Июнь 1, 2024
Abstract:
Inflammatory
cytokines,
interleukin-36
(IL-36),
IL-37,
IL-38
belong
to
IL-1
family.
The
IL-36
subfamily
obtains
pro-
and
anti-inflammatory
effects
on
various
immune
responses.
Cytokine
has
functions
in
immunity,
the
recently
identified
negatively
associated
with
disease
pathogenesis.
To
date,
expression
of
IL-36,
is
reported
dysregulated
osteoarthritis
(OA)
rheumatoid
arthritis
(RA),
may
be
markers
for
arthritis-related
diseases.
Interestingly,
was
different
either
OA
patients
or
animal
models,
IL-36Ra
synovium
RA
patients.
Moreover,
functional
studies
have
demonstrated
significant
role
these
cytokines
progress.
These
processes
were
related
cells
non-immune
cells,
where
regulate
downstream
signalings
then
involve
OA,
development.
In
this
review,
we
comprehensively
discuss
recent
advancements
development
RA.
We
hope
that
targeting
will
become
a
potential
treatment
option
future.
Keywords:
IL-38,
osteoarthritis,
Frontiers in Pharmacology,
Год журнала:
2023,
Номер
14
Опубликована: Окт. 26, 2023
Cardiovascular
diseases
(CVDs),
encompassing
ischaemic
heart
disease,
cardiomyopathy,
and
failure,
among
others,
are
the
most
prevalent
complications
of
diabetes
leading
cause
mortality
in
patients
with
diabetes.
Cell
death
modalities,
including
apoptosis,
necroptosis,
pyroptosis,
have
been
demonstrated
to
be
involved
pathogenesis
CVDs.
As
research
progresses,
accumulating
evidence
also
suggests
involvement
ferroptosis,
a
novel
form
cell
death,
Ferroptosis,
characterised
by
iron-dependent
lipid
peroxidation,
which
culminates
membrane
rupture,
may
present
new
therapeutic
targets
for
diabetes-related
cardiovascular
complications.
Current
treatments
CVDs,
such
as
antihypertensive,
anticoagulant,
lipid-lowering,
plaque-stabilising
drugs,
severe
side
effects
long-term
use.
Traditional
Chinese
medicine,
its
broad
range
activities
minimal
effects,
is
widely
used
China.
Numerous
studies
shown
that
active
components
alkaloids,
polyphenols,
saponins,
can
prevent
CVDs
regulating
ferroptosis.
This
review
summarises
recent
findings
on
regulatory
mechanisms
medicine
against
ferroptosis
aiming
provide
directions
scientific
basis
targeting
prevention
treatment
diabetic
Reviews in Cardiovascular Medicine,
Год журнала:
2025,
Номер
26(3)
Опубликована: Март 5, 2025
Atherosclerosis
(AS)
is
a
chronic
vascular
disease
primarily
affecting
large
and
medium-sized
arteries,
involving
complex
pathological
mechanisms
such
as
inflammatory
responses,
lipid
metabolism
disorders
plaque
formation.
In
recent
years,
several
emerging
research
hotspots
have
appeared
in
the
field
of
atherosclerosis,
including
gut
microbiota,
pyroptosis,
ferroptosis,
autophagy,
cuproptosis,
exosomes
non-coding
RNA.
Traditional
lipid-lowering
drugs
play
crucial
role
treatment
AS
but
are
not
able
to
significantly
reverse
changes.
This
article
aims
summarize
latest
progress
pathogenesis
diagnosis
by
comprehensively
analyzing
relevant
literature
mainly
from
past
five
years.
Additionally,
action
advances
statins,
cholesterol
absorption
inhibitors,
fibrates
novel
reviewed
provide
new
insights
into
AS.
