Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: May 31, 2024

Abstract The immune response holds a pivotal role in cardiovascular disease development. As multifunctional cells of the innate system, macrophages play an essential initial inflammatory that occurs following injury, thereby inducing subsequent damage while also facilitating recovery. Meanwhile, diverse phenotypes and phenotypic alterations strongly associate with distinct types severity diseases, including coronary heart disease, valvular myocarditis, cardiomyopathy, failure, atherosclerosis aneurysm, which underscores importance investigating macrophage regulatory mechanisms within context specific diseases. Besides, recent strides single-cell sequencing technologies have revealed heterogeneity, cell–cell interactions, downstream therapeutic targets at higher resolution, brings new perspectives into macrophage-mediated potential Remarkably, myocardial fibrosis, prevalent characteristic most cardiac remains formidable clinical challenge, necessitating profound investigation impact on fibrosis In this review, we systematically summarize functional plasticity diseases unprecedented insights introduced by technologies, focus different causes characteristics especially relationship between inflammation (myocardial infarction, pressure overload, dilated diabetic cardiomyopathy aging) vascular injury (atherosclerosis aneurysm). Finally, highlight preclinical/clinical targeting strategies translational implications.

Language: Английский

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Programmed death of macrophages in atherosclerosis: mechanisms and therapeutic targets

Nature Reviews Cardiology, Journal Year: 2024, Volume and Issue: 21(5), P. 312 - 325

Published: Jan. 2, 2024

Language: Английский

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The dance of macrophage death: the interplay between the inevitable and the microenvironment

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: March 20, 2024

Macrophages are highly plastic cells ubiquitous in various tissues, where they perform diverse functions. They participate the response to pathogen invasion and inflammation resolution following immune response, as well maintenance of homeostasis proper tissue generally considered long-lived with relatively strong resistance numerous cytotoxic factors. On other hand, their death seems be one principal mechanisms by which macrophages physiological functions or can contribute development certain diseases. In this review, we scrutinize three distinct pro-inflammatory programmed cell pathways - pyroptosis, necroptosis, ferroptosis occurring under specific circumstances, explain how these appear undergo dynamic yet not always final changes before ultimately dying. We achieve that examining interconnectivity types, seem create a coordinated flexible system responding microenvironment. Finally, discuss complexity consequences pyroptotic, necroptotic, ferroptotic pathway induction two pathological conditions atherosclerosis cancer. summarize damage-associated molecular patterns (DAMPs) along microenvironmental factors, macrophage polarization states, associated general outcomes, such comprehensive look at correlations may point out methodologies potential therapeutic approaches.

Language: Английский

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Ferroptosis in age-related vascular diseases: Molecular mechanisms and innovative therapeutic strategies

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 173, P. 116356 - 116356

Published: Feb. 29, 2024

Aging, an inevitable aspect of human existence, serves as one the predominant risk factors for vascular diseases. Delving into mystery disease's pathophysiology, profound involvement programmed cell death (PCD) has been extensively demonstrated. PCD is a fundamental biological process that plays crucial role in both normal physiology and pathology, including recently discovered form, ferroptosis. Ferroptosis characterized by its reliance on iron lipid peroxidation, significant disease pathophysiology increasingly acknowledged. This phenomenon not only offers promising therapeutic target but also deepens our understanding complex relationship between ferroptosis age-related Consequently, this article aims to thoroughly review mechanisms enable effective control inhibition It focuses genetic pharmacological interventions, with goal developing innovative strategies combat

Language: Английский

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The complex interplay between ferroptosis and atherosclerosis

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 178, P. 117183 - 117183

Published: July 30, 2024

Atherosclerosis, characterized by the accumulation of plaque within arterial walls, is an intricate cardiovascular disease that often results in severe health issues. Recent studies have emphasized importance ferroptosis, a controlled type cell death dependent on iron, as critical factor this state. Ferroptosis, distinguished its reliance iron and lipid hydroperoxides, offers unique insight into pathology atherosclerotic lesions. This summary encapsulates current knowledge role ferroptosis plays onset progression atherosclerosis. It explores molecular processes through which peroxidation metabolism contribute to development atheromatous plaques evaluates possibility utilizing novel treatment approach for By illuminating relationship between ferroptosis-related atherosclerosis, review paves way future clinical applications personalized medicine approaches aimed at alleviating effects

Language: Английский

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Role of IL-1 Family Cytokines IL-36, IL-37, IL-38 in Osteoarthritis and Rheumatoid Arthritis: A Comprehensive Review

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 4001 - 4016

Published: June 1, 2024

Abstract: Inflammatory cytokines, interleukin-36 (IL-36), IL-37, IL-38 belong to IL-1 family. The IL-36 subfamily obtains pro- and anti-inflammatory effects on various immune responses. Cytokine has functions in immunity, the recently identified negatively associated with disease pathogenesis. To date, expression of IL-36, is reported dysregulated osteoarthritis (OA) rheumatoid arthritis (RA), may be markers for arthritis-related diseases. Interestingly, was different either OA patients or animal models, IL-36Ra synovium RA patients. Moreover, functional studies have demonstrated significant role these cytokines progress. These processes were related cells non-immune cells, where regulate downstream signalings then involve OA, development. In this review, we comprehensively discuss recent advancements development RA. We hope that targeting will become a potential treatment option future. Keywords: IL-38, osteoarthritis,

Language: Английский

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A New Insight on Atherosclerosis Mechanism and Lipid-Lowering Drugs

Reviews in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 26(3)

Published: March 5, 2025

Atherosclerosis (AS) is a chronic vascular disease primarily affecting large and medium-sized arteries, involving complex pathological mechanisms such as inflammatory responses, lipid metabolism disorders plaque formation. In recent years, several emerging research hotspots have appeared in the field of atherosclerosis, including gut microbiota, pyroptosis, ferroptosis, autophagy, cuproptosis, exosomes non-coding RNA. Traditional lipid-lowering drugs play crucial role treatment AS but are not able to significantly reverse changes. This article aims summarize latest progress pathogenesis diagnosis by comprehensively analyzing relevant literature mainly from past five years. Additionally, action advances statins, cholesterol absorption inhibitors, fibrates novel reviewed provide new insights into AS.

Language: Английский

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IL-37 Improves Palmitic acid-induced lipid deposition in liver cells by inhibiting Ferroptosis to Regulate macrophage polarization

Tissue and Cell, Journal Year: 2025, Volume and Issue: unknown, P. 102977 - 102977

Published: May 1, 2025

Language: Английский

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The role of ferroptosis in diabetic cardiovascular diseases and the intervention of active ingredients of traditional Chinese medicine

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 26, 2023

Cardiovascular diseases (CVDs), encompassing ischaemic heart disease, cardiomyopathy, and failure, among others, are the most prevalent complications of diabetes leading cause mortality in patients with diabetes. Cell death modalities, including apoptosis, necroptosis, pyroptosis, have been demonstrated to be involved pathogenesis CVDs. As research progresses, accumulating evidence also suggests involvement ferroptosis, a novel form cell death, Ferroptosis, characterised by iron-dependent lipid peroxidation, which culminates membrane rupture, may present new therapeutic targets for diabetes-related cardiovascular complications. Current treatments CVDs, such as antihypertensive, anticoagulant, lipid-lowering, plaque-stabilising drugs, severe side effects long-term use. Traditional Chinese medicine, its broad range activities minimal effects, is widely used China. Numerous studies shown that active components alkaloids, polyphenols, saponins, can prevent CVDs regulating ferroptosis. This review summarises recent findings on regulatory mechanisms medicine against ferroptosis aiming provide directions scientific basis targeting prevention treatment diabetic

Language: Английский

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The Protective Role of Interleukin-37 in Cardiovascular Diseases through Ferroptosis Modulation

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 9758 - 9758

Published: Sept. 10, 2024

The role of ferroptosis and iron metabolism dysregulation in the pathophysiology cardiovascular diseases is increasingly recognized. Conditions such as hypertension, cardiomyopathy, atherosclerosis, myocardial ischemia/reperfusion injury, heart failure, complications associated with COVID-19 have been linked to these processes. Inflammation central conditions, prompting exploration into inflammatory immunoregulatory molecular pathways that mediate its contribution disease progression. Notably, emerging evidence highlights interleukin-37 a protective cytokine ability activate nuclear factor erythroid 2-related 2 pathway, inhibit macrophage ferroptosis, attenuate atherosclerosis progression murine models. However, comprehensive review focusing on against CVD currently lacking. This aims fill this gap by summarizing existing knowledge interleukin-37, including regulatory functions impact conditions infarction. We also explore experimental strategies propose targeting modulate presents promising therapeutic approach for prevention treatment diseases.

Language: Английский

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