Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Март 13, 2023
Abstract
Aims
and
methods
This
study
aimed
to
compare
correlate
pharmacotherapy
biomarkers’
plasma
salivary
levels
(appraised
using
colorimetric
assays
of
Lipocalin,
Nesfatin,
Omentin,
Oxytocin,
RBP-4
(retinol-binding
protein-4),
Resistin,
SIRT
1
(sirtuin
1),
Visfatin
ZBED3
(zinc
finger,
BED-type
(ZBED)
protein
3),
adiposity,
atherogenicity
indices
in
61
normoglycemic
newly
diagnosed
drug
naive
pre-diabetic
(PreDM)
MetS
(metabolic
syndrome)
patients
vs.
29
lean,
controls.
Intergroup
Comparisons
was
conducted
by
ANOVA.
Spearman
rank
correlation
also
examined.
Results
About
three
quarters
the
participants
were
females,
with
gender
distribution
similar
between
two
groups
(P
=
0.585).
Among
patients,
almost
half
normoglycemic,
about
43%
prediabetic
8%
diabetic.
The
average
age
48.6
years,
group
being
significantly
older
than
control
<
0.001).
In
accordance
selection
criteria,
glycemic
(FPG
A1c)
lipid
parameters
(TG,
HDL-C
non-HDL-C),
adiposity
(BMI,
WHR,
WtHR,
C-index,
BAI,
LAP,
VAI)
(AIP,
TC/HDL-C,
LDL-C/HDL-C,
non-HDL-C/HDL-C
TG/HDL-C)
all
higher
compared
0.05).
cardiometabolic
risk
biomarkers
pharmacotherapy,
(but
not
salivary)
lipocalin
Salivary
nesfatin
(unlike
nesfatin)
P
0.05)
lean
Notably,
SIRT1
pronouncedly
greater
recruits
comparison
control’s
levels.
Conversely;
concentrations
pool
markedly
exceeded
those
controls’
Oddly
collectively
blood
omentin,
oxytocin,
RBP-4,
resistin,
visfatin
lacked
comparably
pronounced
discrepancies
cases
Exceptionally
amongst
9
studied,
had
proportional
significant
correlations
saliva
levels,
both
total
sample
Plasma
OXT
correlated
though
inversely
SBP
FBG
OXT).
Interestingly
pool;
Proportional
TG,
LAP
VAI,
atherogenecity
delineated.
Collectively
pool,
as
well
remaining
biomarkers;
substantial
associations
clinical
fasting
profile.
Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Янв. 23, 2024
Abstract
Background
Periodontitis
is
a
chronic
oral
inflammatory
disease
that
seriously
affects
people's
quality
of
life.
The
purpose
our
study
was
to
investigate
the
correlation
between
systemic
immune
inflammation
index
(SII)
and
periodontitis
by
utilizing
large
national
survey.
This
will
establish
reference
for
early
identification
management
periodontitis.
Methods
comprised
adult
US
population
who
participated
in
surveillance
project
during
six
years
from
2009
2014.
Through
utilization
univariate
multivariate
weighted
logistic
regression,
we
investigated
Additionally,
employed
sensitivity
analyses
evaluate
robustness
findings.
Results
involved
10,366
participants
with
an
average
age
51.00
years,
whom
49.45%
were
male
(N
=
5126)
50.55%
female
5240).
prevalence
estimated
be
about
38.43%
adults
aged
30
or
older
population.
Our
regression
models
indicated
positive
association
SII
higher
than
978
×
10
9
/L
elder
group
(aged
50
older)
demonstrated
significant
fully
adjusted
model
(Odds
Ratio
[OR]
1.409,
95%
Confidence
Interval
[CI]
1.037,
1.915,
P
0.022).
However,
there
no
statistical
difference
among
50.
findings
confirmed
through
analyses.
Conclusions
highlights
associated
nationally
representative
sample
adults.
And
significantly
high
risk
individuals
older.
Abstract
Background
The
objective
of
this
systematic
review
and
meta-analysis
was
to
evaluate
the
effects
non-surgical
periodontal
therapy
(NSPT)
on
inflammatory-related
cytokines/adipocytokines
in
periodontitis
patients
with
or
without
obesity.
Methods
We
followed
preferred
reporting
items
for
reviews
meta-analyses
statement
registered
study
(CRD42022375331)
Prospective
International
Register
Systematic
Reviews.
screened
randomized-controlled
trials
controlled
clinical
from
six
databases
up
December
2022.
Quality
assessment
performed
RoB-2
ROBINS-I
tools
randomized
non-randomized
trials,
respectively.
Meta-analysis
carried
out
using
a
random-effect
model.
Results
included
seventeen
references
analysis,
sixteen
meta-analysis.
Baseline
results
pro-inflammatory
biomarkers,
including
serum
interleukin
(IL)-6,
gingival
crevicular
fluid
(GCF),
tumor
necrosis
factor
(TNF)-a,
C-reactive
protein
(CRP)/hs-CRP,
GCF
resistin,
were
higher
obesity
subjects
than
normal
weight
subjects.
effect
NSPT
respect
levels
cytokines/adipocytokines,
IL-6,
TNF-a,
CRP/hs-CRP,
adiponectin,
leptin
retinol
binding
4
(RBP4),
then
analyzed
After
three
months
NSPT,
(MD
=
-0.54,
CI
-0.62
–
-0.46),
-2.70,
-4.77
-0.63)
along
RBP4
-0.39,
-0.68–0.10)
decreased
individuals
also
improved
adiponectin
after
2.37,
0.29
4.45)
Conclusions
Obese
status
altered
baseline
(serum
resistin).
Then
can
shift
specific
mediators
anti-inflammatory
biological
fluids,
both
non-obesity
individuals.
reduce
IL-6
together
level
3
months,
besides,
there
is
no
sufficient
evidence
prove
that
obese
have
statistically
significant
decrease
other
cytokines
compared
weight.
increase
months.
Our
findings
imply
potential
ideal
follow-up
intervals
sensitive
biomarkers
bioanalysis
personalized
decision-making
due
patients’
BMI
value.
Journal Of Clinical Periodontology,
Год журнала:
2020,
Номер
48(2), С. 216 - 225
Опубликована: Окт. 24, 2020
Salivary
biomarkers
can
help
in
assessment
of
periodontitis;
however,
concentrations
may
be
altered
the
presence
diabetes.
Hence,
ability
salivary
to
discriminate
periodontally
healthy
type
II
diabetics
(T2DM)
from
T2DM
who
have
periodontitis
was
examined.Ninety-two
participants
(29
with
chronic
periodontitis,
DWP;
32
without
DWoP;
and
31
Not
Periodontitis,
NP)
provided
saliva
clinical
parameters
periodontal
health
were
recorded.
interleukin
(IL)-1β,
IL-6,
matrix
metalloproteinase-8
(MMP-8),
macrophage
inflammatory
protein-1α
(MIP-1α),
adiponectin
resistin
measured
by
immunoassay.Salivary
analyte
for
IL-1β,
MMP-8
correlated
demonstrating
strongest
positive
correlation
PD
≥5
mm
(p
<
0.0001).
Periodontal
reflected
group,
IL-1β
showing
significant
associations
≤
0.04)
that
increased
concentration
DWoP
DWP.
Odds
ratio
(OR)
analyses
showed
discriminated
NP
(OR
8.12;
95%
CI:
1.01-65.33;
p
=
0.03)
(DWP
vs
DWoP,
OR
5.09;
1.24-20.92;
0.03).Salivary
T2DM.
Journal of Personalized Medicine,
Год журнала:
2022,
Номер
12(6), С. 992 - 992
Опубликована: Июнь 17, 2022
(1)
Background:
Our
study
aimed
to
assess
the
association
between
neutrophil
lymphocyte
ratio
(NLR),
platelet
leukocyte
(PLR),
monocyte
(LMR),
red
cell
distribution
width
(RDW),
and
systemic
immune
inflammation
index
(SII)
periodontitis.
(2)
Methods:
We
searched
PubMed,
Embase,
Scopus,
Web
of
Science,
LILACS
databases,
identifying
observational
studies.
The
Newcastle
Ottawa
scale
was
used
evaluate
quality
included
principal
summary
outcome
measure
in
our
random
effects
meta-analysis
mean
difference
(MD).
(3)
Results:
After
screening
682
search
results,
a
total
10
studies
including
3164
subjects
were
selected
for
quantitative
assessment.
found
higher
NLR,
PLR,
LMR
periodontitis
group
compared
control
(0.41
(95%
CI
0.12–0.7),
p
=
0.006;
7.43
0.31–14.54),
0.04;
2.05
0.27–3.83),
0.024).
No
differences
observed
RDW.
(4)
Conclusions:
an
LMR,
PLR
periodontitis,
which
might
be
thought
as
emerging
blood
count
inflammatory
biomarkers
that
could
shed
light
on
link
disbalances,
well
prognosis
grading.
Journal of Periodontal Research,
Год журнала:
2023,
Номер
58(3), С. 493 - 502
Опубликована: Апрель 12, 2023
Biological
regulators
of
periodontal
inflammation,
collagen
degradation,
and
insulin
resistance
have
not
been
determined
in
association
with
severity
periodontitis
response
to
treatment
diabetics.
Our
objective
was
determine
whether
type
2
diabetes
(T2DM)
patients
disease
present
a
distinct
salivary
biomarker
profile
compared
T2DM
without
healthy
subjects
(without
periodontitis)
pre-
post-nonsurgical
therapy.Clinical
parameters
health
whole
unstimulated
saliva
were
collected
from
92
participants
(31
Not
Periodontitis,
NP;
32
periodontitis,
DWoP;
29
DWP)
at
baseline.
The
groups
received
scaling
root
planning
(SRP)
provided
6-week
follow-up.
Salivary
concentrations
interleukin
(IL)-1β,
IL-6,
matrix
metalloproteinase-8
(MMP-8),
resistin
measured
by
immunoassay.The
DWP
group
had
significantly
more
higher
baseline
for
IL-1β,
MMP-8,
(p's
<
.01)
DWoP
NP.
SRP
resulted
significant
improvement
the
groups;
however,
persisted
(p
.001),
remained
than
6
weeks
post-treatment.
Principal
component
analysis
demonstrated
appeared
biologically
similar
NP
group.
Concentrations
these
biomarkers
increased
increasing
.05)
this
study
population.Salivary
appear
serve
as
status
post-treatment,
irrespective
status.
Clinical Oral Investigations,
Год журнала:
2024,
Номер
28(1)
Опубликована: Янв. 9, 2024
The
aim
of
this
study
was
to
evaluate
the
effect
delta
neutrophil
index
(DNI)
on
non-surgical
periodontal
therapy
(NSPT),
whose
role
has
been
documented
in
pathogenesis
and
follow-up
disease.
Journal of Periodontal Research,
Год журнала:
2024,
Номер
59(4), С. 623 - 635
Опубликована: Апрель 9, 2024
This
study
aimed
to
investigate
the
levels
of
serum,
gingival
crevicular
fluid
(GCF),
and
salivary
adipokines
their
possible
relationship
with
periodontitis
obesity.
An
electronic
search
was
conducted
in
following
databases:
PubMed/
Medline,
Scopus,
EBSCOhost
through
February
2023.
Two
independent
reviewers
screened
titles,
abstracts,
full
text
all
studies.
Studies
comparing
GCF,
and/or
saliva
subjects
obesity
(group
1),
normal
weight
2),
health
3)
were
included.
Meta-analyses
meta-regression
performed
on
data
from
included
Seventeen
studies
participants
ranging
30
120
each
group
10
40.
There
a
significant
increase
serum
TNF-α,
leptin,
IL-6,
CRP
between
groups
1
2
(p
<
.05).
In
TNF-α
resistin
significantly
higher
.05)
Group
vs.
2.
Serum
level
leptin
for
3
Meta-regression
analysis
revealed
that
definition
(body
mass
index
(BMI)
cut-off
value
>25
or
>30)
GCF
The
current
indicates
both
can
modulate
pro-inflammatory
cytokines
at
systemic
local
levels.
bidirectional
interaction
via
inflammation
pathway
seems
likely
plausible.
Further
are
required
elucidate
this
mechanism
more
detail.
Dentistry Journal,
Год журнала:
2025,
Номер
13(5), С. 200 - 200
Опубликована: Апрель 30, 2025
Periodontal
diseases,
including
gingivitis
and
periodontitis,
are
chronic
inflammatory
conditions
that
compromise
the
supporting
structures
of
teeth,
often
leading
to
tooth
loss
contributing
systemic
comorbidities.
Increasing
evidence
underscores
critical
role
modifiable
lifestyle
factors,
particularly
diet
physical
activity,
in
influencing
periodontal
health.
This
narrative
review
critically
evaluates
current
body
literature
regarding
impact
dietary
constituents
activity
on
periodontium,
with
a
focus
molecular
mechanisms,
key
biomarkers,
clinical
implications.
It
aims
provide
deeper
understanding
complex
interactions
between
nutrition,
exercise,
health
potential
implications
for
management
preventive
strategies.