Association between the systemic immune inflammation index and periodontitis: a cross-sectional study

Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Янв. 23, 2024

Abstract Background Periodontitis is a chronic oral inflammatory disease that seriously affects people's quality of life. The purpose our study was to investigate the correlation between systemic immune inflammation index (SII) and periodontitis by utilizing large national survey. This will establish reference for early identification management periodontitis. Methods comprised adult US population who participated in surveillance project during six years from 2009 2014. Through utilization univariate multivariate weighted logistic regression, we investigated Additionally, employed sensitivity analyses evaluate robustness findings. Results involved 10,366 participants with an average age 51.00 years, whom 49.45% were male (N = 5126) 50.55% female 5240). prevalence estimated be about 38.43% adults aged 30 or older population. Our regression models indicated positive association SII higher than 978 × 10 9 /L elder group (aged 50 older) demonstrated significant fully adjusted model (Odds Ratio [OR] 1.409, 95% Confidence Interval [CI] 1.037, 1.915, P 0.022). However, there no statistical difference among 50. findings confirmed through analyses. Conclusions highlights associated nationally representative sample adults. And significantly high risk individuals older.

Язык: Английский

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Effect of non-surgical periodontal treatment on cytokines/adipocytokines levels among periodontitis patients with or without obesity: a systematic review and meta-analysis

BMC Oral Health, Год журнала: 2023, Номер 23(1)

Опубликована: Окт. 5, 2023

Abstract Background The objective of this systematic review and meta-analysis was to evaluate the effects non-surgical periodontal therapy (NSPT) on inflammatory-related cytokines/adipocytokines in periodontitis patients with or without obesity. Methods We followed preferred reporting items for reviews meta-analyses statement registered study (CRD42022375331) Prospective International Register Systematic Reviews. screened randomized-controlled trials controlled clinical from six databases up December 2022. Quality assessment performed RoB-2 ROBINS-I tools randomized non-randomized trials, respectively. Meta-analysis carried out using a random-effect model. Results included seventeen references analysis, sixteen meta-analysis. Baseline results pro-inflammatory biomarkers, including serum interleukin (IL)-6, gingival crevicular fluid (GCF), tumor necrosis factor (TNF)-a, C-reactive protein (CRP)/hs-CRP, GCF resistin, were higher obesity subjects than normal weight subjects. effect NSPT respect levels cytokines/adipocytokines, IL-6, TNF-a, CRP/hs-CRP, adiponectin, leptin retinol binding 4 (RBP4), then analyzed After three months NSPT, (MD = -0.54, CI -0.62 – -0.46), -2.70, -4.77 -0.63) along RBP4 -0.39, -0.68–0.10) decreased individuals also improved adiponectin after 2.37, 0.29 4.45) Conclusions Obese status altered baseline (serum resistin). Then can shift specific mediators anti-inflammatory biological fluids, both non-obesity individuals. reduce IL-6 together level 3 months, besides, there is no sufficient evidence prove that obese have statistically significant decrease other cytokines compared weight. increase months. Our findings imply potential ideal follow-up intervals sensitive biomarkers bioanalysis personalized decision-making due patients’ BMI value.

Язык: Английский

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Salivary biomarkers for discriminating periodontitis in the presence of diabetes

Journal Of Clinical Periodontology, Год журнала: 2020, Номер 48(2), С. 216 - 225

Опубликована: Окт. 24, 2020

Salivary biomarkers can help in assessment of periodontitis; however, concentrations may be altered the presence diabetes. Hence, ability salivary to discriminate periodontally healthy type II diabetics (T2DM) from T2DM who have periodontitis was examined.Ninety-two participants (29 with chronic periodontitis, DWP; 32 without DWoP; and 31 Not Periodontitis, NP) provided saliva clinical parameters periodontal health were recorded. interleukin (IL)-1β, IL-6, matrix metalloproteinase-8 (MMP-8), macrophage inflammatory protein-1α (MIP-1α), adiponectin resistin measured by immunoassay.Salivary analyte for IL-1β, MMP-8 correlated demonstrating strongest positive correlation PD ≥5 mm (p < 0.0001). Periodontal reflected group, IL-1β showing significant associations ≤ 0.04) that increased concentration DWoP DWP. Odds ratio (OR) analyses showed discriminated NP (OR 8.12; 95% CI: 1.01-65.33; p = 0.03) (DWP vs DWoP, OR 5.09; 1.24-20.92; 0.03).Salivary T2DM.

Язык: Английский

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Blood Cell Count Inflammatory Markers as Prognostic Indicators of Periodontitis: A Systematic Review and Meta-Analysis

Journal of Personalized Medicine, Год журнала: 2022, Номер 12(6), С. 992 - 992

Опубликована: Июнь 17, 2022

(1) Background: Our study aimed to assess the association between neutrophil lymphocyte ratio (NLR), platelet leukocyte (PLR), monocyte (LMR), red cell distribution width (RDW), and systemic immune inflammation index (SII) periodontitis. (2) Methods: We searched PubMed, Embase, Scopus, Web of Science, LILACS databases, identifying observational studies. The Newcastle Ottawa scale was used evaluate quality included principal summary outcome measure in our random effects meta-analysis mean difference (MD). (3) Results: After screening 682 search results, a total 10 studies including 3164 subjects were selected for quantitative assessment. found higher NLR, PLR, LMR periodontitis group compared control (0.41 (95% CI 0.12–0.7), p = 0.006; 7.43 0.31–14.54), 0.04; 2.05 0.27–3.83), 0.024). No differences observed RDW. (4) Conclusions: an LMR, PLR periodontitis, which might be thought as emerging blood count inflammatory biomarkers that could shed light on link disbalances, well prognosis grading.

Язык: Английский

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Biomarker panel discriminates diabetics with and without periodontitis pre‐ and post‐therapy

Journal of Periodontal Research, Год журнала: 2023, Номер 58(3), С. 493 - 502

Опубликована: Апрель 12, 2023

Biological regulators of periodontal inflammation, collagen degradation, and insulin resistance have not been determined in association with severity periodontitis response to treatment diabetics. Our objective was determine whether type 2 diabetes (T2DM) patients disease present a distinct salivary biomarker profile compared T2DM without healthy subjects (without periodontitis) pre- post-nonsurgical therapy.Clinical parameters health whole unstimulated saliva were collected from 92 participants (31 Not Periodontitis, NP; 32 periodontitis, DWoP; 29 DWP) at baseline. The groups received scaling root planning (SRP) provided 6-week follow-up. Salivary concentrations interleukin (IL)-1β, IL-6, matrix metalloproteinase-8 (MMP-8), resistin measured by immunoassay.The DWP group had significantly more higher baseline for IL-1β, MMP-8, (p's < .01) DWoP NP. SRP resulted significant improvement the groups; however, persisted (p .001), remained than 6 weeks post-treatment. Principal component analysis demonstrated appeared biologically similar NP group. Concentrations these biomarkers increased increasing .05) this study population.Salivary appear serve as status post-treatment, irrespective status.

Язык: Английский

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Can delta neutrophil index values predict the success of periodontal treatment in patients with periodontitis?

Clinical Oral Investigations, Год журнала: 2024, Номер 28(1)

Опубликована: Янв. 9, 2024

The aim of this study was to evaluate the effect delta neutrophil index (DNI) on non-surgical periodontal therapy (NSPT), whose role has been documented in pathogenesis and follow-up disease.

Язык: Английский

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Association of adipokine levels with obesity in periodontal health and disease: A systematic review with meta‐analysis and meta‐regression

Journal of Periodontal Research, Год журнала: 2024, Номер 59(4), С. 623 - 635

Опубликована: Апрель 9, 2024

This study aimed to investigate the levels of serum, gingival crevicular fluid (GCF), and salivary adipokines their possible relationship with periodontitis obesity. An electronic search was conducted in following databases: PubMed/ Medline, Scopus, EBSCOhost through February 2023. Two independent reviewers screened titles, abstracts, full text all studies. Studies comparing GCF, and/or saliva subjects obesity (group 1), normal weight 2), health 3) were included. Meta-analyses meta-regression performed on data from included Seventeen studies participants ranging 30 120 each group 10 40. There a significant increase serum TNF-α, leptin, IL-6, CRP between groups 1 2 (p < .05). In TNF-α resistin significantly higher .05) Group vs. 2. Serum level leptin for 3 Meta-regression analysis revealed that definition (body mass index (BMI) cut-off value >25 or >30) GCF The current indicates both can modulate pro-inflammatory cytokines at systemic local levels. bidirectional interaction via inflammation pathway seems likely plausible. Further are required elucidate this mechanism more detail.

Язык: Английский

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An Overview on the Relation Between Blood Disorders, Periodontitis and Dental Caries

AlQalam Journal of Medical and Applied Sciences, Год журнала: 2025, Номер unknown, С. 36 - 42

Опубликована: Янв. 3, 2025

The relationship between blood disorders, periodontitis, and dental caries reveals a complex interaction oral health systemic conditions. Dental caries, caused by bacterial biofilms environmental factors, chronic inflammatory disease, are both associated with significant implications. This review highlights the bidirectional link these conditions hematological disorders such as anemia, leukemia, thalassemia. Periodontitis-induced inflammation can disseminate systemically, impacting hematopoietic functions contributing to disorders. Conversely, diseases exacerbate periodontal issues impairing immune responses altering parameters, observed in like cyclic neutropenia sickle cell anemia. effects of periodontitis characterized elevated markers, including C-reactive protein (CRP) IL-6, amplifying inflammation. interrelationship underscores necessity integrative healthcare strategies. Regular monitoring proactive management inflammation, addressing underlying essential for improving patient outcomes. advocates holistic diagnostic therapeutic approach manage coexisting challenges effectively.

Язык: Английский

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The Influence of Diet and Physical Activity on Periodontal Health: A Narrative Review

Dentistry Journal, Год журнала: 2025, Номер 13(5), С. 200 - 200

Опубликована: Апрель 30, 2025

Periodontal diseases, including gingivitis and periodontitis, are chronic inflammatory conditions that compromise the supporting structures of teeth, often leading to tooth loss contributing systemic comorbidities. Increasing evidence underscores critical role modifiable lifestyle factors, particularly diet physical activity, in influencing periodontal health. This narrative review critically evaluates current body literature regarding impact dietary constituents activity on periodontium, with a focus molecular mechanisms, key biomarkers, clinical implications. It aims provide deeper understanding complex interactions between nutrition, exercise, health potential implications for management preventive strategies.

Язык: Английский

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Salivary and gingival crevicular fluid biomarkers of periodontal health and/or obesity among children and adolescents: A systematic review and meta-analysis

Heliyon, Год журнала: 2023, Номер 10(1), С. e23782 - e23782

Опубликована: Дек. 18, 2023

To investigate the association of salivary and gingival crevicular fluid (GCF) biomarkers with periodontal status obesity in children adolescents.

Язык: Английский

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