Biosensors,
Год журнала:
2024,
Номер
14(10), С. 506 - 506
Опубликована: Окт. 17, 2024
Parkinson's
disease
(PD)
is
the
second
most
common
neurodegenerative
disorder,
affecting
lives
of
millions
people
worldwide.
Although
mechanism
underlying
PD
pathogenesis
largely
undefined,
increasing
evidence
indicates
that
oxidative
and
nitrosative
stresses
play
a
crucial
role
in
occurrence
development.
Among
them,
stress
has
been
widely
acknowledged,
but
there
relatively
less
attention
given
to
stress,
which
mainly
derived
from
peroxynitrite.
In
present
review,
after
briefly
introducing
background
PD,
we
discuss
physiopathological
function
peroxynitrite
especially
highlight
how
overloaded
involved
pathogenesis.
Then,
summarize
currently
reported
fluorescence
imaging-based
detection
probes.
Moreover,
specifically
emphasize
probes
have
applied
research.
Finally,
propose
perspectives
on
develop
more
applicable
probe
leverage
it
for
theranostics.
Conclusively,
review
broadens
knowledge
pathological
context
sheds
light
utilize
strategies
detection.
ACS Nano,
Год журнала:
2024,
Номер
18(5), С. 3916 - 3968
Опубликована: Янв. 23, 2024
Dynamic
variations
in
the
concentration
and
abnormal
distribution
of
endogenous
biomarkers
are
strongly
associated
with
multiple
physiological
pathological
states.
Therefore,
it
is
crucial
to
design
imaging
systems
capable
real-time
detection
dynamic
changes
for
accurate
diagnosis
effective
treatment
diseases.
Recently,
ratiometric
has
emerged
as
a
widely
used
technique
sensing
due
its
advantage
circumventing
limitations
inherent
conventional
intensity-dependent
signal
readout
methods
while
also
providing
built-in
self-calibration
correction.
Here,
recent
progress
probes
their
applications
outlined.
Ratiometric
classified
according
mechanisms,
photoacoustic
imaging,
optical
including
photoluminescence
self-luminescence
magnetic
resonance
dual-modal
discussed.
The
such
pH,
reactive
oxygen
species
(ROS),
nitrogen
(RNS),
glutathione
(GSH),
gas
molecules,
enzymes,
metal
ions,
hypoxia
discussed
detail.
Additionally,
this
Review
presents
an
overview
challenges
faced
field
along
future
research
directions.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(16)
Опубликована: Апрель 2, 2024
Atherosclerotic
plaque
formation
is
considered
the
primary
pathological
mechanism
underlying
atherosclerotic
cardiovascular
diseases,
leading
to
severe
events
such
as
stroke,
acute
coronary
syndromes,
and
even
sudden
cardiac
death.
Early
detection
timely
intervention
of
plaques
are
challenging
due
lack
typical
symptoms
in
initial
stages.
Therefore,
precise
early
play
a
crucial
role
risk
stratification
achieving
favorable
post-interventional
outcomes.
The
continuously
advancing
nanoplatforms
have
demonstrated
numerous
advantages
including
high
signal-to-noise
ratio,
enhanced
bioavailability,
specific
targeting
capabilities
for
imaging
agents
therapeutic
drugs,
enabling
effective
visualization
management
plaques.
Motivated
by
these
superior
properties,
various
noninvasive
modalities
recognition
preliminary
stage
atherosclerosis
comprehensively
summarized.
Additionally,
several
strategies
proposed
enhance
efficacy
treating
Finally,
existing
challenges
promising
prospects
accelerating
clinical
translation
nanoplatform-based
molecular
therapy
discussed.
In
conclusion,
this
review
provides
an
insightful
perspective
on
diagnosis
Abstract
Pesticides
in
environmental
samples
pose
significant
risks
to
ecosystems
and
human
health
since
they
require
precise
efficient
detection
methods.
Imidacloprid
(IMI),
a
widely
used
neonicotinoid
insecticide,
exemplifies
these
hazards
due
its
potential
toxicity.
This
study
addresses
the
urgent
need
for
improved
monitoring
of
such
contaminants
by
introducing
novel
fluorometric
method
detecting
IMI
using
nitrogen‐doped
graphite
carbon
dots
(N‐GCDs).
The
sensor
operates
quenching
fluorescence
through
interaction
Cu
2+
ions
with
N‐GCDs.
Subsequently,
binds
imidazole
group,
chelates
,
restores
alternating
behavior
allows
accurate
identification
both
IMI.
exhibits
linear
ranges
20–100
nM
10–140
μg/L
IMI,
limits
18
1.2
μg/L,
respectively.
high
sensitivity
this
enables
real‐world
samples,
which
underscores
practical
use
agricultural
safety.
Materials Today Bio,
Год журнала:
2024,
Номер
26, С. 101028 - 101028
Опубликована: Март 24, 2024
The
expansion
applications
of
semiconducting
polymer
dots
(Pdots)
among
optical
nanomaterial
field
have
long
posed
a
challenge
for
researchers,
promoting
their
intelligent
application
in
multifunctional
nano-imaging
systems
and
integrated
nanomedicine
carriers
diagnosis
treatment.
Despite
notable
progress,
several
inadequacies
still
persist
the
Pdots,
including
development
simplified
near-infrared
(NIR)
nanoprobes,
elucidation
inherent
biological
behavior,
integration
information
processing
nanotechnology
into
biomedical
applications.
This
review
aims
to
comprehensively
elucidate
current
status
Pdots
as
classical
nanophotonic
material
by
discussing
its
advantages
limitations
terms
biocompatibility,
adaptability
microenvironments
vivo,
etc.
Multifunctional
surface
chemistry
play
crucial
roles
realizing
Pdots.
Information
visualization
based
on
physicochemical
properties
is
pivotal
achieving
detection,
sensing,
labeling
probes.
Therefore,
we
refined
underlying
mechanisms
constructed
multiple
comprehensive
original
mechanism
summaries
establish
benchmark.
Additionally,
explored
cross-linking
interactions
between
nanomedicine,
potential
yet
complete
metabolic
pathways,
future
research
directions,
innovative
solutions
integrating
treatment
strategies.
presents
possible
expectations
valuable
insights
advancing
specifically
from
chemical,
medical,
photophysical
practitioners'
standpoints.
ABSTRACT
The
advancements
in
early
stratification
and
timely
evaluation
of
therapeutic
effects
have
revolutionized
the
ability
to
assess
curative
outcomes
promptly.
separation
between
diagnosis/treatment
assessment
treatment
response,
along
with
delays
evaluating
therapy
efficacy,
are
significant
contributors
failures.
Traditional
approaches
for
face
challenges
posed
by
tumor
heterogeneity
resistance,
making
it
challenging
determine
effectiveness
a
given
regimen
at
an
stage
clinical
practice.
However,
molecular
imaging
using
activatable
probes
has
overcome
these
obstacles
transformed
field
shifting
focus
towards
developing
functional
visualizing
tumors
as
well
enabling
or
effects.
In
this
article,
we
emphasize
importance
diverse
provide
insights
into
various
therapies’
Finally,
discuss
faced
propose
future
research
directions.
Micromachines,
Год журнала:
2024,
Номер
15(3), С. 331 - 331
Опубликована: Фев. 28, 2024
Detecting
environmental
contaminants
is
crucial
for
protecting
ecosystems
and
human
health.
While
traditional
carbon
dot
(CD)
fluorescent
probes
are
versatile,
they
may
suffer
from
limitations
like
fluctuations
in
signal
intensity,
leading
to
detection
inaccuracies.
In
contrast,
ratiometric
probes,
designed
with
internal
self-calibration
mechanisms,
offer
enhanced
sensitivity
reliability.
This
review
focuses
on
the
design
applications
of
based
CDs
monitoring.
Our
discussion
covers
construction
strategies,
fluorescence
principles,
detecting
various
contaminants,
including
organic
pollutants,
heavy
metal
ions,
other
substances.
We
also
explore
associated
advantages
challenges
provide
insights
into
potential
solutions
future
research
directions.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Май 20, 2024
Abstract
The
creation
of
versatile
platforms
for
developing
dual‐channel
near‐infrared
fluorescent
(NIRF)
and
photoacoustic
(PA)
probes,
especially
those
engineered
to
minimize
channel
crosstalk,
is
crucial
precise
biomarker
detection.
However,
such
remain
scarce.
To
bridge
this
gap,
study
introduces
an
innovative
cyanine‐based
platform,
CySN
.
platform
showcases
remarkable
wavelength‐shifting
properties,
including
large
modality
shift
(68
nm)
PA
(145
after
the
decaging
reaction.
These
substantial
changes
lead
exceptionally
high
ratiometric
NIRF
change
603‐fold
261‐fold.
Leveraging
NIRF/PA
probes
have
been
successfully
developed
detecting
both
small
molecule
(H
2
O
)
enzyme
(esterase).
demonstrate
ability
detect
their
targets
through
detection
with
sensitivity
selectivity
in
vitro.
Furthermore,
effectively
harness
signals
image
target
analytes
living
cells.
Notably,
capability
accurately
diagnose
tumors
by
tumor
markers
esterase),
revealing
a
3.6
7‐fold
enhancement
over
normal
tissue.
Therefore,
holds
potential
further
advance
development
biomolecule
disease
diagnosis.
