Human REM sleep recalibrates neural activity in support of memory formation

Science Advances, Год журнала: 2023, Номер 9(34)

Опубликована: Авг. 25, 2023

The proposed mechanisms of sleep-dependent memory consolidation involve the overnight regulation neural activity at both synaptic and whole-network levels. Now, there is a lack in vivo data humans elucidating if, how, sleep its varied stages balance activity, if such recalibration benefits memory. We combined electrophysiology with two-photon calcium imaging rodents as well intracranial scalp electroencephalography (EEG) to reveal key role for non-oscillatory brain during rapid eye movement (REM) mediate population dynamics. extent this REM predicted success consolidation, expressly modulation hippocampal-neocortical favoring remembering rather than forgetting. findings describe mechanism how human modulates enhance long-term

Язык: Английский

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Combining aperiodic 1/f slopes and brain simulation: An EEG/MEG proxy marker of excitation/inhibition imbalance in Alzheimer's disease

Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring, Год журнала: 2023, Номер 15(3)

Опубликована: Июль 1, 2023

Accumulation and interaction of amyloid-beta (Aβ) tau proteins during progression Alzheimer's disease (AD) are shown to tilt neuronal circuits away from balanced excitation/inhibition (E/I). Current available techniques for noninvasive interrogation E/I in the intact human brain, example, magnetic resonance spectroscopy (MRS), highly restrictive (i.e., limited spatial extent), have low temporal resolution suffer ability distinguish accurately between different neurotransmitters complicating its interpretation. As such, these methods alone offer an incomplete explanation E/I. Recently, aperiodic component neural power spectrum, often referred literature as '1/f slope', has been described a promising scalable biomarker that can track disruptions potentially underlying spectrum clinical conditions, such autism, schizophrenia, or epilepsy, well developmental changes seen aging.

Язык: Английский

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Modulatory dynamics of periodic and aperiodic activity in respiration-brain coupling

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Авг. 5, 2023

Bodily rhythms such as respiration are increasingly acknowledged to modulate neural oscillations underlying human action, perception, and cognition. Conversely, the link between aperiodic brain activity - a non-oscillatory reflection of excitation-inhibition (E:I) balance has remained unstudied. Aiming disentangle potential respiration-related dynamics periodic activity, we applied recently developed algorithms time-resolved parameter estimation resting-state MEG EEG data from two labs (total N = 78 participants). We provide evidence that fluctuations (1/f slope) phase-locked respiratory cycle, which suggests spontaneous state shifts at least partly influenced by peripheral bodily signals. Moreover, differential temporal in their coupling oscillatory raise possibility functional distinction way each component is related respiration. Our findings highlight role physiological influence on signalling.

Язык: Английский

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Network state transitions during cortical development

Nature reviews. Neuroscience, Год журнала: 2024, Номер 25(8), С. 535 - 552

Опубликована: Май 23, 2024

Язык: Английский

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Developmental trajectories of EEG aperiodic and periodic components in children 2–44 months of age

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Июль 10, 2024

Abstract The development of neural circuits has long-lasting effects on brain function, yet our understanding early circuit in humans remains limited. Here, periodic EEG power features and aperiodic components were examined from longitudinal EEGs collected 592 healthy 2–44 month-old infants, revealing age-dependent nonlinear changes suggestive distinct milestones maturation. Developmental peaks include (1) the presence then absence a 9-10 Hz alpha peak between 2-6 months, (2) high beta (20-30 Hz) 4-18 (3) emergence low (12-20 some infants after six months age. We hypothesized that may reflect maturation thalamocortical network development. Infant anesthesia studies observe GABA-modulating anesthetics do not induce mediated frontal coherence until 10-12 Using small cohort ( n = 23) with before during anesthesia, we provide preliminary evidence have higher anesthesia-induced compared to those without peak.

Язык: Английский

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Resting state EEG in young children with Tuberous Sclerosis Complex: associations with medications and seizures

Journal of Neurodevelopmental Disorders, Год журнала: 2025, Номер 17(1)

Опубликована: Янв. 18, 2025

Tuberous Sclerosis Complex (TSC) is a rare genetic condition caused by mutation to TSC1 or TSC2 genes, with population prevalence of 1/7000 births. TSC manifests behaviorally features autism, epilepsy, and intellectual disability. Resting state electroencephalography (EEG) offers window into neural oscillatory activity may serve as an intermediate biomarker between gene expression behavioral manifestations. Such could be useful in clinical trials endpoint predictor treatment response. However, seizures antiepileptic medications also affect resting undermine the utility EEG biomarkers neurodevelopmental disorders such TSC. This paper compares cross-sectional cohort young children (n = 49, ages 12-37 months) 49 age- sex-matched typically developing controls. Within TSC, associations were examined features, seizure severity composite score, use GABA agonists. Compared matched children, showed significantly greater beta power permutation cluster analyses. Children aperiodic offset (reflecting nonoscillatory neuronal firing) after spectra parameterized using SpecParam periodic components. both GABAergic medication independently associated increased peak power. The elevated observed compared controls driven agonist use. It recommended collect data alongside for trials. These results highlight challenge disabilities when epilepsy anti-epileptic are common.

Язык: Английский

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The Age of Reason: Functional Brain Network Development during Childhood

Journal of Neuroscience, Год журнала: 2022, Номер 42(44), С. 8237 - 8251

Опубликована: Окт. 3, 2022

Human childhood is characterized by dramatic changes in the mind and brain. However, little known about large-scale intrinsic cortical network that occur during because of methodological challenges scanning young children. Here, we overcome this barrier using sophisticated acquisition analysis tools to investigate functional development children between ages 4 10 years ( n=92 ; 50 female, 42 male). At multiple spatial scales, age positively associated with brain segregation. system level, was segregation systems involved attention from those abstract cognition, integration among attentional perceptual systems. Associations connectivity are most pronounced visual medial prefrontal cortex, two ends a gradient perceptual, externally oriented cortex abstract, internally cortex. These findings suggest both sensory-association may develop early, contrast classical theories maturation proceeds back front, sensory areas developing first association last. More mature patterns architecture, controlling for age, were better visuospatial reasoning abilities. Our results as architecture becomes more specialized, become able reason world their place it. SIGNIFICANCE STATEMENT Anthropologists have called transition early middle “age reason”, when across cultures independent. We employ cutting-edge neuroimaging approaches associations childhood. Age process external phenomena like past, future, minds others. Surprisingly, observed at gradient, challenging theory open new directions research into how brains reorganize support rapid gains cognitive socioemotional skills reach reason.

Язык: Английский

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Reorganization of adolescent prefrontal cortex circuitry is required for mouse cognitive maturation

Neuron, Год журнала: 2023, Номер 112(3), С. 421 - 440.e7

Опубликована: Ноя. 17, 2023

Most cognitive functions involving the prefrontal cortex emerge during late development. Increasing evidence links this delayed maturation to protracted timeline of development, which likely does not reach full maturity before end adolescence. However, underlying mechanisms that drive emergence and fine-tuning abilities adolescence, caused by circuit wiring, are still unknown. Here, we continuously monitored activity throughout postnatal development mice showed an initial increase was interrupted extensive microglia-mediated breakdown activity, followed rewiring elements achieve adult-like patterns synchrony. Interfering with these processes but adulthood, led a long-lasting microglia-induced disruption neuronal morphology decreased abilities. These results identified nonlinear reorganization circuits adolescence revealed its importance for adult network function processing.

Язык: Английский

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Human neuronal excitation/inhibition balance explains and predicts neurostimulation induced learning benefits

PLoS Biology, Год журнала: 2023, Номер 21(8), С. e3002193 - e3002193

Опубликована: Авг. 31, 2023

Previous research has highlighted the role of excitation/inhibition (E/I) ratio for typical and atypical development, mental health, cognition, learning. Other benefits high-frequency transcranial random noise stimulation (tRNS)—an excitatory form neurostimulation—on We examined E/I as a potential mechanism studied whether tRNS effect on learning depends measured by aperiodic exponent its putative marker. In addition to manipulating using tRNS, we also manipulated level (learning/overlearning) that been shown influence E/I. Participants ( n = 102) received either sham or 20-minute over dorsolateral prefrontal cortex (DLPFC) during mathematical task. showed increased E/I, reflected exponent, lower predicted greater benefit from specifically contrast previous magnetic resonance spectroscopy (MRS)-based studies, found no A further analysis different data set suggest both measures (EEG versus MRS) may reflect, at least partly, biological mechanisms. Our results highlight marker neurostimulation efficacy This mechanistic understanding provides better opportunities augmented personalized interventions.

Язык: Английский

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Time-resolved correlation of distributed brain activity tracks E-I balance and accounts for diverse scale-free phenomena

Cell Reports, Год журнала: 2023, Номер 42(4), С. 112254 - 112254

Опубликована: Март 24, 2023

Much of systems neuroscience posits the functional importance brain activity patterns that lack natural scales sizes, durations, or frequencies. The field has developed prominent, and sometimes competing, explanations for nature this scale-free activity. Here, we reconcile these across species modalities. First, link estimates excitation-inhibition (E-I) balance with time-resolved correlation distributed Second, develop an unbiased method sampling time series constrained by correlation. Third, use to show E-I account diverse phenomena without need attribute additional function phenomena. Collectively, our results simplify existing provide stringent tests on future theories seek transcend explanations.

Язык: Английский

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