Senescence has been the focus of research for many centuries. Despite significant progress in extending average human life expectancy, the process of aging remains largely elusive and, unfortunately, inevitable. In this review, we attempted to summarize the current theories of aging and the approaches to understanding it.
Journal of Ayurveda and Integrative Medicine,
Год журнала:
2017,
Номер
9(3), С. 225 - 232
Опубликована: Дек. 21, 2017
Since
time
immemorial,
humanity
has
been
concerned
with
developing
and
preserving
youthful
vigor,
extending
longevity
by
stopping
or
delaying
the
aging
process.
By
2030,
one
in
five
of
world
population
will
be
over
65
years
old.
Longevity
old
age
are
accompanied
a
variety
health
challenges
studies
indicate
that
elderly
use
between
three
to
times
more
healthcare
services
compared
younger
population.
Modern
medicine
made
great
deal
progress
understanding
process
controlling
age-associated
issues
including
heart
attacks,
strokes,
diabetes,
cancer,
senility,
arthritis.
Thus,
every
individual
is
now
looking
forward
youthful,
productive
lifespan
100
filled
unlimited
opportunity.
Research
experts
focused
on
ways
go
against
natural
order
delay
it.
Interventions
include
among
other
things
anti-aging
pills,
restricted
food
consumption
cloning
body
parts
stay
young
biological
aging.
Ayurveda,
world's
most
authoritative
mind-body-spirit
medicinal
systems,
offers
various
concepts
This
system
includes
therapies
for
healthy
so
as
create
an
optimal
lengthen
individual's
healthspan
living
harmony
nature.
review
explore
aspects
comparing
science
defined
modern
Ayurvedic
treatise
Jara
Vriddhavastha.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(19), С. 11991 - 11991
Опубликована: Окт. 9, 2022
MOTS-c,
a
16
amino
acid
mitochondrial
derived
peptide,
is
encoded
from
the
12S
rRNA
region
of
genome.
Under
stress
conditions,
MOTS-c
translocates
to
nucleus
where
it
regulates
wide
range
genes
in
response
metabolic
dysfunction.
It
colocalized
mitochondria
various
tissues
and
found
plasma,
but
levels
decline
with
age.
Since
has
important
cellular
functions
as
well
possible
hormonal
role,
been
shown
have
beneficial
effects
on
age-related
diseases
including
Diabetes,
Cardiovascular
diseases,
Osteoporosis,
postmenopausal
obesity
Alzheimer.
Aging
characterized
by
gradual
loss
(mitochondrial)
balance,
decreased
muscle
homeostasis
eventual
diminished
physical
capability,
which
potentially
can
be
reversed
treatment.
This
review
examines
latest
findings
biological
nuclear
regulatory
peptide
focuses
role
aging
disorders,
mechanisms
action
therapeutic
potential.
Life,
Год журнала:
2023,
Номер
13(4), С. 1045 - 1045
Опубликована: Апрель 19, 2023
Keap1
(Kelch-like
ECH-associated
protein
1)
is
one
of
the
major
negative
regulators
transcription
factor
Nrf2
(nuclear
erythroid-2-related
2),
which
induces
expression
numerous
proteins
defending
cell
against
different
stress
conditions.
generally
negatively
regulated
by
post-translational
modification
(mostly
via
its
cysteine
residues)
and
interaction
with
other
that
compete
for
binding.
Cysteine
residues
in
have
effects
on
regulation,
as
basic
(Lys,
Arg,
His)
close
proximity
to
them
increase
potential.
In
this
paper,
we
present
an
evolutionary
analysis
involved
both
mechanisms
regulation
broader
context
KLHL
family
vertebrates.
We
identified
typical
domain
structure
several
outside
(namely
KBTBD
2,
3,
4,
6,
7,
8,
12
14).
found
cysteines
are
flanked
(namely,
C14,
C38,
C151,
C226,
C241,
C273,
C288,
C297,
C319,
C613)
and,
therefore,
may
be
considered
more
susceptible
regulatory
modification.
The
binding
site
completely
conserved
vertebrates
but
absent
or
located
nonaligned
DA
BC
loops
Kelch
within
family.
development
specific
substrate
regions
could
diversification
