The preservation of reproductive health of the population is an important factor of demographic policy of the state. According to some authors from 14 to 30% of couples of reproductive age suffer from infertility; male factor in such marriages is detected in more than half of the cases. As you know, in recent years there has been a significant deterioration in the main indicators of reproductive function of men. Increased the number of andrological diseases, morphological disorders of the male reproductive system, almost halved the production of sperm in men of reproductive age. The reason probably lies behind a whole …
International Journal of General Medicine,
Journal Year:
2022,
Volume and Issue:
Volume 15, P. 5985 - 5997
Published: July 1, 2022
Background:
Despite
the
evidence
of
declining
sperm
counts
worldwide
and
increasing
prevalence
male
infertility,
there
has
been
limited
documentation
potential
causes
risk
factors
for
infertility.
With
methods
primary
treatment
understanding
will
pinpoint
specific
lines
prevention.
Objective:
We
reviewed
published
studies
on
infertility
identify
gaps
in
literature
enabling
more
focused
research
innovations.
Design/Setting:
The
study
was
a
scoping
review.
review
included
scientific/academic
publications.
It
not
to
any
region
or
date.
following
databases
were
searched:
Cumulative
Index
Nursing
Allied
Health
Literature,
Wiley
online,
HINARI,
Science
Direct,
PubMed/Medline,
Google
Scholar,
African
Journals
Online,
WHO
Repository.
In
total,
1295
articles
identified.
After
removing
357
duplicates,
938
screened,
71
identified
inclusion,
while
60
met
inclusion
criteria.
Results:
Four
broad
1)
biological/physiological/genetic
causes,
2)
behavioral/lifestyle
factors,
3)
environmental
4)
socio-demographic
factors.
However,
no
substantive
results
actual
under
each
category
identified,
leaving
further
experimentation.
Conclusion:
indicate
knowledge
studies.
that
need
be
bridged
enable
fuller
highlighted.
Keywords:
review,
spermatozoa
defects
Journal of Dietary Supplements,
Journal Year:
2018,
Volume and Issue:
16(2), P. 245 - 256
Published: Feb. 16, 2018
The
objective
was
to
evaluate
the
effect
of
docosahexaenoic
acid
(DHA)
and
eicosapentaenoic
(EPA)
on
sperm
parameters
including
total
concentration,
motility,
DHA,
seminal
plasma
DHA
concentration
in
infertile
men.
literature
search
conducted
PubMed,
Google
Scholar,
Scopus
from
January
1,
1990
December
20,
2017.
systematic
review
meta-analysis
were
based
randomized
controlled
trials
men
with
or
EPA
treatments,
either
alone
combination
other
micronutrients.
Three
studies
met
inclusion
criteria:
147
patients
intervention
group
143
control
group.
analysis
showed
that
omega-3
treatments
significantly
increased
motility
(RR
5.82,
95%
CI
[2.91,
8.72],
p
<.
0001,
I2
=
76%)
1.61,
[0.15,
3.07],
=.
03,
98%).
Compared
controls,
interventions
did
not
affect
0.31,
[-8.13,
8.76],
94,
95%)
0.50,
[-4.17,
5.16],
83,
99%).
observed
heterogeneity
may
be
due
administration
period
dosage
fatty
acids
across
studies.
Funnel
plot
shows
no
evidence
publication
bias.
This
indicates
supplementing
resulted
a
significant
improvement
plasma.
BMC Medical Genetics,
Journal Year:
2018,
Volume and Issue:
19(1)
Published: April 16, 2018
Testis-expressed
gene
11
(TEX11)
is
an
X-linked
and
essential
for
meiotic
recombination
chromosomal
synapsis.
TEX11
deficiency
causes
arrest
male
infertility,
many
mutations
have
been
found
in
azoospermic
infertile
men.
This
study
reported
one
novel
mutation
(2653G
→
T,
exon
29,
GenBank
accession
number,
NM_031276)
two
brothers
with
azoospermia.
was
firstly
screened
out
by
whole-exome
sequencing
(WES)
further
verified
amplifying
the
specific
29.
Surprisingly,
same
exonic
missense
(W856C)
observed
but
not
their
mother.
Histological
analysis
of
testicular
biopsy
from
both
revealed
no
post-meiotic
round
spermatids
mature
spermatozoa
were
seminiferous
tubules.
expression
strongly
spermatogonia
weakly
spermatocytes,
Sertoli
cells
interstitial
cells.
We
identified
summarized
literature
regarding
infertility.
previous
indicate
that
are
closely
associated
especially
azoospermia,
although
auxiliary
clinical
analyses
needed
to
figure
Toxics,
Journal Year:
2023,
Volume and Issue:
11(4), P. 330 - 330
Published: March 30, 2023
Approximately
9%
of
couples
are
infertile,
with
half
these
cases
relating
to
male
factors.
While
many
infertility
associated
genetic
and
lifestyle
factors,
approximately
30%
still
idiopathic.
Contaminants
emerging
concern
(CECs)
denote
substances
identified
in
the
environment
for
first
time
or
detected
at
low
concentrations
during
water
quality
analysis.
Since
CEC
production
use
have
increased
recent
decades,
CECs
now
ubiquitous
surface
groundwater.
increasingly
observed
human
tissues,
parallel
reports
indicate
that
semen
is
continuously
declining,
supporting
notion
may
play
a
role
infertility.
This
narrative
review
focuses
on
several
(including
pesticides
pharmaceuticals)
nearshore
marine
False
Bay,
Cape
Town,
South
Africa,
deliberates
their
potential
effects
fertility
offspring
exposed
parents,
as
well
spermatozoa
toxicological
studies.
Collective
findings
report
chronic
vivo
exposure
pesticides,
including
atrazine,
simazine,
chlorpyrifos,
likely
be
detrimental
reproduction
organisms,
sperm
performance
vitro.
Similarly,
pharmaceuticals
such
diclofenac
naproxen
impairs
motility
both
These
contaminants
also
key
health
disease
sired
by
parents
CECs.
On
other
side
double-edged
sword,
we
propose
due
its
sensitivity
environmental
conditions,
could
used
bioindicator
eco-
repro-toxicology
American Journal of Men s Health,
Journal Year:
2025,
Volume and Issue:
19(1)
Published: Jan. 1, 2025
Variations
in
the
estrogen
receptor
genes,
particularly
Xba1
(rs9340799)
SNP
ESR1
gene,
may
influence
effects
of
on
male
fertility.
Results
from
previous
studies
this
for
infertility
have
been
inconclusive.
This
review
aimed
to
determine
association
with
infertility.
Relevant
case–control
published
English
were
searched
Google
Scholar,
Embase,
Scopus,
Web
Science,
Cochrane
Library,
and
PubMed
using
keywords
ESR,
polymorphism,
Studies
animals,
reviews,
abstracts
excluded.
Pooled
odds
ratios
(ORs)
calculated
four
genetic
models,
heterogeneity
assessed
by
I
2
.
A
fixed
or
random
effect
model
was
applied
based
,
trial
sequential
analysis
(TSA)
conducted
5%
significance
type
error
95%
power.
expression
levels
examined
testes,
hypothalamus,
prostate,
pituitary
GTEx
Analysis.
Nine
(four
Asian,
Caucasian,
one
African)
met
criteria.
The
G
allele
protective
against
overall
(OR:
0.80;
confidence
interval
[CI]
=
[0.70,
0.92])
Caucasian
men
0.71;
CI
[0.54,
0.92]).
Lower
risk
observed
Asian
(AA
vs.
GG
OR:
0.65;
[0.43,
0.98])
0.49;
[0.28,
0.83]).
TSA
indicated
no
further
are
likely
change
these
results.
No
significant
due
SNP.
present
meta-analysis
suggests
that
is
infertility,
current
data
sufficient
confirm
findings.
Journal of Human Reproductive Sciences,
Journal Year:
2019,
Volume and Issue:
12(3), P. 199 - 199
Published: Jan. 1, 2019
Context:
Male
infertility
is
a
medical
problem,
attributed
to
50%
of
infertility.
Seminal
plasma
can
be
an
anticipating
factor
as
it
comprises
secretions
accessory
sex
gland,
thus
offering
novel
and
precise
ways
understand
potential
roles
these
biochemical
markers
in
male
Aim:
The
objective
this
study
was
assess
the
correlation
between
sperm
parameters
envisaging
Subjects
Design:
We
enlisted
105
men
with
fertility
issue
patients
25
fertile
controls
evaluate
markers,
namely
fructose
citric
acid
ascertaining
Materials
Methods:
semen
samples
from
were
collected
properly
analyzed
according
World
Health
Organization-2010
manual.
Later
centrifuged,
seminal
collected,
assessment
carried
out
by
standard
protocols.
Statistics:
Descriptive
statistics,
independent
t-test,
one-way
ANOVA,
Pearson
used
for
statistical
analysis
different
variables
using
SPSS
20.0.
mean
count
motility
all
infertile
conditions
displayed
significant
difference
when
compared
(P
<
0.05).
Results:
levels
oligozoospermia
showed
nonsignificance
Asthenozoospermia,
asthenoteratozoospermia,
azoospermia
had
significance
0.05)
levels.
coefficient
negative
(r
=
−0.564)
−0.574)
Whereas
concentration
positive
0.458)
0.446).
Conclusion:
Therefore,
evaluation
certain
fluid
may
benefit
understanding
functionality
glands
which
subsidizes
significantly
volume.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(3), P. 1945 - 1945
Published: Jan. 18, 2023
The
cryopreservation
of
spermatogonia
stem
cells
(SSCs)
has
been
widely
used
as
an
alternative
treatment
for
infertility.
However,
itself
induces
cryoinjury
due
to
oxidative
and
osmotic
stress,
leading
reduction
in
the
survival
rate
functionality
SSCs.
Glial-derived
neurotrophic
factor
family
receptor
alpha
1
(GFRα1)
promyelocytic
leukemia
zinc
finger
(PLZF)
are
expressed
during
self-renewal
differentiation
SSCs,
making
them
key
tools
identifying
To
best
our
knowledge,
involvement
GFRα1
PLZF
determining
SSCs
after
with
therapeutic
intervention
is
limited.
Therefore,
purpose
this
review
determine
role
biomarkers
evaluating
intervention.
Therapeutic
intervention,
such
use
antioxidants,
enhancement
protocols,
cell
encapsulation,
cryoprotectant
agents
(CPA),
equilibrium
time
temperature
increase
expression
PLZF,
resulting
maintaining
In
conclusion,
have
potential
ensure
cells.
